DK1071422T3 - Kombinationer af riluzol og levodopa til behandling af parkinsons sygdom - Google Patents
Kombinationer af riluzol og levodopa til behandling af parkinsons sygdomInfo
- Publication number
- DK1071422T3 DK1071422T3 DK99915809T DK99915809T DK1071422T3 DK 1071422 T3 DK1071422 T3 DK 1071422T3 DK 99915809 T DK99915809 T DK 99915809T DK 99915809 T DK99915809 T DK 99915809T DK 1071422 T3 DK1071422 T3 DK 1071422T3
- Authority
- DK
- Denmark
- Prior art keywords
- riluzole
- levodopa
- disease
- parkinson
- combinations
- Prior art date
Links
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title abstract 2
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title abstract 2
- 208000018737 Parkinson disease Diseases 0.000 title abstract 2
- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004502 levodopa Drugs 0.000 title abstract 2
- 229960004181 riluzole Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9805153A FR2777781B1 (fr) | 1998-04-24 | 1998-04-24 | Associations riluzole et l-dopa pour le traitement de la maladie de parkinson |
| PCT/FR1999/000953 WO1999055336A1 (fr) | 1998-04-24 | 1999-04-22 | Associations de riluzole et de levodopa pour le traitement de la maladie de parkinson |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1071422T3 true DK1071422T3 (da) | 2008-06-16 |
Family
ID=9525640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99915809T DK1071422T3 (da) | 1998-04-24 | 1999-04-22 | Kombinationer af riluzol og levodopa til behandling af parkinsons sygdom |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6387936B1 (el) |
| EP (1) | EP1071422B1 (el) |
| JP (1) | JP2002512963A (el) |
| KR (1) | KR100597170B1 (el) |
| AT (1) | ATE386520T1 (el) |
| AU (1) | AU768069B2 (el) |
| CA (1) | CA2329636C (el) |
| CY (1) | CY1110448T1 (el) |
| CZ (1) | CZ300825B6 (el) |
| DE (1) | DE69938179T2 (el) |
| DK (1) | DK1071422T3 (el) |
| ES (1) | ES2300141T3 (el) |
| FR (1) | FR2777781B1 (el) |
| HU (1) | HU228902B1 (el) |
| IL (1) | IL139164A (el) |
| NO (1) | NO329032B1 (el) |
| PT (1) | PT1071422E (el) |
| RU (1) | RU2225204C2 (el) |
| SK (1) | SK285531B6 (el) |
| UA (1) | UA70319C2 (el) |
| WO (1) | WO1999055336A1 (el) |
| ZA (1) | ZA200005758B (el) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2786101B1 (fr) * | 1998-11-24 | 2002-07-05 | Aventis Laboratoire | Utilisation de la nicergoline dans le traitement de la spasticite |
| DE60041365D1 (de) * | 1999-06-04 | 2009-02-26 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Verwendung von Riluzol zur Behandlung Multipler Sklerose |
| GB0007193D0 (en) * | 2000-03-25 | 2000-05-17 | Univ Manchester | Treatment of movrmrnt disorders |
| US8158149B2 (en) * | 2004-05-12 | 2012-04-17 | Chelsea Therapeutics, Inc. | Threo-DOPS controlled release formulation |
| WO2004100929A1 (en) | 2003-05-12 | 2004-11-25 | Synergia Pharma, Inc. | Threo-dops controlled release formulation |
| WO2005025561A1 (en) * | 2003-09-04 | 2005-03-24 | Synergia Pharma, Inc. | Compositions and methods for orthostatic intolerance |
| WO2005112906A2 (en) * | 2004-05-21 | 2005-12-01 | Duke University | Method for augmenting the effects of serotonin reuptake inhibitors |
| SE0401842D0 (sv) * | 2004-07-12 | 2004-07-12 | Dizlin Medical Design Ab | Infusion and injection solution of levodopa |
| JP5112876B2 (ja) * | 2004-11-07 | 2013-01-09 | エフ. ギルフォード ティモシー | 還元型グルタチオン経口投与のためのリポソーム処方物 |
| GB0504103D0 (en) * | 2005-02-28 | 2005-04-06 | Syngenta Ltd | Novel method |
| US20070148238A1 (en) * | 2005-06-23 | 2007-06-28 | Spherics, Inc. | Dosage forms for movement disorder treatment |
| US20080131492A1 (en) * | 2006-06-23 | 2008-06-05 | Spherics, Inc. | Dosage forms for movement disorder treatment |
| HRP20120479T1 (hr) * | 2006-06-28 | 2012-07-31 | Chelsea@Therapeutics@Inc | Farmaceutski sastavi sa droksidopom |
| WO2008079404A2 (en) * | 2006-12-22 | 2008-07-03 | Combinatorx, Incorporated | Pharmaceutical compositions for treatment of parkinson's disease and related disorders |
| NZ579368A (en) * | 2007-03-09 | 2012-03-30 | Chelsea Therapeutics Inc | Droxidopa and pharmaceutical composition thereof for the treatment of fibromyalgia |
| EP2514417A3 (en) * | 2007-05-07 | 2013-01-30 | Chelsea Therapeutics, Inc. | Droxidopa and pharmaceutical composition thereof for the treatment of mood disorders, sleep disorders, or attention deficit disorders |
| US8703809B2 (en) * | 2008-06-30 | 2014-04-22 | Novartis Ag | Combination products |
| MX2011004769A (es) * | 2008-11-06 | 2011-11-29 | Biotie Therapies Inc | Tratamiento de sindrome de pierna sin reposo y alteraciones del sueño. |
| EP2228054A1 (en) * | 2009-03-13 | 2010-09-15 | ITALFARMACO S.p.A. | Riluzole aqueous suspensions |
| WO2012054815A1 (en) | 2010-10-22 | 2012-04-26 | Duke University | Slow-release formulations of 5-hydroxytryptophan as an adjunct to pro-serotonergic therapies |
| JP5880913B2 (ja) | 2011-05-17 | 2016-03-09 | 三郎 佐古田 | パーキンソン病の体幹症状(姿勢反射異常)の治療剤 |
| WO2014172372A1 (en) | 2013-04-15 | 2014-10-23 | Northwestern University | Treatment for dopaminergic disorders |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2700117B1 (fr) * | 1993-01-07 | 1995-02-03 | Rhone Poulenc Rorer Sa | Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens. |
| RU2057529C1 (ru) * | 1994-05-30 | 1996-04-10 | Алексей Михайлович Коршунов | Способ лечения синдрома паркинсонизма |
-
1998
- 1998-04-24 FR FR9805153A patent/FR2777781B1/fr not_active Expired - Fee Related
-
1999
- 1999-04-22 DK DK99915809T patent/DK1071422T3/da active
- 1999-04-22 DE DE69938179T patent/DE69938179T2/de not_active Expired - Lifetime
- 1999-04-22 RU RU2000129121/15A patent/RU2225204C2/ru not_active IP Right Cessation
- 1999-04-22 CZ CZ20003908A patent/CZ300825B6/cs not_active IP Right Cessation
- 1999-04-22 ES ES99915809T patent/ES2300141T3/es not_active Expired - Lifetime
- 1999-04-22 UA UA2000105983A patent/UA70319C2/uk unknown
- 1999-04-22 KR KR1020007011786A patent/KR100597170B1/ko not_active Expired - Fee Related
- 1999-04-22 WO PCT/FR1999/000953 patent/WO1999055336A1/fr not_active Ceased
- 1999-04-22 HU HU0101645A patent/HU228902B1/hu not_active IP Right Cessation
- 1999-04-22 JP JP2000545534A patent/JP2002512963A/ja not_active Withdrawn
- 1999-04-22 EP EP99915809A patent/EP1071422B1/fr not_active Expired - Lifetime
- 1999-04-22 CA CA002329636A patent/CA2329636C/fr not_active Expired - Fee Related
- 1999-04-22 IL IL13916499A patent/IL139164A/xx not_active IP Right Cessation
- 1999-04-22 AU AU34255/99A patent/AU768069B2/en not_active Ceased
- 1999-04-22 SK SK1588-2000A patent/SK285531B6/sk not_active IP Right Cessation
- 1999-04-22 AT AT99915809T patent/ATE386520T1/de active
- 1999-04-22 PT PT99915809T patent/PT1071422E/pt unknown
-
2000
- 2000-10-17 ZA ZA200005758A patent/ZA200005758B/en unknown
- 2000-10-20 NO NO20005290A patent/NO329032B1/no not_active IP Right Cessation
- 2000-10-24 US US09/694,860 patent/US6387936B1/en not_active Expired - Lifetime
-
2008
- 2008-04-24 CY CY20081100457T patent/CY1110448T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL139164A0 (en) | 2001-11-25 |
| AU3425599A (en) | 1999-11-16 |
| ATE386520T1 (de) | 2008-03-15 |
| WO1999055336A1 (fr) | 1999-11-04 |
| CZ300825B6 (cs) | 2009-08-19 |
| RU2225204C2 (ru) | 2004-03-10 |
| CY1110448T1 (el) | 2015-04-29 |
| SK15882000A3 (sk) | 2001-04-09 |
| NO329032B1 (no) | 2010-08-02 |
| IL139164A (en) | 2005-12-18 |
| CA2329636A1 (fr) | 1999-11-04 |
| DE69938179D1 (de) | 2008-04-03 |
| US6387936B1 (en) | 2002-05-14 |
| ES2300141T3 (es) | 2008-06-01 |
| CZ20003908A3 (cs) | 2001-02-14 |
| UA70319C2 (en) | 2004-10-15 |
| FR2777781B1 (fr) | 2004-04-09 |
| FR2777781A1 (fr) | 1999-10-29 |
| SK285531B6 (sk) | 2007-03-01 |
| JP2002512963A (ja) | 2002-05-08 |
| PT1071422E (pt) | 2008-05-05 |
| CA2329636C (fr) | 2009-09-08 |
| KR20010042960A (ko) | 2001-05-25 |
| AU768069B2 (en) | 2003-12-04 |
| EP1071422B1 (fr) | 2008-02-20 |
| NO20005290D0 (no) | 2000-10-20 |
| HU228902B1 (en) | 2013-06-28 |
| DE69938179T2 (de) | 2009-02-12 |
| KR100597170B1 (ko) | 2006-07-05 |
| NO20005290L (no) | 2000-10-20 |
| EP1071422A1 (fr) | 2001-01-31 |
| ZA200005758B (en) | 2002-01-17 |
| HUP0101645A3 (en) | 2002-10-28 |
| HUP0101645A2 (hu) | 2001-09-28 |
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