DK1787126T3 - Fremgangsmåde til karakterisering af en polyklonal cellelinie - Google Patents
Fremgangsmåde til karakterisering af en polyklonal cellelinieInfo
- Publication number
- DK1787126T3 DK1787126T3 DK05760790T DK05760790T DK1787126T3 DK 1787126 T3 DK1787126 T3 DK 1787126T3 DK 05760790 T DK05760790 T DK 05760790T DK 05760790 T DK05760790 T DK 05760790T DK 1787126 T3 DK1787126 T3 DK 1787126T3
- Authority
- DK
- Denmark
- Prior art keywords
- cell line
- polyclonal
- platform
- polyclonal cell
- characterizing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000012512 characterization method Methods 0.000 abstract 2
- 238000012252 genetic analysis Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000012514 protein characterization Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Document Processing Apparatus (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200401133 | 2004-07-20 | ||
| DKPA200401991 | 2004-12-22 | ||
| PCT/DK2005/000504 WO2006007853A2 (fr) | 2004-07-20 | 2005-07-20 | Procedure de caracterisation structurelle d'une proteine polyclonale recombinee ou d'une lignee de cellules polyclonales |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1787126T3 true DK1787126T3 (da) | 2009-12-21 |
Family
ID=35427551
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05760790T DK1787126T3 (da) | 2004-07-20 | 2005-07-20 | Fremgangsmåde til karakterisering af en polyklonal cellelinie |
| DK09151073.5T DK2053408T3 (da) | 2004-07-20 | 2005-07-20 | Fremgangsmåde til strukturel karakterisering af et rekombinant polyklonalt protein eller en polyklonal cellelinje |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09151073.5T DK2053408T3 (da) | 2004-07-20 | 2005-07-20 | Fremgangsmåde til strukturel karakterisering af et rekombinant polyklonalt protein eller en polyklonal cellelinje |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8288109B2 (fr) |
| EP (2) | EP1787126B1 (fr) |
| JP (1) | JP4870667B2 (fr) |
| KR (1) | KR101319848B1 (fr) |
| AT (2) | ATE443870T1 (fr) |
| AU (1) | AU2005263334C1 (fr) |
| BR (1) | BRPI0513714A (fr) |
| CA (1) | CA2574146C (fr) |
| DE (1) | DE602005016818D1 (fr) |
| DK (2) | DK1787126T3 (fr) |
| ES (2) | ES2332524T3 (fr) |
| IL (2) | IL180169A (fr) |
| MX (1) | MX2007000551A (fr) |
| NO (1) | NO20070931L (fr) |
| NZ (1) | NZ552264A (fr) |
| PL (2) | PL2053408T3 (fr) |
| RU (1) | RU2426795C2 (fr) |
| WO (1) | WO2006007853A2 (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2512647C (fr) * | 2003-01-07 | 2013-10-08 | Symphogen A/S | Methode de production de proteines polyclonales de recombinaison |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| BRPI0513706A (pt) | 2004-07-20 | 2008-05-13 | Symphogen As | anticorpo policlonal recombinante anti-rhesus d e métodos de produção |
| RU2426795C2 (ru) | 2004-07-20 | 2011-08-20 | Симфоген А/С | Способ структурной характеристики рекомбинантного поликлонального белка или поликлональной клеточной линии |
| JP2009518320A (ja) * | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
| US8338376B2 (en) | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
| MX2009008908A (es) * | 2007-03-01 | 2009-08-28 | Symphogen As | Metodo para clonacion de anticuerpos analogos. |
| PL2132229T3 (pl) * | 2007-03-01 | 2016-12-30 | Kompozycje rekombinowanych przeciwciał anty-receptor czynnika wzrostu naskórka | |
| CN101679513A (zh) * | 2007-03-06 | 2010-03-24 | 西福根有限公司 | 用于治疗呼吸道合胞病毒感染的重组抗体 |
| EP2139509A2 (fr) * | 2007-03-15 | 2010-01-06 | Biogen Idec MA, Inc. | Traitement de troubles auto-immuns |
| JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
| NZ581316A (en) * | 2007-05-25 | 2012-02-24 | Symphogen As | Method for manufacturing a recombinant polyclonal protein |
| CN101821289A (zh) * | 2007-09-07 | 2010-09-01 | 西福根有限公司 | 重组制造抗rsv抗体的方法 |
| CA2702322A1 (fr) | 2007-11-22 | 2009-05-28 | Symphogen A/S | Procede de caracterisation d'une proteine polyclonale recombinante |
| BRPI0910454A2 (pt) * | 2008-04-23 | 2018-03-27 | Symphogen As | processo para produção de uma proteína policlonal |
| EP2331577B1 (fr) | 2008-08-29 | 2017-06-07 | Symphogen A/S | Compositions de l'anticorps de recombinaison anti-récepteur du facteur de croissance anti-épidermique egfr |
| MX2011001930A (es) * | 2008-08-29 | 2011-04-21 | Symphogen As | Metodo para clonar anticuerpos derivados de aves. |
| US8821879B2 (en) | 2009-09-04 | 2014-09-02 | Xoma Technology Ltd. | Anti-botulism antibody coformulations |
| JP2013507603A (ja) * | 2009-10-09 | 2013-03-04 | シムフォゲン・アクティーゼルスカブ | 署名ペプチドおよび質量分析による混合物中の個々の組換えタンパク質の多重定量化 |
| EP2558494B1 (fr) * | 2010-04-15 | 2018-05-23 | AbbVie Inc. | Protéines de liaison à la bêta amyloïde |
| ES2692379T3 (es) | 2010-11-01 | 2018-12-03 | Symphogen A/S | Anticuerpos anti-HER3 y composiciones |
| JP2016514091A (ja) | 2013-02-08 | 2016-05-19 | ミスフォールディング ダイアグノスティクス, インコーポレイテッド | トランスサイレチン抗体およびその使用 |
| EP3729958B1 (fr) * | 2013-03-15 | 2023-05-03 | Mayo Foundation for Medical Education and Research | Identification et surveillance d'immunoglobulines monoclonales par la masse moléculaire |
| UY35517A (es) | 2013-04-04 | 2014-10-31 | Mabxience S A | Un procedimiento para aumentar la formación de ácido piroglutamico de una proteína |
| WO2015093925A1 (fr) * | 2013-12-19 | 2015-06-25 | CASTRO ALDRETE, Jorge Isaac | Méthode de production d'anticorps spécifiques |
| TW201623331A (zh) * | 2014-03-12 | 2016-07-01 | 普羅帝納生物科學公司 | 抗黑色素瘤細胞黏著分子(mcam)抗體類及使用彼等之相關方法 |
| US11680948B2 (en) | 2016-08-12 | 2023-06-20 | Abreos Biosciences, Inc. | Detection and quantification of natalizumab |
| GB201710691D0 (en) * | 2017-07-04 | 2017-08-16 | Ge Healthcare Bio Sciences Ab | Method in bioprocess purification system |
| MA52945A (fr) * | 2018-06-22 | 2021-04-28 | Genmab As | Procédé de production d'un mélange contrôlé d'au moins deux anticorps différents |
| CN112816595A (zh) * | 2021-01-06 | 2021-05-18 | 海默斯(重庆)医学生物技术有限公司 | 一种重组角蛋白液体制剂及其纯度检测方法 |
| WO2025038736A1 (fr) * | 2023-08-15 | 2025-02-20 | Gigagen, Inc. | Procédés d'analyse de protéines polyclonales recombinantes |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0162918A1 (fr) | 1983-11-28 | 1985-12-04 | The Board Of Trustees Of The Leland Stanford Junior University | ANTICORPS MONOCLONAL HUMAIN CONTRE L'ANTIGENE Rh(D) ET SES UTILISATIONS |
| IL78775A (en) * | 1985-05-15 | 1992-06-21 | Biotech Australia Pty Ltd | Oral vaccines |
| CA1293460C (fr) | 1985-10-07 | 1991-12-24 | Brian Lee Sauer | Recombinaison a des sites specifiques de l'adn dans les levures |
| US5126130A (en) | 1986-11-24 | 1992-06-30 | The Childrens Hospital Incorporated | Monoclonal antibodies reactive with specific antigenic sites on human cytomegalovirus glycoprotein a |
| GB8722019D0 (en) | 1987-09-18 | 1987-10-28 | Central Blood Lab Authority | Human anti-rh(d)monoclonal antibodies |
| GB8722018D0 (en) | 1987-09-18 | 1987-10-28 | Central Blood Lab Authority | Human anti-rh(d)monoclonal antibodies |
| GB8722020D0 (en) | 1987-09-18 | 1987-10-28 | Central Blood Lab Authority | Human anti-rh(d)monoclonal antibodies |
| WO1990005144A1 (fr) | 1988-11-11 | 1990-05-17 | Medical Research Council | Ligands a domaine unique, recepteurs comprenant lesdits ligands, procedes pour leur production, et emploi desdits ligands et recepteurs |
| GB8906129D0 (en) | 1989-03-17 | 1989-05-04 | Central Blood Lab Authority | Pharmaceutical preparations |
| GB8919761D0 (en) | 1989-09-01 | 1989-10-18 | Central Blood Lab Authority | Chemical compounds |
| WO1992015694A1 (fr) | 1991-03-08 | 1992-09-17 | The Salk Institute For Biological Studies | Modification de genes induite par recombinase dans des cellules de mammifere, compositions et cellules utiles a cet effet |
| US5837268A (en) * | 1991-10-16 | 1998-11-17 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
| US5252216A (en) * | 1992-03-24 | 1993-10-12 | Smithkline Beecham Corporation | Protein purification |
| PL302438A1 (en) | 1992-06-26 | 1994-07-25 | Aetsrn | Human anti-rh(d) monoclonal antibodies and cellular lines producing them |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| DK1231268T3 (da) | 1994-01-31 | 2005-11-21 | Univ Boston | Polyklonale antistofbiblioteker |
| FR2724182B1 (fr) | 1994-09-02 | 1996-12-13 | Pasteur Institut | Obtention d'un anticorps monoclonal recombinant a partir d'un anticorps monoclonal humain anti-rhesus d, sa production en cellules d'insecte, et ses utilisations |
| US6111166A (en) | 1994-09-19 | 2000-08-29 | Medarex, Incorporated | Transgenic mice expressing human Fcα and β receptors |
| EP0920509B1 (fr) | 1996-06-24 | 2004-07-28 | ZLB Bioplasma AG | Polypeptides capables de former des structures de liaison a l'ant igene avec une specificite pour les antigenes de rhesus d, adn les codant et procede pour leur preparation et leur utilisation |
| US6255455B1 (en) | 1996-10-11 | 2001-07-03 | The Trustees Of The University Of Pennsylvania | Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof |
| US5876925A (en) | 1996-10-11 | 1999-03-02 | The Trustees Of The University Of Pennsylvania | Magnetically activated cell sorting for production of proteins |
| CA2283740C (fr) | 1997-03-14 | 2006-06-27 | Idec Pharmaceuticals Corporation | Procede pour integrer des genes a des sites specifiques dans des cellules de mammifere par recombinaison homologue et vecteurs utilises pour la mise en oeuvre de ce procede |
| JPH11174038A (ja) * | 1997-12-10 | 1999-07-02 | Tosoh Corp | 蛋白質の分離精製法 |
| US6632672B2 (en) | 1998-08-19 | 2003-10-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for genomic modification |
| US20020155114A1 (en) | 1998-08-31 | 2002-10-24 | James D. Marks | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| WO2001006233A1 (fr) * | 1999-07-16 | 2001-01-25 | Human Genome Sciences, Inc. | Surveillance en temps reel et in situ et supervision, en reaction a une spectroscopie aux infrarouges, d'un processus de biofabrication |
| DK1234022T3 (da) | 1999-07-23 | 2010-07-19 | Univ California | DNA-rekombination i eukaryote celler med bakteriofag PHIC31-rekombinationssystemet |
| EP1106625A1 (fr) | 1999-11-17 | 2001-06-13 | ZLB Bioplasma AG | Séquences péptidiques spécifiques pour rhesus D |
| EP1358202A2 (fr) | 2000-02-08 | 2003-11-05 | The Regents Of The University Of Michigan | Separation et affichage de proteines |
| JP2003534533A (ja) | 2000-02-08 | 2003-11-18 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | タンパク質のディファレンシャルディスプレイのマッピング |
| AU2001234893A1 (en) | 2000-02-08 | 2001-08-20 | The Regents Of The University Of Michigan | Protein mapping |
| EP1283720B1 (fr) | 2000-05-26 | 2007-04-18 | Symphogen A/S | Anticorps polyclonaux recombines ou purifies, destines au traitement des allergies |
| US6610472B1 (en) | 2000-10-31 | 2003-08-26 | Genetastix Corporation | Assembly and screening of highly complex and fully human antibody repertoire in yeast |
| EP1337631A2 (fr) * | 2000-11-28 | 2003-08-27 | Applied Molecular Evolution, Inc. | Bibliotheques d'expression eucaryotes et methodes d'utilisation eukaryotic expression libraries and methods of use |
| DE60142650D1 (de) | 2000-12-26 | 2010-09-02 | Inst Systems Biology Seattle | Schnelle und quantitative Proteomanalyse und entsprechende Verfahren |
| US7541003B2 (en) * | 2001-07-17 | 2009-06-02 | Bio-Rad Laboratories, Inc. | Latex based adsorbent chip |
| ATE327512T1 (de) * | 2001-12-08 | 2006-06-15 | Micromass Ltd | Massenspektrometrie-verfahren |
| AU2003237282A1 (en) | 2002-05-31 | 2003-12-19 | The Regents Of The University Of Michigan | Automated protein analysis system comprising capillary electrophoresis-tandem mass spectrometry |
| SI1523496T1 (sl) * | 2002-07-18 | 2011-11-30 | Merus B V | Rekombinantno proizvajanje zmesi protiteles |
| JP2004101477A (ja) * | 2002-09-12 | 2004-04-02 | Yoshio Yamauchi | 2次元高速液体クロマトグラフ装置及びそれを用いた蛋白質分析装置 |
| WO2004035169A2 (fr) | 2002-10-15 | 2004-04-29 | The Regents Of The University Of Michigan | Systeme de separation multidimensionelle des proteines |
| US20060275766A1 (en) * | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
| CA2512647C (fr) * | 2003-01-07 | 2013-10-08 | Symphogen A/S | Methode de production de proteines polyclonales de recombinaison |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| BRPI0513706A (pt) | 2004-07-20 | 2008-05-13 | Symphogen As | anticorpo policlonal recombinante anti-rhesus d e métodos de produção |
| RU2426795C2 (ru) | 2004-07-20 | 2011-08-20 | Симфоген А/С | Способ структурной характеристики рекомбинантного поликлонального белка или поликлональной клеточной линии |
| JP2009518320A (ja) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
| KR20080113223A (ko) | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
| CA2702322A1 (fr) | 2007-11-22 | 2009-05-28 | Symphogen A/S | Procede de caracterisation d'une proteine polyclonale recombinante |
-
2005
- 2005-07-20 RU RU2007106050/10A patent/RU2426795C2/ru not_active IP Right Cessation
- 2005-07-20 DK DK05760790T patent/DK1787126T3/da active
- 2005-07-20 EP EP05760790A patent/EP1787126B1/fr not_active Expired - Lifetime
- 2005-07-20 JP JP2007521795A patent/JP4870667B2/ja not_active Expired - Fee Related
- 2005-07-20 DK DK09151073.5T patent/DK2053408T3/da active
- 2005-07-20 AT AT05760790T patent/ATE443870T1/de active
- 2005-07-20 CA CA2574146A patent/CA2574146C/fr not_active Expired - Fee Related
- 2005-07-20 ES ES05760790T patent/ES2332524T3/es not_active Expired - Lifetime
- 2005-07-20 ES ES09151073T patent/ES2381531T3/es not_active Expired - Lifetime
- 2005-07-20 BR BRPI0513714-4A patent/BRPI0513714A/pt not_active Application Discontinuation
- 2005-07-20 WO PCT/DK2005/000504 patent/WO2006007853A2/fr not_active Ceased
- 2005-07-20 PL PL09151073T patent/PL2053408T3/pl unknown
- 2005-07-20 US US11/658,021 patent/US8288109B2/en not_active Expired - Fee Related
- 2005-07-20 EP EP09151073A patent/EP2053408B1/fr not_active Expired - Lifetime
- 2005-07-20 AU AU2005263334A patent/AU2005263334C1/en not_active Ceased
- 2005-07-20 KR KR1020077003954A patent/KR101319848B1/ko not_active Expired - Fee Related
- 2005-07-20 MX MX2007000551A patent/MX2007000551A/es active IP Right Grant
- 2005-07-20 NZ NZ552264A patent/NZ552264A/en not_active IP Right Cessation
- 2005-07-20 PL PL05760790T patent/PL1787126T3/pl unknown
- 2005-07-20 AT AT09151073T patent/ATE548657T1/de active
- 2005-07-20 DE DE602005016818T patent/DE602005016818D1/de not_active Expired - Lifetime
-
2006
- 2006-12-19 IL IL180169A patent/IL180169A/en not_active IP Right Cessation
-
2007
- 2007-02-19 NO NO20070931A patent/NO20070931L/no not_active Application Discontinuation
-
2009
- 2009-12-29 IL IL203017A patent/IL203017A/en not_active IP Right Cessation
-
2012
- 2012-10-16 US US13/653,316 patent/US9029091B2/en not_active Expired - Fee Related
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