DK1638969T3 - CGRP-receptorantagonister - Google Patents

CGRP-receptorantagonister

Info

Publication number: DK1638969T3
Authority: DK; Denmark
Prior art keywords: receptor antagonists; cgrp receptor; cgrp; antagonists; receptor
Prior art date: 2003-04-15

Application number

DK04749887T

Other languages

Danish (da)

English (en)

Inventor

Christopher S Burgey

Zhengwu J Deng

Diem N Nguyen

Daniel V Paone

Anthony W Shaw

Theresa M Williams

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-15

Filing date

2004-04-09

Publication date

2009-01-26

2004-04-09 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

2009-01-26 Application granted granted Critical

2009-01-26 Publication of DK1638969T3 publication Critical patent/DK1638969T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Hematology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK04749887T 2003-04-15 2004-04-09 CGRP-receptorantagonister DK1638969T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US46308903P	2003-04-15	2003-04-15
US51035203P	2003-10-10	2003-10-10
PCT/US2004/010851 WO2004092166A2 (fr)	2003-04-15	2004-04-09	Antagonistes des recepteurs cgrp

Publications (1)

Publication Number	Publication Date
DK1638969T3 true DK1638969T3 (da)	2009-01-26

Family

ID=33303112

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04749887T DK1638969T3 (da)	2003-04-15	2004-04-09	CGRP-receptorantagonister

Country Status (32)

Country	Link
US (6)	US6953790B2 (fr)
EP (2)	EP1638969B1 (fr)
JP (1)	JP3967766B2 (fr)
KR (1)	KR100769030B1 (fr)
CN (1)	CN100384843C (fr)
AR (1)	AR045887A1 (fr)
AT (1)	ATE413400T1 (fr)
AU (1)	AU2004230926B2 (fr)
BR (1)	BRPI0409601A (fr)
CA (1)	CA2522220C (fr)
CL (1)	CL2004000788A1 (fr)
CO (1)	CO5640130A2 (fr)
CY (1)	CY1108714T1 (fr)
DE (1)	DE602004017608D1 (fr)
DK (1)	DK1638969T3 (fr)
EC (1)	ECSP056097A (fr)
ES (1)	ES2314417T3 (fr)
HR (1)	HRP20080666T3 (fr)
IS (1)	IS2759B (fr)
JO (1)	JO2355B1 (fr)
MA (1)	MA27728A1 (fr)
MX (1)	MXPA05011166A (fr)
NO (1)	NO327655B1 (fr)
NZ (1)	NZ543357A (fr)
PE (1)	PE20050020A1 (fr)
PL (1)	PL1638969T3 (fr)
PT (1)	PT1638969E (fr)
RU (1)	RU2308458C2 (fr)
SI (1)	SI1638969T1 (fr)
TW (1)	TWI314931B (fr)
UA (1)	UA82877C2 (fr)
WO (2)	WO2004092168A1 (fr)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100558728C (zh) *	2002-06-05	2009-11-11	布里斯托尔-迈尔斯斯奎布公司	降钙素基因相关肽受体拮抗剂
US7842808B2 (en)	2002-06-05	2010-11-30	Bristol-Myers Squibb Company	Anti-migraine spirocycles
US7220862B2 (en)	2002-06-05	2007-05-22	Bristol-Myers Squibb Company	Calcitonin gene related peptide receptor antagonists
WO2004091514A2 (fr) *	2003-04-15	2004-10-28	Merck & Co., Inc.	Antagonistes des recepteurs de cgrp
GB0310881D0 (en) *	2003-05-12	2003-06-18	Merck Sharp & Dohme	Pharmaceutical formulation
WO2005000807A2 (fr) *	2003-06-26	2005-01-06	Merck & Co., Inc.	Antagonistes du recepteur cgrp de benzodiazepine
US7476665B2 (en) *	2003-06-26	2009-01-13	Merck & Co., Inc.	Benzodiazepine CGRP receptor antagonists
US7569578B2 (en)	2003-12-05	2009-08-04	Bristol-Meyers Squibb Company	Heterocyclic anti-migraine agents
AU2005208834B2 (en) *	2004-01-29	2009-10-08	Merck Sharp & Dohme Corp.	CGRP receptor antagonists
CN101090885A (zh) *	2004-02-23	2007-12-19	塔夫茨大学信托人	作为构象限定的肽模拟物抑制剂的内酰胺类化合物
TW200533398A (en)	2004-03-29	2005-10-16	Bristol Myers Squibb Co	Novel therapeutic agents for the treatment of migraine
CN101072771B (zh) *	2004-10-07	2010-09-29	默沙东公司	Cgrp受体拮抗剂
WO2006044449A2 (fr) *	2004-10-14	2006-04-27	Merck & Co., Inc.	Antagonistes des recepteurs du cgrp (peptide lie au gene de la calcitonine)
CA2584241A1 (fr)	2004-10-22	2006-05-04	Merck & Co., Inc.	Antagonistes de recepteurs cgrp
US7384930B2 (en)	2004-11-03	2008-06-10	Bristol-Myers Squibb Company	Constrained compounds as CGRP-receptor antagonists
US7384931B2 (en) *	2004-11-03	2008-06-10	Bristol-Myers Squibb Company	Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en)	2004-12-03	2008-11-11	Bristol-Myers Squibb Company	Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
GB2467060B (en) *	2005-02-11	2010-09-01	Cambridge Entpr Ltd	Ligands for G-protein coupled receptors
GB2423085C (en) *	2005-02-11	2011-11-09	Cambridge Entpr Ltd	Ligands for G-protein coupled receptors
CA2599925A1 (fr) *	2005-03-14	2006-09-21	Merck & Co., Inc.	Antagonistes du recepteur du cgrp
US7834007B2 (en)	2005-08-25	2010-11-16	Bristol-Myers Squibb Company	CGRP antagonists
US8168592B2 (en)	2005-10-21	2012-05-01	Amgen Inc.	CGRP peptide antagonists and conjugates
KR20080068062A (ko)	2005-11-14	2008-07-22	리나트 뉴로사이언스 코퍼레이션	칼시토닌 유전자-관련 펩티드에 대해 지시되는 길항제 항체및 그의 사용 방법
CN100371327C (zh) *	2005-11-17	2008-02-27	江苏工业学院	2-氨基-6-烷氧基-3-硝基吡啶的一步合成法
WO2007061677A2 (fr) *	2005-11-18	2007-05-31	Merck & Co., Inc.	Antagoniste du recepteur cgpr de spirolactam aryle
DE602007001692D1 (de) *	2006-04-10	2009-09-03	Merck & Co Inc	Herstellungsverfahren für ein zwischenprodukt eines caprolactam-cgrp-antagonisten
AU2007238894A1 (en) *	2006-04-10	2007-10-25	Merck Sharp & Dohme Corp.	Process for the preparation of pyridine heterocycle CGRP antagonist intermediate
EP2007395A1 (fr) *	2006-04-10	2008-12-31	Merck & Co., Inc.	Sel antagoniste de cgrp
ATE440843T1 (de)	2006-04-10	2009-09-15	Merck & Co Inc	Verfahren zur herstellung von cgrp-antagonisten
ATE517903T1 (de)	2006-05-02	2011-08-15	Bristol Myers Squibb Co	Verbindungen mit eingeschränkter konformation als cgrp rezeptor antagonisten.
US7470680B2 (en) *	2006-05-03	2008-12-30	Bristol-Myers Squibb Company	Constrained compounds as CGRP-receptor antagonists
WO2007133491A1 (fr) *	2006-05-09	2007-11-22	Merck & Co., Inc.	Antagonistes de récepteurs cgrp monocycliques substitués
US7834000B2 (en)	2006-06-13	2010-11-16	Vertex Pharmaceuticals Incorporated	CGRP receptor antagonists
US8163737B2 (en)	2006-06-13	2012-04-24	Vertex Pharmaceuticals Incorporated	CGRP receptor antagonists
AU2007258294A1 (en) *	2006-06-13	2007-12-21	Vertex Pharmaceuticals Incorporated	CGRP receptor antagonists
US8227603B2 (en)	2006-08-01	2012-07-24	Cytokinetics, Inc.	Modulating skeletal muscle
DK2069352T5 (en)	2006-08-02	2017-04-03	Cytokinetics Inc	SPECIFIC CHEMICAL UNITS, COMPOSITIONS AND PROCEDURES
US8299248B2 (en)	2006-08-02	2012-10-30	Cytokinetics, Incorporated	Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use
AU2007293032A1 (en) *	2006-09-08	2008-03-13	Merck Sharp & Dohme Corp.	Liquid pharmaceutical formulations for oral administration of a CGRP antagonist
WO2008147518A1 (fr)	2007-05-23	2008-12-04	Merck & Co., Inc.	Antagonistes de récepteur d'orexine pipéridyl pipéridine
GB0712392D0 (en) *	2007-06-26	2007-08-01	Glaxo Group Ltd	Novel compounds
US20090075977A1 (en) *	2007-09-17	2009-03-19	Protia, Llc	Deuterium-enriched mk0974
CA2722536A1 (fr) *	2008-02-05	2009-08-13	Merck & Co., Inc.	Promedicaments d'antagoniste des recepteurs du cgrp
JP2011512410A (ja) *	2008-02-19	2011-04-21	メルク・シャープ・エンド・ドーム・コーポレイション	イミダゾベンゾアゼピンｃｇｒｐ受容体アンタゴニスト
ES2689322T3 (es)	2008-03-04	2018-11-13	Teva Pharmaceuticals International Gmbh	Métodos para tratar el dolor crónico
US8143403B2 (en)	2008-04-11	2012-03-27	Bristol-Myers Squibb Company	CGRP receptor antagonists
US8044043B2 (en)	2008-04-11	2011-10-25	Bristol-Myers Squibb Company	CGRP receptor antagonists
US20100009967A1 (en) *	2008-06-30	2010-01-14	Majid Mahjour	Solid dosage formulations of telcagepant potassium
CA2739927A1 (fr)	2008-10-21	2010-04-29	Merck Sharp & Dohme Corp.	Antagonistes des recepteurs de l'orexine de type azepane disubstitue
US8715715B2 (en)	2008-11-03	2014-05-06	Nal Pharmaceuticals Ltd.	Dosage form for insertion into the mouth
RU2535074C2 (ru)	2009-08-28	2014-12-10	Лэйбрис Байолоджикс, Инк.	Способы лечения висцеральной боли путем введения антител-антагонистов, направленных против пептида, связанного с геном кальцитонина
US8314117B2 (en) *	2009-10-14	2012-11-20	Bristol-Myers Squibb Company	CGRP receptor antagonists
US8669368B2 (en)	2010-10-12	2014-03-11	Bristol-Myers Squibb Company	Process for the preparation of cycloheptapyridine CGRP receptor antagonists
TWI487706B (zh)	2010-11-12	2015-06-11	Merck Sharp & Dohme	六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑
WO2012129014A1 (fr) *	2011-03-18	2012-09-27	Merck Sharp & Dohme Corp.	Antagonistes spirohydantoïnes des récepteurs cgrp de type carboxamide de pipéridine
US8748429B2 (en)	2011-04-12	2014-06-10	Bristol-Myers Squibb Company	CGRP receptor antagonists
US9745373B2 (en)	2011-05-20	2017-08-29	Alderbio Holdings Llc	Anti-CGRP compositions and use thereof
SG194973A1 (en)	2011-05-20	2013-12-30	Alderbio Holdings Llc	Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers
AU2012258976B8 (en)	2011-05-20	2017-07-20	H. Lundbeck A/S	Use of anti-CGRP or anti-CGRP-R antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea
EP2731611B1 (fr)	2011-07-13	2019-09-18	Cytokinetics, Inc.	Polythérapie pour sla
AR088352A1 (es)	2011-10-19	2014-05-28	Merck Sharp & Dohme	Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina
PT3254681T (pt)	2012-02-27	2019-10-01	Bristol Myers Squibb Co	Sal de n-(5s,6s,9r)-5-amino-6-(2,3-difluorofenil)-6,7,8,9- tetrahidro-5h-ciclohepta[b]piridin-9-il-4-(2-oxo-2,3- dihidro-1h-imidazo[4,5-b]piridin-1-il)piperidina-1- carboxilato
JP6062528B2 (ja)	2012-03-29	2017-01-18	バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒＩｎｔｅｌｌｅｃｔｕａｌＰｒｏｐｅｒｔｙＧｍｂＨ	５−アミノピリミジン誘導体及び望ましくない植物の成長を防除するためのそれらの使用
US20170114122A1 (en)	2015-10-23	2017-04-27	Alderbio Holdings Llc	Regulation of glucose metabolism using anti-cgrp antibodies
US12168004B2 (en)	2014-02-05	2024-12-17	Merck Sharp & Dohme Llc	Treatment of migraine
KR20230107902A (ko)	2014-02-05	2023-07-18	머크 샤프 앤드 돔 엘엘씨	Cgrp-활성 화합물에 대한 정제 제제
AU2015230933B2 (en)	2014-03-21	2020-08-13	Teva Pharmaceuticals International Gmbh	Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
US10556945B2 (en)	2014-03-21	2020-02-11	Teva Pharmaceuticals International Gmbh	Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
GB201417707D0 (en)	2014-10-07	2014-11-19	Viral Ltd	Pharmaceutical compounds
WO2017001434A1 (fr) *	2015-06-29	2017-01-05	Galderma Research & Development	Composés de type antagonistes des récepteurs du cgrp pour traitement par voie topique de maladies de la peau
GB201519194D0 (en)	2015-10-30	2015-12-16	Heptares Therapeutics Ltd	CGRP receptor antagonists
GB201519196D0 (en)	2015-10-30	2015-12-16	Heptares Therapeutics Ltd	CGRP Receptor Antagonists
GB201519195D0 (en)	2015-10-30	2015-12-16	Heptares Therapeutics Ltd	CGRP Receptor Antagonists
KR20220031944A (ko)	2016-09-23	2022-03-14	테바 파마슈티컬스 인터내셔널 게엠베하	불응성 편두통의 치료
EP3366286A1 (fr)	2017-02-22	2018-08-29	Johannes Keller	Composés destinés au traitement de septicémie
GB201707938D0 (en)	2017-05-17	2017-06-28	Univ Sheffield	Compounds
JP7281470B2 (ja)	2018-01-19	2023-05-25	イドーシアファーマシューティカルズリミテッド	Ｃ５ａ受容体調節剤
US12383545B1 (en)	2018-06-08	2025-08-12	Allergan Pharmaceuticals International Limited	Treatment of migraine
CN108892635A (zh) *	2018-09-07	2018-11-27	江苏工程职业技术学院	一种西沙必利关键中间体的制备方法
AU2020206241A1 (en)	2019-01-08	2021-08-26	H. Lundbeck A/S	Acute treatment and rapid treatment of headache using anti-CGRP antibodies
GB201908430D0 (en) *	2019-06-12	2019-07-24	Heptares Therapeutics Ltd	Cgrp antagonist compounds
GB201908420D0 (en)	2019-06-12	2019-07-24	Heptares Therapeutics Ltd	Cgrp antagonist compounds
KR20210124867A (ko)	2020-04-06	2021-10-15	하. 룬드벡 아크티에셀스카브	항-cgrp 항체를 사용하는 편두통 관련 성가심 증상 (mbs) 의 치료
AU2021319090A1 (en)	2020-07-29	2023-03-02	Allergan Pharmaceuticals International Limited	Treatment of migraine
WO2022140537A1 (fr)	2020-12-22	2022-06-30	Allergan Pharmaceuticals International Limited	Traitement de la migraine
WO2022185224A1 (fr)	2021-03-02	2022-09-09	Mark Hasleton	Traitement et/ou réduction de l'apparition de migraine
US20250109188A1 (en)	2021-08-24	2025-04-03	Cgrp Diagnostics Gmbh	Preventative treatment of migraine
JP2024533756A (ja)	2021-09-27	2024-09-12	アラガンファーマスーティカルズインターナショナルリミテッド	アトゲパントを含む片頭痛の併用療法
CN116903616B (zh) *	2023-07-17	2025-08-01	江西同和药业股份有限公司	一种瑞美吉泮中间体的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4166452A (en)	1976-05-03	1979-09-04	Generales Constantine D J Jr	Apparatus for testing human responses to stimuli
US4256108A (en)	1977-04-07	1981-03-17	Alza Corporation	Microporous-semipermeable laminated osmotic system
US4265874A (en)	1980-04-25	1981-05-05	Alza Corporation	Method of delivering drug with aid of effervescent activity generated in environment of use
DE19503160A1 (de) *	1995-02-01	1996-08-08	Bayer Ag	Verwendung von Phenylcyclohexylcarbonsäureamiden
WO1996035713A1 (fr)	1995-05-08	1996-11-14	Pfizer, Inc.	Dipeptides stimulant la liberation de l'hormone de croissance
JP2002525371A (ja) *	1998-09-30	2002-08-13	メルクシャープエンドドームリミテッド	Ｃｇｒｐリガンドとしてのベンゾイミダゾリニルピペリジン
EP1120415B1 (fr)	1998-09-30	2003-07-23	Taisho Pharmaceutical Co., Ltd	Composes d'isoxazolylthiophene substitue
CN100558728C (zh) *	2002-06-05	2009-11-11	布里斯托尔-迈尔斯斯奎布公司	降钙素基因相关肽受体拮抗剂
WO2004091514A2 (fr) *	2003-04-15	2004-10-28	Merck & Co., Inc.	Antagonistes des recepteurs de cgrp

2004
- 2004-04-07 JO JO200445A patent/JO2355B1/en active
- 2004-04-09 BR BRPI0409601-0A patent/BRPI0409601A/pt not_active IP Right Cessation
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- 2004-04-09 CA CA002522220A patent/CA2522220C/fr not_active Expired - Fee Related
- 2004-04-09 EP EP04749887A patent/EP1638969B1/fr not_active Expired - Lifetime
- 2004-04-09 AU AU2004230926A patent/AU2004230926B2/en not_active Ceased
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- 2004-04-09 DE DE602004017608T patent/DE602004017608D1/de not_active Expired - Lifetime
- 2004-04-09 DK DK04749887T patent/DK1638969T3/da active
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- 2004-04-09 EP EP08105721.8A patent/EP2039694B1/fr not_active Expired - Lifetime
- 2004-04-09 KR KR1020057019692A patent/KR100769030B1/ko not_active Expired - Fee Related
- 2004-04-09 AT AT04749887T patent/ATE413400T1/de active
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Also Published As

Publication number	Publication date
BRPI0409601A (pt)	2006-04-18
JP2006523697A (ja)	2006-10-19
US7534784B2 (en)	2009-05-19
PE20050020A1 (es)	2005-02-18
RU2005135440A (ru)	2006-03-20
NO327655B1 (no)	2009-09-07
EP1638969B1 (fr)	2008-11-05
EP1638969A2 (fr)	2006-03-29
TW200505903A (en)	2005-02-16
US20100298303A1 (en)	2010-11-25
ES2314417T3 (es)	2009-03-16
US20090192139A1 (en)	2009-07-30
US6953790B2 (en)	2005-10-11
US20050256098A1 (en)	2005-11-17
UA82877C2 (en)	2008-05-26
US20070225272A1 (en)	2007-09-27
NO20055375L (no)	2005-11-14
CA2522220C (fr)	2009-06-23
US7452903B2 (en)	2008-11-18
IS8055A (is)	2005-09-29
JP3967766B2 (ja)	2007-08-29
MXPA05011166A (es)	2005-12-14
TWI314931B (en)	2009-09-21
HRP20080666T3 (en)	2009-01-31
CO5640130A2 (es)	2006-05-31
AU2004230926A1 (en)	2004-10-28
JO2355B1 (en)	2006-12-12
CN100384843C (zh)	2008-04-30
US20040229861A1 (en)	2004-11-18
PL1638969T3 (pl)	2009-04-30
NZ543357A (en)	2008-08-29
WO2004092166A2 (fr)	2004-10-28
DE602004017608D1 (de)	2008-12-18
CL2004000788A1 (es)	2005-02-25
CA2522220A1 (fr)	2004-10-28
US7893052B2 (en)	2011-02-22
EP2039694B1 (fr)	2014-03-26
IS2759B (is)	2011-10-15
HK1090922A1 (en)	2007-01-05
CY1108714T1 (el)	2014-04-09
ECSP056097A (es)	2006-03-01
RU2308458C2 (ru)	2007-10-20
KR20050121734A (ko)	2005-12-27
MA27728A1 (fr)	2006-01-02
SI1638969T1 (sl)	2009-02-28
WO2004092166A3 (fr)	2005-01-20
US7772224B2 (en)	2010-08-10
EP2039694A1 (fr)	2009-03-25
ATE413400T1 (de)	2008-11-15
US20080280857A1 (en)	2008-11-13
CN1802376A (zh)	2006-07-12
AR045887A1 (es)	2005-11-16
US7235545B2 (en)	2007-06-26
KR100769030B1 (ko)	2007-10-22
WO2004092168A1 (fr)	2004-10-28
PT1638969E (pt)	2009-01-16
AU2004230926B2 (en)	2008-07-17

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