DK1697350T3 - Tricykliske modulatorer af cellekernereceptor for steroidhormon - Google Patents

Tricykliske modulatorer af cellekernereceptor for steroidhormon

Info

Publication number: DK1697350T3
Authority: DK; Denmark
Prior art keywords: tricyclic; modulators; nuclear receptor; steroid hormone; cell nuclear
Prior art date: 2003-12-19

Application number

DK04811084T

Other languages

Danish (da)

English (en)

Inventor

Donald P Matthews

Konstantinos Gavardinas

Jonathan Edward Green

Prabhakar Kondaji Jadhav

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-12-19

Filing date

2004-12-08

Publication date

2008-10-13

2004-12-08 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2008-10-13 Application granted granted Critical

2008-10-13 Publication of DK1697350T3 publication Critical patent/DK1697350T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Transplantation (AREA)
Child & Adolescent Psychology (AREA)
Gastroenterology & Hepatology (AREA)

DK04811084T 2003-12-19 2004-12-08 Tricykliske modulatorer af cellekernereceptor for steroidhormon DK1697350T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US53128303P	2003-12-19	2003-12-19
PCT/US2004/038233 WO2005066161A1 (fr)	2003-12-19	2004-12-08	Modulateurs tricycliques du recepteur nucleaire de l'hormone steroide

Publications (1)

Publication Number	Publication Date
DK1697350T3 true DK1697350T3 (da)	2008-10-13

Family

ID=34748755

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK04811084T DK1697350T3 (da)	2003-12-19	2004-12-08	Tricykliske modulatorer af cellekernereceptor for steroidhormon

Country Status (21)

Country	Link
US (1)	US7803814B2 (fr)
EP (1)	EP1697350B1 (fr)
JP (1)	JP4846596B2 (fr)
CN (1)	CN1918151A (fr)
AR (1)	AR046951A1 (fr)
AT (1)	ATE399163T1 (fr)
AU (1)	AU2004312293A1 (fr)
BR (1)	BRPI0416882A (fr)
CA (1)	CA2549053C (fr)
CY (1)	CY1108309T1 (fr)
DE (1)	DE602004014640D1 (fr)
DK (1)	DK1697350T3 (fr)
ES (1)	ES2308296T3 (fr)
IL (1)	IL175996A0 (fr)
MX (1)	MXPA06007055A (fr)
NO (1)	NO20063329L (fr)
PL (1)	PL1697350T3 (fr)
PT (1)	PT1697350E (fr)
SI (1)	SI1697350T1 (fr)
WO (1)	WO2005066161A1 (fr)
ZA (1)	ZA200604889B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200400816A (en) *	2002-06-26	2004-01-16	Lilly Co Eli	Tricyclic steroid hormone nuclear receptor modulators
EP1838672B1 (fr) *	2004-12-23	2015-02-18	Athersys, Inc.	Amines tertiaires de 4-piperidinol en tant qu'inhibiteurs du recepteur 3 de l'histamine destinees au traitement de l'obesite et d'autres troubles du systeme nerveux central
DE102005022020A1 (de) *	2005-05-12	2006-11-23	Merckle Gmbh	Dibenzocycloheptanverbindungen und pharmazeutische Mittel, welche diese Verbindungen enthalten
TWI385161B (zh)	2006-02-02	2013-02-11	Mitsubishi Tanabe Pharma Corp	含氮雜雙環化合物
US8034940B2 (en)	2006-08-09	2011-10-11	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
RS20090208A (sr)	2006-10-31	2010-06-30	Pfizer Products Inc.	Pirazolin jedinjenja kao antagonisti mineralokortikoid receptora
PE20091057A1 (es) *	2007-12-19	2009-07-20	Lilly Co Eli	Antagonistas del receptor mineralcorticoide y metodos de uso
MX2010007607A (es) *	2008-01-11	2010-08-23	Lilly Co Eli	(e)-n-{3-[1-(8-fluoro-11h-10-oxa-1-aza-dibenzo [a,d] ciclohepten-5iliden)-propil}-fenil}-metilsulfon amida como modulador de receptor glucocorticoide para el tratamiento de reumatoide.
US20110112299A1 (en) *	2008-07-03	2011-05-12	Kyowa Hakko Kirin Co., Ltd.	Tetracyclic compound
CA2751901C (fr) *	2009-03-12	2013-08-06	Eli Lilly And Company	Antagoniste du recepteur des mineralocorticoides et procedes d'utilisation
WO2011081173A1 (fr) *	2009-12-29	2011-07-07	協和発酵キリン株式会社	Composé tétracyclique
CA2796307A1 (fr)	2010-05-10	2011-11-17	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Procedes et compositions pour le traitement de l'accumulation de fluides dans et/ou sous la retine
EP2582365B1 (fr)	2010-06-16	2019-03-20	INSERM (Institut National de la Santé et de la Recherche Médicale)	Compositions pour stimuler la réépithélialisation durant la cicatrisation d'une blessure
US8722709B2 (en)	2010-11-10	2014-05-13	Boehringer Ingelheim International Gmbh	Mineralocorticoid receptor antagonists
TW201311678A (zh) *	2011-08-03	2013-03-16	Kyowa Hakko Kirin Co Ltd	二苯并氧呯衍生物
CA3216489A1 (fr) *	2021-04-12	2022-10-20	Impact Therapeutics (Shanghai), Inc.	Composes bicycliques condenses substitues servant d'inhibiteurs de parp et leur utilisation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2603713B1 (fr)	1986-09-10	1992-07-24	Canon Kk	Derive nouveau de 5h-dibenzo(a,d)cycloheptane-(ene)ylidene, son procede de production et support electrophotographique photosensible le contenant
JPH01161245A (ja)	1987-12-18	1989-06-23	Canon Inc	電子写真感光体
CA1338625C (fr)	1988-06-09	1996-10-01	Kyowa Hakko Kogyo Co., Ltd.	Composes tricycliques
US5093210A (en)	1989-06-30	1992-03-03	Ricoh Company, Ltd.	Electroluminescent device
JPH0446352A (ja)	1990-06-14	1992-02-17	Minolta Camera Co Ltd	感光体
AR014195A1 (es) *	1997-12-29	2001-02-07	Ortho Mcneil Pharm Inc	Compuestos de trifenilpropanamida utiles para el tratamiento de procesos inflamatorios, composiciones anti-inflamatorias que los comprenden, ymetodos para prepararlos
JP2002541144A (ja)	1999-01-26	2002-12-03	ダナ−ファーバーキャンサーインスティテュート，インコーポレイテッド	医薬的に活性のある化合物及びその使用方法
PL206962B1 (pl) *	2001-12-19	2010-10-29	Bristol Myers Squibb Co	Związek heterocykliczny o budowie skondensowanej
US7250442B2 (en) *	2002-03-15	2007-07-31	Eli Lilly And Company	Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators
TW200400816A (en) *	2002-06-26	2004-01-16	Lilly Co Eli	Tricyclic steroid hormone nuclear receptor modulators

2004
- 2004-12-08 DK DK04811084T patent/DK1697350T3/da active
- 2004-12-08 CA CA2549053A patent/CA2549053C/fr not_active Expired - Fee Related
- 2004-12-08 JP JP2006545655A patent/JP4846596B2/ja not_active Expired - Fee Related
- 2004-12-08 CN CNA2004800418534A patent/CN1918151A/zh active Pending
- 2004-12-08 WO PCT/US2004/038233 patent/WO2005066161A1/fr not_active Ceased
- 2004-12-08 DE DE602004014640T patent/DE602004014640D1/de not_active Expired - Lifetime
- 2004-12-08 US US10/576,761 patent/US7803814B2/en not_active Expired - Fee Related
- 2004-12-08 MX MXPA06007055A patent/MXPA06007055A/es unknown
- 2004-12-08 SI SI200430840T patent/SI1697350T1/sl unknown
- 2004-12-08 PL PL04811084T patent/PL1697350T3/pl unknown
- 2004-12-08 ES ES04811084T patent/ES2308296T3/es not_active Expired - Lifetime
- 2004-12-08 AT AT04811084T patent/ATE399163T1/de not_active IP Right Cessation
- 2004-12-08 BR BRPI0416882-8A patent/BRPI0416882A/pt not_active Application Discontinuation
- 2004-12-08 AU AU2004312293A patent/AU2004312293A1/en not_active Abandoned
- 2004-12-08 EP EP04811084A patent/EP1697350B1/fr not_active Expired - Lifetime
- 2004-12-08 PT PT04811084T patent/PT1697350E/pt unknown
- 2004-12-17 AR ARP040104730A patent/AR046951A1/es unknown
2006
- 2006-05-29 IL IL175996A patent/IL175996A0/en unknown
- 2006-06-13 ZA ZA200604889A patent/ZA200604889B/en unknown
- 2006-07-18 NO NO20063329A patent/NO20063329L/no not_active Application Discontinuation
2008
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Also Published As

Publication number	Publication date
DE602004014640D1 (de)	2008-08-07
CN1918151A (zh)	2007-02-21
ZA200604889B (en)	2007-11-28
JP2007515431A (ja)	2007-06-14
EP1697350A1 (fr)	2006-09-06
IL175996A0 (en)	2006-10-05
AU2004312293A1 (en)	2005-07-21
WO2005066161A1 (fr)	2005-07-21
CA2549053A1 (fr)	2005-07-21
US7803814B2 (en)	2010-09-28
ES2308296T3 (es)	2008-12-01
CA2549053C (fr)	2012-08-28
US20070037788A1 (en)	2007-02-15
SI1697350T1 (sl)	2008-12-31
BRPI0416882A (pt)	2007-02-27
MXPA06007055A (es)	2007-01-30
NO20063329L (no)	2006-09-14
EP1697350B1 (fr)	2008-06-25
PL1697350T3 (pl)	2008-11-28
CY1108309T1 (el)	2014-02-12
PT1697350E (pt)	2008-09-18
ATE399163T1 (de)	2008-07-15
JP4846596B2 (ja)	2011-12-28
AR046951A1 (es)	2006-01-04

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HK1075886A (en)	2005-12-30	Tricyclic steroid hormone nuclear receptor modulators
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