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DK1560823T3 - 4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-ligander - Google Patents

4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-ligander

Info

Publication number
DK1560823T3
DK1560823T3 DK03779845T DK03779845T DK1560823T3 DK 1560823 T3 DK1560823 T3 DK 1560823T3 DK 03779845 T DK03779845 T DK 03779845T DK 03779845 T DK03779845 T DK 03779845T DK 1560823 T3 DK1560823 T3 DK 1560823T3
Authority
DK
Denmark
Prior art keywords
receptor
orl
substituted
aminocyclohexane derivatives
opiate
Prior art date
Application number
DK03779845T
Other languages
Danish (da)
English (en)
Inventor
Claudia Hinze
Hans Schick
Helmut Sonnenschein
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Application granted granted Critical
Publication of DK1560823T3 publication Critical patent/DK1560823T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK03779845T 2002-11-11 2003-11-05 4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-ligander DK1560823T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10252666A DE10252666A1 (de) 2002-11-11 2002-11-11 N-Piperidyl-cyclohexan-Derivate
PCT/EP2003/012306 WO2004043949A1 (fr) 2002-11-11 2003-11-05 Derives de 1-aminocyclohexane 4-substitue utilises comme ligands de recepteur orl1 et de recepteur d'opiace mu

Publications (1)

Publication Number Publication Date
DK1560823T3 true DK1560823T3 (da) 2008-11-10

Family

ID=32308522

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03779845T DK1560823T3 (da) 2002-11-11 2003-11-05 4-Substituerede 1-aminocyclohexanderivater til anvendelse som ORL-1-receptor- og Á-opiat-receptor-ligander

Country Status (13)

Country Link
US (1) US7759385B2 (fr)
EP (1) EP1560823B1 (fr)
AR (1) AR041941A1 (fr)
AT (1) ATE400569T1 (fr)
AU (1) AU2003287993A1 (fr)
CY (1) CY1108378T1 (fr)
DE (2) DE10252666A1 (fr)
DK (1) DK1560823T3 (fr)
ES (1) ES2309373T3 (fr)
PE (1) PE20040833A1 (fr)
PT (1) PT1560823E (fr)
SI (1) SI1560823T1 (fr)
WO (1) WO2004043949A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate
DE602004021206D1 (de) * 2003-07-24 2009-07-02 Euro Celtique Sa Zur Behandlung oder Vorbeugung von Schmerzen geeignete Heteroaryl-Tetrahydropiperidyl-Verbindungen
HRP20090404T1 (hr) * 2003-07-24 2009-08-31 Euro-Celtique S.A. Spojevi piperidina i farmaceutski sastavi koji ih sadržavaju
DE10337184A1 (de) * 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
DE102004023507A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexylessigsäure-Derivate
DE102004023632A1 (de) * 2004-05-10 2005-12-08 Grünenthal GmbH Substituierte Cyclohexylcarbonsäure-Derivate
DE102004023635A1 (de) * 2004-05-10 2006-04-13 Grünenthal GmbH Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023522A1 (de) * 2004-05-10 2005-12-01 Grünenthal GmbH Substituierte Cyclohexyl-1,4-diamin-Derivate
DE102006033109A1 (de) * 2006-07-18 2008-01-31 Grünenthal GmbH Substituierte Heteroaryl-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
EP2178534A4 (fr) 2007-07-17 2011-03-30 Merck Sharp & Dohme Inhibiteurs époxyde hydrolase solubles, compositions contenant de tels composés et procédés de traitement
CN101848910B (zh) * 2007-11-05 2013-12-04 默克专利股份公司 作为选择性11-β-羟基类固醇脱氢酶1型抑制剂的7-氮杂吲哚衍生物
AR070398A1 (es) * 2008-02-22 2010-03-31 Gruenenthal Chemie Derivados sustituidos de indol
SI2271613T1 (sl) 2008-03-27 2014-08-29 Grunenthal Gmbh Hidroksimetilcikloheksilamini
CA2719743A1 (fr) 2008-03-27 2009-10-01 Gruenenthal Gmbh Cyclohexyldiamines substituees
US8288430B2 (en) 2008-03-27 2012-10-16 Grunenthal Gmbh Spiro(5.5)undecane derivatives
RU2532545C2 (ru) * 2008-03-27 2014-11-10 Грюненталь Гмбх Замещенные производные 4-аминоциклогексана
AR071066A1 (es) 2008-03-27 2010-05-26 Gruenenthal Chemie Derivados de (hetero) aril-ciclohexano
TWI450899B (zh) 2008-03-27 2014-09-01 被取代之螺環環已烷衍生物
US9580409B2 (en) 2011-11-07 2017-02-28 Sunovion Pharmaceuticals, Inc. Modulators of opioid receptors and methods of use thereof
US10702498B2 (en) 2015-07-09 2020-07-07 The Regents Of The University Of California MU opioid receptor modulators
WO2017023894A1 (fr) * 2015-08-03 2017-02-09 Raze Therapeutics, Inc. Inhibiteurs de mthfd2 et utilisation desdits inhibiteurs
WO2019195634A1 (fr) 2018-04-04 2019-10-10 Epiodyne, Inc. Modulateurs du récepteur opioïde, produits et procédés associés
TW202026281A (zh) * 2018-12-12 2020-07-16 西班牙商艾斯提夫製藥股份有限公司 用於治療疼痛和疼痛相關病症之新吡咯啶–2– 甲酸衍生物
WO2020120606A1 (fr) * 2018-12-12 2020-06-18 Esteve Pharmaceuticals, S.A. Nouveaux dérivés d'acide pyrrolidine-2-carboxylique pour le traitement de la douleur et d'états pathologiques associés à la douleur
CA3165903A1 (fr) 2019-12-26 2021-07-01 Gilgamesh Pharmaceuticals, Inc. Derives arylcyclohexylamine et leur utilisation dans le traitement de troubles psychiatriques
LT4084791T (lt) 2020-02-18 2025-02-25 Gilgamesh Pharmaceuticals, Inc. Specifiniai triptaminai, skirti nuotaikos sutrikimams gydyti
TW202304869A (zh) 2021-04-05 2023-02-01 美商艾碧奧戴股份有限公司 類鴉片受體調節劑
US12157722B1 (en) 2023-08-03 2024-12-03 Gilgamesh Pharmaceuticals, Inc. Crystalline hydrochloride salts of N-ethyl-2-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine
US12129234B1 (en) 2023-08-03 2024-10-29 Gilgamesh Pharmaceuticals, Inc. Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113555A (en) * 1973-11-08 1978-09-12 Svenska Traforskningsinstitutet Hard board or medium density board, process for production thereof and means for practicizing the process
US4113866A (en) * 1977-04-01 1978-09-12 The Upjohn Company Analgetic compounds, compositions and process of treatment
TWI238064B (en) * 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
US6172087B1 (en) * 1998-06-03 2001-01-09 Gpi Nil Holding, Inc. N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
MA26659A1 (fr) * 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
US7456198B2 (en) * 1999-12-06 2008-11-25 Purdue Pharma L.P. Benzimidazole compounds having nociceptin receptor affinity
GB0012240D0 (en) * 2000-05-19 2000-07-12 Merck Sharp & Dohme Therapeutic agents
AU2001294196B2 (en) * 2000-10-06 2005-11-17 Tanabe Seiyaku Co., Ltd. Nitrogenous five-membered ring compounds
DE10252665A1 (de) * 2002-11-11 2004-06-03 Grünenthal GmbH 4-Aminomethyl-1-aryl-cyclohexylamin-Derivate

Also Published As

Publication number Publication date
PE20040833A1 (es) 2004-11-17
US7759385B2 (en) 2010-07-20
EP1560823B1 (fr) 2008-07-09
US20050277674A1 (en) 2005-12-15
WO2004043949A1 (fr) 2004-05-27
EP1560823A1 (fr) 2005-08-10
ATE400569T1 (de) 2008-07-15
AU2003287993A1 (en) 2004-06-03
AR041941A1 (es) 2005-06-01
DE50310122D1 (de) 2008-08-21
CY1108378T1 (el) 2014-02-12
DE10252666A1 (de) 2004-08-05
PT1560823E (pt) 2008-09-25
SI1560823T1 (sl) 2008-12-31
ES2309373T3 (es) 2008-12-16

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