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DE69823694D1 - Thrombin-rezeptor antagonisten - Google Patents

Thrombin-rezeptor antagonisten

Info

Publication number
DE69823694D1
DE69823694D1 DE69823694T DE69823694T DE69823694D1 DE 69823694 D1 DE69823694 D1 DE 69823694D1 DE 69823694 T DE69823694 T DE 69823694T DE 69823694 T DE69823694 T DE 69823694T DE 69823694 D1 DE69823694 D1 DE 69823694D1
Authority
DE
Germany
Prior art keywords
receptor antagonists
thrombin receptor
thrombin
antagonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69823694T
Other languages
English (en)
Other versions
DE69823694T2 (de
Inventor
Samuel Chackalamannil
Theodros Asberom
Yan Xia
Dario Doller
C Clasby
F Czarniecki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69823694D1 publication Critical patent/DE69823694D1/de
Application granted granted Critical
Publication of DE69823694T2 publication Critical patent/DE69823694T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
DE69823694T 1997-11-25 1998-11-23 Thrombin-rezeptor antagonisten Expired - Lifetime DE69823694T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97797997A 1997-11-25 1997-11-25
PCT/US1998/024523 WO1999026943A1 (en) 1997-11-25 1998-11-23 Thrombin receptor antagonists

Publications (2)

Publication Number Publication Date
DE69823694D1 true DE69823694D1 (de) 2004-06-09
DE69823694T2 DE69823694T2 (de) 2005-04-21

Family

ID=25525702

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69823694T Expired - Lifetime DE69823694T2 (de) 1997-11-25 1998-11-23 Thrombin-rezeptor antagonisten

Country Status (30)

Country Link
EP (1) EP1036072B1 (de)
JP (2) JP3449620B2 (de)
KR (1) KR100393492B1 (de)
CN (2) CN101274929A (de)
AR (1) AR017189A1 (de)
AT (1) ATE266025T1 (de)
AU (1) AU747204B2 (de)
BR (1) BR9812793A (de)
CA (1) CA2309352C (de)
CO (1) CO4990946A1 (de)
CZ (1) CZ298578B6 (de)
DE (1) DE69823694T2 (de)
DK (1) DK1036072T3 (de)
ES (1) ES2219919T3 (de)
HU (1) HUP0100607A3 (de)
ID (1) ID24726A (de)
IL (1) IL135797A (de)
MY (1) MY140887A (de)
NO (1) NO322022B1 (de)
NZ (1) NZ504218A (de)
PE (1) PE133799A1 (de)
PL (1) PL195027B1 (de)
PT (1) PT1036072E (de)
RU (1) RU2204557C2 (de)
SA (1) SA99190972B1 (de)
SK (1) SK285153B6 (de)
TR (1) TR200001480T2 (de)
TW (1) TWI236476B (de)
WO (1) WO1999026943A1 (de)
ZA (1) ZA9810685B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000229961A (ja) * 1998-12-11 2000-08-22 Sagami Chem Res Center ヒドロナフト［２，３−ｃ］フラン誘導体およびその製造方法
JP4577751B2 (ja) * 1999-09-02 2010-11-10 塩野義製薬株式会社 芳香族ヘテロ環誘導体を含有するインテグラーゼ阻害剤
US7235567B2 (en) * 2000-06-15 2007-06-26 Schering Corporation Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist
TWI302913B (en) * 2000-06-15 2008-11-11 Schering Corp Thrombin receptor antagonists
US7488742B2 (en) * 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
EP1764366A3 (de) * 2000-06-15 2007-10-03 Schering Corporation Thrombinrezeptorantagonisten
JP3795458B2 (ja) 2001-04-19 2006-07-12 エーザイ株式会社 ２−イミノピロリジン誘導体
JP4307260B2 (ja) * 2001-10-18 2009-08-05 シェーリング コーポレイション トロンビンレセプタアンタゴニストとしてのヒンバシン類似物
PT1495018E (pt) 2002-04-16 2008-02-19 Schering Corp Antagonistas tricíclicos de receptores de trombina
ES2211315B1 (es) * 2002-11-12 2005-10-16 Almirall Prodesfarma, S.A. Nuevos compuestos triciclicos.
KR20050104376A (ko) 2003-02-19 2005-11-02 에자이 가부시키가이샤 고리형상 벤즈아미딘 유도체의 제조방법
JPWO2005108370A1 (ja) 2004-04-16 2008-03-21 味の素株式会社 ベンゼン化合物
EP1751144B1 (de) * 2004-05-28 2008-08-27 Schering Corporation Gehinderte himbacinanaloga als thrombinrezeptorantagonisten
EP2075250B1 (de) * 2004-10-08 2015-03-04 Merck Sharp & Dohme Corp. Thrombinrezeptorantagonisten
PT1853592E (pt) * 2005-01-14 2011-05-10 Schering Corp S?ntese de an?logos da himbacina
EP2399912B1 (de) * 2005-01-14 2015-02-25 Merck Sharp & Dohme Corp. Exo-selektive Synthese von Himbacin-Analoga
AR056919A1 (es) * 2005-01-14 2007-11-07 Schering Corp SíNTESIS EXO- Y DIASTEREO- SELECTIVAS DE ANÁLOGOS DE HIMBACINA
TWI367112B (en) * 2006-06-30 2012-07-01 Schering Corp Immediate-release tablet formulations of a thrombin receptor antagonist
WO2008042422A2 (en) * 2006-10-04 2008-04-10 Schering Corporation Bicyclic and tricyclic derivatives as thrombin receptor antagonists
PL2558462T3 (pl) 2010-04-16 2015-03-31 Sanofi Sa Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1
WO2011128421A1 (de) 2010-04-16 2011-10-20 Sanofi Trizyklische pyridyl-vinyl-pyrrole als par1-inhibitoren
CN108658910B (zh) * 2017-03-29 2020-11-03 北京新领先医药科技发展有限公司 一种沃拉帕沙中间体1-α的制备方法
CN113387947B (zh) * 2021-07-12 2022-07-01 中国科学院成都生物研究所 调节雌激素受体合成活性的吡唑并吡啶衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773792A (en) 1968-03-08 1973-11-20 Itt Rayonier Inc Acetates of plicatic acid and processes for the preparation thereof
US4486445A (en) 1983-01-12 1984-12-04 E. I. Du Pont De Nemours And Company Justicidin insecticidal and antiviral compounds
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
IL106197A (en) * 1992-07-30 1999-11-30 Cor Therapeutics Inc Agagonists for the rhombin receptors and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
BR9812793A (pt) 2000-10-17
NO20002659D0 (no) 2000-05-24
ATE266025T1 (de) 2004-05-15
KR20010032439A (ko) 2001-04-25
AR017189A1 (es) 2001-08-22
IL135797A (en) 2003-09-17
SK285153B6 (sk) 2006-07-07
KR100393492B1 (ko) 2003-08-02
TWI236476B (en) 2005-07-21
EP1036072A1 (de) 2000-09-20
ZA9810685B (en) 1999-12-23
CA2309352C (en) 2005-01-25
CO4990946A1 (es) 2000-12-26
MY140887A (en) 2010-01-29
NO20002659L (no) 2000-07-24
ES2219919T3 (es) 2004-12-01
PL341114A1 (en) 2001-03-26
PT1036072E (pt) 2004-08-31
NZ504218A (en) 2002-04-26
SK7592000A3 (en) 2001-02-12
EP1036072B1 (de) 2004-05-06
JP3449620B2 (ja) 2003-09-22
DK1036072T3 (da) 2004-09-06
AU747204B2 (en) 2002-05-09
WO1999026943A1 (en) 1999-06-03
PE133799A1 (es) 2000-01-10
SA99190972B1 (ar) 2006-07-30
HUP0100607A3 (en) 2002-06-28
DE69823694T2 (de) 2005-04-21
PL195027B1 (pl) 2007-08-31
AU1415899A (en) 1999-06-15
CN101274929A (zh) 2008-10-01
ID24726A (id) 2000-08-03
CN1290265A (zh) 2001-04-04
IL135797A0 (en) 2001-05-20
CZ298578B6 (cs) 2007-11-14
JP2003128670A (ja) 2003-05-08
CA2309352A1 (en) 1999-06-03
NO322022B1 (no) 2006-08-07
TR200001480T2 (tr) 2000-09-21
HUP0100607A2 (hu) 2002-05-29
CZ20001856A3 (cs) 2000-10-11
RU2204557C2 (ru) 2003-05-20
HK1031726A1 (en) 2001-06-22
JP2001524479A (ja) 2001-12-04

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