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TR200102069T2 - Vasopresin reseptörü antagonistleri olarak trisiklik benzodiazepinler. - Google Patents

Vasopresin reseptörü antagonistleri olarak trisiklik benzodiazepinler.

Info

Publication number
TR200102069T2
TR200102069T2 TR2001/02069T TR200102069T TR200102069T2 TR 200102069 T2 TR200102069 T2 TR 200102069T2 TR 2001/02069 T TR2001/02069 T TR 2001/02069T TR 200102069 T TR200102069 T TR 200102069T TR 200102069 T2 TR200102069 T2 TR 200102069T2
Authority
TR
Turkey
Prior art keywords
heart failure
tricyclic benzodiazepines
receptor antagonists
benzodiazepines
vasopressin receptor
Prior art date
Application number
TR2001/02069T
Other languages
English (en)
Inventor
J. Hoekstra William
B. Dyatkin Alexey
E. Maryanoff Bruce
M. Matthews Jay
Original Assignee
Ortho-Mcneil Pharmaceutical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical, Inc. filed Critical Ortho-Mcneil Pharmaceutical, Inc.
Publication of TR200102069T2 publication Critical patent/TR200102069T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Mevcut bulus formül (I) ve (II) trisiklik benzodiazepinlerine yöneliktir, bunlar yüksek damar direnci ve kalp yetmezligini içeren rahatsizliklarin tedavisinde vasopresin antagonistleri olarak yararlidirlar. Ayrica, mevcut bulusun trisiklik benzodiazepinlerini içeren farmasötik bilesimler ve hipertansiyon, kronik kalp yetmezligi, kalp yetmezligi, koroner vasospazm, kalp iskemisi, karaciger sirozu, böbrek vasospazmi, böbrek yetmezligi, beyin ödemi ve iskemisi, felç, tromboz veya su tutulmasi gibi rahatsizliklarin tedavi yöntemleri de tarif edilmektedir.
TR2001/02069T 1999-01-19 1999-12-21 Vasopresin reseptörü antagonistleri olarak trisiklik benzodiazepinler. TR200102069T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11635899P 1999-01-19 1999-01-19
US46865099A 1999-12-21 1999-12-21

Publications (1)

Publication Number Publication Date
TR200102069T2 true TR200102069T2 (tr) 2001-11-21

Family

ID=26814157

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02069T TR200102069T2 (tr) 1999-01-19 1999-12-21 Vasopresin reseptörü antagonistleri olarak trisiklik benzodiazepinler.

Country Status (27)

Country Link
US (2) US6713475B2 (tr)
EP (1) EP1147115B3 (tr)
KR (1) KR100771184B1 (tr)
CN (1) CN1174986C (tr)
AR (1) AR035837A1 (tr)
AT (1) ATE249465T1 (tr)
AU (1) AU772397B2 (tr)
BR (1) BRPI9917086B8 (tr)
CA (1) CA2360767C (tr)
CZ (1) CZ302647B6 (tr)
DE (2) DE69911259D1 (tr)
DK (1) DK1147115T5 (tr)
ES (1) ES2207333T7 (tr)
HK (1) HK1038361B (tr)
HU (1) HU229074B1 (tr)
IL (2) IL144270A0 (tr)
ME (1) ME00129B (tr)
MY (1) MY128065A (tr)
NO (1) NO327896B1 (tr)
NZ (1) NZ512960A (tr)
PL (1) PL205704B1 (tr)
PT (1) PT1147115E (tr)
RS (1) RS50820B (tr)
TR (1) TR200102069T2 (tr)
TW (1) TWI289564B (tr)
UA (1) UA70984C2 (tr)
WO (1) WO2000043398A2 (tr)

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JP2004530668A (ja) 2001-04-12 2004-10-07 ワイス バソプレッシンアゴニストとしてのｎ−ビフェニルカルボニル−およびｎ−フェニルピリジルカルボニル置換二および三環アゼピンおよびジアゼピン
CN1294134C (zh) 2001-04-12 2007-01-10 惠氏公司 环己基苯基血管升压素激动剂
PL370114A1 (en) 2001-10-29 2005-05-16 Ortho-Mcneil Pharmaceutical, Inc. Bridged bicycle (1,4) benzodiazepine vasopressin receptor antagonists
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AP2005003376A0 (en) * 2003-02-19 2005-09-30 Pfizer Triazole compounds useful in therapy.
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US7119088B2 (en) 2003-02-19 2006-10-10 Pfizer Inc. Triazole compounds useful in therapy
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DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
WO2008007661A1 (en) * 2006-07-11 2008-01-17 Takeda Pharmaceutical Company Limited Tricyclic heterocyclic compound and use thereof
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
ES2903231T3 (es) 2008-02-26 2022-03-31 Jenavalve Tech Inc Stent para el posicionamiento y anclaje de una prótesis valvular en un sitio de implantación en el corazón de un paciente
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CA2739900C (en) * 2008-11-18 2016-11-08 F. Hoffmann-La Roche Ag Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
NZ592076A (en) * 2008-11-28 2012-06-29 Hoffmann La Roche Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists
DE102009033392A1 (de) * 2009-07-16 2011-01-20 Merck Patent Gmbh Heterocyclische Verbindungen als Autotaxin-Inhibitoren II
EP2480538A1 (en) * 2009-09-24 2012-08-01 Shire-Movetis N.V. [1,4]-benzodiazepines as vasopressin v2 receptor antagonists
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
CA2799459A1 (en) 2010-05-25 2011-12-01 Jenavalve Technology Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US8828989B2 (en) 2011-09-26 2014-09-09 Hoffmann-La Roche Inc. Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
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Also Published As

Publication number Publication date
CZ20012598A3 (cs) 2002-08-14
BRPI9917086B8 (pt) 2016-05-24
MY128065A (en) 2007-01-31
IL144270A0 (en) 2002-05-23
AU772397B2 (en) 2004-04-29
US6713475B2 (en) 2004-03-30
KR20010101577A (ko) 2001-11-14
KR100771184B1 (ko) 2007-10-29
CN1174986C (zh) 2004-11-10
EP1147115B3 (en) 2008-12-24
DK1147115T5 (da) 2008-12-08
HUP0105034A2 (hu) 2002-04-29
EP1147115B1 (en) 2003-09-10
HK1038361B (en) 2004-05-07
DE69911259T4 (de) 2009-07-09
CA2360767A1 (en) 2000-07-27
NO20013515D0 (no) 2001-07-16
CA2360767C (en) 2009-11-03
US7317005B2 (en) 2008-01-08
TWI289564B (en) 2007-11-11
NO20013515L (no) 2001-09-17
CN1339038A (zh) 2002-03-06
HU229074B1 (en) 2013-07-29
ES2207333T3 (es) 2004-05-16
AU772397C (en) 2000-08-07
RS50820B (sr) 2010-08-31
NO327896B1 (no) 2009-10-12
US20020103373A1 (en) 2002-08-01
HUP0105034A3 (en) 2004-11-29
UA70984C2 (uk) 2004-11-15
US20040242866A1 (en) 2004-12-02
MEP17808A (en) 2010-06-10
AR035837A1 (es) 2004-07-21
BR9917086A (pt) 2001-10-30
ME00129B (me) 2010-10-10
BR9917086B1 (pt) 2013-12-03
WO2000043398A2 (en) 2000-07-27
ATE249465T1 (de) 2003-09-15
DE69911259T2 (de) 2004-12-02
NZ512960A (en) 2004-01-30
PL349778A1 (en) 2002-09-09
PL205704B1 (pl) 2010-05-31
CZ302647B6 (cs) 2011-08-17
WO2000043398A3 (en) 2001-01-11
DK1147115T3 (da) 2004-01-12
AU2201400A (en) 2000-08-07
ES2207333T7 (es) 2009-06-18
IL144270A (en) 2010-04-29
EP1147115A2 (en) 2001-10-24
PT1147115E (pt) 2004-02-27
HK1038361A1 (en) 2002-03-15
YU51901A (sh) 2004-03-12
DE69911259D1 (de) 2003-10-16

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