DK2589599T3 - Hidtil ukendte hydroxy-6-heteroarylphenanthridiner og deres anvendelse som PDE4-inhibitorer - Google Patents
Hidtil ukendte hydroxy-6-heteroarylphenanthridiner og deres anvendelse som PDE4-inhibitorerInfo
- Publication number
- DK2589599T3 DK2589599T3 DK12196702T DK12196702T DK2589599T3 DK 2589599 T3 DK2589599 T3 DK 2589599T3 DK 12196702 T DK12196702 T DK 12196702T DK 12196702 T DK12196702 T DK 12196702T DK 2589599 T3 DK2589599 T3 DK 2589599T3
- Authority
- DK
- Denmark
- Prior art keywords
- heteroarylphenanthridines
- pde4 inhibitors
- new hydroxy
- hydroxy
- new
- Prior art date
Links
- 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 title 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 title 1
Classifications
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04004973 | 2004-03-03 | ||
| EP04106359 | 2004-12-07 | ||
| EP05716889.0A EP1723135B1 (en) | 2004-03-03 | 2005-03-02 | Novel hydroxy-6-heroarylphenanthridines and their use as pde4 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2589599T3 true DK2589599T3 (da) | 2014-10-06 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05716889.0T DK1723135T5 (da) | 2004-03-03 | 2005-03-02 | Ukendte hydroxy-6-heteroarylphenanthridiner og deres anvendelse som pde4-inhibitorer |
| DK12196702T DK2589599T3 (da) | 2004-03-03 | 2005-03-02 | Hidtil ukendte hydroxy-6-heteroarylphenanthridiner og deres anvendelse som PDE4-inhibitorer |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05716889.0T DK1723135T5 (da) | 2004-03-03 | 2005-03-02 | Ukendte hydroxy-6-heteroarylphenanthridiner og deres anvendelse som pde4-inhibitorer |
Country Status (29)
| Country | Link |
|---|---|
| US (8) | US8003798B2 (da) |
| EP (2) | EP2589599B1 (da) |
| JP (2) | JP4801039B2 (da) |
| KR (2) | KR101152439B1 (da) |
| CN (6) | CN104803974A (da) |
| AR (1) | AR049319A1 (da) |
| AU (1) | AU2005219576B2 (da) |
| BR (1) | BRPI0508321B1 (da) |
| CA (1) | CA2557752C (da) |
| CO (1) | CO5700749A2 (da) |
| CY (2) | CY1114319T1 (da) |
| DK (2) | DK1723135T5 (da) |
| EA (2) | EA014155B1 (da) |
| ES (2) | ES2427256T3 (da) |
| HK (4) | HK1207635A1 (da) |
| HR (2) | HRP20130828T1 (da) |
| IL (2) | IL177073A (da) |
| ME (1) | ME01955B (da) |
| MX (2) | MX341474B (da) |
| NO (2) | NO336538B1 (da) |
| NZ (1) | NZ549108A (da) |
| PL (2) | PL1723135T3 (da) |
| PT (2) | PT2589599E (da) |
| RS (2) | RS52916B (da) |
| SG (1) | SG182194A1 (da) |
| SI (2) | SI1723135T1 (da) |
| TW (2) | TWI404704B (da) |
| WO (1) | WO2005085225A1 (da) |
| ZA (1) | ZA200606176B (da) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2496459C (en) | 2002-08-29 | 2013-06-25 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| ES2400823T3 (es) | 2004-02-18 | 2013-04-12 | Takeda Gmbh | Nuevas hidroxi-6-fenilfenantridinas sustituidas con guanidinilo como inhibidores eficaces de fosfodiesterasa (PDE) 4 |
| CN104803974A (zh) | 2004-03-03 | 2015-07-29 | 塔科达有限责任公司 | 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途 |
| US20080119505A1 (en) | 2005-02-01 | 2008-05-22 | Altana Pharma Ag | Novel 6-Pyridylphenanthridines |
| CA2598858A1 (en) * | 2005-03-02 | 2006-09-08 | Nycomed Gmbh | 6 -heteroaryl-1, 2, 3,4,4a, 1ob-hexahydro-phenanthridines as pde-4 inhibitors for the treatment of inflammatory disorders |
| KR101421914B1 (ko) * | 2005-03-02 | 2014-07-22 | 다케다 게엠베하 | 6-헤테로시클릴 치환된 헥사히드로페난트리딘 유도체의 신규한 염 |
| NZ574710A (en) * | 2006-09-07 | 2012-02-24 | Nycomed Gmbh | Combination treatment comprising the PDE4 inhibitor Compound A ((2R,4aR, 10bR)6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1 ,2,3,4,4a,10b-hexahydrophenanthridin-2-ol) for diabetes mellitus |
| EA200901546A1 (ru) | 2007-05-17 | 2010-04-30 | Кортекс Фармасеутикалс, Инк. | Дизамещенные амиды для усиления глутаматергических синаптических ответов |
| WO2009025823A1 (en) * | 2007-08-21 | 2009-02-26 | Amgen Inc. | Phosphodiesterase 10 inhibitors |
| WO2009109525A1 (en) * | 2008-03-03 | 2009-09-11 | Nycomed Gmbh | Use of a specific pde4 inhibitor for the treatment and/or prophylaxis of non-alcoholic fatty liver disease |
| AR074318A1 (es) | 2008-11-14 | 2011-01-05 | Nycomed Gmbh | Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias. |
| JP2017503814A (ja) * | 2014-01-22 | 2017-02-02 | タケダ ゲー・エム・ベー・ハーTakeda GmbH | 部分的コントロール状態の重症喘息またはコントロール不良状態の重症喘息のpde4インヒビターを用いた(およびロイコトリエン調節薬と組み合わせて用いた)治療 |
| CN103936661B (zh) * | 2014-04-04 | 2016-08-24 | 常州大学 | 一种6-烷基菲啶衍生物的合成方法 |
| MA42519A (fr) * | 2015-07-29 | 2018-06-06 | Takeda Gmbh | Inhibiteur de la pde4 pour le traitement de la néphropathie diabétique |
| US11179384B2 (en) | 2016-08-26 | 2021-11-23 | Takeda Gmbh | Treatment of nonalcoholic fatty liver disease |
| AU2018234059A1 (en) | 2017-03-16 | 2019-10-31 | Takeda Gmbh | Treatment of idiopathic pulmonary fibrosis |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| WO2020113088A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Diarylhydantoin compounds and methods of use thereof |
| TWI785816B (zh) * | 2019-08-30 | 2022-12-01 | 國立陽明交通大學 | 11-芳香基噌啉[2,3-f]菲啶鹽化合物及其製造方法 |
| TWI753296B (zh) * | 2019-08-30 | 2022-01-21 | 國立陽明交通大學 | 11-芳香基噌啉[2,3-f]菲啶鹽化合物及其製造方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9027055D0 (en) * | 1990-12-13 | 1991-02-06 | Sandoz Ltd | Organic compounds |
| AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| US5712298A (en) | 1993-07-02 | 1998-01-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors |
| HU221380B1 (en) | 1996-01-31 | 2002-09-28 | Byk Gulden Lomberg Chem Fab | Phosphodiesterase inhibitor phenanthridines derivatives and use thereof |
| DK0889886T5 (da) * | 1996-03-26 | 2003-02-24 | Altana Pharma Ag | Hidtil ukendte, i 6-stilling substituerede phenanthridiner |
| US6127378A (en) * | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| JPH1020274A (ja) * | 1996-07-05 | 1998-01-23 | Fujitsu Ltd | 液晶表示駆動回路及び液晶表示装置 |
| PL189641B1 (pl) | 1996-11-11 | 2005-09-30 | Altana Pharma Ag | Benzonaftyrydyny, środki farmaceutyczne je zawierające oraz zastosowanie benzonaftyrydyn |
| WO1998040382A1 (en) | 1997-03-07 | 1998-09-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel tetrazoles |
| AU8106598A (en) | 1997-06-03 | 1998-12-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine |
| ES2184318T3 (es) | 1997-07-25 | 2003-04-01 | Altana Pharma Ag | 6-alquilfenantridinas sustituidas. |
| JP2001510825A (ja) | 1997-07-25 | 2001-08-07 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規テトラゾール誘導体 |
| PL191094B1 (pl) | 1997-07-25 | 2006-03-31 | Altana Pharma Ag | Nowe podstawione 6-fenylofenantrydyny, środek farmaceutyczny zawierający te pochodne oraz ich zastosowanie |
| TR200001256T2 (tr) * | 1997-11-04 | 2000-11-21 | Pfizer Products Inc. | Terapötik olarak aktif bileşimler. |
| US6306869B1 (en) | 1998-05-05 | 2001-10-23 | Byk Gulden Lomberg Chemische Febrik Gmbh | N-oxides |
| JP2002523505A (ja) | 1998-08-31 | 2002-07-30 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | Pde3−及びpde−4抑制作用を有するベンゾナフチリデン−n−オキシド |
| DE60025327T2 (de) * | 1999-01-15 | 2006-08-24 | Altana Pharma Ag | 6-arylphenanthridine mit pde-iv hemmender wirkung |
| JP2002534506A (ja) | 1999-01-15 | 2002-10-15 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | Pde−iv抑制作用を有する多重に置換された6−フェニルフェナントリジン |
| JP2002534505A (ja) | 1999-01-15 | 2002-10-15 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規フェナントリジン−n−オキシド |
| CZ300366B6 (cs) | 1999-01-15 | 2009-05-06 | Nycomed Gmbh | Fenylfenanthridinová sloucenina, farmaceutický prostredek s jejím obsahem a její použití |
| WO2000042034A1 (en) | 1999-01-15 | 2000-07-20 | Byk Gulden | Phenanthridine-n-oxides with pde-iv inhibiting activity |
| CN1146562C (zh) * | 1999-10-25 | 2004-04-21 | 奥坦纳医药公司 | 作为pde4抑制剂的四氢噻喃2,3-二氮杂萘酮类衍生物 |
| WO2001051470A1 (en) | 2000-01-11 | 2001-07-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridine-n-oxides |
| US6924292B2 (en) | 2000-03-23 | 2005-08-02 | Takeda Chemical Industries, Ltd. | Furoisoquinoline derivatives, process for producing the same and use thereof |
| AU2001267589A1 (en) | 2000-07-14 | 2002-01-30 | Byk Gulden Lomberg Chemische Fabrik G.M.B.H. | Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines |
| WO2002005616A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Novel 6-phenylphenanthridines |
| US6884802B2 (en) | 2000-07-14 | 2005-04-26 | Altana Pharma Ag | 6-heteroarylphenanthridines |
| WO2002066476A1 (en) | 2001-02-21 | 2002-08-29 | Altana Pharma Ag | 6-phenylbenzonaphthyridines |
| JP2005537312A (ja) | 2002-08-17 | 2005-12-08 | アルタナ ファルマ アクチエンゲゼルシャフト | 新規のフェナントリジン |
| RS20050117A (sr) | 2002-08-17 | 2007-06-04 | Altana Pharma Ag., | Novi benzonaftiridini |
| CA2496459C (en) | 2002-08-29 | 2013-06-25 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| ES2279215T3 (es) | 2002-08-29 | 2007-08-16 | Altana Pharma Ag | 2-hidroxi-6-fenilfenantridinas como inhibidores de pde-4. |
| RU2247262C2 (ru) | 2003-05-19 | 2005-02-27 | Федеральное государственное унитарное предприятие Российский Федеральный Ядерный Центр-Всероссийский Научно-исследовательский институт технической физики им. акад. Е.И. Забабахина (РФЯЦ- ВНИИТФ) | Плунжерный насос сверхвысокого давления |
| ES2400823T3 (es) | 2004-02-18 | 2013-04-12 | Takeda Gmbh | Nuevas hidroxi-6-fenilfenantridinas sustituidas con guanidinilo como inhibidores eficaces de fosfodiesterasa (PDE) 4 |
| CN104803974A (zh) | 2004-03-03 | 2015-07-29 | 塔科达有限责任公司 | 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途 |
| AR049419A1 (es) | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| WO2005084104A2 (en) | 2004-03-09 | 2005-09-15 | Altana Pharma Ag | Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| EP1725532A1 (en) | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| KR20060130697A (ko) | 2004-03-10 | 2006-12-19 | 알타나 파마 아게 | 신규한 아미도-치환 히드록시-6-페닐페난트리딘 및 pde4억제제로서의 이의 용도 |
| AU2005221831A1 (en) | 2004-03-10 | 2005-09-22 | Nycomed Gmbh | Novel thio-containing hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors |
| KR101421914B1 (ko) | 2005-03-02 | 2014-07-22 | 다케다 게엠베하 | 6-헤테로시클릴 치환된 헥사히드로페난트리딘 유도체의 신규한 염 |
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2005
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