DK0968194T3 - Atropisomerer af 3-aryl-4(3H)-quinazolinoner og deres anvendelse som AMPA-receptor-antagonister - Google Patents
Atropisomerer af 3-aryl-4(3H)-quinazolinoner og deres anvendelse som AMPA-receptor-antagonisterInfo
- Publication number
- DK0968194T3 DK0968194T3 DK98900978T DK98900978T DK0968194T3 DK 0968194 T3 DK0968194 T3 DK 0968194T3 DK 98900978 T DK98900978 T DK 98900978T DK 98900978 T DK98900978 T DK 98900978T DK 0968194 T3 DK0968194 T3 DK 0968194T3
- Authority
- DK
- Denmark
- Prior art keywords
- quinazolinones
- atropisomers
- aryl
- receptor antagonists
- ampa receptor
- Prior art date
Links
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 title 1
- 229940098747 AMPA receptor antagonist Drugs 0.000 title 1
- 239000000775 AMPA receptor antagonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Adhesives Or Adhesive Processes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3890597P | 1997-02-28 | 1997-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0968194T3 true DK0968194T3 (da) | 2004-08-16 |
Family
ID=21902563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98900978T DK0968194T3 (da) | 1997-02-28 | 1998-02-06 | Atropisomerer af 3-aryl-4(3H)-quinazolinoner og deres anvendelse som AMPA-receptor-antagonister |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US6306864B1 (da) |
| EP (1) | EP0968194B1 (da) |
| JP (1) | JP2000509731A (da) |
| KR (1) | KR100358636B1 (da) |
| CN (1) | CN1248248A (da) |
| AP (1) | AP859A (da) |
| AR (1) | AR011170A1 (da) |
| AT (1) | ATE267817T1 (da) |
| AU (1) | AU744028B2 (da) |
| BG (1) | BG103689A (da) |
| BR (1) | BR9807872A (da) |
| CA (1) | CA2282277C (da) |
| DE (1) | DE69824157T2 (da) |
| DK (1) | DK0968194T3 (da) |
| DZ (1) | DZ2440A1 (da) |
| EA (1) | EA001963B1 (da) |
| ES (1) | ES2219866T3 (da) |
| GT (1) | GT199800038A (da) |
| HR (1) | HRP980106A2 (da) |
| HU (1) | HUP0000914A3 (da) |
| ID (1) | ID22711A (da) |
| IL (1) | IL130900A0 (da) |
| IS (1) | IS1952B (da) |
| MA (1) | MA24484A1 (da) |
| NO (1) | NO313630B1 (da) |
| NZ (1) | NZ336628A (da) |
| OA (1) | OA11089A (da) |
| PA (1) | PA8447001A1 (da) |
| PE (1) | PE58399A1 (da) |
| PL (1) | PL335418A1 (da) |
| PT (1) | PT968194E (da) |
| SK (1) | SK113299A3 (da) |
| TN (1) | TNSN98035A1 (da) |
| TR (1) | TR199902093T2 (da) |
| TW (1) | TW504508B (da) |
| UA (1) | UA61097C2 (da) |
| UY (1) | UY24897A1 (da) |
| WO (1) | WO1998038173A1 (da) |
| YU (1) | YU41299A (da) |
| ZA (1) | ZA981666B (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1103772C (zh) | 1996-05-15 | 2003-03-26 | 辉瑞大药厂 | 新的2,3－二取代－4(3h)－喹唑啉酮类化合物 |
| US6323208B1 (en) * | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
| JPH11279158A (ja) * | 1998-02-09 | 1999-10-12 | Pfizer Prod Inc | キナゾリン―４―オン誘導体の製造方法 |
| CA2406278C (en) * | 2000-04-25 | 2012-06-05 | Icos Corporation | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| AU2001262723C1 (en) | 2000-06-12 | 2006-05-11 | Eisai R&D Management Co., Ltd. | 1,2-dihydropyridine compounds, process for preparation of the same and use thereof |
| WO2002016329A1 (fr) | 2000-08-18 | 2002-02-28 | Ajinomoto Co., Inc. | Nouveaux derives de phenylalanine |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| US6939968B2 (en) * | 2002-12-23 | 2005-09-06 | Bristol-Myers Squibb Company | Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives |
| US20080146562A1 (en) * | 2003-08-08 | 2008-06-19 | Ulysses Pharmaceutical Products Inc., | Halogenated quinazolinyl nitrofurans as antibacterial agents |
| WO2005014585A1 (en) * | 2003-08-08 | 2005-02-17 | Ulysses Pharmaceutical Products Inc. | Halogenated quinazolinyl nitrofurans as antibacterial agents |
| GB0325390D0 (en) * | 2003-10-30 | 2003-12-03 | Novartis Ag | Organic compounds |
| CN103784458B (zh) | 2003-12-22 | 2015-10-14 | 味之素株式会社 | 苯基丙氨酸衍生物 |
| LT1761540T (lt) | 2004-05-13 | 2017-02-27 | Icos Corporation | Chinazolinonai kaip žmogaus fosfatidilinozitol-3-kinazės-delta inhibitoriai |
| MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| GB0416730D0 (en) * | 2004-07-27 | 2004-09-01 | Novartis Ag | Organic compounds |
| JP2009514954A (ja) | 2005-11-04 | 2009-04-09 | ハイドラ バイオサイエンシズ インコーポレイテッド | Ｔｒｐｖ３機能を変調するための化合物 |
| WO2008041118A2 (en) | 2006-10-04 | 2008-04-10 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists |
| WO2008140750A1 (en) | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Compounds for modulating trpv3 function |
| CN101429166B (zh) * | 2007-11-07 | 2013-08-21 | 上海特化医药科技有限公司 | 喹唑啉酮衍生物及其制备方法和用途 |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| EP3427739A1 (en) | 2008-11-13 | 2019-01-16 | Gilead Calistoga LLC | Therapies for hematologic malignancies |
| NZ595307A (en) | 2009-03-24 | 2013-11-29 | Gilead Calistoga Llc | Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| EA201270184A1 (ru) | 2009-07-21 | 2012-08-30 | ГИЛИЭД КАЛИСТОГА ЭлЭлСи | Лечение расстройств печени ингибиторами pi3k |
| ES2848273T3 (es) | 2012-03-05 | 2021-08-06 | Gilead Calistoga Llc | Formas polimórficas de (S)-2-(1-(9H-purin-6-ilamino)propilo)-5-fluoro-3-fenilquinazolina-4(3H)-ona |
| CN103275086B (zh) * | 2013-05-30 | 2015-04-15 | 温州大学 | 一种6-取代喹唑啉并喹唑啉酮化合物及其合成方法和用途 |
| ES2752552T3 (es) | 2013-12-20 | 2020-04-06 | Gilead Calistoga Llc | Métodos de proceso para inhibidores de fosfatidilinositol 3-quinasa |
| EP3083623A1 (en) | 2013-12-20 | 2016-10-26 | Gilead Calistoga LLC | Polymorphic forms of a hydrochloride salt of (s) -2-(9h-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3h) -one |
| US9533909B2 (en) | 2014-03-31 | 2017-01-03 | Corning Incorporated | Methods and apparatus for material processing using atmospheric thermal plasma reactor |
| NZ726360A (en) | 2014-06-13 | 2018-04-27 | Gilead Sciences Inc | Phosphatidylinositol 3-kinase inhibitors |
| DE102014217021A1 (de) * | 2014-08-27 | 2016-03-03 | Skf Lubrication Systems Germany Ag | Gehäuse für eine Vorrichtung zum dosierten Verteilen eines Mediums sowie eine Dosiereinrichtung zur Verwendung in dem Gehäuse |
| BR112021010953A2 (pt) | 2018-12-14 | 2021-08-24 | Eisai R&D Management Co., Ltd. | Formulações farmacêuticas de base aquosa de compostos de 1,2-di-hidropiridina |
| IL295088A (en) | 2020-01-29 | 2022-09-01 | Kamari Pharma Ltd | Compounds and compositions for use in treating skin disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1195321B (de) * | 1962-03-16 | 1965-06-24 | Troponwerke Dinklage & Co | Verfahren zur Herstellung von substituierten Chinazolon-(4)-derivaten |
| DE1670416A1 (de) * | 1966-12-30 | 1971-02-11 | Chem Fab Von Heyden Gmbh Muenc | Verfahren zur Herstellung von aminosubstituierten Chinazolinonderivaten |
| US3748325A (en) * | 1970-04-06 | 1973-07-24 | Karamchand Premchand Private | Process for the preparation of quinazolinone derivatives |
| US4183931A (en) * | 1977-09-08 | 1980-01-15 | Research Corporation | 2-Ketoalkyl-4(3H)-quinazolinones |
| GB9022785D0 (en) * | 1990-10-19 | 1990-12-05 | Merck Sharp & Dohme | Therapeutic agents |
| WO1992013535A1 (en) * | 1991-02-06 | 1992-08-20 | Research Corporation Technologies, Inc. | Anticonvulsant substituted quinazolones |
| US5777271A (en) * | 1996-01-18 | 1998-07-07 | Commscope, Inc. | Cable having an at least partially oxidized armor layer |
| CN1103772C (zh) * | 1996-05-15 | 2003-03-26 | 辉瑞大药厂 | 新的2,3－二取代－4(3h)－喹唑啉酮类化合物 |
-
1998
- 1998-02-06 SK SK1132-99A patent/SK113299A3/sk unknown
- 1998-02-06 ID IDW990937A patent/ID22711A/id unknown
- 1998-02-06 PL PL98335418A patent/PL335418A1/xx unknown
- 1998-02-06 BR BR9807872A patent/BR9807872A/pt not_active Application Discontinuation
- 1998-02-06 HU HU0000914A patent/HUP0000914A3/hu unknown
- 1998-02-06 IL IL13090098A patent/IL130900A0/xx unknown
- 1998-02-06 TR TR1999/02093T patent/TR199902093T2/xx unknown
- 1998-02-06 CN CN98802638A patent/CN1248248A/zh active Pending
- 1998-02-06 AT AT98900978T patent/ATE267817T1/de not_active IP Right Cessation
- 1998-02-06 EA EA199900693A patent/EA001963B1/ru not_active IP Right Cessation
- 1998-02-06 AU AU56768/98A patent/AU744028B2/en not_active Ceased
- 1998-02-06 US US09/367,960 patent/US6306864B1/en not_active Expired - Fee Related
- 1998-02-06 KR KR1019997007887A patent/KR100358636B1/ko not_active Expired - Fee Related
- 1998-02-06 EP EP98900978A patent/EP0968194B1/en not_active Expired - Lifetime
- 1998-02-06 WO PCT/IB1998/000150 patent/WO1998038173A1/en not_active Application Discontinuation
- 1998-02-06 DK DK98900978T patent/DK0968194T3/da active
- 1998-02-06 YU YU41299A patent/YU41299A/sh unknown
- 1998-02-06 CA CA002282277A patent/CA2282277C/en not_active Expired - Fee Related
- 1998-02-06 NZ NZ336628A patent/NZ336628A/xx unknown
- 1998-02-06 DE DE69824157T patent/DE69824157T2/de not_active Expired - Fee Related
- 1998-02-06 ES ES98900978T patent/ES2219866T3/es not_active Expired - Lifetime
- 1998-02-06 PT PT98900978T patent/PT968194E/pt unknown
- 1998-02-06 JP JP10537448A patent/JP2000509731A/ja active Pending
- 1998-02-17 PA PA19988447001A patent/PA8447001A1/es unknown
- 1998-02-19 GT GT199800038A patent/GT199800038A/es unknown
- 1998-02-20 UY UY24897A patent/UY24897A1/es not_active Application Discontinuation
- 1998-02-23 PE PE1998000126A patent/PE58399A1/es not_active Application Discontinuation
- 1998-02-25 TN TNTNSN98035A patent/TNSN98035A1/fr unknown
- 1998-02-25 MA MA24978A patent/MA24484A1/fr unknown
- 1998-02-25 TW TW087102714A patent/TW504508B/zh not_active IP Right Cessation
- 1998-02-25 DZ DZ980050A patent/DZ2440A1/xx active
- 1998-02-26 AR ARP980100871A patent/AR011170A1/es not_active Application Discontinuation
- 1998-02-26 AP APAP/P/1998/001199A patent/AP859A/en active
- 1998-02-27 ZA ZA9801666A patent/ZA981666B/xx unknown
- 1998-02-27 HR HR60/038,905A patent/HRP980106A2/hr not_active Application Discontinuation
- 1998-06-02 UA UA99084849A patent/UA61097C2/uk unknown
-
1999
- 1999-07-30 IS IS5140A patent/IS1952B/is unknown
- 1999-08-20 OA OA9900187A patent/OA11089A/en unknown
- 1999-08-24 BG BG103689A patent/BG103689A/bg unknown
- 1999-08-27 NO NO19994177A patent/NO313630B1/no not_active IP Right Cessation
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