DK1147115T5 - Tricycliske benzodiazepiner som vasopressinreceptorantagonister - Google Patents

Tricycliske benzodiazepiner som vasopressinreceptorantagonister

Info

Publication number: DK1147115T5
Authority: DK; Denmark
Prior art keywords: receptor antagonists; vasopressin receptor; tricyclic benzodiazepines; benzodiazepines; tricyclic
Prior art date: 1999-01-19

Application number

DK99966495T

Other languages

Danish (da)

English (en)

Other versions

DK1147115T3 (da

Inventor

Jay M Matthews

William J Hoekstra

Alexey B Dyatkin

Bruce E Maryanoff

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-19

Filing date

1999-12-21

Publication date

2008-12-08

1999-12-21 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2004-01-12 Publication of DK1147115T3 publication Critical patent/DK1147115T3/da

2008-12-08 Application granted granted Critical

2008-12-08 Publication of DK1147115T5 publication Critical patent/DK1147115T5/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK99966495T 1999-01-19 1999-12-21 Tricycliske benzodiazepiner som vasopressinreceptorantagonister DK1147115T5 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US11635899P	1999-01-19	1999-01-19
US46865099A	1999-12-21	1999-12-21
PCT/US1999/030423 WO2000043398A2 (fr)	1999-01-19	1999-12-21	Benzodiazepines tricycliques utilisees en tant qu'antagonistes du recepteur de la vasopressine

Publications (2)

Publication Number	Publication Date
DK1147115T3 DK1147115T3 (da)	2004-01-12
DK1147115T5 true DK1147115T5 (da)	2008-12-08

Family

ID=26814157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99966495T DK1147115T5 (da)	1999-01-19	1999-12-21	Tricycliske benzodiazepiner som vasopressinreceptorantagonister

Country Status (27)

Country	Link
US (2)	US6713475B2 (fr)
EP (1)	EP1147115B3 (fr)
KR (1)	KR100771184B1 (fr)
CN (1)	CN1174986C (fr)
AR (1)	AR035837A1 (fr)
AT (1)	ATE249465T1 (fr)
AU (1)	AU772397B2 (fr)
BR (1)	BRPI9917086B8 (fr)
CA (1)	CA2360767C (fr)
CZ (1)	CZ302647B6 (fr)
DE (2)	DE69911259T4 (fr)
DK (1)	DK1147115T5 (fr)
ES (1)	ES2207333T7 (fr)
HK (1)	HK1038361B (fr)
HU (1)	HU229074B1 (fr)
IL (2)	IL144270A0 (fr)
ME (1)	ME00129B (fr)
MY (1)	MY128065A (fr)
NO (1)	NO327896B1 (fr)
NZ (1)	NZ512960A (fr)
PL (1)	PL205704B1 (fr)
PT (1)	PT1147115E (fr)
RS (1)	RS50820B (fr)
TR (1)	TR200102069T2 (fr)
TW (1)	TWI289564B (fr)
UA (1)	UA70984C2 (fr)
WO (1)	WO2000043398A2 (fr)

Families Citing this family (39)

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PL205704B1 (pl) *	1999-01-19	2010-05-31	Ortho Mcneil Pharm Inc	Związki tricyklicznej benzodiazepiny, kompozycja farmaceutyczna zawierająca te związki oraz ich zastosowanie
ATE367815T1 (de) *	2000-10-04	2007-08-15	Astellas Pharma Inc	Verwendung von einem vasopressin-antagonisten wie conivaptan zur herstellung eines medikaments für die behandlung der pulmonalen hypertension
EP1381608B1 (fr)	2001-04-12	2007-10-10	Wyeth	Cyclohexylphenyles ayant une activite d'agonistes de la vasopressine
US6903091B2 (en)	2001-04-12	2005-06-07	Wyeth	Biphenyl vasopressin agonists
CA2465497A1 (fr) *	2001-10-29	2003-05-08	Ortho-Mcneil Pharmaceutical, Inc.	Antagonistes du recepteur de la vasopressine a base de (1,4) benzodiazepine bicyclique ponte
EP1364968A1 (fr) *	2002-05-23	2003-11-26	Bayer Aktiengesellschaft	Diagnostic et traitement des maladies associées au récepteur 1 d'arginine-vasopressine (AVPR1)
GB0303852D0 (en) *	2003-02-19	2003-03-26	Pfizer Ltd	Triazole compounds useful in therapy
DE602004003914T2 (de) *	2003-02-19	2007-05-31	Pfizer Inc.	Für die therapie geeignete triazolverbindungen
US7119088B2 (en)	2003-02-19	2006-10-10	Pfizer Inc.	Triazole compounds useful in therapy
CA2585449A1 (fr) *	2004-10-28	2006-05-11	Janssen Pharmaceutica N.V.	Nouvelles [1,4]benzodiazepines convenant comme antagonistes du recepteur v-2 de la vasopressine
DE102005003632A1 (de)	2005-01-20	2006-08-17	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20070213813A1 (en)	2005-12-22	2007-09-13	Symetis Sa	Stent-valves for valve replacement and associated methods and systems for surgery
WO2008007661A1 (fr) *	2006-07-11	2008-01-17	Takeda Pharmaceutical Company Limited	Composé hétérocyclique tricycique et son utilisation
US7896915B2 (en)	2007-04-13	2011-03-01	Jenavalve Technology, Inc.	Medical device for treating a heart valve insufficiency
WO2011104269A1 (fr)	2008-02-26	2011-09-01	Jenavalve Technology Inc.	Stent pour le positionnement et l'ancrage d'une prothèse valvulaire dans un site d'implantation dans le cœur d'un patient
US9044318B2 (en)	2008-02-26	2015-06-02	Jenavalve Technology Gmbh	Stent for the positioning and anchoring of a valvular prosthesis
PL2356123T3 (pl) *	2008-11-13	2013-03-29	Hoffmann La Roche	Spiro-5,6-dihudro-4h-2,3,5,10b- tetraazabenzo[e]azuleny
KR101385433B1 (ko) *	2008-11-18	2014-04-14	에프. 호프만-라 로슈 아게	다이하이드로테트라아자벤조아줄렌의 알킬사이클로헥실에터
DK2370441T3 (da) *	2008-11-28	2013-10-21	Hoffmann La Roche	Arylcyclohexylethere af dihydrotetraazabenzoazulener til anvendelse som vasopressin v1a-receptorantagonister
DE102009033392A1 (de) *	2009-07-16	2011-01-20	Merck Patent Gmbh	Heterocyclische Verbindungen als Autotaxin-Inhibitoren II
US20120184537A1 (en)	2009-09-24	2012-07-19	Shire-Movetis N.V.	[1,4]-benzodiazepines as vasopressin v2 receptor antagonists
US8420633B2 (en)	2010-03-31	2013-04-16	Hoffmann-La Roche Inc.	Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en)	2010-04-13	2013-06-11	Hoffmann-La Roche Inc.	Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en)	2010-04-21	2013-07-23	Hoffmann-La Roche Inc.	Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en)	2010-04-26	2013-07-09	Hoffmann-La Roche Inc.	Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en)	2010-05-10	2013-08-20	Hoffmann-La Roche Inc.	Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
US10856978B2 (en)	2010-05-20	2020-12-08	Jenavalve Technology, Inc.	Catheter system
WO2011147849A1 (fr)	2010-05-25	2011-12-01	Jenavalve Technology Inc.	Valvule prothétique et endoprothèse mise en place par cathétérisme comprenant une valvule prothétique et un stent
US8828989B2 (en)	2011-09-26	2014-09-09	Hoffmann-La Roche Inc.	Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
EP4098226A1 (fr)	2013-08-30	2022-12-07	JenaValve Technology, Inc.	Endoprothèse comprenant une armature radialement repliable et une valve prothétique
WO2016089830A1 (fr) *	2014-12-05	2016-06-09	Merck Sharp & Dohme Corp.	Nouveaux composés tricycliques utilisés en tant qu'inhibiteurs d'enzymes idh mutantes
US10442819B2 (en)	2014-12-05	2019-10-15	Merck Sharp & Dohme Corp.	Tricyclic compounds as inhibitors of mutant IDH enzymes
EP3226690B1 (fr) *	2014-12-05	2020-05-20	Merck Sharp & Dohme Corp.	Nouveaux composés tricycliques comme inhibiteurs d'enzymes idh mutantes
EP3270825B1 (fr)	2015-03-20	2020-04-22	JenaValve Technology, Inc.	Système de pose de prothèse de valvule cardiaque
WO2016177562A1 (fr)	2015-05-01	2016-11-10	Jenavalve Technology, Inc.	Dispositif et procédé à débit réduit de stimulateur cardiaque lors d'un remplacement de valvules cardiaques
EP4183371A1 (fr)	2016-05-13	2023-05-24	JenaValve Technology, Inc.	Système de pose de prothèse de valvule cardiaque et procédé de pose de prothèse de valvule cardiaque avec gaine d'introduction et système de chargement
JP7094965B2 (ja)	2017-01-27	2022-07-04	イエナバルブテクノロジーインク	心臓弁模倣
EP3875078A1 (fr) *	2020-03-06	2021-09-08	Dompe' Farmaceutici S.P.A.	Des composes pour pour le traitement de covid-19
WO2024102411A1 (fr)	2022-11-09	2024-05-16	Jenavalve Technology, Inc.	Système de cathéter pour le déploiement séquentiel d'un implant expansible

Family Cites Families (8)

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US3732212A (en)	1970-04-20	1973-05-08	Sterling Drug Inc	1,2,3,10,11,11a-hexahydro-5h-pyrrolo(2,1-c)(1,4)benzodiazepine-5,11-diones
US3763183A (en) *	1972-07-10	1973-10-02	Sterling Drug Inc	1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines
US3860600A (en)	1972-07-10	1975-01-14	Sterling Drug Inc	Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines
US5516774A (en) *	1993-07-29	1996-05-14	American Cyanamid Company	Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5521173A (en) *	1995-01-17	1996-05-28	American Home Products Corporation	Tricyclic benzazepine vasopressin antagonists
EP0987266A4 (fr)	1997-03-31	2000-07-26	Wakamoto Pharma Co Ltd	Derives de biphenyle et compositions medicinales
ES2229525T3 (es) *	1997-07-30	2005-04-16	Wyeth	Agonistas triciclicos de la vasopresina.
PL205704B1 (pl) *	1999-01-19	2010-05-31	Ortho Mcneil Pharm Inc	Związki tricyklicznej benzodiazepiny, kompozycja farmaceutyczna zawierająca te związki oraz ich zastosowanie

1999
- 1999-12-21 PL PL349778A patent/PL205704B1/pl unknown
- 1999-12-21 DK DK99966495T patent/DK1147115T5/da active
- 1999-12-21 EP EP99966495A patent/EP1147115B3/fr not_active Expired - Lifetime
- 1999-12-21 CA CA002360767A patent/CA2360767C/fr not_active Expired - Fee Related
- 1999-12-21 PT PT99966495T patent/PT1147115E/pt unknown
- 1999-12-21 WO PCT/US1999/030423 patent/WO2000043398A2/fr not_active Ceased
- 1999-12-21 HU HU0105034A patent/HU229074B1/hu not_active IP Right Cessation
- 1999-12-21 TR TR2001/02069T patent/TR200102069T2/xx unknown
- 1999-12-21 IL IL14427099A patent/IL144270A0/xx unknown
- 1999-12-21 NZ NZ512960A patent/NZ512960A/en not_active IP Right Cessation
- 1999-12-21 KR KR1020017009039A patent/KR100771184B1/ko not_active Expired - Fee Related
- 1999-12-21 DE DE69911259T patent/DE69911259T4/de not_active Expired - Lifetime
- 1999-12-21 DE DE69911259A patent/DE69911259D1/de not_active Expired - Lifetime
- 1999-12-21 UA UA2001075136A patent/UA70984C2/uk unknown
- 1999-12-21 HK HK02100064.9A patent/HK1038361B/en not_active IP Right Cessation
- 1999-12-21 ES ES99966495T patent/ES2207333T7/es active Active
- 1999-12-21 AT AT99966495T patent/ATE249465T1/de active
- 1999-12-21 ME MEP-2008-178A patent/ME00129B/fr unknown
- 1999-12-21 BR BRPI9917086A patent/BRPI9917086B8/pt not_active IP Right Cessation
- 1999-12-21 CZ CZ20012598A patent/CZ302647B6/cs not_active IP Right Cessation
- 1999-12-21 CN CNB998164887A patent/CN1174986C/zh not_active Expired - Fee Related
- 1999-12-21 AU AU22014/00A patent/AU772397B2/en not_active Ceased
2000
- 2000-01-18 AR ARP000100214A patent/AR035837A1/es active IP Right Grant
- 2000-01-19 MY MYPI20000169A patent/MY128065A/en unknown
- 2000-02-24 TW TW089100772A patent/TWI289564B/zh not_active IP Right Cessation
- 2000-12-21 RS YUP-519/01A patent/RS50820B/sr unknown
2001
- 2001-07-11 IL IL144270A patent/IL144270A/en not_active IP Right Cessation
- 2001-07-16 NO NO20013515A patent/NO327896B1/no not_active IP Right Cessation
- 2001-07-24 US US09/911,605 patent/US6713475B2/en not_active Expired - Lifetime
2004
- 2004-02-10 US US10/775,675 patent/US7317005B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CZ20012598A3 (cs)	2002-08-14
HU229074B1 (en)	2013-07-29
PL205704B1 (pl)	2010-05-31
BRPI9917086B8 (pt)	2016-05-24
WO2000043398A3 (fr)	2001-01-11
CN1174986C (zh)	2004-11-10
CA2360767C (fr)	2009-11-03
HUP0105034A2 (hu)	2002-04-29
MEP17808A (en)	2010-06-10
AR035837A1 (es)	2004-07-21
HK1038361B (en)	2004-05-07
PL349778A1 (en)	2002-09-09
ATE249465T1 (de)	2003-09-15
RS50820B (sr)	2010-08-31
BR9917086A (pt)	2001-10-30
IL144270A (en)	2010-04-29
US20020103373A1 (en)	2002-08-01
YU51901A (sh)	2004-03-12
CZ302647B6 (cs)	2011-08-17
BR9917086B1 (pt)	2013-12-03
ME00129B (fr)	2010-10-10
EP1147115B1 (fr)	2003-09-10
ES2207333T7 (es)	2009-06-18
ES2207333T3 (es)	2004-05-16
CA2360767A1 (fr)	2000-07-27
DE69911259D1 (de)	2003-10-16
AU772397B2 (en)	2004-04-29
NO20013515D0 (no)	2001-07-16
KR20010101577A (ko)	2001-11-14
DK1147115T3 (da)	2004-01-12
NZ512960A (en)	2004-01-30
DE69911259T4 (de)	2009-07-09
EP1147115B3 (fr)	2008-12-24
TWI289564B (en)	2007-11-11
IL144270A0 (en)	2002-05-23
DE69911259T2 (de)	2004-12-02
NO327896B1 (no)	2009-10-12
US6713475B2 (en)	2004-03-30
AU772397C (en)	2000-08-07
WO2000043398A2 (fr)	2000-07-27
AU2201400A (en)	2000-08-07
EP1147115A2 (fr)	2001-10-24
TR200102069T2 (tr)	2001-11-21
PT1147115E (pt)	2004-02-27
KR100771184B1 (ko)	2007-10-29
MY128065A (en)	2007-01-31
US7317005B2 (en)	2008-01-08
HUP0105034A3 (en)	2004-11-29
HK1038361A1 (en)	2002-03-15
UA70984C2 (uk)	2004-11-15
US20040242866A1 (en)	2004-12-02
CN1339038A (zh)	2002-03-06
NO20013515L (no)	2001-09-17

Publication	Publication Date	Title
DK1147115T5 (da)	2008-12-08	Tricycliske benzodiazepiner som vasopressinreceptorantagonister
DK1224175T3 (da)	2004-07-12	Benzodiazepinderivater som metabotropiske glutamatreceptorantagonister
IL164585A (en)	2010-11-30	Tricyclic thrombin receptor antagonists
CY2010003I1 (el)	2012-01-25	Αγωνιστες των βητα-2 αδρενεργικων υποδοχεων
BR9710087A (pt)	1999-08-10	Antagonistas de vasopressina de benzazepina tricíclicos
ATE280157T1 (de)	2004-11-15	4-aroyl-piperidin-ccr-3 rezeptor antagonisten iii
PL356990A1 (en)	2004-07-12	Isoxazolecarboxamide derivatives as alpha1-adrenergic receptor antagonists
DK0811008T3 (da)	2004-01-26	Bicycliske benzazepinderivater som vasopressinantagonister
NO20015779L (no)	2001-11-27	Bradykinin-reseptorantagonister
PL350234A1 (en)	2002-11-18	Heterocyclic benzenesulphonamide compounds as bradykinine antagonists
PT1171419E (pt)	2005-04-29	Derivados de bifenilo como antagonistas do receptor da neuroquinina-1
GB0026327D0 (en)	2000-12-13	Thrombin receptor antagonists
DK1131291T3 (da)	2005-02-28	4-aroyl-piperidin-CCR-3-receptorantagonister III
SE0003996D0 (sv)	2000-11-01	Receptorantagonister
SI1155013T1 (en)	2003-12-31	Heterocyclic benzenesulphonamide compounds as bradykinine antagonists