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NO20076681L - Ny metode for fremstilling av tiotropiumsalter - Google Patents

Ny metode for fremstilling av tiotropiumsalter

Info

Publication number
NO20076681L
NO20076681L NO20076681A NO20076681A NO20076681L NO 20076681 L NO20076681 L NO 20076681L NO 20076681 A NO20076681 A NO 20076681A NO 20076681 A NO20076681 A NO 20076681A NO 20076681 L NO20076681 L NO 20076681L
Authority
NO
Norway
Prior art keywords
preparation
new method
tiotropium salts
tiotropium
salts
Prior art date
Application number
NO20076681A
Other languages
English (en)
Other versions
NO340877B1 (no
Inventor
Jorg Brandenburg
Waldemar Pfrengle
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20076681L publication Critical patent/NO20076681L/no
Publication of NO340877B1 publication Critical patent/NO340877B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det beskrives en ny fremgangsmåte for fremstilling av tiotropiumsalter med den generelle Formel (I), hvor X kan ha de betydninger som er angitt i patentkravene og i beskrivelsen.
NO20076681A 2005-07-27 2007-12-28 Ny fremgangsmåte for fremstilling av tiotropiumsalter NO340877B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005035112A DE102005035112A1 (de) 2005-07-27 2005-07-27 Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
PCT/EP2006/064559 WO2007012626A2 (de) 2005-07-27 2006-07-24 Neues verfahren zur herstellung von tiotropiumsalzen

Publications (2)

Publication Number Publication Date
NO20076681L true NO20076681L (no) 2008-02-13
NO340877B1 NO340877B1 (no) 2017-07-03

Family

ID=37110331

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20076681A NO340877B1 (no) 2005-07-27 2007-12-28 Ny fremgangsmåte for fremstilling av tiotropiumsalter
NO20170613A NO20170613A1 (no) 2005-07-27 2017-04-11 Ny fremgangsmåte for fremstilling av tiotropiumsalter

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20170613A NO20170613A1 (no) 2005-07-27 2017-04-11 Ny fremgangsmåte for fremstilling av tiotropiumsalter

Country Status (24)

Country Link
US (5) US20070027320A1 (no)
EP (2) EP3153512A1 (no)
JP (1) JP5210861B2 (no)
KR (1) KR101299929B1 (no)
CN (2) CN104356129A (no)
AR (1) AR057690A1 (no)
AU (1) AU2006274012B2 (no)
BR (1) BRPI0614062B8 (no)
CA (1) CA2616222C (no)
DE (1) DE102005035112A1 (no)
DK (1) DK1910354T3 (no)
EA (1) EA014271B1 (no)
EC (1) ECSP088138A (no)
ES (1) ES2613952T3 (no)
HU (1) HUE032259T2 (no)
IL (1) IL188989A (no)
MX (1) MX2008001093A (no)
NO (2) NO340877B1 (no)
NZ (1) NZ566039A (no)
PL (1) PL1910354T3 (no)
TW (3) TWI486345B (no)
UA (1) UA94914C2 (no)
WO (1) WO2007012626A2 (no)
ZA (1) ZA200711113B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008089852A1 (de) * 2007-01-26 2008-07-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg Neues verfahren zur herstellung von tiotropiumsalzen
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
EP1997819A1 (de) * 2007-05-25 2008-12-03 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopinestern
EP2036898A2 (de) * 2007-09-13 2009-03-18 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von 1,3-Dioxolan-2Onen sowie von Carbonsäureestern durch Transacylierung unter Basischen Reaktionsbedingungen
PT2240477E (pt) * 2008-01-10 2014-11-19 Generics Uk Ltd Um novo processo para a preparação de ésteres de escopina
WO2011015884A1 (en) * 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
US8697719B2 (en) 2009-08-07 2014-04-15 Generics [Uk] Limited Anhydrate of tiotropium bromide
CZ305012B6 (cs) * 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
WO2021133280A1 (en) * 2019-12-27 2021-07-01 Deva Holding An improved process for preparation of scopine hydrobromide

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US7441045B2 (en) * 1999-12-13 2008-10-21 F5 Networks, Inc. Method and system for balancing load distribution on a wide area network
US6934686B1 (en) 2000-06-30 2005-08-23 I2 Technologies Us, Inc. Warranty transaction system and method
US7574499B1 (en) * 2000-07-19 2009-08-11 Akamai Technologies, Inc. Global traffic management system using IP anycast routing and dynamic load-balancing
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) * 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
US7237017B1 (en) * 2001-03-13 2007-06-26 Panamsat Corporation Micronode in a satellite based content delivery system
EP1410217A4 (en) * 2001-04-02 2006-09-20 Akamai Tech Inc SCALABLE, VERY EFFICIENT AND VERY AVAILABLE DISTRIBUTED STORAGE SYSTEM FOR INTERNET CONTENT
MXPA03010791A (es) * 2001-05-25 2004-03-02 Boehringer Ingelheim Pharma Combinacion de inhibidor de pde4 y tiotropio a sus derivados para tratamiento de enfermedades obstructivas de vias respiratorias y de otras enfermedades inflamatorias.
WO2003027906A2 (en) * 2001-09-28 2003-04-03 Savvis Communications Corporation System and method for policy dependent name to address resolutioin.
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US7305429B2 (en) * 2002-06-10 2007-12-04 Utstarcom, Inc. Method and apparatus for global server load balancing
EP1504756A1 (en) * 2003-08-06 2005-02-09 Kyowa Hakko Kogyo Co., Ltd Medicament compositions comprising a heterocyclic compound and an anticholinergic
CN102070630B (zh) * 2003-11-03 2013-04-17 贝林格尔.英格海姆国际有限公司 结晶噻托碘铵、包含该结晶噻托碘铵的药物制剂及其用途
EP1682543B1 (de) * 2003-11-03 2010-08-18 Boehringer Ingelheim International Gmbh Verfahren zur herstellung neuer tiotropiumsalze
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
NZ564697A (en) * 2005-06-15 2010-04-30 Boehringer Ingelheim Int Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
NZ566039A (en) 2011-07-29
TWI486346B (zh) 2015-06-01
CA2616222C (en) 2014-09-23
TWI486345B (zh) 2015-06-01
US20150225395A1 (en) 2015-08-13
NO20170613A1 (no) 2008-02-13
CN101309920A (zh) 2008-11-19
DK1910354T3 (en) 2017-02-13
UA94914C2 (ru) 2011-06-25
CN104356129A (zh) 2015-02-18
KR101299929B1 (ko) 2013-08-27
NO340877B1 (no) 2017-07-03
WO2007012626A3 (de) 2010-05-06
BRPI0614062B1 (pt) 2020-11-17
JP2009507769A (ja) 2009-02-26
BRPI0614062A2 (pt) 2011-03-09
MX2008001093A (es) 2008-03-11
AU2006274012A1 (en) 2007-02-01
PL1910354T3 (pl) 2017-04-28
JP5210861B2 (ja) 2013-06-12
WO2007012626A2 (de) 2007-02-01
TW201418253A (zh) 2014-05-16
IL188989A0 (en) 2008-08-07
US20130116435A1 (en) 2013-05-09
EP1910354A2 (de) 2008-04-16
EA200800324A1 (ru) 2008-08-29
US20070027320A1 (en) 2007-02-01
BRPI0614062B8 (pt) 2021-05-25
CA2616222A1 (en) 2007-02-01
ZA200711113B (en) 2010-08-25
IL188989A (en) 2012-10-31
DE102005035112A1 (de) 2007-02-15
EP3153512A1 (de) 2017-04-12
TWI443097B (zh) 2014-07-01
ES2613952T3 (es) 2017-05-29
ECSP088138A (es) 2008-02-20
HUE032259T2 (en) 2017-09-28
AU2006274012B2 (en) 2011-11-03
TW200738704A (en) 2007-10-16
EA014271B1 (ru) 2010-10-29
KR20080032634A (ko) 2008-04-15
TW201418252A (zh) 2014-05-16
US20100210844A1 (en) 2010-08-19
EP1910354B1 (de) 2016-11-09
AR057690A1 (es) 2007-12-12
US20140323732A1 (en) 2014-10-30

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