[go: up one dir, main page]

DK3346008T3 - Rekombinante mikroorganismer og anvendelser deraf - Google Patents

Rekombinante mikroorganismer og anvendelser deraf Download PDF

Info

Publication number
DK3346008T3
DK3346008T3 DK18156987.2T DK18156987T DK3346008T3 DK 3346008 T3 DK3346008 T3 DK 3346008T3 DK 18156987 T DK18156987 T DK 18156987T DK 3346008 T3 DK3346008 T3 DK 3346008T3
Authority
DK
Denmark
Prior art keywords
recombinant microorganisms
microorganisms
recombinant
Prior art date
Application number
DK18156987.2T
Other languages
English (en)
Inventor
Wendy Chen
Fungmin Liew
Michael Koepke
Original Assignee
Lanzatech New Zealand Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49670710&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3346008(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lanzatech New Zealand Ltd filed Critical Lanzatech New Zealand Ltd
Application granted granted Critical
Publication of DK3346008T3 publication Critical patent/DK3346008T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1229—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01088—Hydroxymethylglutaryl-CoA reductase (1.1.1.88)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01267—1-Deoxy-D-xylulose-5-phosphate reductoisomerase (1.1.1.267)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
    • C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
    • C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01007—1-Deoxy-D-xylulose-5-phosphate synthase (2.2.1.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01009—Acetyl-CoA C-acetyltransferase (2.3.1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
    • C12Y203/0301—Hydroxymethylglutaryl-CoA synthase (2.3.3.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/0101—(2E,6E)-Farnesyl diphosphate synthase (2.5.1.10), i.e. geranyltranstransferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/0109—All-trans-octaprenyl-diphosphate synthase (2.5.1.90)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01036—Mevalonate kinase (2.7.1.36)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01148—4-(Cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase (2.7.1.148)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/04—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C12Y207/04002—Phosphomevalonate kinase (2.7.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/0706—2-C-Methyl-D-erythritol 4-phosphate cytidylyltransferase (2.7.7.60)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01033—Diphosphomevalonate decarboxylase (4.1.1.33), i.e. mevalonate-pyrophosphate decarboxylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03027—Isoprene synthase (4.2.3.27)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03046—Alpha-farnesene synthase (4.2.3.46)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y406/00—Phosphorus-oxygen lyases (4.6)
    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
    • C12Y406/01012—2-C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (4.6.1.12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/03—Intramolecular oxidoreductases (5.3) transposing C=C bonds (5.3.3)
    • C12Y503/03002—Isopentenyl-diphosphate DELTA-isomerase (5.3.3.2)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK18156987.2T 2012-06-01 2013-06-04 Rekombinante mikroorganismer og anvendelser deraf DK3346008T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261654412P 2012-06-01 2012-06-01
EP13797982.9A EP2855662B1 (en) 2012-06-01 2013-06-04 Recombinant microorganisms and uses therefor

Publications (1)

Publication Number Publication Date
DK3346008T3 true DK3346008T3 (da) 2021-01-11

Family

ID=49670710

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18156987.2T DK3346008T3 (da) 2012-06-01 2013-06-04 Rekombinante mikroorganismer og anvendelser deraf
DK13797982.9T DK2855662T3 (da) 2012-06-01 2013-06-04 Rekombinante mikroorganismer og anvendelser deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK13797982.9T DK2855662T3 (da) 2012-06-01 2013-06-04 Rekombinante mikroorganismer og anvendelser deraf

Country Status (10)

Country Link
US (5) US20130323820A1 (da)
EP (3) EP3346008B1 (da)
JP (2) JP6643083B2 (da)
CN (3) CN111304260A (da)
DK (2) DK3346008T3 (da)
EA (1) EA028892B1 (da)
ES (2) ES2841725T3 (da)
IN (1) IN2014DN10236A (da)
PL (2) PL3346008T3 (da)
WO (1) WO2013180584A1 (da)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130323820A1 (en) 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
CA2886137C (en) 2012-10-23 2021-10-19 Sekisui Chemical Co., Ltd. Recombinant cell, and method for producing isoprene
RU2013146377A (ru) * 2013-10-17 2015-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") СПОСОБ ПОЛУЧЕНИЯ ИЗОПРЕНА С ИСПОЛЬЗОВАНИЕМ БАКТЕРИИ РОДА Bacillus
CA2936251C (en) 2014-01-28 2017-11-07 Lanzatech New Zealand Limited Method of producing a recombinant microorganism
EA036071B1 (ru) 2014-01-30 2020-09-22 Ланцатек Нью Зилэнд Лимитед Рекомбинантные карбокситрофные ацетогенные бактерии и способ получения продуктов при их культивировании
JP6325862B2 (ja) * 2014-03-25 2018-05-16 積水化学工業株式会社 組換え細胞、並びに、環式モノテルペンの生産方法
JP2016059313A (ja) * 2014-09-17 2016-04-25 積水化学工業株式会社 組換え細胞、並びに、イソプレン又は環式イソプレノイドの生産方法
CN107002012B (zh) 2014-10-22 2019-04-26 朗泽科技新西兰有限公司 多阶段生物反应器方法
JP2017531441A (ja) 2014-10-22 2017-10-26 ランザテク・ニュージーランド・リミテッド ガス試験装置及び方法
CN107002028A (zh) * 2014-12-08 2017-08-01 朗泽科技新西兰有限公司 呈现通过发酵路径的增大的通量的重组微生物
WO2016138050A1 (en) 2015-02-23 2016-09-01 Lanzatech New Zealand Limited Recombinant acetogenic bacterium for the conversion of methane to products
DE102015103608A1 (de) * 2015-03-11 2016-09-15 Basf Se Verfahren zur mikrobiellen de novo Synthese von Terpenen
WO2017029553A2 (en) 2015-08-17 2017-02-23 Conradie Alex Van Eck Methods, cells and reagents for production of isoprene, derivatives and intermediates thereof
US20170145441A1 (en) 2015-08-17 2017-05-25 INVISTA North America S.à.r.l. Methods, hosts, and reagents related thereto for production of unsaturated pentahydrocarbons, derivatives and intermediates thereof
CA3151149C (en) 2015-10-13 2024-03-26 Lanzatech Nz, Inc. Genetically engineered bacterium comprising energy-generating fermentation pathway
WO2017094053A1 (ja) * 2015-11-30 2017-06-08 積水化学工業株式会社 組換え細胞、組換え細胞の製造方法、並びに、有機化合物の生産方法
DK3384005T3 (da) * 2015-12-03 2022-04-11 Lanzatech Nz Inc Arginin som eneste nitrogenkilde til C1-fikserende mikroorganisme
US10358661B2 (en) 2015-12-28 2019-07-23 Lanzatech New Zealand Limited Microorganism with modified hydrogenase activity
ES2955708T3 (es) 2016-02-01 2023-12-05 Lanzatech Nz Inc Proceso integrado de fermentación y electrólisis
AU2017222688B2 (en) 2016-02-26 2023-05-25 Lanzatech Nz, Inc. CRISPR/Cas systems for C-1 fixing bacteria
US10294498B2 (en) 2016-05-14 2019-05-21 Lanzatech, Inc. Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods
US20190233854A1 (en) * 2016-10-13 2019-08-01 Sekisui Chemical Co., Ltd. Obligately anaerobic acetic acid-producing microorganism, and recombinant microorganism
KR102000755B1 (ko) * 2016-12-27 2019-07-17 한국과학기술원 외부 유전자가 도입된 재조합 미생물 및 상기 미생물을 이용하여 개미산과 이산화탄소로부터 유용물질을 제조하는 방법
GB201701548D0 (en) * 2017-01-31 2017-03-15 Univ Manchester Process for producing monoterpenes
CN117402799A (zh) 2017-02-27 2024-01-16 积水化学工业株式会社 重组细胞、重组细胞的制备方法以及异戊二烯或萜烯的生产方法
WO2019006255A1 (en) 2017-06-30 2019-01-03 Invista North America S.A.R.L. METHODS, MATERIALS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS AND DERIVATIVES
WO2019006257A1 (en) * 2017-06-30 2019-01-03 Invista North America .S.A.R.L. METHODS, SYNTHETIC HOSTS AND REAGENTS FOR HYDROCARBON BIOSYNTHESIS
WO2019051069A1 (en) 2017-09-08 2019-03-14 Lanzatech, Inc. METHODS AND SYSTEMS FOR PRODUCING METABOLITES USING SUBSTRATES CONTAINING C1 COMPOUNDS RICH IN HYDROGEN
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
CN109722404B (zh) * 2017-10-30 2021-03-12 中国石油化工股份有限公司 利用纤维素制备金合欢烯的工程菌株及方法
JP2021505154A (ja) 2017-12-07 2021-02-18 ザイマージェン インコーポレイテッド 発酵によって（６ｅ）−８−ヒドロキシゲラニオールを生産するための設計された生合成経路
CN111936631A (zh) 2017-12-19 2020-11-13 朗泽科技有限公司 用于生物产生乙二醇的微生物和方法
WO2019126778A1 (en) 2017-12-21 2019-06-27 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
WO2019157507A1 (en) 2018-02-12 2019-08-15 Lanzatech, Inc. A process for improving carbon conversion efficiency
KR102122898B1 (ko) * 2018-02-26 2020-06-15 주식회사 엠디헬스케어 블라우티아 속 세균 유래 나노소포 및 이의 용도
AU2019257224B2 (en) 2018-04-20 2024-12-19 Lanzatech, Inc. Intermittent electrolysis streams
KR102549843B1 (ko) 2018-11-19 2023-06-29 란자테크, 인크. 발효와 가스화의 통합
BR112021015449A2 (pt) 2019-02-08 2021-10-05 Lanzatech, Inc. Métodos para recuperar produto a partir de um caldo de fermentação e para recuperar produto a partir de uma corrente enriquecida com produto
CN109666683B (zh) * 2019-02-27 2021-10-29 昆明理工大学 乙酰辅酶A乙酰转移酶基因RKAcaT2及其应用
BR112021018090A2 (pt) 2019-03-20 2021-11-23 Global Bioenergies Organismo ou micro-organismo recombinante, uso do organismo ou micro-organismo recombinante e método para a produção de isobuteno
CN109777815B (zh) * 2019-03-28 2021-10-29 昆明理工大学 HMG-CoA合成酶基因RKHMGCS及其应用
EP3997235A4 (en) 2019-07-11 2024-05-08 Lanzatech, Inc. PROCESS FOR OPTIMIZING GAS USE
CN110702821B (zh) * 2019-11-26 2022-06-07 四川大学华西医院 一种慢性阻塞性肺疾病分型检测试剂盒
WO2021165229A1 (en) 2020-02-17 2021-08-26 Scientist Of Fortune S.A. Method for the incorporation of formaldehyde into biomass
US11932818B2 (en) 2020-03-16 2024-03-19 Lanzatech, Inc. Tail gas of gas fermentation to dry gasification feedstock
AU2021237368B2 (en) 2020-03-18 2025-05-08 Lanzatech, Inc. Fermentative production of 2-phenylethanol from gaseous substrates
WO2021222265A1 (en) 2020-04-29 2021-11-04 Lanzatech, Inc. FERMENTATIVE PRODUCTION OF β-KETOADIPATE FROM GASEOUS SUBSTRATES
US11760989B2 (en) 2020-06-06 2023-09-19 Lanzatech, Inc. Microorganism with knock-in at acetolactate decarboxylase gene locus
CN116348603B (zh) 2021-02-08 2024-07-02 朗泽科技有限公司 重组微生物及其用途
CN115181803B (zh) * 2021-04-07 2025-03-21 暨南大学 检测多子小瓜虫的Taqman探针qPCR检测引物组和应用
CN117098850A (zh) 2021-04-09 2023-11-21 朗泽科技有限公司 用于提供原料的方法和设备
WO2023004293A1 (en) 2021-07-20 2023-01-26 Lanzatech, Inc. Recombinant microorganisms and uses therefor
TW202307202A (zh) 2021-08-06 2023-02-16 美商朗澤科技有限公司 用於改良乙二醇之生物產生的微生物及方法
EP4144838A1 (en) 2021-09-06 2023-03-08 Global Bioenergies Organisms producing less crotonic acid
WO2023031482A1 (en) 2021-09-06 2023-03-09 Global Bioenergies Organisms producing less crotonic acid
US12091648B2 (en) 2021-11-03 2024-09-17 Lanzatech, Inc. System and method for generating bubbles in a vessel
US12280331B2 (en) 2022-04-29 2025-04-22 Lanzatech, Inc. Low residence time gas separator
US12077800B2 (en) 2022-06-16 2024-09-03 Lanzatech, Inc. Liquid distributor system and process of liquid distribution
AU2023286621A1 (en) 2022-06-21 2025-01-09 Lanzatech, Inc. Microorganisms and methods for the continuous co-production of tandem repeat proteins and chemical products from c1-substrates
WO2023250389A1 (en) 2022-06-21 2023-12-28 Lanzatech, Inc. Microorganisms and methods for the continuous co-production of high-value, specialized proteins and chemical products from c1-substrates
US12129503B2 (en) 2022-08-10 2024-10-29 Lanzatech, Inc. Carbon sequestration in soils with production of chemical products
US12281344B2 (en) 2023-06-05 2025-04-22 Lanzatech, Inc. Integrated gas fermentation
US12359224B2 (en) 2023-06-05 2025-07-15 Lanzatech, Inc. Integrated gas fermentation and carbon black processes
CN119876212A (zh) * 2025-03-25 2025-04-25 江西农业大学 一种瘤胃丁酸弧菌RnfC蛋白的原核表达纯化方法

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2002A (en) 1841-03-12 Tor and planter for plowing
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
US5593886A (en) 1992-10-30 1997-01-14 Gaddy; James L. Clostridium stain which produces acetic acid from waste gases
EP2305825B1 (en) * 1998-07-06 2015-01-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
UA72220C2 (uk) 1998-09-08 2005-02-15 Байоенджініерінг Рісорсиз, Інк. Незмішувана з водою суміш розчинник/співрозчинник для екстрагування оцтової кислоти, спосіб одержання оцтової кислоти (варіанти), спосіб анаеробного мікробного бродіння для одержання оцтової кислоти (варіанти), модифікований розчинник та спосіб його одержання
JP4883872B2 (ja) 2000-07-25 2012-02-22 エモース・フアンデーシヨン・インコーポレーテツド 微生物発酵によるエタノール生産を向上させる方法
JP4280627B2 (ja) * 2001-06-06 2009-06-17 ディーエスエム アイピー アセッツ ビー．ブイ． 改善されたイソプレノイド産生法
NZ546496A (en) 2006-04-07 2008-09-26 Lanzatech New Zealand Ltd Gas treatment process
WO2007136847A2 (en) * 2006-05-19 2007-11-29 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
US7704723B2 (en) 2006-08-31 2010-04-27 The Board Of Regents For Oklahoma State University Isolation and characterization of novel clostridial species
DK2066778T3 (da) * 2006-09-26 2016-04-18 Amyris Biotechnologies Inc Fremstilling af isoprenoider og isoprenoid-prækursorer
NZ553984A (en) 2007-03-19 2009-07-31 Lanzatech New Zealand Ltd Alcohol production process
EP2152854A2 (en) * 2007-05-01 2010-02-17 Acidophil LLC Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism
US20090082495A1 (en) * 2007-09-20 2009-03-26 Rene Jean Zimmer Pneumatic Tire
EP2217711B2 (en) * 2007-09-20 2025-04-23 Amyris, Inc. Production of isoprenoids
US8222013B2 (en) 2007-11-13 2012-07-17 Lanzatech New Zealand Limited Bacteria and methods of use thereof
RU2545699C2 (ru) * 2007-12-13 2015-04-10 ДАНИСКО ЮЭс ИНК. Композиции и способы получения изопрена
WO2009094485A1 (en) * 2008-01-22 2009-07-30 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
EP2706111A1 (en) * 2008-03-03 2014-03-12 Joule Unlimited Technologies, Inc. Engineered CO2 fixing microorganisms producing carbon-based products of interest
US20110144393A1 (en) 2008-06-09 2011-06-16 Lanza Tech New Zealand Limited Production of butanediol by anaerobic microbial fermentation
US8481286B2 (en) * 2008-08-12 2013-07-09 Allylix, Inc. Method for production of isoprenoid compounds
MY161071A (en) * 2008-12-30 2017-04-14 Danisco Us Inc Methods of producing isoprene and a co-product
TWI427149B (zh) * 2009-06-17 2014-02-21 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
US8759047B2 (en) * 2009-09-16 2014-06-24 Coskata, Inc. Process for fermentation of syngas from indirect gasification
CN102686734A (zh) 2009-12-22 2012-09-19 环球生物能源股份有限公司 使用二磷酸甲羟戊酸脱羧酶从甲羟戊酸生产3-甲基丁-3-烯-1-醇的方法
CN102791869B (zh) 2010-03-10 2015-08-19 朗泽科技新西兰有限公司 通过发酵的酸产生
US8143037B2 (en) 2010-03-19 2012-03-27 Coskata, Inc. Ethanologenic Clostridium species, Clostridium coskatii
CN103025688A (zh) * 2010-06-17 2013-04-03 丹尼斯科美国公司 包含异戊二烯衍生物的燃料组合物
US8987431B2 (en) * 2010-07-01 2015-03-24 Coskata, Inc. Essential genes encoding conserved metabolic pathway function in autotrophic solventogenic clostridial species
EP2598630B1 (en) 2010-07-28 2015-11-25 Lanzatech New Zealand Limited Novel bacteria and methods of use thereof
CA2807558A1 (en) * 2010-08-06 2012-02-09 Danisco Us Inc. Production of isoprene under neutral ph conditions
EP2606138A2 (en) 2010-08-19 2013-06-26 Lanzatech New Zealand Limited A process for producing chemicals using microbial fermentation of substrates comprising carbon monoxide
US20130157322A1 (en) 2010-08-26 2013-06-20 Lanzatech New Zealand Limited Process for producing ethanol and ethylene via fermentation
US8759070B2 (en) * 2010-09-10 2014-06-24 University Of Delaware Recombinant clostridia that fix CO2 and CO and uses thereof
US20110236941A1 (en) 2010-10-22 2011-09-29 Lanzatech New Zealand Limited Recombinant microorganism and methods of production thereof
US20110256600A1 (en) * 2011-02-02 2011-10-20 Lanzatech New Zealand Limited Recombinant Microorganisms and Methods of Use Thereof
JP6199747B2 (ja) 2011-02-25 2017-09-20 ランザテク・ニュージーランド・リミテッド 組換え微生物およびそれらの使用
US20130122562A1 (en) 2011-08-04 2013-05-16 Danisco Us Inc. Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase
AU2012305021B2 (en) 2011-09-08 2016-06-09 Lanzatech Nz, Inc. A fermentation process
EP2764108A2 (en) * 2011-10-07 2014-08-13 Danisco US Inc. Methods for increasing microbial production of isoprene, isoprenoids, and isoprenoid precursor molecules using glucose and acetate co-metabolism
AU2012332996A1 (en) 2011-10-07 2014-04-24 Danisco Us Inc. Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
EP2766492B1 (en) 2011-10-11 2018-06-06 Metabolic Explorer Fermentative production of prenol
US9994878B2 (en) 2012-05-30 2018-06-12 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
WO2013181647A2 (en) * 2012-06-01 2013-12-05 Danisco Us Inc. Compositions and methods of producing isoprene and/or industrrial bio-products using anaerobic microorganisms
US20130323820A1 (en) * 2012-06-01 2013-12-05 Lanzatech New Zealand Limited Recombinant microorganisms and uses therefor
CN113186144A (zh) 2012-06-08 2021-07-30 朗泽科技新西兰有限公司 重组微生物和其用途
US9347076B2 (en) 2012-06-21 2016-05-24 Lanzatech New Zealand Limited Recombinant microorganisms that make biodiesel
SG11201501254RA (en) 2012-08-28 2015-03-30 Lanzatech New Zealand Ltd Recombinant microorganisms and uses therefor
WO2015081331A1 (en) 2013-11-29 2015-06-04 Lanzatech New Zealand Limited Methods and systems for improving fermentation efficiency
CN107002028A (zh) 2014-12-08 2017-08-01 朗泽科技新西兰有限公司 呈现通过发酵路径的增大的通量的重组微生物
CA3151149C (en) 2015-10-13 2024-03-26 Lanzatech Nz, Inc. Genetically engineered bacterium comprising energy-generating fermentation pathway
US11046978B2 (en) 2016-03-16 2021-06-29 William Marsh Rice University Synthesis of isoprenoids and derivatives
CN111936631A (zh) 2017-12-19 2020-11-13 朗泽科技有限公司 用于生物产生乙二醇的微生物和方法

Also Published As

Publication number Publication date
EP2855662B1 (en) 2018-03-21
DK2855662T3 (da) 2018-06-25
JP2015519065A (ja) 2015-07-09
EP2855662A4 (en) 2015-12-30
US20130323820A1 (en) 2013-12-05
WO2013180584A1 (en) 2013-12-05
CN111304260A (zh) 2020-06-19
EP3346008A1 (en) 2018-07-11
CN104822823B8 (zh) 2020-05-22
EP2855662A1 (en) 2015-04-08
US20150191747A1 (en) 2015-07-09
CN104822823B (zh) 2020-02-14
JP6636550B2 (ja) 2020-01-29
CN104822823A (zh) 2015-08-05
ES2674984T3 (es) 2018-07-05
US20180142265A1 (en) 2018-05-24
ES2841725T3 (es) 2021-07-09
US12286660B2 (en) 2025-04-29
EA201492206A1 (ru) 2015-09-30
EA028892B1 (ru) 2018-01-31
CN111218418A (zh) 2020-06-02
PL2855662T3 (pl) 2018-08-31
EP3346008B1 (en) 2020-10-07
EP3795680A1 (en) 2021-03-24
US20210062229A1 (en) 2021-03-04
US11459589B2 (en) 2022-10-04
PL3346008T3 (pl) 2021-04-19
US10913958B2 (en) 2021-02-09
US20230013524A1 (en) 2023-01-19
IN2014DN10236A (da) 2015-08-07
JP6643083B2 (ja) 2020-02-12
JP2018110584A (ja) 2018-07-19

Similar Documents

Publication Publication Date Title
DK3346008T3 (da) Rekombinante mikroorganismer og anvendelser deraf
DK2920313T3 (da) Rekombinante adenovira og anvendelse deraf
DK2920197T3 (da) Prolinlåste sammenhæftede peptider og anvendelser deraf
DK2850202T3 (da) Fremgangsmåder og grupper
DK2914291T3 (da) Anti-komplement-c1s-antistoffer og anvendelser deraf
DK3597644T3 (da) Kationiske aminlipider og anvendelser deraf
SG11201501254RA (en) Recombinant microorganisms and uses therefor
DK2855736T3 (da) Elektrolysator og energisystem
DK3363902T3 (da) Crispr-baseret genommodifikation og -regulering
BR112013021524A2 (pt) micro-organismos recombinantes e usos dos mesmos
BR112015003227A2 (pt) processos de clicoconjugação e composições
DK3293183T3 (da) Hæmmerforbindelser
DK3415157T3 (da) N-acyldipeptidderivater og anvendelser deraf
IL232262A (en) Therapeutic agents and uses thereof
EP2818054A4 (en) METHOD FOR COOKING STEAM NOODLES AND DEVICE FOR COOKING STEAM NOODLES
DK3453723T3 (da) Anti-ASIC1-antistoffer og anvendelser deraf
EP2879794A4 (en) CELL CULTURE
DK2745849T3 (da) Polydeoxyribonukleotidsammensætning og anvendelser deraf
DK3326642T3 (da) Langtidsvirkende koagulationsfaktorer og brugen deraf
DK2917181T3 (da) Heteroarylderivater og anvendelser deraf
IL237926A0 (en) Combinations and their uses
FR2988733B1 (fr) Microorganisme recombinant
CL2014002030A1 (es) Alfa-amilasa
DK2704744T3 (da) Komplementfaktor-b-analoger og anvendelser deraf
EP2842163A4 (en) NONLINEAR MEMRISTORS