DK3107993T3 - Rekombinante mikroorganismer til forbedret fremstilling af mevalonat, isopren, isoprenoide forløbere, isoprenoider og acetyl-coa-afledte produkter - Google Patents
Rekombinante mikroorganismer til forbedret fremstilling af mevalonat, isopren, isoprenoide forløbere, isoprenoider og acetyl-coa-afledte produkter Download PDFInfo
- Publication number
- DK3107993T3 DK3107993T3 DK15708996.2T DK15708996T DK3107993T3 DK 3107993 T3 DK3107993 T3 DK 3107993T3 DK 15708996 T DK15708996 T DK 15708996T DK 3107993 T3 DK3107993 T3 DK 3107993T3
- Authority
- DK
- Denmark
- Prior art keywords
- derivated
- isoprenoids
- mevalonate
- isoprenoid
- coa
- Prior art date
Links
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 title 2
- 150000003505 terpenes Chemical class 0.000 title 2
- KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 title 1
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 0 CC(C)(**)C1CCCCC1 Chemical compound CC(C)(**)C1CCCCC1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461942546P | 2014-02-20 | 2014-02-20 | |
| PCT/US2015/016954 WO2015127305A2 (en) | 2014-02-20 | 2015-02-20 | Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-coa-derived products |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3107993T3 true DK3107993T3 (da) | 2020-11-23 |
Family
ID=52633654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15708996.2T DK3107993T3 (da) | 2014-02-20 | 2015-02-20 | Rekombinante mikroorganismer til forbedret fremstilling af mevalonat, isopren, isoprenoide forløbere, isoprenoider og acetyl-coa-afledte produkter |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10648004B2 (da) |
| EP (1) | EP3107993B1 (da) |
| JP (1) | JP6744819B2 (da) |
| BR (1) | BR112016018774A2 (da) |
| DK (1) | DK3107993T3 (da) |
| WO (1) | WO2015127305A2 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3107993B1 (en) | 2014-02-20 | 2020-08-26 | Danisco US Inc. | Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-coa-derived products |
| WO2018111792A1 (en) * | 2016-12-16 | 2018-06-21 | Danisco Us Inc. | Bifunctional phosphoketolase-phosphotransacetylase fusion polypeptides |
| WO2018136425A1 (en) * | 2017-01-17 | 2018-07-26 | White Dog Labs, Inc. | Proteinic biomass preparation comprising a non-native organism of the clostridia class |
| JP2021505154A (ja) | 2017-12-07 | 2021-02-18 | ザイマージェン インコーポレイテッド | 発酵によって（６ｅ）−８−ヒドロキシゲラニオールを生産するための設計された生合成経路 |
| WO2019126778A1 (en) | 2017-12-21 | 2019-06-27 | Zymergen Inc. | Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone |
| WO2019165418A1 (en) * | 2018-02-26 | 2019-08-29 | William Marsh Rice University | Improved acetyl-coa-derived biosynthesis |
| CN112041455A (zh) * | 2018-04-27 | 2020-12-04 | 长濑产业株式会社 | 景天庚酮糖的制备方法 |
| CN109486720B (zh) * | 2018-12-18 | 2020-08-04 | 江南大学 | 一种产l-木酮糖的枯草芽孢杆菌及其应用 |
| JP6917434B2 (ja) * | 2019-10-25 | 2021-08-11 | 長瀬産業株式会社 | 好気性菌の代謝酵素破壊株およびその培養法 |
| CN111607546B (zh) * | 2020-04-30 | 2022-08-09 | 中国科学院青岛生物能源与过程研究所 | 一种高产法尼烯的基因工程菌及其构建方法与应用 |
| US20250320529A1 (en) * | 2021-07-12 | 2025-10-16 | Danisco Us Inc. | Recombinant yeast cell |
| KR102572850B1 (ko) * | 2022-07-11 | 2023-08-31 | 대상 주식회사 | L-글루탐산을 생산하는 코리네박테리움 속 변이 미생물 및 이를 이용한 l-글루탐산의 생산 방법 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19629568C1 (de) | 1996-07-15 | 1998-01-08 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Isopren |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| JPWO2003095651A1 (ja) | 2002-05-10 | 2005-09-15 | 協和醗酵工業株式会社 | メバロン酸の製造方法 |
| US7531337B2 (en) * | 2002-06-07 | 2009-05-12 | Wisconsin Alumni Research Foundation | Method of controlling acetylation of metabolic enzymes |
| BR0314498A (pt) | 2002-10-04 | 2005-08-16 | Du Pont | Linhagens de e. coli e método para a bioprodução de 1,3-propanodiol |
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| WO2007024718A2 (en) * | 2005-08-19 | 2007-03-01 | The Regents Of The University Of California | Genetically modified host cells and use of same for producing isoprenoid compounds |
| DK2024504T4 (da) | 2006-05-26 | 2023-02-27 | Amyris Inc | Fremstilling af isoprenoider |
| JP4986547B2 (ja) | 2006-09-04 | 2012-07-25 | 株式会社Ａｄｅｋａ | 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法 |
| RU2545699C2 (ru) | 2007-12-13 | 2015-04-10 | ДАНИСКО ЮЭс ИНК. | Композиции и способы получения изопрена |
| WO2009100231A2 (en) | 2008-02-06 | 2009-08-13 | The Regents Of The University Of California | Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi |
| CA2719923A1 (en) * | 2008-04-08 | 2009-10-15 | Amyris Biotechnologies, Inc. | Expression of heterologous sequences |
| RU2516343C2 (ru) | 2008-04-23 | 2014-05-20 | ДАНИСКО ЮЭс ИНК. | Варианты изопренсинтазы, применяемые для улучшения продуцирования изопрена микроорганизмами |
| US7632995B2 (en) | 2008-05-09 | 2009-12-15 | Monsanto Technology Llc | Plants and seeds of hybrid corn variety CH852179 |
| EP2310490B1 (en) | 2008-07-02 | 2019-01-02 | Danisco US Inc. | Methods for producing isoprene |
| HU3516U (en) | 2008-07-31 | 2008-11-28 | Zoltan Kuthi | Anti-theft protection of draining for fuel tanks |
| SG169652A1 (en) | 2008-09-15 | 2011-04-29 | Danisco Us Inc | Reduction of carbon dioxide emission during isoprene production by fermentation |
| US8476049B2 (en) | 2008-09-15 | 2013-07-02 | Danisco Us Inc. | Conversion of prenyl derivatives to isoprene |
| WO2010031077A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
| US8569026B2 (en) | 2008-09-15 | 2013-10-29 | Danisco Us Inc. | Systems using cell culture for production of isoprene |
| US8361762B2 (en) | 2008-09-15 | 2013-01-29 | Danisco Us Inc. | Increased isoprene production using the archaeal lower mevalonate pathway |
| MY161071A (en) | 2008-12-30 | 2017-04-14 | Danisco Us Inc | Methods of producing isoprene and a co-product |
| US20100297749A1 (en) | 2009-04-21 | 2010-11-25 | Sapphire Energy, Inc. | Methods and systems for biofuel production |
| CN102656265A (zh) | 2009-04-23 | 2012-09-05 | 丹尼斯科美国公司 | 异戊二烯合酶的三维结构及其用于产生变体的用途 |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| TWI434921B (zh) | 2009-06-17 | 2014-04-21 | Danisco Us Inc | 從生物異戊二烯組合物製造燃料成分之方法及系統 |
| TWI427149B (zh) | 2009-06-17 | 2014-02-21 | Danisco Us Inc | 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造 |
| CA2773675A1 (en) | 2009-09-15 | 2011-03-24 | Sapphire Energy, Inc. | A system for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp. |
| US8569562B2 (en) | 2009-12-18 | 2013-10-29 | Danisco Us Inc. | Purification of isoprene from renewable resources |
| WO2011079314A2 (en) | 2009-12-23 | 2011-06-30 | Danisco Us Inc. | Compositions and methods of pgl for the increased production of isoprene |
| US20130122562A1 (en) | 2011-08-04 | 2013-05-16 | Danisco Us Inc. | Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-coa synthase |
| AU2012332996A1 (en) | 2011-10-07 | 2014-04-24 | Danisco Us Inc. | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
| US8895277B2 (en) * | 2012-05-02 | 2014-11-25 | Danisco Us Inc. | Legume isoprene synthase for production of isoprene |
| WO2014015210A2 (en) * | 2012-07-20 | 2014-01-23 | Glycos Biotechnologies, Inc. | Microorganisms and processes for the conversion of glycerol to isoprene |
| EP3107993B1 (en) | 2014-02-20 | 2020-08-26 | Danisco US Inc. | Recombinant microorganisms for the enhanced production of mevalonate, isoprene, isoprenoid precursors, isoprenoids, and acetyl-coa-derived products |
-
2015
- 2015-02-20 EP EP15708996.2A patent/EP3107993B1/en active Active
- 2015-02-20 BR BR112016018774A patent/BR112016018774A2/pt not_active Application Discontinuation
- 2015-02-20 DK DK15708996.2T patent/DK3107993T3/da active
- 2015-02-20 US US15/120,037 patent/US10648004B2/en active Active
- 2015-02-20 WO PCT/US2015/016954 patent/WO2015127305A2/en not_active Ceased
- 2015-02-20 JP JP2016553501A patent/JP6744819B2/ja active Active
-
2020
- 2020-05-11 US US16/872,329 patent/US11685937B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6744819B2 (ja) | 2020-08-19 |
| US11685937B2 (en) | 2023-06-27 |
| BR112016018774A2 (pt) | 2017-10-10 |
| EP3107993A2 (en) | 2016-12-28 |
| EP3107993B1 (en) | 2020-08-26 |
| US10648004B2 (en) | 2020-05-12 |
| JP2017506078A (ja) | 2017-03-02 |
| WO2015127305A2 (en) | 2015-08-27 |
| US20200340017A1 (en) | 2020-10-29 |
| US20170159074A1 (en) | 2017-06-08 |
| WO2015127305A3 (en) | 2015-12-03 |
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