DK1226230T3 - Lactobacillus helveticus, der producerer antihypertensive di- og tripeptider - Google Patents

Lactobacillus helveticus, der producerer antihypertensive di- og tripeptider

Info

Publication number: DK1226230T3
Authority: DK; Denmark
Prior art keywords: tripeptides; lactobacillus helveticus; producing antihypertensive; product; antihypertensive
Prior art date: 1999-11-01

Application number

DK00972940T

Other languages

English (en)

Inventor

Annika Maeyrae-Maekinen

Tarja Suomalainen

Original Assignee

Valio Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-01

Filing date

2000-10-30

Publication date

2005-04-04

2000-10-30 Application filed by Valio Ltd filed Critical Valio Ltd

2005-04-04 Application granted granted Critical

2005-04-04 Publication of DK1226230T3 publication Critical patent/DK1226230T3/da

Links

230000003276 anti-hypertensive effect Effects 0.000 title abstract 2
240000002605 Lactobacillus helveticus Species 0.000 title 1
235000013967 Lactobacillus helveticus Nutrition 0.000 title 1
229940054346 lactobacillus helveticus Drugs 0.000 title 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
241000894006 Bacteria Species 0.000 abstract 1
239000000654 additive Substances 0.000 abstract 1
230000000996 additive effect Effects 0.000 abstract 1
239000005018 casein Substances 0.000 abstract 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
235000021240 caseins Nutrition 0.000 abstract 1
239000004615 ingredient Substances 0.000 abstract 1
235000014655 lactic acid Nutrition 0.000 abstract 1
239000004310 lactic acid Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/123—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
- A23C9/1234—Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/14—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
- A23C9/142—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
- A23C9/1427—Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by dialysis, reverse osmosis or hyperfiltration, e.g. for concentrating or desalting
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
- A23J3/343—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins
- A23J3/344—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins of dairy proteins of casein
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/52—Adding ingredients
- A23L2/66—Proteins
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/147—Helveticus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Medicinal Chemistry (AREA)
Nutrition Science (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biophysics (AREA)
Water Supply & Treatment (AREA)
Mycology (AREA)
Heart & Thoracic Surgery (AREA)
Public Health (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

DK00972940T 1999-11-01 2000-10-30 Lactobacillus helveticus, der producerer antihypertensive di- og tripeptider DK1226230T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FI992360A FI113741B (fi)	1999-11-01	1999-11-01	Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi
EP00972940A EP1226230B1 (en)	1999-11-01	2000-10-30	Lactobacillus helveticus producing antihypertensive di- and tripeptides
PCT/FI2000/000941 WO2001032836A1 (en)	1999-11-01	2000-10-30	Lactobacillus helvetius producing antihypertensive di- and tripeptides

Publications (1)

Publication Number	Publication Date
DK1226230T3 true DK1226230T3 (da)	2005-04-04

Family

ID=8555541

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK00972940T DK1226230T3 (da)	1999-11-01	2000-10-30	Lactobacillus helveticus, der producerer antihypertensive di- og tripeptider
DK00972941T DK1226267T3 (da)	1999-11-01	2000-10-30	Fremgangsmåde til fremstilling af et produkt, der indeholder antihypertensive tripeptider

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK00972941T DK1226267T3 (da)	1999-11-01	2000-10-30	Fremgangsmåde til fremstilling af et produkt, der indeholder antihypertensive tripeptider

Country Status (23)

Country	Link
US (2)	US6972282B1 (da)
EP (2)	EP1226230B1 (da)
JP (2)	JP3695648B2 (da)
KR (2)	KR100718709B1 (da)
CN (2)	CN1197956C (da)
AT (2)	ATE285470T1 (da)
AU (2)	AU769432B2 (da)
CA (2)	CA2388354A1 (da)
CZ (2)	CZ302271B6 (da)
DE (2)	DE60016959T2 (da)
DK (2)	DK1226230T3 (da)
EE (2)	EE05461B1 (da)
ES (2)	ES2234686T3 (da)
FI (1)	FI113741B (da)
HR (2)	HRP20020377B1 (da)
HU (2)	HU226200B1 (da)
NO (2)	NO20022062L (da)
NZ (2)	NZ518470A (da)
PL (2)	PL364790A1 (da)
PT (2)	PT1226230E (da)
RU (2)	RU2270855C2 (da)
WO (2)	WO2001032905A1 (da)
ZA (2)	ZA200203172B (da)

Families Citing this family (53)

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FI113741B (fi) *	1999-11-01	2004-06-15	Valio Oy	Menetelmä verenpainetta alentavia peptidejä sisältävän tuotteen valmistamiseksi
FI112031B (fi)	2002-02-25	2003-10-31	Valio Oy	Biologisesti aktiivisen tuotteen uusi käyttö
US20050256057A1 (en)	2002-06-04	2005-11-17	Luppo Edens	Protein hydrolysate rich in tripeptides
EP1529114A1 (en) *	2002-08-09	2005-05-11	Chr. Hansen A/S	Process for preparing peptides with anti-hypertensive properties
EA200501093A1 (ru) *	2003-01-06	2005-12-29	Юнилевер Н.В.	ФЕРМЕНТИРОВАННЫЙ МОЛОЧНЫЙ ПРОДУКТ, СОДЕРЖАЩИЙ ТРИПЕПТИДЫ VPP (Val-Pro-Pro) И/ИЛИ IPP (Ile-Pro-Pro)
TWI411441B (zh) *	2003-03-18	2013-10-11	Suntory Holdings Ltd	血管收縮素轉化酶抑制性肽類
US7718171B2 (en)	2003-04-07	2010-05-18	Chr. Hansen A/S	Reducing heart rate in mammals using milk derived fermentation products produced using Lactobacillus helveticus
CA2523410A1 (en) *	2003-05-05	2004-11-18	Unilever Plc	Hydrolysed casein product comprising tripeptides ipp and/or vpp
US20080292750A1 (en) *	2004-03-19	2008-11-27	Camoina Nederland Holding B.V.	Method of Preparing a Food Ingredient and Food Product Having Angiotensin-I-Converting Enzyme Inhibiting Properties and Products Thus Obtained
TW200536552A (en) *	2004-03-31	2005-11-16	Calpis Co Ltd	Hepatopathy preventive or inhibitory agents and functional food for preventing or inhibiting hepatopathy
US7862808B2 (en)	2004-07-01	2011-01-04	Mead Johnson Nutrition Company	Method for preventing or treating respiratory infections and acute otitis media in infants using Lactobacillus rhamnosus LGG and Bifidobacterium lactis Bb-12
JP4723501B2 (ja) *	2004-07-05	2011-07-13	カルピス株式会社	ペプチド混合物の製造法、抗高血圧ペプチド含有発酵乳の製造法及び抗高血圧ペプチド製剤の製造法
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EP1685764A1 (en)	2005-01-27	2006-08-02	Globus Egg Sciences B.V.	Anti-hypertensive functional food products
BRPI0514903A (pt)	2004-09-03	2008-06-24	Hansens Lab	proteìnas vegetais ou leite fermentado compreendendo ligando de receptor e uso dos mesmos
FR2876876B1 (fr) *	2004-10-22	2007-02-16	Gervais Danone Sa	Protection d'ingredients alimentaires bioactifs par l'utilisation de microorganismes presentant une capacite de metabolisation reduite
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EP1879465A1 (en) *	2005-02-09	2008-01-23	Unilever N.V.	Composition comprising peptide
ES2599859T3 (es) *	2005-02-24	2017-02-03	Dsm Ip Assets B.V.	Proceso enzimático para producir I-P-P a partir de caseína kappa
US7303745B2 (en)	2005-04-15	2007-12-04	Bristol-Myers Squibb Company	Method for preventing or treating the development of respiratory allergies
NZ713149A (en) *	2005-11-28	2017-02-24	Dsm Ip Assets Bv	Enzyme preparations yielding a clean taste
KR101048663B1 (ko) *	2006-02-14	2011-07-12	칼피스가부시키가이샤	동맥경화 예방제, 혈관 내막의 비후 억제제 및 혈관 내피 기능 개선제
KR20080095898A (ko)	2006-02-14	2008-10-29	칼피스가부시키가이샤	혈관확장제
PT1820850E (pt) *	2006-02-20	2009-05-29	Gervais Danone Sa	Novas estirpes de lactobacillus helveticus
ATE421572T1 (de) *	2006-02-20	2009-02-15	Gervais Danone Sa	Neue stämme von lactobacillus helveticus
EP1820851B9 (fr) *	2006-02-20	2012-06-27	Compagnie Gervais Danone	Souches de Lactobacillus helveticus ne fermentant pas le lactose
CN100370019C (zh) *	2006-04-21	2008-02-20	江南大学	一种具有抗高血压作用的植物乳杆菌cw006
RU2457852C2 (ru) *	2006-05-15	2012-08-10	Валио Лтд	Новое применение терапевтически эффективных пептидов
CN101443031A (zh) *	2006-05-15	2009-05-27	瓦利奥有限公司	治疗用肽的新应用
KR101492650B1 (ko) *	2006-09-04	2015-02-12	유키지루시 메그밀크 가부시키가이샤	혈중 아디포넥틴 농도 증가 촉진 및/또는 감소 억제제 및 내장 지방 축적 억제제
ES2557160T3 (es) *	2006-10-23	2016-01-22	Nestec S.A.	Modulación del aroma y el sabor mediante biotransformación en productos lácteos
EP1952703B1 (de) *	2007-02-02	2010-08-25	May, Amadeus Alexander	Produkt mit lebenden probiotischen Mikroorganismen
US11759477B2 (en)	2007-02-26	2023-09-19	Heartbeet Ltd.	Compositions of nitrates and methods of use thereof
US10842813B2 (en)	2007-02-26	2020-11-24	Heartbeet Ltd	Compositions of nitrates and methods of use thereof
EP2130546B1 (en) *	2007-03-27	2013-02-27	Calpis Co., Ltd.	Tripeptides for use in treating heart wall thickening
AU2009256950A1 (en) *	2008-06-12	2009-12-17	Nestec S.A.	Lactobacillus helveticus strains for producing hypotensive peptides
DE102008032828A1 (de)	2008-07-02	2010-01-07	Technische Universität Dresden	Tryptophanhaltige Peptide aus alpha-Lactalbumin mit blutdrucksenkender und vasoprotektiver Wirkung für biofunktionelle Lebensmittel
FI122531B (fi) *	2009-09-30	2012-03-15	Valio Oy	Juusto ja menetelmä sen valmistamiseksi
CN102786579B (zh) *	2012-07-17	2014-07-09	上海交通大学	抗高血压活性肽vip
CN102786580A (zh) *	2012-07-17	2012-11-21	上海交通大学	抗高血压活性肽ivp
RU2580052C1 (ru) *	2014-12-24	2016-04-10	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Горский государственный аграрный университет"	Штамм lactobacillus helveticus вкпм в-11176, полученный на доступных питательных средах
RU2577112C1 (ru) *	2014-12-25	2016-03-10	Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Горский государственный аграрный университет"	Штамм lactobacillus helveticus вкпм в-11175, полученный на доступных питательных средах
DK3788881T3 (da)	2016-12-02	2022-10-03	Fairlife Llc	Ikke-brunfarvende laktosefrit mælkepulver og fremgangsmåder til fremstilling deraf
RU2685912C1 (ru) *	2018-03-14	2019-04-23	Федеральное государственное автономное научное учреждение "Научно-исследовательский институт хлебопекарной промышленности"	Штамм бактерий lactobacillus amylolyticus, используемый для приготовления термофильной заквашенной заварки
RU2728171C2 (ru) *	2018-11-08	2020-07-28	Общество с ограниченной ответственностью "Инновационные биотехнологии" (ООО "Инбиотех")	Штамм бактерий Lactobacillus helveticus T-5068, используемый в качестве закваски прямого внесения для приготовления кисломолочных продуктов
CN109517763B (zh) *	2018-12-27	2022-03-22	内蒙古农业大学	瑞士乳杆菌h11及其应用
TWI713972B (zh) *	2019-01-14	2020-12-21	大江生醫股份有限公司	改善呼吸道健康之益生菌株及其組合物與用途
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CN112029784A (zh) *	2020-09-16	2020-12-04	内蒙古农业大学	一个与蛋白水解能力相关的基因及基于该基因的高蛋白水解能力瑞士乳杆菌的筛选方法
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1999
- 1999-11-01 FI FI992360A patent/FI113741B/fi not_active IP Right Cessation
2000
- 2000-10-30 HU HU0203256A patent/HU226200B1/hu not_active IP Right Cessation
- 2000-10-30 NZ NZ518470A patent/NZ518470A/xx unknown
- 2000-10-30 KR KR1020027005618A patent/KR100718709B1/ko not_active Expired - Fee Related
- 2000-10-30 NZ NZ518493A patent/NZ518493A/xx unknown
- 2000-10-30 KR KR1020027005619A patent/KR100704441B1/ko not_active Expired - Fee Related
- 2000-10-30 AU AU11499/01A patent/AU769432B2/en not_active Ceased
- 2000-10-30 DE DE60016959T patent/DE60016959T2/de not_active Expired - Fee Related
- 2000-10-30 DK DK00972940T patent/DK1226230T3/da active
- 2000-10-30 DK DK00972941T patent/DK1226267T3/da active
- 2000-10-30 CA CA002388354A patent/CA2388354A1/en not_active Abandoned
- 2000-10-30 AT AT00972940T patent/ATE285470T1/de not_active IP Right Cessation
- 2000-10-30 EE EEP200200230A patent/EE05461B1/xx not_active IP Right Cessation
- 2000-10-30 US US10/111,942 patent/US6972282B1/en not_active Expired - Fee Related
- 2000-10-30 HU HU0203185A patent/HUP0203185A3/hu unknown
- 2000-10-30 DE DE60010742T patent/DE60010742T2/de not_active Expired - Lifetime
- 2000-10-30 ES ES00972940T patent/ES2234686T3/es not_active Expired - Lifetime
- 2000-10-30 PT PT00972940T patent/PT1226230E/pt unknown
- 2000-10-30 EP EP00972940A patent/EP1226230B1/en not_active Expired - Lifetime
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- 2000-10-30 CN CNB008153930A patent/CN1197956C/zh not_active Expired - Fee Related
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- 2000-10-30 RU RU2002114327/13A patent/RU2270855C2/ru active
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- 2000-10-30 CN CNB008153353A patent/CN1164761C/zh not_active Expired - Fee Related
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- 2000-10-30 PL PL355670A patent/PL204119B1/pl not_active IP Right Cessation
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- 2000-10-30 AT AT00972941T patent/ATE266735T1/de active
- 2000-10-30 AU AU11498/01A patent/AU777795B2/en not_active Ceased
2002
- 2002-04-22 ZA ZA200203172A patent/ZA200203172B/xx unknown
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Also Published As

Publication number	Publication date
EP1226230A1 (en)	2002-07-31
KR20020060220A (ko)	2002-07-16
ATE285470T1 (de)	2005-01-15
CA2387738A1 (en)	2001-05-10
HUP0203256A3 (en)	2005-11-28
ATE266735T1 (de)	2004-05-15
EP1226230B1 (en)	2004-12-22
CN1387564A (zh)	2002-12-25
PT1226230E (pt)	2005-04-29
JP3695648B2 (ja)	2005-09-14
NO20022062L (no)	2002-06-28
WO2001032836A1 (en)	2001-05-10
CZ294146B6 (cs)	2004-10-13
FI19992360L (fi)	2001-05-02
EP1226267A1 (en)	2002-07-31
CN1387577A (zh)	2002-12-25
NO20022061L (no)	2002-06-28
HU226200B1 (en)	2008-06-30
AU769432B2 (en)	2004-01-29
CZ20021431A3 (cs)	2002-08-14
DK1226267T3 (da)	2004-09-20
CZ302271B6 (cs)	2011-01-19
ZA200203179B (en)	2003-07-22
ES2220557T3 (es)	2004-12-16
HUP0203185A3 (en)	2005-07-28
CN1197956C (zh)	2005-04-20
CN1164761C (zh)	2004-09-01
EE200200230A (et)	2003-06-16
RU2270855C2 (ru)	2006-02-27
EP1226267B1 (en)	2004-05-12
KR100718709B1 (ko)	2007-05-16
NO20022062D0 (no)	2002-04-30
PT1226267E (pt)	2004-08-31
NO330951B1 (no)	2011-08-22
DE60010742T2 (de)	2005-05-12
NZ518470A (en)	2003-03-28
HUP0203256A2 (hu)	2003-01-28
WO2001032905A1 (en)	2001-05-10
US6890529B1 (en)	2005-05-10
NZ518493A (en)	2003-03-28
HUP0203185A2 (hu)	2003-01-28
DE60010742D1 (de)	2004-06-17
JP2003513636A (ja)	2003-04-15
HRP20020377A2 (en)	2003-08-31
EE200200231A (xx)	2003-06-16
AU1149801A (en)	2001-05-14
JP2003513621A (ja)	2003-04-15
AU1149901A (en)	2001-05-14
HRP20020378B1 (en)	2005-06-30
ZA200203172B (en)	2003-09-23
KR20020064895A (ko)	2002-08-10
ES2234686T3 (es)	2005-07-01
CZ20021369A3 (cs)	2002-07-17
DE60016959D1 (de)	2005-01-27
CA2387738C (en)	2008-09-16
NO20022061D0 (no)	2002-04-30
JP4172681B2 (ja)	2008-10-29
FI113741B (fi)	2004-06-15
PL364790A1 (pl)	2004-12-13
PL355670A1 (pl)	2004-05-04
US6972282B1 (en)	2005-12-06
RU2276689C2 (ru)	2006-05-20
EE05461B1 (et)	2011-08-15
AU777795B2 (en)	2004-10-28
CA2388354A1 (en)	2001-05-10
DE60016959T2 (de)	2005-12-22
KR100704441B1 (ko)	2007-04-24
PL204119B1 (pl)	2009-12-31
HRP20020378A2 (en)	2003-08-31
HRP20020377B1 (en)	2005-06-30

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