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DK1257280T3 - Farmaceutisk sammensætning af mikroniseret drospirenon og et östrogen til hormonsubstitutionsterapi - Google Patents

Farmaceutisk sammensætning af mikroniseret drospirenon og et östrogen til hormonsubstitutionsterapi

Info

Publication number
DK1257280T3
DK1257280T3 DK01900579T DK01900579T DK1257280T3 DK 1257280 T3 DK1257280 T3 DK 1257280T3 DK 01900579 T DK01900579 T DK 01900579T DK 01900579 T DK01900579 T DK 01900579T DK 1257280 T3 DK1257280 T3 DK 1257280T3
Authority
DK
Denmark
Prior art keywords
drospirenone
estrogen
pharmaceutical composition
replacement therapy
hormone replacement
Prior art date
Application number
DK01900579T
Other languages
Danish (da)
English (en)
Inventor
Wolfgang Heil
Juergen Hilmann
Ralph Lipp
Rolf Schuermann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26071749&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1257280(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK1257280T3 publication Critical patent/DK1257280T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
DK01900579T 2000-01-18 2001-01-18 Farmaceutisk sammensætning af mikroniseret drospirenon og et östrogen til hormonsubstitutionsterapi DK1257280T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48402600A 2000-01-18 2000-01-18
EP00200183 2000-01-18

Publications (1)

Publication Number Publication Date
DK1257280T3 true DK1257280T3 (da) 2005-12-12

Family

ID=26071749

Family Applications (2)

Application Number Title Priority Date Filing Date
DK01900579T DK1257280T3 (da) 2000-01-18 2001-01-18 Farmaceutisk sammensætning af mikroniseret drospirenon og et östrogen til hormonsubstitutionsterapi
DK05076969T DK1611892T3 (da) 2000-01-18 2001-01-18 Farmaceutiske sammensætninger indeholdende drospirenon

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK05076969T DK1611892T3 (da) 2000-01-18 2001-01-18 Farmaceutiske sammensætninger indeholdende drospirenon

Country Status (30)

Country Link
EP (2) EP1257280B1 (fr)
JP (2) JP5128743B2 (fr)
KR (2) KR100913910B1 (fr)
CN (2) CN101934078A (fr)
AT (2) ATE442147T1 (fr)
AU (3) AU2001225413B2 (fr)
BG (1) BG65849B1 (fr)
BR (1) BR0107683A (fr)
CA (1) CA2394165C (fr)
CY (1) CY1109567T1 (fr)
CZ (1) CZ20022411A3 (fr)
DE (2) DE60139907D1 (fr)
DK (2) DK1257280T3 (fr)
EE (1) EE05533B1 (fr)
ES (2) ES2332226T3 (fr)
HK (1) HK1047248B (fr)
HU (1) HUP0204291A3 (fr)
IL (3) IL150775A0 (fr)
ME (1) ME00292B (fr)
MX (1) MXPA02006613A (fr)
NO (1) NO335570B1 (fr)
NZ (1) NZ520630A (fr)
PL (1) PL201878B1 (fr)
PT (1) PT1611892E (fr)
RS (1) RS52149B (fr)
RU (2) RU2275198C2 (fr)
SI (2) SI1611892T1 (fr)
SK (2) SK288129B6 (fr)
WO (1) WO2001052857A1 (fr)
ZA (2) ZA200206551B (fr)

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RS50262B2 (sr) * 1999-08-31 2018-10-31 Bayer Pharma AG Farmaceutska kombinacija etinilestradiola i drospirenona za primenu kao kontraceptivnog sredstva
EP1216713A1 (fr) * 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions de complexes de estrogen-cyclodextrine
WO2003006027A1 (fr) 2001-07-13 2003-01-23 Schering Aktiengesellschaft Combinaison de drospirenone et d'un sulfamate d'oestrogene destinee a une hormonotherapie substitutive
US20030229057A1 (en) * 2002-03-11 2003-12-11 Caubel Patrick Michel Continuous sulfatase inhibiting progestogen hormone replacement therapy
HRP20041121A2 (en) * 2002-04-26 2005-02-28 Schering Aktiengesellschaft Treatment of hypertension in women receiving hormone replacement therapy
US7786101B2 (en) 2002-11-05 2010-08-31 Bayer Schering Pharma Ag Cardiovascular protection using anti-aldosteronic progestins
AU2002368326A1 (en) * 2002-11-05 2004-06-07 Schering Aktiengesellschaft Hormone replacement therapy with drospirenone
DE60330888D1 (de) * 2002-11-05 2010-02-25 Bayer Schering Pharma Ag Verwendung von drospirenon zur behandlung von hypertension
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ES2325591T3 (es) 2004-03-10 2009-09-09 Bayer Schering Pharma Aktiengesellschaft Composiciones que comprenden drospirenona dispersada molecularmente.
DE102004023984A1 (de) * 2004-05-14 2005-12-08 Hf Arzneimittelforschung Gmbh Filmförmiges, oral zu verabreichendes Arzneimittel, enthaltend Estriol
US8022053B2 (en) 2004-11-02 2011-09-20 Bayer Schering Pharma Aktiengesellschaft Oral solid dosage forms containing a low dose of estradiol
EP1954240A2 (fr) * 2005-07-15 2008-08-13 Bayer Schering Pharma Aktiengesellschaft Dispositifs d'administration d'un medicament transdermique contenant le drospirenone
DE102005056527A1 (de) * 2005-11-25 2007-07-12 Grünenthal GmbH Verwendung einer Kombination aus Ethinylestradiol und Chlormadinonacetat zur Herstellung eines Arzneimittels
US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
CN101489563A (zh) * 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
DE102007011105A1 (de) 2007-03-02 2008-09-04 Bayer Schering Pharma Aktiengesellschaft Mineralcorticoid-Rezeptor-Antagonisten zur Behandlung von Endometriose
CN101623287B (zh) * 2008-07-07 2012-02-08 天津金耀集团有限公司 一种屈螺酮类似物的治疗更年期综合症的药物组合物
ES2344675B1 (es) * 2008-12-19 2011-04-28 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular.
UY32836A (es) 2009-08-12 2011-03-31 Bayer Schering Pharma Ag Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato
BR112012026115B1 (pt) * 2010-04-15 2019-12-24 Bayer Ip Gmbh forma de dosagem oral sólida, seu uso, e unidade de acondicionamento
ES2533584T3 (es) * 2010-04-15 2015-04-13 Bayer Intellectual Property Gmbh Formas de dosificación oral sólidas de dosis baja para TSH
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
KR20140088197A (ko) 2011-11-04 2014-07-09 바이엘 파마 악티엔게젤샤프트 18-메틸-6,7-메틸렌-3-옥소-17-프레그느-4-엔-21,17β-카르보락톤, 상기 화합물을 함유하는 약제학적 제제 및 자궁내막증 치료에 있어서 이들의 용도
TW201350122A (zh) * 2012-04-23 2013-12-16 Bayer Pharma AG １８－甲基－１５β，１６β－亞甲基－１９－降－２０－螺氧－４－烯－３－酮的子宮內用途，包含１８－甲基－１５β，１６β－亞甲基－１９－降－２０－螺氧－４－烯－３－酮的子宮內系統，及其於避孕及婦科治療之用途
UA115576C2 (uk) 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
TW201607943A (zh) 2013-12-19 2016-03-01 拜耳製藥公司 作為ｅｐ４配體之新穎苯并咪唑衍生物
JP6866560B2 (ja) 2015-06-18 2021-04-28 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロール成分を含有する口腔内崩壊性投与単位
CA3178291A1 (fr) 2016-08-05 2018-04-12 Estetra Srl Methode de prise en charge de la dysmenorrhee et des douleurs menstruelles
CN110809473A (zh) 2017-06-01 2020-02-18 延世大学校产学协力团 用于预防或治疗骨相关疾病的药物组合物
JOP20200260A1 (ar) * 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物
CN115813937B (zh) * 2022-12-01 2025-04-11 南通联亚药业股份有限公司 一种稳定的包含屈螺酮和雌二醇的药物组合物及其制备方法
CN118356456A (zh) * 2024-04-17 2024-07-19 且安生物科技有限责任公司 一种抗炎护巢草本提取制备方法

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Also Published As

Publication number Publication date
JP5128743B2 (ja) 2013-01-23
ATE442147T1 (de) 2009-09-15
HUP0204291A3 (en) 2003-05-28
RU2002122113A (ru) 2004-03-10
MXPA02006613A (es) 2003-10-15
NZ520630A (en) 2004-09-24
BG106915A (bg) 2003-04-30
AU2001225413B2 (en) 2005-06-23
EP1611892B1 (fr) 2009-09-09
RU2275198C2 (ru) 2006-04-27
EP1257280A1 (fr) 2002-11-20
KR100747965B1 (ko) 2007-08-08
ZA200206551B (en) 2006-04-29
BR0107683A (pt) 2002-11-12
SK288129B6 (sk) 2013-10-02
MEP38008A (en) 2011-02-10
RS52149B (sr) 2012-08-31
SK287719B6 (en) 2011-07-06
ATE305789T1 (de) 2005-10-15
SI1611892T1 (sl) 2010-01-29
AU2541301A (en) 2001-07-31
DK1611892T3 (da) 2009-11-02
YU54602A (sh) 2006-01-16
HK1047248A1 (en) 2003-02-14
HK1047248B (en) 2005-12-30
JP5563227B2 (ja) 2014-07-30
RU2402331C2 (ru) 2010-10-27
DE60113809T2 (de) 2006-06-22
IL150775A (en) 2008-08-07
JP2003520239A (ja) 2003-07-02
EE05533B1 (et) 2012-04-16
EP1611892A2 (fr) 2006-01-04
IL150775A0 (en) 2003-02-12
CN101934078A (zh) 2011-01-05
PL201878B1 (pl) 2009-05-29
ME00292B (fr) 2011-05-10
PL356987A1 (en) 2004-07-12
IL191131A0 (en) 2008-11-03
NO20022966L (no) 2002-09-18
ZA200601285B (en) 2008-01-08
PT1611892E (pt) 2009-11-20
DE60139907D1 (de) 2009-10-22
BG65849B1 (bg) 2010-03-31
WO2001052857A1 (fr) 2001-07-26
SI1257280T1 (sl) 2006-02-28
JP2009120615A (ja) 2009-06-04
NO20022966D0 (no) 2002-06-20
CY1109567T1 (el) 2014-08-13
HK1082433A1 (en) 2006-06-09
HUP0204291A2 (hu) 2003-04-28
KR100913910B1 (ko) 2009-08-26
EP1257280B1 (fr) 2005-10-05
DE60113809D1 (de) 2006-02-16
CA2394165C (fr) 2010-04-13
ES2247054T3 (es) 2006-03-01
CN1395488A (zh) 2003-02-05
RU2005140938A (ru) 2007-07-10
SK10322002A3 (sk) 2003-03-04
ES2332226T3 (es) 2010-01-29
EE200200401A (et) 2003-10-15
AU2005209600B2 (en) 2008-08-07
KR20070051956A (ko) 2007-05-18
NO335570B1 (no) 2014-12-29
CA2394165A1 (fr) 2001-07-26
IL191131A (en) 2010-12-30
AU2005209600A1 (en) 2005-09-29
KR20020088066A (ko) 2002-11-25
CZ20022411A3 (cs) 2003-02-12
EP1611892A3 (fr) 2006-02-01

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