DK1602660T3 - Aminophosphonsyrederivater, additionssalte deraf og S1P-receptormodulatorer - Google Patents

Aminophosphonsyrederivater, additionssalte deraf og S1P-receptormodulatorer

Info

Publication number: DK1602660T3
Authority: DK; Denmark
Prior art keywords: acid derivatives; receptor modulators; aminophosphonic acid; addition salts; aminophosphonic
Prior art date: 2003-02-18

Application number

DK04712184.3T

Other languages

English (en)

Inventor

Yasushi Kohno

Kazuhiko Kuriyama

Wataru Hori

Kiyoaki Tanaka

Original Assignee

Kyorin Seiyaku Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-02-18

Filing date

2004-02-18

Publication date

2011-05-23

2004-02-18 Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk

2011-05-23 Application granted granted Critical

2011-05-23 Publication of DK1602660T3 publication Critical patent/DK1602660T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
- A—HUMAN NECESSITIES
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
- C—CHEMISTRY; METALLURGY
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
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- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
- C—CHEMISTRY; METALLURGY
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- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Otolaryngology (AREA)
Communicable Diseases (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)

DK04712184.3T 2003-02-18 2004-02-18 Aminophosphonsyrederivater, additionssalte deraf og S1P-receptormodulatorer DK1602660T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2003039269		2003-02-18
PCT/JP2004/001783 WO2004074297A1 (ja)	2003-02-18	2004-02-18	アミノホスホン酸誘導体とその付加塩及びs1p受容体調節剤

Publications (1)

Publication Number	Publication Date
DK1602660T3 true DK1602660T3 (da)	2011-05-23

Family

ID=32905163

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04712184.3T DK1602660T3 (da)	2003-02-18	2004-02-18	Aminophosphonsyrederivater, additionssalte deraf og S1P-receptormodulatorer

Country Status (17)

Country	Link
US (2)	US7456157B2 (da)
EP (2)	EP1602660B1 (da)
JP (1)	JP4564918B2 (da)
KR (1)	KR101005171B1 (da)
CN (1)	CN100344638C (da)
AT (1)	ATE504590T1 (da)
AU (1)	AU2004213297B2 (da)
BR (1)	BRPI0407658A (da)
CA (1)	CA2515574C (da)
CY (1)	CY1111529T1 (da)
DE (1)	DE602004032118D1 (da)
DK (1)	DK1602660T3 (da)
ES (1)	ES2360394T3 (da)
MX (1)	MXPA05008760A (da)
PT (1)	PT1602660E (da)
SI (1)	SI1602660T1 (da)
WO (1)	WO2004074297A1 (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7482491B2 (en) *	2002-09-19	2009-01-27	Kyorin Pharmaceutical Co., Ltd.	Amino alcohol derivative, addition salt thereof, and immunosuppressant
WO2004074297A1 (ja)	2003-02-18	2004-09-02	Kyorin Pharmaceutical Co., Ltd.	アミノホスホン酸誘導体とその付加塩及びs1p受容体調節剤
US7638637B2 (en)	2003-11-03	2009-12-29	University Of Virginia Patent Foundation	Orally available sphingosine 1-phosphate receptor agonists and antagonists
AU2005264431B2 (en) *	2004-07-16	2010-08-19	Kyorin Pharmaceutical Co., Ltd.	Method of effectively using medicine and method concerning prevention of side effect
BRPI0514316A (pt)	2004-08-13	2008-06-10	Praecis Pharm Inc	métodos e composições para modulação de atividade de receptor de esfingosina-1-fosfato (s1p)
US20060223866A1 (en) *	2004-08-13	2006-10-05	Praecis Pharmaceuticals, Inc.	Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
PT2511262T (pt) *	2004-10-12	2017-03-30	Kyorin Seiyaku Kk	Processo para a produção de cloridrato de 2-amino-2-[2-[4-(3- benziloxi-feniltio)-2-clorofenil[etil]-1,3-propanodiol
US7888527B2 (en)	2004-12-06	2011-02-15	University Of Virginia Patent Foundation	Aryl amide sphingosine 1-phosphate analogs
CA2820510A1 (en) *	2005-09-09	2007-03-15	Novartis Ag	Treatment of autoimmune diseases
BRPI0617077A2 (pt) *	2005-10-07	2015-01-06	Kyorin Seiyaku Kk	Agente terapêutico para tratamento de doenças do fígado contendo 2-amina-1, 3-propanediol derivativo como ingrediente ativo, e método para tratamento de doenças do fígado
EP1986623A2 (en)	2006-01-27	2008-11-05	University Of Virginia Patent Foundation	Method for treatment of neuropathic pain
TWI389683B (zh) *	2006-02-06	2013-03-21	Kyorin Seiyaku Kk	A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
JP2009526073A (ja)	2006-02-09	2009-07-16	ユニバーシティオブバージニアパテントファンデーション	二環式スフィンゴシン−１−リン酸受容体アナログ
EP2099768A2 (en) *	2006-08-04	2009-09-16	Praecis Pharmaceuticals Incorporated	Agonists of the sphingosine-1-phosphate receptor
CA2659599C (en)	2006-08-08	2014-06-17	Kyorin Pharmaceutical Co., Ltd.	Amino alcohol derivative and immunosuppressive agent having same as an active ingredient
NZ574011A (en)	2006-08-08	2011-10-28	Kyorin Seiyaku Kk	Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient
NZ576893A (en)	2006-11-21	2012-01-12	Univ Virginia Patent Found	Tetralin analogs having sphingosine 1-phosphate agonist activity
WO2008064320A2 (en)	2006-11-21	2008-05-29	University Of Virginia Patent Foundation	Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity
EP2097371A2 (en)	2006-11-21	2009-09-09	University Of Virginia Patent Foundation	Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity
EP3733161A1 (en)	2007-10-12	2020-11-04	Novartis AG	Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators
TW200946105A (en)	2008-02-07	2009-11-16	Kyorin Seiyaku Kk	Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient
ES2572893T3 (es)	2008-03-24	2016-06-02	Kyorin Pharmaceutical Co., Ltd.	Método para la cristalización de hidrocloruro de 2-amino-2-[2-[4-(3-benciloxifeniltio)-2-clorofenil]etil]-1,3-propanodiol
EP2292594A4 (en) *	2008-05-19	2014-10-15	Kyorin Seiyaku Kk	METHOD FOR PRODUCING AN OPTICALLY ACTIVE AMINO ALCOHOL DERIVATIVE
CN102123735A (zh) *	2008-05-20	2011-07-13	杏林制药株式会社	诱导缓解维持剂
US8580841B2 (en)	2008-07-23	2013-11-12	Arena Pharmaceuticals, Inc.	Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders
AU2009276343A1 (en) *	2008-08-01	2010-02-04	Bioxiness Pharmaceuticals, Inc.	Methionine analogs and methods of using same
CN105816453B (zh)	2008-08-27	2021-03-05	艾尼纳制药公司	用于治疗自身免疫性病症和炎性病症的作为s1p1受体激动剂的经取代的三环酸衍生物
WO2010043000A1 (en) *	2008-10-17	2010-04-22	Akaal Pharma Pty Ltd	S1p receptors modulators and their use thereof
SI2452944T1 (sl)	2009-07-09	2015-01-30	Kyorin Pharmaceutical Co., Ltd.	Difenilsulfidni derivati in zdravila, ki jih vsebujejo kot aktivno sestavino
SG182610A1 (en)	2010-01-27	2012-08-30	Arena Pharm Inc	Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
CA2789480A1 (en)	2010-03-03	2011-09-09	Arena Pharmaceuticals, Inc.	Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
AU2011249789B2 (en)	2010-05-06	2015-03-19	Novartis Ag	Dosage regimen of diaryl sulfide derivatives
KR20130066630A (ko)	2010-05-06	2013-06-20	노파르티스 아게	자가면역 질환의 치료
US8653270B2 (en)	2010-11-22	2014-02-18	Allergan, Inc.	Compounds as receptor modulators with therapeutic utility
TWI519539B (zh) *	2010-12-21	2016-02-01	Kyorin Seiyaku Kk	Diphenyl sulfide derivatives and pharmaceuticals as an active ingredient thereof
US8673308B2 (en)	2011-02-23	2014-03-18	Als Therapy Development Institute	Targeting of CD8+ T-lymphocytes to treat neurodegenerative diseases
CN103492359B (zh) *	2011-04-02	2015-11-25	中国人民解放军军事医学科学院毒物药物研究所	氨基苯丙醇类化合物及其用于制备免疫抑制剂的用途
US8946301B2 (en)	2011-11-29	2015-02-03	Als Therapy Development Institute	Targeting of T-lymphocytes to treat amyotrophic lateral sclerosis
EP2842937B1 (en) *	2012-04-23	2018-01-17	Mitsubishi Tanabe Pharma Corporation	Amine compound and use thereof for medical purposes
US11007175B2 (en)	2015-01-06	2021-05-18	Arena Pharmaceuticals, Inc.	Methods of treating conditions related to the S1P1 receptor
BR112017027656B1 (pt)	2015-06-22	2023-12-05	Arena Pharmaceuticals, Inc.	Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo
CA3053418A1 (en)	2017-02-16	2018-08-23	Arena Pharmaceuticals, Inc.	Compounds and methods for treatment of primary biliary cholangitis
JP2020507610A (ja)	2017-02-16	2020-03-12	アリーナファーマシューティカルズ，インコーポレイテッド	腸管外症状を伴う炎症性腸疾患の治療のための化合物および方法
BR112020024762A2 (pt)	2018-06-06	2021-03-23	Arena Pharmaceuticals, Inc.	métodos de tratamento de condições relacionadas ao receptor s1p1
CN119751336A (zh)	2018-09-06	2025-04-04	艾尼纳制药公司	可用于治疗自身免疫性病症和炎性病症的化合物
EP4438037A1 (en)	2021-01-28	2024-10-02	Priothera SAS	Methods of treatment with s1p receptor modulators
AU2021424131A1 (en)	2021-01-28	2023-07-27	Priothera Limited	Methods of treatment with s1p receptor modulators
JP2025506506A (ja)	2022-02-16	2025-03-11	プリオセラエスエーエス	Ｓ１ｐ受容体モジュレーターと組み合わせたｃａｒ細胞を用いた処置方法
EP4282407A1 (en)	2022-05-27	2023-11-29	Priothera SAS	Treatment of cancer with s1p receptor agonists
WO2025109119A1 (en)	2023-11-22	2025-05-30	Priothera Sas	Methods of treatment with multispecific antigen-binding proteins in combination with s1p receptor modulators

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5447922A (en) *	1994-08-24	1995-09-05	Bristol-Myers Squibb Company	α-phosphonosulfinic squalene synthetase inhibitors
WO2001098301A1 (en)	2000-06-20	2001-12-27	Japan Tobacco Inc.	Pyrazolopyridine compounds and use thereof as drugs
AU8533101A (en)	2000-08-31	2002-03-13	Merck & Co Inc	Phosphate derivatives as immunoregulatory agents
AU2002237988B2 (en)	2001-01-30	2008-01-03	University Of Virginia Patent Foundation	Agonists and antagonists of sphingosine-1-phosphate receptors
ATE447970T1 (de)	2001-02-08	2009-11-15	Ono Pharmaceutical Co	Mittel zur behandlung von harnwegserkrankungen, umfassend mittel zur kontrolle des lpa-rezeptors
WO2002076995A2 (en)	2001-03-26	2002-10-03	Novartis Ag	2-amino-propanol derivatives
EP1391199B1 (en)	2001-05-10	2008-12-10	Ono Pharmaceutical Co., Ltd.	Carboxylic acid derivatives and drugs containing the same as the active ingredient
WO2003020313A1 (en)	2001-09-04	2003-03-13	Ono Pharmaceutical Co., Ltd.	Remedies for respiratory diseases comprising sphingosine-1-phosphate receptor controller
JP2005112721A (ja)	2001-11-06	2005-04-28	Maruha Corp	含窒素化合物、製造法、及びその利用方法
JP4035759B2 (ja)	2001-11-06	2008-01-23	独立行政法人産業技術総合研究所	アミノアルコールリン酸化合物、製造方法、及びその利用方法
WO2003051876A1 (en)	2001-12-14	2003-06-26	Japan Tobacco Inc.	Pyrazolopyridine derivatives and medicinal use thereof
AU2003216054B2 (en) *	2002-01-18	2007-01-04	Merck & Co., Inc.	Selective S1P1/Edg1 receptor agonists
JP4709488B2 (ja)	2002-01-18	2011-06-22	メルク・シャープ・エンド・ドーム・コーポレイション	Ｅｄｇ受容体作動薬としてのＮ−（ベンジル）アミノアルキルカルボン酸化合物、ホスフィン酸化合物、ホスホン酸化合物およびテトラゾール類
AU2003207567B2 (en)	2002-01-18	2008-01-24	Merck Sharp & Dohme Corp.	Edg receptor agonists
CA2477423A1 (en)	2002-03-01	2003-09-12	Merck & Co., Inc.	Aminoalkylphosphonates and related compounds as edg receptor agonists
PL372103A1 (en) *	2002-05-16	2005-07-11	Novartis Ag	Use of edg receptor binding agents in cancer
JP4166218B2 (ja) *	2002-09-13	2008-10-15	ノバルティスアクチエンゲゼルシャフト	アミノ−プロパノール誘導体
MXPA05008531A (es) *	2003-02-11	2005-11-17	Irm Llc	Compuestos biciclicos novedosos y composiciones.
WO2004074297A1 (ja)	2003-02-18	2004-09-02	Kyorin Pharmaceutical Co., Ltd.	アミノホスホン酸誘導体とその付加塩及びs1p受容体調節剤

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- 2004-02-18 JP JP2005502730A patent/JP4564918B2/ja not_active Expired - Fee Related
- 2004-02-18 SI SI200431656T patent/SI1602660T1/sl unknown
- 2004-02-18 AT AT04712184T patent/ATE504590T1/de active
- 2004-02-18 EP EP04712184A patent/EP1602660B1/en not_active Expired - Lifetime
- 2004-02-18 DK DK04712184.3T patent/DK1602660T3/da active
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- 2004-02-18 EP EP09178067A patent/EP2172472B1/en not_active Expired - Lifetime
- 2004-02-18 DE DE602004032118T patent/DE602004032118D1/de not_active Expired - Lifetime
- 2004-02-18 BR BRPI0407658-3A patent/BRPI0407658A/pt not_active Application Discontinuation
- 2004-02-18 MX MXPA05008760A patent/MXPA05008760A/es active IP Right Grant
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Also Published As

Publication number	Publication date
SI1602660T1 (sl)	2011-06-30
WO2004074297A1 (ja)	2004-09-02
DE602004032118D1 (de)	2011-05-19
US7759326B2 (en)	2010-07-20
EP2172472A2 (en)	2010-04-07
AU2004213297A1 (en)	2004-09-02
EP1602660A4 (en)	2008-03-19
CN100344638C (zh)	2007-10-24
CN1751054A (zh)	2006-03-22
US20060160771A1 (en)	2006-07-20
JP4564918B2 (ja)	2010-10-20
ATE504590T1 (de)	2011-04-15
JPWO2004074297A1 (ja)	2006-06-01
BRPI0407658A (pt)	2006-02-21
ES2360394T3 (es)	2011-06-03
EP2172472A3 (en)	2010-06-30
KR101005171B1 (ko)	2011-01-04
EP1602660A1 (en)	2005-12-07
US7456157B2 (en)	2008-11-25
CA2515574A1 (en)	2004-09-02
EP1602660B1 (en)	2011-04-06
CY1111529T1 (el)	2015-08-05
MXPA05008760A (es)	2006-03-21
AU2004213297B2 (en)	2009-03-19
CA2515574C (en)	2012-03-13
US20080275008A1 (en)	2008-11-06
KR20050109069A (ko)	2005-11-17
EP2172472B1 (en)	2012-12-26
PT1602660E (pt)	2011-06-15

Publication	Publication Date	Title
DK1602660T3 (da)	2011-05-23	Aminophosphonsyrederivater, additionssalte deraf og S1P-receptormodulatorer
HRP20120323T1 (en)	2012-05-31	Diarylhydantoin compounds
NO20006251L (no)	2001-02-07	Benzotiepin-1,1-dioksidderivater, fremgangsmåte for deres fremstilling, legemidler som inneholder disse forbindelsene og deres anvendelse
TW200734314A (en)	2007-09-16	Piperazine compounds having herbicidal action
DE60210944D1 (de)	2006-06-01	N-substituierte heterocyclische nichtaryl-nmda/nr2b-antagonisten
DE602005023185D1 (de)	2010-10-07	Prodrugs mit neuen biospaltbaren verbindern
NO20082136L (no)	2008-06-30	1,5-substituerte indol-2-yl-amidderivater
IS7857A (is)	2005-08-18	Setnar pýrróló-pýrasól afleiður sem kínasa hindrar
WO2007067711A3 (en)	2009-05-14	Certain chemical entities, compositions, and methods for modulating trpv1
IT1311922B1 (it)	2002-03-20	Composti farmaceutici.
DK1694318T3 (da)	2007-06-25	(S)-2-N-propylamino-5-hydroxytetralin som D3-agonistisk terapeutikum
DK2263674T3 (da)	2014-10-27	10,10-Dialkyl-prostansyrederivater som midler til sænkning af intraokulært tryk
DK1611144T3 (da)	2010-11-22	Derivater af 2-(8,9-dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)alkyl-phosphonsyre og deres avendelse som n-methyl-D-aspartat (NMDA)-receptor-antagonister
NO20082214L (no)	2008-07-31	1,1-Diokso-tiomorfolinyl-indolyl-metanonderivater for anvendelse som H3-modulatorer
DK1578741T3 (da)	2011-09-26	Aromatiske forbindelser som anti-inflammatoriske, immunmodulatoriske og anti-proliferative midler
NO20054787L (no)	2005-11-14	Indenderivater som farmasotiske midler
NO20054169D0 (no)	2005-09-07	3-(1-[3-(1,3-benzotiazol-6-yl) propylkarbamoyl]sykloalkyl]propansyrederivater som NEP-inhibitorer.
NO20052699L (no)	2005-06-06	4(fenylpiperazinyl-metyl)benzamid-derivater og deres anvendelse ved behandling av smerte og gastrointestinale lidelser.
NO20053715D0 (no)	2005-08-01	10,10-dialkylprostanoinsyrederivater som midler for a senke intraokulaert trykk
MX2009005242A (es)	2009-08-19	Derivados de 3-(hetero)arilisoquinolinamida sustituida en posición 5, 6 o 7 y uso terapeutico del mismo.
NO20063859L (no)	2006-08-29	Cykloalkylsubstituerte 7-amino-4-kinolon-3-karboksylsyrederivater, fremgangsmate for fremstilling derav og anvendelse derav som medikamenter
ATE517623T1 (de)	2011-08-15	Verwendung von methylphenidat-derivaten
TW200740753A (en)	2007-11-01	4,5-Diarylpyrrole derivatives, preparation thereof and therapeutic use thereof
ATE522214T1 (de)	2011-09-15	Therapeutisches mittel für nahrungskompetenzstörungen im magen
NO20054418L (no)	2005-09-23	Substituert benzoylureidopyridylpiperidin- og -pyrrolidinkarboksylsyrederivater, deres fremstilling og anvendelse