|
TWI329105B
(en)
|
2002-02-01 |
2010-08-21 |
Rigel Pharmaceuticals Inc |
2,4-pyrimidinediamine compounds and their uses
|
|
RS51752B
(sr)
|
2002-07-29 |
2011-12-31 |
Rigel Pharmaceuticals |
Metode tretiranja i prevencije autoimunih oboljenja jedinjenjima 2,4-pirimidindiamina
|
|
HRP20130602T1
(en)
|
2003-07-30 |
2013-07-31 |
Rigel Pharmaceuticals, Inc. |
2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
|
|
WO2006042102A2
(en)
*
|
2004-10-05 |
2006-04-20 |
Neurogen Corporation |
Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds
|
|
AU2005298637B8
(en)
|
2004-10-29 |
2012-12-06 |
Janssen Sciences Ireland Uc |
HIV inhibiting bicyclic pyrimidine derivatives
|
|
CA2608367C
(en)
|
2005-06-08 |
2014-08-19 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
US20070203161A1
(en)
|
2006-02-24 |
2007-08-30 |
Rigel Pharmaceuticals, Inc. |
Compositions and methods for inhibition of the jak pathway
|
|
ATE444294T1
(de)
*
|
2005-10-28 |
2009-10-15 |
Irm Llc |
Verbindungen und zusammensetzungen als proteinkinaseinhibitoren
|
|
US20090275070A1
(en)
*
|
2005-11-23 |
2009-11-05 |
Housey Gerard M |
Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators
|
|
ES2622493T3
(es)
|
2006-02-24 |
2017-07-06 |
Rigel Pharmaceuticals, Inc. |
Composiciones y métodos para la inhibición de la ruta de JAK
|
|
US8168383B2
(en)
|
2006-04-14 |
2012-05-01 |
Cell Signaling Technology, Inc. |
Gene defects and mutant ALK kinase in human solid tumors
|
|
EP2450437B1
(en)
|
2006-04-14 |
2017-05-17 |
Cell Signaling Technology, Inc. |
Gene defects and mutant ALK kinase in human solid tumors
|
|
JO3235B1
(ar)
*
|
2006-05-26 |
2018-03-08 |
Astex Therapeutics Ltd |
مركبات بيررولوبيريميدين و استعمالاتها
|
|
HRP20110621T2
(hr)
|
2006-09-15 |
2013-12-06 |
Pfizer Products Inc. |
SPOJEVI PIRIDO[2,3-d]PIRIMIDINONA I NJIHOVA UPOTREBA KAO INHIBITORI PI3
|
|
ES2633318T3
(es)
|
2006-10-23 |
2017-09-20 |
Cephalon, Inc. |
Derivados bicíclicos fusionados de 2,4-diaminopirimidina como inhibidores de ALK y c-Met
|
|
WO2008063888A2
(en)
|
2006-11-22 |
2008-05-29 |
Plexxikon, Inc. |
Compounds modulating c-fms and/or c-kit activity and uses therefor
|
|
US20100298557A1
(en)
*
|
2006-12-28 |
2010-11-25 |
Taisho Pharmaceutical Co., Ltd |
Pyrazolopyrimidine compound
|
|
WO2009020990A1
(en)
*
|
2007-08-08 |
2009-02-12 |
Smithkline Beecham Corporation |
2- [ (2-{phenylamino}-1h-pyrrolo [2, 3-d] pyrimidin-4-yl) amino] benzamide derivatives as igf-1r inhibitors for the treatment of cancer
|
|
WO2009071480A2
(en)
*
|
2007-12-04 |
2009-06-11 |
Nerviano Medical Sciences S.R.L. |
Substituted dihydropteridin-6-one derivatives, process for their preparation and their use as kinase inhibitors
|
|
AU2009211338B2
(en)
*
|
2008-02-06 |
2011-12-15 |
Novartis Ag |
Pyrrolo[2, 3-D] pyrimidines and use thereof as tyrosine kinase inhibitors
|
|
WO2009143389A1
(en)
|
2008-05-21 |
2009-11-26 |
Ariad Pharmaceuticals, Inc. |
Phosphorous derivatives as kinase inhibitors
|
|
US9273077B2
(en)
|
2008-05-21 |
2016-03-01 |
Ariad Pharmaceuticals, Inc. |
Phosphorus derivatives as kinase inhibitors
|
|
BRPI0917791B1
(pt)
|
2008-08-22 |
2022-03-22 |
Novartis Ag |
Compostos de pirrolopirimidina como inibidores de cdk, bem como composição farmacêutica e combinação
|
|
TW201035100A
(en)
|
2008-12-19 |
2010-10-01 |
Cephalon Inc |
Pyrrolotriazines as ALK and JAK2 inhibitors
|
|
GB0903759D0
(en)
*
|
2009-03-04 |
2009-04-15 |
Medical Res Council |
Compound
|
|
MY160737A
(en)
|
2009-04-03 |
2017-03-15 |
Hoffmann La Roche |
Propane-i-sulfonic acid {3- [5-(4-chloro-phenyl) -1h -pyrrolo [2, 3-b] pyridine-3-carbonyl] -2,4 difluoro-phenyl} - amide compositions and uses thereof
|
|
CN102666545B
(zh)
*
|
2009-10-20 |
2016-04-06 |
塞尔卓姆有限公司 |
作为jak抑制剂的杂环吡唑并嘧啶类似物
|
|
SG10201407129SA
(en)
|
2009-11-06 |
2014-12-30 |
Plexxikon Inc |
Compounds and methods for kinase modulation, and indications therefor
|
|
JP2011148751A
(ja)
*
|
2010-01-25 |
2011-08-04 |
Konica Minolta Holdings Inc |
含窒素縮合複素環化合物の製造方法
|
|
TWI518325B
(zh)
*
|
2010-02-04 |
2016-01-21 |
自治醫科大學 |
對alk抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
|
|
UY33227A
(es)
|
2010-02-19 |
2011-09-30 |
Novartis Ag |
Compuestos de pirrolopirimidina como inhibidores de la cdk4/6
|
|
TWI619713B
(zh)
*
|
2010-04-21 |
2018-04-01 |
普雷辛肯公司 |
用於激酶調節的化合物和方法及其適應症
|
|
WO2011146313A1
(en)
|
2010-05-19 |
2011-11-24 |
The University Of North Carolina At Chapel Hill |
Pyrazolopyrimidine compounds for the treatment of cancer
|
|
BR112013006272A2
(pt)
|
2010-09-17 |
2019-09-24 |
Purdue Pharma Lp |
compostos de piridina e seus usos
|
|
AR083797A1
(es)
*
|
2010-11-10 |
2013-03-20 |
Novartis Ag |
Succinato de dimetil-amida del acido 7-ciclopentil-2-(5-piperazin-1-il-piridin-2-il-amino)-7h-pirrolo-[2,3-d]pirimidin-6-carboxilico, proceso para prepararla, intermediarios de dicha sintesis y proceso de preparacion de los mismos
|
|
JP2013542966A
(ja)
*
|
2010-11-19 |
2013-11-28 |
エフ.ホフマン−ラ ロシュ アーゲー |
ピラゾロピリジンならびにtyk2阻害剤としてのピラゾロピリジン及びそれらの使用
|
|
WO2012088266A2
(en)
|
2010-12-22 |
2012-06-28 |
Incyte Corporation |
Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
|
|
CN102093364B
(zh)
|
2011-01-07 |
2015-01-28 |
北京赛林泰医药技术有限公司 |
作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物
|
|
CN103476776B
(zh)
*
|
2011-01-07 |
2016-09-28 |
北京赛林泰医药技术有限公司 |
作为FAK/Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物
|
|
CN103517710B
(zh)
|
2011-02-07 |
2017-05-31 |
普莱希科公司 |
用于激酶调节的化合物
|
|
WO2012143320A1
(en)
|
2011-04-18 |
2012-10-26 |
Cellzome Limited |
(7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors
|
|
CN103501612B
(zh)
|
2011-05-04 |
2017-03-29 |
阿里亚德医药股份有限公司 |
抑制表皮生长因子受体导致的癌症中细胞增殖的化合物
|
|
SG194847A1
(en)
*
|
2011-05-17 |
2013-12-30 |
Plexxikon Inc |
Kinase modulation and indications therefor
|
|
KR20140063700A
(ko)
*
|
2011-09-20 |
2014-05-27 |
셀좀 리미티드 |
키나제 억제제로서의 피라졸로[4,3-c]피리딘 유도체
|
|
CN103958510B
(zh)
|
2011-10-03 |
2016-10-19 |
北卡罗来纳大学教堂山分校 |
用于治疗癌症的吡咯并嘧啶化合物
|
|
MX2014005927A
(es)
|
2011-11-15 |
2014-06-05 |
Novartis Ag |
Combinacion de un inhibidor de la fosfoinositida-3-cinasa y un modulador de la senda del transductor y activador de la señal de transcripcion 5 de la cinasa janus 2.
|
|
CA2865420C
(en)
|
2012-03-06 |
2020-06-02 |
Cephalon, Inc. |
Fused bicyclic 2,4-diaminopyrimidine derivative as a dual alk and fak inhibitor
|
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
|
JP6469567B2
(ja)
|
2012-05-05 |
2019-02-13 |
アリアド・ファーマシューティカルズ・インコーポレイテッド |
Egfr発動性がんの細胞増殖阻害用化合物
|
|
WO2013170671A1
(zh)
*
|
2012-05-14 |
2013-11-21 |
华东理工大学 |
蝶啶酮衍生物及其作为egfr、blk、flt3抑制剂的应用
|
|
CN104302627A
(zh)
|
2012-05-22 |
2015-01-21 |
北卡罗来纳大学教堂山分校 |
用于治疗癌症的嘧啶化合物
|
|
US9150570B2
(en)
|
2012-05-31 |
2015-10-06 |
Plexxikon Inc. |
Synthesis of heterocyclic compounds
|
|
UA125503C2
(uk)
|
2012-06-13 |
2022-04-13 |
Інсайт Холдинґс Корпорейшн |
Заміщені трициклічні сполуки як інгібітори fgfr
|
|
US9388185B2
(en)
|
2012-08-10 |
2016-07-12 |
Incyte Holdings Corporation |
Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
|
|
WO2014062774A1
(en)
|
2012-10-17 |
2014-04-24 |
The University Of North Carolina At Chapel Hill |
Pyrazolopyrimidine compounds for the treatment of cancer
|
|
KR102156398B1
(ko)
*
|
2012-11-06 |
2020-09-15 |
상하이 포천 파마슈티컬 씨오 엘티디 |
Alk 키나아제 억제제
|
|
US9771330B2
(en)
|
2012-11-27 |
2017-09-26 |
The University Of North Carolina At Chapel Hill |
Pyrimidine compounds for the treatment of cancer
|
|
CN103864792B
(zh)
*
|
2012-12-12 |
2017-01-18 |
山东亨利医药科技有限责任公司 |
作为酪氨酸激酶抑制剂的含氮并环类化合物
|
|
WO2014089913A1
(zh)
*
|
2012-12-12 |
2014-06-19 |
山东亨利医药科技有限责任公司 |
作为酪氨酸激酶抑制剂的并环化合物
|
|
US9266892B2
(en)
|
2012-12-19 |
2016-02-23 |
Incyte Holdings Corporation |
Fused pyrazoles as FGFR inhibitors
|
|
US9611283B1
(en)
|
2013-04-10 |
2017-04-04 |
Ariad Pharmaceuticals, Inc. |
Methods for inhibiting cell proliferation in ALK-driven cancers
|
|
MY181497A
(en)
|
2013-04-19 |
2020-12-23 |
Incyte Holdings Corp |
Bicyclic heterocycles as fgfr inhibitors
|
|
WO2014193932A1
(en)
|
2013-05-29 |
2014-12-04 |
Cephalon, Inc. |
Pyrrolotriazines as alk inhibitors
|
|
WO2015038417A1
(en)
*
|
2013-09-10 |
2015-03-19 |
Asana Biosciences, Llc |
Compounds for regulating fak and/or src pathways
|
|
RU2550346C2
(ru)
|
2013-09-26 |
2015-05-10 |
Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" |
Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
|
|
CN107002119A
(zh)
|
2014-03-24 |
2017-08-01 |
豪夫迈·罗氏有限公司 |
使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联
|
|
CN106458914B
(zh)
*
|
2014-03-28 |
2020-01-14 |
常州捷凯医药科技有限公司 |
作为axl抑制剂的杂环化合物
|
|
US20150291606A1
(en)
|
2014-04-11 |
2015-10-15 |
The University Of North Carolina At Chapel Hill |
Mertk-specific pyrrolopyrimidine compounds
|
|
EP3137468B1
(en)
*
|
2014-05-01 |
2021-10-06 |
Novartis AG |
Compounds and compositions as toll-like receptor 7 agonists
|
|
PL3137470T3
(pl)
|
2014-05-01 |
2021-10-11 |
Novartis Ag |
Związki i kompozycje jako agonisty receptora toll-like 7
|
|
US10851105B2
(en)
|
2014-10-22 |
2020-12-01 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
CN105111215B
(zh)
*
|
2014-12-12 |
2019-06-18 |
苏州晶云药物科技股份有限公司 |
一种周期蛋白依赖性激酶抑制剂的晶型及其制备方法
|
|
CN104610265A
(zh)
*
|
2014-12-31 |
2015-05-13 |
芜湖杨燕制药有限公司 |
一种化合物及其制备方法
|
|
CN104606197A
(zh)
*
|
2014-12-31 |
2015-05-13 |
芜湖杨燕制药有限公司 |
一种化合物的抗肿瘤用途
|
|
MA41551A
(fr)
|
2015-02-20 |
2017-12-26 |
Incyte Corp |
Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
|
|
CR20170390A
(es)
|
2015-02-20 |
2017-10-23 |
Incyte Holdings Corp |
Heterociclos biciclicos como inhibidores de fgfr
|
|
US9580423B2
(en)
|
2015-02-20 |
2017-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR4 inhibitors
|
|
MA44334A
(fr)
|
2015-10-29 |
2018-09-05 |
Novartis Ag |
Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
|
|
CN106831780A
(zh)
*
|
2015-12-03 |
2017-06-13 |
南开大学 |
具有cdk4/6和hdac抑制活性的新型杂环衍生物
|
|
US10709708B2
(en)
|
2016-03-17 |
2020-07-14 |
The University Of North Carolina At Chapel Hill |
Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor
|
|
CN108658855A
(zh)
*
|
2017-03-28 |
2018-10-16 |
中国海洋大学 |
一种含氮双环化合物及其制备方法和用途
|
|
CN108658854A
(zh)
*
|
2017-03-28 |
2018-10-16 |
中国海洋大学 |
一种生物碱化合物及其制备方法和作为海洋防污剂的应用
|
|
AR111960A1
(es)
|
2017-05-26 |
2019-09-04 |
Incyte Corp |
Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
|
|
TWI790120B
(zh)
|
2017-06-02 |
2023-01-11 |
美商輝瑞大藥廠 |
對flt3具特異性之抗體及其用途
|
|
BR112020022392A2
(pt)
|
2018-05-04 |
2021-02-02 |
Incyte Corporation |
formas sólidas de um inibidor de fgfr e processos para preparação das mesmas
|
|
PE20210919A1
(es)
|
2018-05-04 |
2021-05-19 |
Incyte Corp |
Sales de un inhibidor de fgfr
|
|
US11066404B2
(en)
|
2018-10-11 |
2021-07-20 |
Incyte Corporation |
Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
|
|
CN111484496B
(zh)
*
|
2019-01-29 |
2022-11-29 |
江苏开元药业有限公司 |
2-氨基-吡咯并嘧啶和吡唑并嘧啶类化合物及其制备方法和用途
|
|
WO2020168197A1
(en)
|
2019-02-15 |
2020-08-20 |
Incyte Corporation |
Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
|
|
TW202100520A
(zh)
|
2019-03-05 |
2021-01-01 |
美商英塞特公司 |
作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
|
|
US11628162B2
(en)
|
2019-03-08 |
2023-04-18 |
Incyte Corporation |
Methods of treating cancer with an FGFR inhibitor
|
|
KR102697799B1
(ko)
*
|
2019-03-22 |
2024-08-23 |
쇼우야오 홀딩스 (베이징) 코., 엘티디. |
Wee1 억제제 및 이의 제조 및 용도
|
|
WO2020205560A1
(en)
|
2019-03-29 |
2020-10-08 |
Incyte Corporation |
Sulfonylamide compounds as cdk2 inhibitors
|
|
WO2020223558A1
(en)
|
2019-05-01 |
2020-11-05 |
Incyte Corporation |
Tricyclic amine compounds as cdk2 inhibitors
|
|
US11440914B2
(en)
|
2019-05-01 |
2022-09-13 |
Incyte Corporation |
Tricyclic amine compounds as CDK2 inhibitors
|
|
US11591329B2
(en)
|
2019-07-09 |
2023-02-28 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
TW202115024A
(zh)
|
2019-08-14 |
2021-04-16 |
美商英塞特公司 |
作為cdk2 抑制劑之咪唑基嘧啶基胺化合物
|
|
US12122767B2
(en)
|
2019-10-01 |
2024-10-22 |
Incyte Corporation |
Bicyclic heterocycles as FGFR inhibitors
|
|
CN119930610A
(zh)
|
2019-10-11 |
2025-05-06 |
因赛特公司 |
作为cdk2抑制剂的双环胺
|
|
GEP20247679B
(en)
|
2019-10-14 |
2024-10-10 |
Incyte Corp |
Bicyclic heterocycles as fgfr inhibitors
|
|
WO2021076728A1
(en)
|
2019-10-16 |
2021-04-22 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
JP7720840B2
(ja)
|
2019-12-04 |
2025-08-08 |
インサイト・コーポレイション |
Fgfr阻害剤としての三環式複素環
|
|
PE20221504A1
(es)
|
2019-12-04 |
2022-09-30 |
Incyte Corp |
Derivados de un inhibidor de fgfr
|
|
IL293836A
(en)
*
|
2019-12-13 |
2022-08-01 |
Nippon Shinyaku Co Ltd |
Compound and preparation as pdgf receptor kinase inhibitor
|
|
WO2021146424A1
(en)
|
2020-01-15 |
2021-07-22 |
Incyte Corporation |
Bicyclic heterocycles as fgfr inhibitors
|
|
KR20230043955A
(ko)
*
|
2020-07-23 |
2023-03-31 |
시토신랩 테라퓨틱스 코., 엘티디. |
키나아제 억제 활성을 갖는 화합물
|
|
WO2022083560A1
(zh)
*
|
2020-10-19 |
2022-04-28 |
南京药石科技股份有限公司 |
Tyk2选择性抑制剂及其用途
|
|
TW202304459A
(zh)
|
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