DK1549650T3 - Substituerede C-imidazo[1,2-a]pyridin-3yl-methylaminer - Google Patents
Substituerede C-imidazo[1,2-a]pyridin-3yl-methylaminerInfo
- Publication number
- DK1549650T3 DK1549650T3 DK03807842T DK03807842T DK1549650T3 DK 1549650 T3 DK1549650 T3 DK 1549650T3 DK 03807842 T DK03807842 T DK 03807842T DK 03807842 T DK03807842 T DK 03807842T DK 1549650 T3 DK1549650 T3 DK 1549650T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- cycloalkyl
- optionally
- methylcyclobutyl
- methylcyclopropyl
- Prior art date
Links
- DBGFNLVRAFYZBI-UHFFFAOYSA-N n-methylpyridin-3-amine Chemical class CNC1=CC=CN=C1 DBGFNLVRAFYZBI-UHFFFAOYSA-N 0.000 title 1
- -1 OEt Chemical group 0.000 abstract 14
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 abstract 5
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 5
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 1
- 101100134927 Gallus gallus COR8 gene Proteins 0.000 abstract 1
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 1
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- WBLIXGSTEMXDSM-UHFFFAOYSA-N chloromethane Chemical compound Cl[CH2] WBLIXGSTEMXDSM-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- UHCBBWUQDAVSMS-UHFFFAOYSA-N fluoroethane Chemical compound CCF UHCBBWUQDAVSMS-UHFFFAOYSA-N 0.000 abstract 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 150000005232 imidazopyridines Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- NYPWXWJZKUUEQD-UHFFFAOYSA-N n,n-dimethyl-1-(7-methylimidazo[1,2-a]pyridin-3-yl)methanamine Chemical compound C1=C(C)C=CN2C(CN(C)C)=CN=C21 NYPWXWJZKUUEQD-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10246890A DE10246890A1 (de) | 2002-10-08 | 2002-10-08 | Substituierte C-Imidazo[1,2-alpyridin-3-yl-methylamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1549650T3 true DK1549650T3 (da) | 2006-07-31 |
Family
ID=32038330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03807842T DK1549650T3 (da) | 2002-10-08 | 2003-10-06 | Substituerede C-imidazo[1,2-a]pyridin-3yl-methylaminer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7342025B2 (es) |
| EP (1) | EP1549650B1 (es) |
| AT (1) | ATE321046T1 (es) |
| AU (1) | AU2003300132A1 (es) |
| CY (1) | CY1105019T1 (es) |
| DE (2) | DE10246890A1 (es) |
| DK (1) | DK1549650T3 (es) |
| ES (1) | ES2260693T3 (es) |
| PT (1) | PT1549650E (es) |
| WO (1) | WO2004033453A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10050663A1 (de) * | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
| DE10247269A1 (de) * | 2002-10-10 | 2004-04-22 | Grünenthal GmbH | Substituierte C-Imidazo[1,2-a]pyridin-3-yl-methylamine |
| ES2761180T3 (es) | 2005-12-23 | 2020-05-19 | Ariad Pharma Inc | Compuestos bicíclicos de heteroarilo |
| US8236841B2 (en) | 2006-09-13 | 2012-08-07 | Kyowa Hakko Kirin Co., Ltd. | Fused heterocycle derivative |
| EP1964840A1 (en) * | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]pyridines and their use as pharmaceuticals |
| HRP20130660T1 (en) * | 2007-04-03 | 2013-08-31 | Array Biopharma, Inc. | Imidazo[1,2-a]pyridine compounds as receptor tyrosine kinase inhibitors |
| EP2671582B1 (en) | 2011-02-01 | 2016-07-13 | Kyowa Hakko Kirin Co., Ltd. | Ring-fused heterocyclic derivative |
| EP2881394B1 (en) | 2012-07-31 | 2018-03-21 | Kyowa Hakko Kirin Co., Ltd. | Condensed ring heterocyclic compound |
| CN104628721A (zh) * | 2015-01-22 | 2015-05-20 | 湖南华腾制药有限公司 | 一种咪唑并[1,2-a]吡啶衍生物的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1536351A (fr) * | 1967-07-03 | 1968-08-27 | Pyridylimidazopyridines | |
| JPH11505524A (ja) * | 1995-05-01 | 1999-05-21 | 藤沢薬品工業株式会社 | イミダゾ１，２−ａピリジンおよびイミダゾ１，２−ａピリデジン誘導体、および骨吸収阻害剤としてのその用途 |
| DE19734184A1 (de) * | 1997-08-07 | 1999-02-11 | Agfa Gevaert Ag | Fotografisches Silberhalogenidmaterial |
| DE19948434A1 (de) * | 1999-10-08 | 2001-06-07 | Gruenenthal Gmbh | Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine |
| DE10040016A1 (de) * | 2000-08-16 | 2002-02-28 | Boehringer Ingelheim Pharma | Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| US6514969B2 (en) | 2000-08-16 | 2003-02-04 | Boehringer Ingelheim Pharma Kg | β-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions |
| SE0100567D0 (sv) * | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
| SE0100568D0 (sv) * | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
| DE10247269A1 (de) * | 2002-10-10 | 2004-04-22 | Grünenthal GmbH | Substituierte C-Imidazo[1,2-a]pyridin-3-yl-methylamine |
-
2002
- 2002-10-08 DE DE10246890A patent/DE10246890A1/de not_active Withdrawn
-
2003
- 2003-10-06 AT AT03807842T patent/ATE321046T1/de active
- 2003-10-06 ES ES03807842T patent/ES2260693T3/es not_active Expired - Lifetime
- 2003-10-06 AU AU2003300132A patent/AU2003300132A1/en not_active Abandoned
- 2003-10-06 WO PCT/EP2003/011011 patent/WO2004033453A1/de not_active Ceased
- 2003-10-06 DE DE50302769T patent/DE50302769D1/de not_active Expired - Lifetime
- 2003-10-06 EP EP03807842A patent/EP1549650B1/de not_active Expired - Lifetime
- 2003-10-06 PT PT03807842T patent/PT1549650E/pt unknown
- 2003-10-06 DK DK03807842T patent/DK1549650T3/da active
-
2005
- 2005-04-07 US US11/100,535 patent/US7342025B2/en not_active Expired - Fee Related
-
2006
- 2006-04-07 CY CY20061100485T patent/CY1105019T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE321046T1 (de) | 2006-04-15 |
| US7342025B2 (en) | 2008-03-11 |
| DE50302769D1 (de) | 2006-05-11 |
| WO2004033453A1 (de) | 2004-04-22 |
| DE10246890A1 (de) | 2004-04-22 |
| EP1549650A1 (de) | 2005-07-06 |
| ES2260693T3 (es) | 2006-11-01 |
| AU2003300132A1 (en) | 2004-05-04 |
| EP1549650B1 (de) | 2006-03-22 |
| PT1549650E (pt) | 2006-07-31 |
| CY1105019T1 (el) | 2009-11-04 |
| US20050239822A1 (en) | 2005-10-27 |
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