[go: up one dir, main page]

BR0314498A - Linhagens de e. coli e método para a bioprodução de 1,3-propanodiol - Google Patents

Linhagens de e. coli e método para a bioprodução de 1,3-propanodiol

Info

Publication number
BR0314498A
BR0314498A BR0314498-4A BR0314498A BR0314498A BR 0314498 A BR0314498 A BR 0314498A BR 0314498 A BR0314498 A BR 0314498A BR 0314498 A BR0314498 A BR 0314498A
Authority
BR
Brazil
Prior art keywords
propanediol
produce
strains
coli
microorganism
Prior art date
Application number
BR0314498-4A
Other languages
English (en)
Inventor
Marguerite A Cervin
Phillipe Soucaille
Fernando Valle
Original Assignee
Du Pont
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont, Genencor Int filed Critical Du Pont
Publication of BR0314498A publication Critical patent/BR0314498A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C12P7/20—Glycerol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"LINHAGENS DE E.COLI E MéTODO PARA A BIOPRODUçãO DE 1,3PROPANODIOL". A presente invenção fornece um microorganismo útil para a produção biológica de 1,3-propanodiol a partir de fonte de carbono fermentável em rendimento mais alto que o anteriormente conhecido. A complexidade das necessidades de cofator necessita do uso de um catalisador de célula inteira para um processo industrial que utiliza esta seq³ência de reação para produzir 1,3-propanodiol. A presente invenção fornece um microorganismo com rupturas em genes especificados e alterações nos níveis de expressão de genes especificados que é útil em processo de rendimento superior para a produção de 1,3-propanodiol.
BR0314498-4A 2002-10-04 2003-10-06 Linhagens de e. coli e método para a bioprodução de 1,3-propanodiol BR0314498A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41619202P 2002-10-04 2002-10-04
PCT/US2003/031805 WO2004033646A2 (en) 2002-10-04 2003-10-06 Process for the biological production of 1,3-propanediol with high yield

Publications (1)

Publication Number Publication Date
BR0314498A true BR0314498A (pt) 2005-08-16

Family

ID=32093824

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0314498-4A BRPI0314498B1 (pt) 2002-10-04 2003-10-06 Escherichia coli transgênica e método para a bioprodução de 1,3-propanodiol
BR0314498-4A BR0314498A (pt) 2002-10-04 2003-10-06 Linhagens de e. coli e método para a bioprodução de 1,3-propanodiol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BRPI0314498-4A BRPI0314498B1 (pt) 2002-10-04 2003-10-06 Escherichia coli transgênica e método para a bioprodução de 1,3-propanodiol

Country Status (13)

Country Link
US (2) US7371558B2 (pt)
EP (1) EP1576123B1 (pt)
JP (1) JP4592418B2 (pt)
KR (1) KR101148255B1 (pt)
CN (1) CN100471946C (pt)
AT (1) ATE493490T1 (pt)
AU (1) AU2003287028B2 (pt)
BR (2) BRPI0314498B1 (pt)
CA (1) CA2501574C (pt)
DE (1) DE60335574D1 (pt)
ES (1) ES2356526T3 (pt)
MX (1) MXPA05003382A (pt)
WO (1) WO2004033646A2 (pt)

Families Citing this family (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003205041A1 (en) * 2002-07-12 2004-01-29 Ajinomoto Co., Inc. Method for producing target substance by fermentation
US20050079617A1 (en) * 2003-10-03 2005-04-14 Cervin Marguerite A. Glucose transport mutants for production of biomaterial
EP1546304B1 (en) * 2002-10-04 2013-05-08 Danisco US Inc. Improved production of bacterial strains
US7524660B2 (en) * 2005-05-05 2009-04-28 E.I. Du Pont De Nemours And Company Utilization of fructose in microbial production strains
JP2007082476A (ja) * 2005-09-22 2007-04-05 Nippon Shokubai Co Ltd グリセリンから３−ヒドロキシプロピオン酸を製造する方法
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US20080274526A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of isobutanol
NZ566406A (en) 2005-10-26 2012-04-27 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
US8206970B2 (en) 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
JP5130811B2 (ja) * 2006-07-19 2013-01-30 東レ株式会社 連続発酵による１，３−プロパンジオールの製造方法
JP2010508013A (ja) * 2006-10-31 2010-03-18 メタボリック エクスプローラー グリセロールから１，３−プロパンジオールを高収量で生物学的に製造する方法
WO2008052596A1 (en) * 2006-10-31 2008-05-08 Metabolic Explorer Process for the biological production of n-butanol with high yield
EP2126042A4 (en) * 2007-01-12 2010-08-04 Univ Colorado Regents COMPOSITIONS AND METHODS FOR INCREASING TOLERANCE FOR THE PRODUCTION BY MICRO-ORGANISMS OF PRODUCED ORGANIC CHEMICALS
US8673601B2 (en) * 2007-01-22 2014-03-18 Genomatica, Inc. Methods and organisms for growth-coupled production of 3-hydroxypropionic acid
BRPI0808972B1 (pt) 2007-03-23 2016-11-29 Metabolic Explorer Sa método para a preparação de uma cepa de escherichia coli para a produção de 1,2-propanodiol a partir de uma fonte de carbono
BRPI0809039A2 (pt) * 2007-03-23 2014-09-16 Metabolic Explorer Sa Microorganismos metabolicamente projetados úteis para a produção de 1,2-propanodiol
EP2142637A1 (en) * 2007-03-23 2010-01-13 Metabolic Explorer Metabolically engineered microorganism useful for the production of acetol
EP2126101B1 (en) * 2007-03-23 2015-09-02 Metabolic Explorer Microorganisms and methods for production of 1,2-propanediol and acetol
CN101130782B (zh) * 2007-07-23 2011-01-26 江南大学 以葡萄糖为底物产1,3-丙二醇重组酿酒酵母的构建方法
CA2696018A1 (en) * 2007-08-10 2009-04-09 Genomatica, Inc. Methods for the synthesis of olefins and derivatives
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
AU2008334945C1 (en) 2007-12-13 2013-09-05 Danisco Us Inc. Compositions and methods for producing isoprene
CA2712779C (en) 2008-01-22 2021-03-16 Genomatica, Inc. Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
AR072446A1 (es) * 2008-03-02 2010-09-01 Dow Global Technologies Inc Proceso de hidrogenacion mejorado
BRPI0909690A2 (pt) 2008-03-05 2019-02-26 Genomatica Inc organismos produtores de alcoóis primários
PL2265709T3 (pl) * 2008-03-27 2018-05-30 Genomatica, Inc. Mikroorganizmy do produkcji kwasu adypinowego i innych związków
ZA201007564B (en) 2008-04-23 2012-01-25 Goodyear Tire & Rubber Isoprene synthase variants for improved microbial production of isoprene
AU2009242615A1 (en) 2008-05-01 2009-11-05 Genomatica, Inc. Microorganisms for the production of methacrylic acid
WO2009155382A1 (en) * 2008-06-17 2009-12-23 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
MY150780A (en) 2008-06-30 2014-02-28 Goodyear Tire & Rubber Polymers of isoprene from renewable resources
RU2563513C2 (ru) 2008-07-02 2015-09-20 ДАНИСКО ЮЭс ИНК. Композиции и способы получения изопрена, не содержащего с5-углеводородов в условиях нарушения взаимосвязи между продуцированием изопрена и ростом клеток и/или в условиях продуцирования изопрена на безопасных рабочих уровнях
AU2009270773A1 (en) 2008-07-16 2010-01-21 The Texas A&M University System Transformation of glycerol and cellulosic materials into high energy fuels
US20100021978A1 (en) * 2008-07-23 2010-01-28 Genomatica, Inc. Methods and organisms for production of 3-hydroxypropionic acid
AU2009273953B2 (en) * 2008-07-23 2013-08-29 Opx Biotechnologies, Inc Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-HP)
EP2326709A4 (en) * 2008-09-15 2013-01-23 Opx Biotechnologies Inc METHODS, SYSTEMS AND COMPOSITIONS RELATED TO REDUCED MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID (3-HP) IN ALDEHYDMETABOLITE
WO2010031079A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Systems using cell culture for production of isoprene
SG169614A1 (en) 2008-09-15 2011-04-29 Goodyear Tire & Rubber Conversion of prenyl derivatives to isoprene
CA2737223A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
US8361762B2 (en) 2008-09-15 2013-01-29 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
GB0820631D0 (en) * 2008-11-11 2008-12-17 London School Hygiene & Tropical Medicine Vectors
WO2010057022A1 (en) * 2008-11-14 2010-05-20 Genomatica, Inc. Microorganisms for the production of methyl ethyl ketone and 2-butanol
CN102395671B (zh) * 2008-12-03 2014-06-25 韩国生命工学研究院 用于制造1，3-丙二醇的丙三醇氧化途径中阻隔的突变体
JP2012511928A (ja) * 2008-12-16 2012-05-31 ゲノマチカ， インク． 合成ガス及び他の炭素源の有用な製品への変換のための微生物及び方法
WO2010078457A2 (en) 2008-12-30 2010-07-08 Danisco Us Inc. Methods of producing isoprene and a co-product
ES2549003T3 (es) 2008-12-31 2015-10-22 Metabolic Explorer Método para la preparación de dioles
CN102686735A (zh) * 2009-03-05 2012-09-19 佛罗里达大学研究基金会有限公司 产乙醇细菌及它们在乙醇生产中的应用
WO2010104224A1 (ko) * 2009-03-12 2010-09-16 한국생명공학연구원 글리세롤 산화대사경로를 차단시킨 재조합 균주를 이용한 １、3-프로판디올의 제조방법
EP2233562A1 (en) 2009-03-24 2010-09-29 Metabolic Explorer Method for producing high amount of glycolic acid by fermentation
CN102656265A (zh) 2009-04-23 2012-09-05 丹尼斯科美国公司 异戊二烯合酶的三维结构及其用于产生变体的用途
ES2593117T3 (es) * 2009-04-30 2016-12-05 Genomatica, Inc. Organismos para la producción de 1,3-butanodiol
AU2010242849A1 (en) 2009-04-30 2011-11-24 Genomatica, Inc. Organisms for the production of isopropanol, n-butanol, and isobutanol
KR102099295B1 (ko) 2009-05-07 2020-04-09 게노마티카 인코포레이티드 아디페이트, 헥사메틸렌디아민 및 6-아미노카프로산의 생합성을 위한 미생물 및 방법
JP2012526561A (ja) * 2009-05-15 2012-11-01 ゲノマチカ， インク． シクロヘキサノンの産生のための生物
WO2010144746A2 (en) * 2009-06-10 2010-12-16 Genomatica, Inc. Microorganisms and methods for carbon-efficient biosynthesis of mek and 2-butanol
US20110144377A1 (en) * 2009-06-16 2011-06-16 E. I. Du Pont Nemours And Company Process for the biological production of 3-hydroxypropionic acid with high yield
TW201412988A (zh) 2009-06-17 2014-04-01 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
US8969053B2 (en) 2009-07-30 2015-03-03 Metabolic Explorer Mutant YqhD enzyme for the production of a biochemical by fermentation
EP2462221B1 (en) 2009-08-05 2017-02-22 Genomatica, Inc. Semi-synthetic terephthalic acid via microorganisms that produce muconic acid
EP2933338A3 (en) 2009-09-09 2016-01-06 Genomatica, Inc. Microorganisms and methods for the co-production of isopropanol with primary alcohols, diols and acids
MX353237B (es) 2009-09-23 2018-01-08 Danisco Us Inc Enzimas de glicosil hidrolasa novedosas y usos de las mismas.
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
GB2487866A (en) 2009-09-27 2012-08-08 Opx Biotechnologies Inc Method for producing 3-Hydroxypropionic acid and other products
MX2012004291A (es) 2009-10-13 2012-08-17 Genomatica Inc Microorganismos para la produccion de 1,4-butanoidol, 4-hidroxibutanal, 4-hidroxibutiril-coa, putrescina y compuestos y metodos relacionados con los mismos.
US8852903B2 (en) 2009-10-23 2014-10-07 E I Du Pont De Nemours And Company Co-metabolism of fructose and glucose in microbial production strains
BR112012009332A2 (pt) 2009-10-23 2015-09-15 Genomatica Inc micro-organismo para a produção de anilina
EP2495328B1 (en) * 2009-10-29 2016-03-30 Korea Research Institute of Bioscience and Biotechnology Novel method for producing 3-hydroxypropionic acid from glycerol
US10017793B2 (en) 2009-11-18 2018-07-10 Myriant Corporation Metabolic evolution of Escherichia coli strains that produce organic acids
EP2501797A4 (en) 2009-11-18 2013-04-17 Myriant Corp TECHNIQUES OF MICROBES FOR THE EFFECTIVE MANUFACTURE OF CHEMICALS
KR101695605B1 (ko) 2009-11-18 2017-01-11 미리안트 코포레이션 유기산들을 생산하는 대장균의 대사적 진화
CA2781400A1 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an organic acid and/or related chemicals
US20110136190A1 (en) * 2009-12-04 2011-06-09 E. I. Du Pont De Nemours And Company Recombinant bacteria for producing glycerol and glycerol-derived products from sucrose
KR20120120493A (ko) * 2009-12-10 2012-11-01 게노마티카 인코포레이티드 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체
JP5643838B2 (ja) 2009-12-18 2014-12-17 ダニスコ・ユーエス・インク 再生可能資源からのイソプレンの精製
US8778647B2 (en) 2009-12-22 2014-07-15 Danisco Us Inc. Methods of producing isoprene comprising a membrane bioreactor
US8455236B2 (en) 2009-12-23 2013-06-04 Danisco Us Inc. Compositions and methods of PGL for the increased production of isoprene
US10138499B2 (en) 2009-12-23 2018-11-27 Danisco Us Inc. Methods for improving the efficiency of simultaneous saccharification and fermentation reactions
MX2012008738A (es) * 2010-01-29 2012-08-31 Genomatica Inc Microorganismos y metodos para la biosintesis de p-toluato y tereftalato.
US8048661B2 (en) * 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
US9023636B2 (en) 2010-04-30 2015-05-05 Genomatica, Inc. Microorganisms and methods for the biosynthesis of propylene
KR20180005263A (ko) 2010-05-05 2018-01-15 게노마티카 인코포레이티드 부타디엔을 생합성하기 위한 미생물 및 방법
KR101220499B1 (ko) * 2010-05-25 2013-01-10 한국생명공학연구원 글리세롤로부터 3-하이드록시프로피온산을 고수율로 제조하는 방법
BR112012032276A2 (pt) 2010-06-17 2016-11-16 Danisco Us Inc composições de combustível compreendendo derivados de isopreno
TWI500768B (zh) * 2010-07-05 2015-09-21 Metabolic Explorer Sa 由蔗糖製備１，３－丙二醇之方法
BR112013001635A2 (pt) 2010-07-26 2016-05-24 Genomatica Inc micro-organismo e métodos para a biossíntese de aromáticos, 2, 4-pentadienoato e 1,3-butadieno
WO2012019169A1 (en) 2010-08-06 2012-02-09 Danisco Us Inc. Production of isoprene under neutral ph conditions
KR101247881B1 (ko) * 2010-08-27 2013-03-26 주식회사 씨티씨바이오 비타민 ｂ―１２ 생성능을 갖는 재조합 미생물 및 상기 재조합 미생물을 이용한 ３―하이드록시프로피온산의 제조방법
JP2014502148A (ja) 2010-10-27 2014-01-30 ダニスコ・ユーエス・インク イソプレン生産の向上を目的としたイソプレン合成酵素変異体
US8129170B1 (en) 2010-12-06 2012-03-06 E.I. Du Pont De Nemours And Company Recombinant bacteria having the ability to metabolize sucrose
WO2012088450A1 (en) 2010-12-22 2012-06-28 Danisco Us Inc. Biological production of pentose sugars using recombinant cells
BR112013018316A2 (pt) 2010-12-22 2018-09-11 Danisco Us Inc composições e métodos para produção aprimorada de isopreno usando dois tipos de enzimas ispg
MX2013010512A (es) 2011-03-17 2013-10-07 Danisco Inc Metodo para reducir la viscosidad en un proceso de sacarificacion.
AU2012228968B2 (en) 2011-03-17 2017-05-18 Danisco Us Inc. Cellulase compositions and methods of using the same for improved conversion of lignocellulosic biomass into fermentable sugars
AU2012249389A1 (en) 2011-04-29 2013-11-14 Danisco Us Inc. Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, HMG-CoA synthase and HMG-CoA reductase enzymatic activities
SG194690A1 (en) 2011-04-29 2013-12-30 Danisco Us Inc Recombinant microorganisms for enhanced production of mevalonate,isoprene, and isoprenoids
EP2540834A1 (en) 2011-06-29 2013-01-02 Metabolic Explorer Method for the preparation of 1,3-propanediol
JP2013013353A (ja) * 2011-07-01 2013-01-24 Daicel Corp １，３−プロパンジオールの製造方法
CA2841175C (en) * 2011-07-12 2016-02-02 Scientist Of Fortune S.A. Recombinant microorganism for the production of useful metabolites
US20130034658A1 (en) * 2011-08-01 2013-02-07 E. I. Du Pont De Nemours And Company Poly-trimethylene terephthalate solid core fibrillation-resistant filament having a substantially triangular cross section, a spinneret for producing the filament, and a carpet made therefrom
JP2014528705A (ja) 2011-08-04 2014-10-30 ダニスコ・ユーエス・インク アセトアセチルＣｏＡシンターゼを用いるイソプレン、イソプレノイド前駆体、及びイソプレノイドの生産
US8951764B2 (en) 2011-08-05 2015-02-10 Danisco Us Inc. Production of isoprenoids under neutral pH conditions
JP2013070675A (ja) * 2011-09-28 2013-04-22 Daicel Corp アルキルジオールを産生する組換え菌の培養方法
DK2764084T4 (da) 2011-10-07 2021-12-06 Danisco Us Inc Anvendelse af phosphoketolase i fremstillingen af mevalonat, isoprenoid-udgangsstoffer, og isopren
DK2771460T3 (en) 2011-10-27 2017-06-06 Danisco Us Inc ISOPRENE SYNTHASE VARIETIES WITH IMPROVED SOLUBILITY FOR THE PREPARATION OF ISOPRENE
SG11201403163QA (en) 2011-12-23 2014-09-26 Danisco Us Inc Enhanced production of isoprene using host cells having decreased ispa activity
EP2794876A1 (en) 2011-12-23 2014-10-29 Danisco US Inc. Production of isoprene under reduced oxygen inlet levels
WO2013126721A1 (en) * 2012-02-23 2013-08-29 Massachusetts Institute Of Technology Engineering microbes and metabolic pathways for the production of ethylene glycol
US9017961B2 (en) 2012-03-05 2015-04-28 E.I. Du Pont De Nemours And Company Recombinant bacteria comprising novel sucrose transporters
US8686114B2 (en) 2012-03-05 2014-04-01 E I Du Pont De Nemours And Company Variant sucrose transporter polypeptides
US9315831B2 (en) 2012-03-30 2016-04-19 Danisco Us Inc. Direct starch to fermentable sugar as feedstock for the production of isoprene, isoprenoid precursor molecules, and/or isoprenoids
US8895277B2 (en) 2012-05-02 2014-11-25 Danisco Us Inc. Legume isoprene synthase for production of isoprene
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
PL2875121T3 (pl) 2012-07-20 2018-06-29 Prevtec Microbia Inc. Niepatogenny szczep E. coli F18 i jego zastosowanie
CA2881666A1 (en) 2012-08-10 2014-02-13 Opx Biotechnologies, Inc. Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2708598A1 (en) * 2012-09-14 2014-03-19 Basf Se Serinol production in glycerol catabolism deficient escherichia coli strains
CN104781399A (zh) 2012-10-31 2015-07-15 丹尼斯科美国公司 来自稻瘟病菌的β-葡糖苷酶
CA2889193A1 (en) 2012-10-31 2014-05-08 Danisco Us Inc. Beta-glucosidase from neurospora crassa
CA2888757A1 (en) 2012-10-31 2014-05-08 Danisco Us Inc. Compositions and methods of use
CA2892054A1 (en) 2012-12-07 2014-06-12 Ling Hua Compositions and methods of use
WO2014088934A1 (en) 2012-12-07 2014-06-12 Danisco Us Inc. Compositions and methods of use
WO2014100726A2 (en) 2012-12-21 2014-06-26 Danisco Us Inc. Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway
CN103146740B (zh) * 2013-03-06 2014-08-20 中国科学院南海海洋研究所 一株生产1,3-丙二醇的工程菌及其构建方法
WO2014146026A1 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
BR112015023583A2 (pt) 2013-03-15 2017-08-22 Dow Global Technologies Llc Método para vaporização 3-hp a partir de uma solução, vapor, solução 3-hp condensada, composição, produto químico à jusante, produto de consumo, sistema para purificação de 3-hp, método para produzir uma solução de 3-hp, método para decompor a amônia de 3-hp (a3-hp) e método para decompor a3-hp
CN105555952A (zh) 2013-04-10 2016-05-04 丹尼斯科美国公司 用于乙酰辅酶a-衍生代谢物、异戊二烯、类异戊二烯前体和类异戊二烯的改善生产的磷酸解酮酶
CA2915980A1 (en) 2013-06-21 2014-12-24 Danisco Us Inc. Compositions and methods for clostridial transformation
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
BR112016001026A2 (pt) 2013-07-19 2017-10-24 Cargill Inc organismo geneticamente modificado
WO2015034948A1 (en) 2013-09-03 2015-03-12 Myriant Corporation A process for manufacturing acrylic acid, acrylonitrile and 1,4-butanediol from 1,3-propanediol
US20160298157A1 (en) 2013-12-04 2016-10-13 Danisco Us Inc. Compositions comprising a beta-glucosidase polypeptide and methods of use
CN103642765B (zh) * 2013-12-25 2015-11-18 南京工业大学 醇脱氢酶突变体及其应用
DK3107993T3 (da) 2014-02-20 2020-11-23 Danisco Us Inc Rekombinante mikroorganismer til forbedret fremstilling af mevalonat, isopren, isoprenoide forløbere, isoprenoider og acetyl-coa-afledte produkter
KR20150110144A (ko) 2014-03-24 2015-10-02 삼성전자주식회사 글리세롤, 3-hp, 또는 아크릴산 생산능을 갖는 재조합 미생물 및 그를 이용하여 글리세롤, 3-hp, 또는 아크릴산을 생산하는 방법
EP2993228B1 (en) 2014-09-02 2019-10-09 Cargill, Incorporated Production of fatty acid esters
EP3201330A1 (en) 2014-09-30 2017-08-09 Danisco US Inc. Compositions comprising beta mannanase and methods of use
WO2016054168A1 (en) 2014-09-30 2016-04-07 Danisco Us Inc Compositions comprising beta mannanase and methods of use
WO2016054176A1 (en) 2014-09-30 2016-04-07 Danisco Us Inc Compositions comprising beta-mannanase and methods of use
WO2016054194A1 (en) 2014-09-30 2016-04-07 1/1Danisco Us Inc Compositions comprising beta-mannanase and methods of use
WO2016054185A1 (en) 2014-09-30 2016-04-07 Danisco Us Inc Compositions comprising beta-mannanase and methods of use
BR112017008595A2 (pt) 2014-10-27 2017-12-19 Danisco Us Inc composições e métodos referentes à beta-glucosidase
CN105734002B (zh) * 2014-12-10 2019-06-25 中粮集团有限公司 一种重组谷氨酸生产菌株及其制备方法与应用
EP3050970B1 (en) 2015-01-28 2019-09-18 Metabolic Explorer Modified microorganism for optimized production of 1,4-butanediol
KR101748930B1 (ko) * 2015-02-09 2017-06-20 지에스칼텍스 주식회사 다이올 생산용 재조합 미생물
RU2760290C1 (ru) 2016-07-08 2021-11-23 Метаболик Эксплорер Способ ферментативной продукции целевых молекул микроорганизмами, включающими гены, кодирующие фосфотрансферазную систему (фтс) сахаров
CN106399217B (zh) * 2016-12-06 2019-10-18 江南大学 一种敲除arcA提高克雷伯氏菌1,3-丙二醇产量的方法
US11345938B2 (en) 2017-02-02 2022-05-31 Cargill, Incorporated Genetically modified cells that produce C6-C10 fatty acid derivatives
EP3577220A2 (en) 2017-02-06 2019-12-11 Zymergen, Inc. Engineered biosynthetic pathways for production of tyramine by fermentation
JP7198555B2 (ja) 2017-04-27 2023-01-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア カンナビノイドおよびカンナビノイド誘導体を産生するための微生物および方法
WO2019036140A1 (en) 2017-07-17 2019-02-21 Zymergen Inc. METALLO-ORGANIC STRESS MATERIALS
CA3078323A1 (en) 2017-10-05 2019-08-15 Zymergen Inc. Optically transparent polyimides
CN111699247A (zh) 2017-12-07 2020-09-22 齐默尔根公司 通过发酵产生(6e)-8-羟基香叶醇的经改造的生物合成途径
BR112020012704A8 (pt) 2017-12-21 2022-03-03 Zymergen Inc Nepetalactol oxidorredutases, nepetalactol sintases, e micróbios capazes de produzir nepetalactona
KR102053330B1 (ko) 2018-04-23 2019-12-06 한국과학기술연구원 글리세롤을 포함하는 미생물 발효용 조성물 및 이를 이용한 부티르산의 생산방법
CN110656075B (zh) * 2018-06-28 2022-11-11 中国科学院青岛生物能源与过程研究所 一种合成乙酰辅酶a衍生产品的通用性底盘细胞及其构建方法与应用
MX2021001619A (es) * 2018-08-10 2021-05-12 Metabolic Explorer Sa Microorganismos con produccion mejorada de 1,3-propanodiol y acido butirico.
WO2020069142A1 (en) 2018-09-26 2020-04-02 Demetrix, Inc. Optimized expression systems for expressing berberine bridge enzyme and berberine bridge enzyme-like polypeptides
CN109321610B (zh) * 2018-11-01 2022-11-04 上海交通大学 微生物发酵法高效制备2-氨基-1,3-丙二醇
CN109609426B (zh) * 2019-01-04 2022-02-15 花安堂生物科技集团有限公司 一种以甲醇/甲醛和葡萄糖为共底物生产1,3-丙二醇的方法
CN113474361B (zh) * 2019-02-24 2023-11-14 昂科斯密斯生物技术私人有限公司 由细菌连续生产重组glp-1肽的方法
MX2021014057A (es) 2019-05-22 2022-02-21 Demetrix Inc Polipéptidos de sintasas de cannabinoides optimizados.
KR102802031B1 (ko) * 2019-09-04 2025-04-29 주식회사 엘지화학 Crispr 시스템을 이용한 포도당으로부터 글리세롤로의 전환률 향상 방법
BR112022004797A2 (pt) 2019-09-18 2022-06-21 Demetrix Inc Polipeptídeos otimizados de ácido tetra-hidrocanabinólico (thca) sintase
WO2021183448A1 (en) 2020-03-09 2021-09-16 Demetrix, Inc. Optimized olivetolic acid cyclase polypeptides
KR20230076829A (ko) * 2020-09-30 2023-05-31 게노미엄, 아이엔씨. 바이오아크롤레인 및 바이오아크릴산을 생산하는 발효 공정
EP4242312A4 (en) * 2020-11-05 2024-04-24 Lg Chem, Ltd. MICROORGANISMS HAVING THE CAPACITY TO PRODUCE 3-HYDROXYPROPIONIC ACID FROM GLUCOSE AND THEIR USES
IT202000031979A1 (it) 2020-12-22 2022-06-22 Novamont Spa Processo di purificazione di una miscela comprendente dioli e acetali
CN114806981B (zh) * 2021-01-18 2023-05-23 中国科学院上海高等研究院 克雷伯氏菌工程菌在生产1,3-丙二醇中的应用
JP2024508944A (ja) 2021-03-08 2024-02-28 エキソポリマー インコーポレイテッド 局所用のバイオポリマー
IT202100006419A1 (it) 2021-03-17 2022-09-17 Novamont Spa Recupero di dioli da una miscela
CN113881614B (zh) * 2021-09-10 2023-07-28 江苏清大智兴生物技术有限公司 一种提升1,3-丙二醇生产菌株性能的工程菌及其应用
WO2023076358A1 (en) 2021-10-26 2023-05-04 Exopolymer, Inc. Heat stable and/or heat activated biopolymers
CN114149955B (zh) * 2021-12-09 2023-09-26 齐鲁工业大学 一种高效生产甘油的基因工程菌及其构建方法与应用
CN115820519B (zh) * 2022-08-26 2024-07-19 天津大学 一种高效定向电子通量至电子转移链的重组希瓦氏菌株的构建方法及用途
WO2024059626A2 (en) 2022-09-14 2024-03-21 Exopolymer, Inc. Biopolymers for ophthalmic use
WO2024059627A1 (en) 2022-09-14 2024-03-21 Exopolymer, Inc. Biopolymers for use in wound care
CN118475621A (zh) 2023-06-19 2024-08-09 杭州恩和生物科技有限公司 生产7-脱氢胆固醇的融合多肽及其使用方法
CN118086444B (zh) * 2024-04-28 2024-06-28 山东德普新材料科技有限公司 一种发酵联产1,3-丙二醇和3-羟基丙酸的方法
CN119709886A (zh) * 2024-12-18 2025-03-28 天津大学 一种利用光酶还原sam自由基酶生物合成1,3-丙二醇的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702401A (en) * 1993-06-23 1997-12-30 Shaffer; Benjamin Intra-articular measuring device
DK0827542T3 (da) * 1995-05-05 2008-08-18 Genencor Int Anvendelse af glucose-transport-mutanter til fremstilling af forbindelser fra den aromatiske pathway
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
AU733534B2 (en) 1996-11-13 2001-05-17 E.I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant microorganisms
AU1619199A (en) 1997-12-02 1999-06-16 E.I. Du Pont De Nemours And Company Method for the production of glycerol by recombinant organisms
US6432686B1 (en) * 1998-05-12 2002-08-13 E. I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport
US6613552B1 (en) * 1999-01-29 2003-09-02 Board Of Trustees Operating Michigan State University Biocatalytic synthesis of shikimic acid
CA2733616C (en) 1999-08-18 2016-09-27 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high titer
JP4380029B2 (ja) 2000-07-05 2009-12-09 味の素株式会社 微生物を利用した物質の製造法
JP4776146B2 (ja) * 2001-01-10 2011-09-21 ザ・ペン・ステート・リサーチ・ファンデーション 細胞代謝をモデル化する方法及びシステム
BR0209081A (pt) * 2001-04-20 2004-06-22 Du Pont Processo de remoção de produto e sistema de remoção de produto in situ
CN100366730C (zh) * 2002-04-22 2008-02-06 纳幕尔杜邦公司 用于遗传工程的启动子和质粒系统

Also Published As

Publication number Publication date
JP4592418B2 (ja) 2010-12-01
EP1576123A4 (en) 2007-09-12
MXPA05003382A (es) 2005-06-22
ES2356526T3 (es) 2011-04-08
BRPI0314498B1 (pt) 2019-08-20
CN100471946C (zh) 2009-03-25
CN1860221A (zh) 2006-11-08
WO2004033646A2 (en) 2004-04-22
CA2501574A1 (en) 2004-04-22
DE60335574D1 (de) 2011-02-10
US7745184B2 (en) 2010-06-29
US7371558B2 (en) 2008-05-13
US20040152174A1 (en) 2004-08-05
JP2006512907A (ja) 2006-04-20
KR20050088072A (ko) 2005-09-01
EP1576123B1 (en) 2010-12-29
AU2003287028A1 (en) 2004-05-04
US20080176302A1 (en) 2008-07-24
WO2004033646A3 (en) 2006-05-11
EP1576123A2 (en) 2005-09-21
ATE493490T1 (de) 2011-01-15
AU2003287028B2 (en) 2008-09-04
KR101148255B1 (ko) 2012-08-08
CA2501574C (en) 2013-12-03

Similar Documents

Publication Publication Date Title
BR0314498A (pt) Linhagens de e. coli e método para a bioprodução de 1,3-propanodiol
Valle et al. Metabolic engineering for the optimization of hydrogen production in Escherichia coli: a review
BR0306740A (pt) Célula hospedeira transformada com um construto de ácido nucléico, molécula de ácido nucleico isolada, e, processos para a produção de etanol, e de um produto de fermentação
ATE311460T1 (de) Hefestämme zur herstellung von milchsäure
MX2010009984A (es) Selección de organismos capaces de fermentar sustratos mixtos.
BR0010806A (pt) Métodos e materiais para a sìntese de produtos orgânicos
ATE491156T1 (de) Bio-elektrochemisches verfahren zur herstellung von wasserstoff
BR0012712A (pt) Métodos de produção de l-aminoácidos aumentando-se o nadph celular
WO2004067755A3 (en) A self-contained and streamlined methane and/or high purity hydrogen generation system
AU5102899A (en) Process and materials for production of glucosamine
DE60330044D1 (de) Il-21-produktion in prokaryontischen wirten
CY1110827T1 (el) Μια μεθοδος παραγωγης ηλεκτρικου οξεος απο ακατεργαστα υδρολυματα
EP1314782A4 (en) PROCESS FOR THE PRODUCTION OF BIOTERPINES
DE69913495D1 (de) Verfahren zur hydrofluorierung von chlorierten kohlenwasserstoffen
BR0017078A (pt) Processo para produção de hidrogênio a partir de material orgânico decomposto por via anaeróbica
DE602007013447D1 (de) Glutaminsäure in hoher ausbeute produzierender mikroorganismus und verfahren zur produktion von glutaminsäure damit
Dong et al. A newly isolated and identified vitamin B12 producing strain: Sinorhizobium meliloti 320
CA2468158A1 (en) System and method for the production of biogas and compost
TW200504211A (en) New nitrile hydratase
TW200634151A (en) Transformant expressing nitrile hydratase
MY122370A (en) Rhodococcus microorganisms and process for producing amide compounds.
Li et al. Conversion of organics and minerals into electricity and microalgae using a dual-membrane cylinder photo-microbial fuel cell
ATE505550T1 (de) Fermentationsverfahren
AU2002212690A1 (en) Process for producing d-serine
WO2007032798A3 (en) Method for sustained microbial production of hydrogen gas in a bioreactor using klebsiella oxytoca

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 24 E 25 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/08/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/08/2019, OBSERVADAS AS CONDICOES LEGAIS