DK0809499T3 - Visse 1,4,5-trisubstituerede imidazolforbindelser, der er egnede som cytokin - Google Patents

Visse 1,4,5-trisubstituerede imidazolforbindelser, der er egnede som cytokin

Info

Publication number: DK0809499T3
Authority: DK; Denmark
Prior art keywords: cytokine; certain; compounds suitable; imidazole compounds; trisubstituted imidazole
Prior art date: 1995-01-09

Application number

DK96902151T

Other languages

Danish (da)

English (en)

Inventor

Jerry Leroy Adams

Ravi Shanker Garigipati

John Cheung-Lun Lee

Timothy F Gallagher

Jeffrey Charles Boehm

Joseph Sisko

Zhi-Qiang Peng

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-09

Filing date

1996-01-11

Publication date

2004-03-29

1996-01-11 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

2004-03-29 Application granted granted Critical

2004-03-29 Publication of DK0809499T3 publication Critical patent/DK0809499T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Virology (AREA)
Pulmonology (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Neurology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Psychiatry (AREA)

DK96902151T 1995-01-09 1996-01-11 Visse 1,4,5-trisubstituerede imidazolforbindelser, der er egnede som cytokin DK0809499T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US36996495A	1995-01-09	1995-01-09
US08/472,366 US5593992A (en)	1993-07-16	1995-06-07	Compounds

Publications (1)

Publication Number	Publication Date
DK0809499T3 true DK0809499T3 (da)	2004-03-29

Family

ID=27004764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK96902151T DK0809499T3 (da)	1995-01-09	1996-01-11	Visse 1,4,5-trisubstituerede imidazolforbindelser, der er egnede som cytokin

Country Status (33)

Country	Link
US (5)	US5593992A (fr)
EP (2)	EP1264827A1 (fr)
JP (2)	JP3330952B2 (fr)
CN (1)	CN1138546C (fr)
AP (1)	AP1270A (fr)
AR (1)	AR002267A1 (fr)
AT (1)	ATE254613T1 (fr)
AU (1)	AU705207C (fr)
BG (1)	BG63769B1 (fr)
BR (1)	BR9606904A (fr)
CA (1)	CA2209938A1 (fr)
CZ (1)	CZ215897A3 (fr)
DE (1)	DE69630777T2 (fr)
DK (1)	DK0809499T3 (fr)
DZ (1)	DZ1961A1 (fr)
ES (1)	ES2210348T3 (fr)
FI (1)	FI972901L (fr)
HU (1)	HUP9702409A3 (fr)
ID (3)	ID23273A (fr)
IL (7)	IL134322A (fr)
IN (3)	IN184957B (fr)
MA (1)	MA23770A1 (fr)
MX (1)	MX9705142A (fr)
NO (3)	NO973167L (fr)
NZ (1)	NZ301204A (fr)
OA (1)	OA10738A (fr)
PL (1)	PL322249A1 (fr)
PT (1)	PT809499E (fr)
RU (2)	RU2196139C2 (fr)
SI (1)	SI0809499T1 (fr)
SK (1)	SK90297A3 (fr)
TW (1)	TW523511B (fr)
WO (1)	WO1996021452A1 (fr)

Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5916891A (en)	1992-01-13	1999-06-29	Smithkline Beecham Corporation	Pyrimidinyl imidazoles
EP0724588B1 (fr) *	1993-09-17	1999-11-10	Smithkline Beecham Corporation	Proteine fixatrice de medicaments
US6203803B1 (en)	1994-12-14	2001-03-20	Societe L'oreal S.A.	Use of a substance P antagonist in a cosmetic composition, and the composition thus obtained
EP0802908A4 (fr) *	1995-01-12	2001-04-11	Smithkline Beecham Corp	Nouveaux composes
EP0737471A3 (fr) *	1995-04-10	2000-12-06	L'oreal	Utilisation d'un sel d'une métal alcalino-terreux comme inhibiteur de TNF-alpha dans une composition unique et composition obtenue
US6369068B1 (en)	1995-06-07	2002-04-09	Smithkline Beecham Corporation	Amino substituted pyrimidine containing compounds
US5739143A (en) *	1995-06-07	1998-04-14	Smithkline Beecham Corporation	Imidazole compounds and compositions
US5658903A (en) *	1995-06-07	1997-08-19	Smithkline Beecham Corporation	Imidazole compounds, compositions and use
FR2740341B1 (fr) *	1995-10-26	1997-12-19	Oreal	Utilisation de sel de lanthanide, d'etain, de zinc, de manganese, d'yttrium, de cobalt, de baryum, de strontium dans une composition pour la peau
ZA9610687B (en) *	1995-12-22	1997-09-29	Smithkline Beecham Corp	Novel synthesis.
US6046208A (en) *	1996-01-11	2000-04-04	Smithkline Beecham Corporation	Substituted imidazole compounds
US5977103A (en) *	1996-01-11	1999-11-02	Smithkline Beecham Corporation	Substituted imidazole compounds
ZA97175B (en)	1996-01-11	1997-11-04	Smithkline Beecham Corp	Novel substituted imidazole compounds.
AP9700912A0 (en) *	1996-01-11	1997-01-31	Smithkline Beecham Corp	Novel cycloalkyl substituted imidazoles
JP2000507224A (ja) *	1996-03-08	2000-06-13	スミスクライン・ビーチャム・コーポレイション	Ｃｓａｉｄ化合物の血管形成の抑制物質としての使用
JP2000507558A (ja) *	1996-03-25	2000-06-20	スミスクライン・ビーチャム・コーポレイション	Ｃｎｓ損傷についての新規な治療
EP0956018A4 (fr) *	1996-08-21	2000-01-12	Smithkline Beecham Corp	Composes d'imidazole, compositions les contenant et leur utilisation
DK0948495T3 (da)	1996-11-19	2004-06-01	Amgen Inc	Aryl- og heteroarylsubstitueret, kondenseret pyrrol som antiinflammatoriske midler
US6410729B1 (en)	1996-12-05	2002-06-25	Amgen Inc.	Substituted pyrimidine compounds and methods of use
US6096753A (en)	1996-12-05	2000-08-01	Amgen Inc.	Substituted pyrimidinone and pyridone compounds and methods of use
AP999A (en) *	1997-01-10	2001-08-11	Smithkline Beecham Corp	Novel substituted imidazole compounds.
US5929076A (en) *	1997-01-10	1999-07-27	Smithkline Beecham Corporation	Cycloalkyl substituted imidazoles
US6432947B1 (en) *	1997-02-19	2002-08-13	Berlex Laboratories, Inc.	N-heterocyclic derivatives as NOS inhibitors
PL191111B1 (pl)	1997-04-24	2006-03-31	Ortho Mcneil Pharm Inc	Podstawione imidazole, sposób ich wytwarzania, kompozycje zawierające podstawione imidazole oraz ich zastosowanie
US6979686B1 (en)	2001-12-07	2005-12-27	Pharmacia Corporation	Substituted pyrazoles as p38 kinase inhibitors
RU2249591C2 (ru) *	1997-05-22	2005-04-10	Дж.Д. Серл Энд Ко.	3(5)-гетероарилзамещенные пиразолы в качестве ингибиторов киназы p38
CA2288787A1 (fr)	1997-05-22	1998-11-26	G.D. Searle And Co.	Derives de pyrazole comme inhibiteurs de kinase p38
TR200000235T2 (tr) *	1997-05-22	2000-05-22	G.D. Searle &Co.	p38 kinaz inhibitörleri olarak ikame edilmiş pirazoller.
US6514977B1 (en)	1997-05-22	2003-02-04	G.D. Searle & Company	Substituted pyrazoles as p38 kinase inhibitors
US6087496A (en)	1998-05-22	2000-07-11	G. D. Searle & Co.	Substituted pyrazoles suitable as p38 kinase inhibitors
SK286940B6 (sk)	1997-06-12	2009-07-06	Aventis Pharma Limited	Spôsob prípravy imidazolového derivátu
AU7966198A (en)	1997-06-13	1998-12-30	Smithkline Beecham Corporation	Novel pyrazole and pyrazoline substituted compounds
WO1998057966A1 (fr)	1997-06-19	1998-12-23	Smithkline Beecham Corporation	Nouveaux composes imidazole a substitution d'aryloxypymiridine
EP0994858A1 (fr) *	1997-06-30	2000-04-26	Ortho-McNeil Pharmaceutical, Inc.	Imidazoles substituees en 2 utilisables pour le traitement de maladies inflammatoires
TW517055B (en)	1997-07-02	2003-01-11	Smithkline Beecham Corp	Novel substituted imidazole compounds
US7301021B2 (en) *	1997-07-02	2007-11-27	Smithkline Beecham Corporation	Substituted imidazole compounds
US6489325B1 (en)	1998-07-01	2002-12-03	Smithkline Beecham Corporation	Substituted imidazole compounds
US6562832B1 (en)	1997-07-02	2003-05-13	Smithkline Beecham Corporation	Substituted imidazole compounds
AR016294A1 (es) *	1997-07-02	2001-07-04	Smithkline Beecham Corp	Compuesto de imidazol sustituido, composicion farmaceutica que la contiene, su uso en la fabricacion de un medicamento y procedimiento para supreparacion
US6251914B1 (en)	1997-07-02	2001-06-26	Smithkline Beecham Corporation	Cycloalkyl substituted imidazoles
WO1999017776A1 (fr) *	1997-10-08	1999-04-15	Smithkline Beecham Corporation	Nouveaux composes substitues de cycloalcenyle
EP1021173A1 (fr) *	1997-10-10	2000-07-26	Imperial College Innovations Limited	Emploi de composes de csaid?tm pour le traitement des contractions uterines
US6022884A (en)	1997-11-07	2000-02-08	Amgen Inc.	Substituted pyridine compounds and methods of use
US7041694B1 (en)	1997-12-17	2006-05-09	Cornell Research Foundation, Inc.	Cyclooxygenase-2 inhibition
US6335340B1 (en)	1997-12-19	2002-01-01	Smithkline Beecham Corporation	compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses
KR20010025087A (ko)	1998-05-22	2001-03-26	스튜어트 알. 수터	신규한 2-알킬 치환된 이미다졸 화합물
JP2002516325A (ja) *	1998-05-26	2002-06-04	スミスクライン・ビーチャム・コーポレイション	新規な置換イミダゾール化合物
US6858617B2 (en)	1998-05-26	2005-02-22	Smithkline Beecham Corporation	Substituted imidazole compounds
AU4395399A (en) *	1998-07-02	2000-01-24	Sankyo Company Limited	Five-membered heteroaryl compounds
US6207687B1 (en) *	1998-07-31	2001-03-27	Merck & Co., Inc.	Substituted imidazoles having cytokine inhibitory activity
US6599910B1 (en) *	1998-08-20	2003-07-29	Smithkline Beecham Corporation	Substituted triazole compounds
JP2002528506A (ja) *	1998-11-04	2002-09-03	スミスクライン・ビーチャム・コーポレイション	ピリジン−４−イルまたはピリミジン−４−イル置換ピラジン
US6239279B1 (en)	1998-12-16	2001-05-29	Smithkline Beecham Corporation	Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
WO2000040243A1 (fr)	1999-01-08	2000-07-13	Smithkline Beecham Corporation	Nouveaux composes
US6930101B1 (en)	1999-05-17	2005-08-16	The Regents Of The University Of California	Thiazolopyrimidines useful as TNFα inhibitors
WO2000078757A1 (fr) *	1999-06-17	2000-12-28	Shionogi Bioresearch Corp.	Inhibiteurs de production de il-12
IL137365A0 (en) *	1999-07-21	2001-07-24	Sankyo Co	Heteroaryl-substituted pyrrole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US7122666B2 (en)	1999-07-21	2006-10-17	Sankyo Company, Limited	Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
JP2003514899A (ja)	1999-11-23	2003-04-22	スミスクライン・ビーチャム・コーポレイション	ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４‐ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物
DE60023025T2 (de)	1999-11-23	2006-07-13	Smithkline Beecham Corp.	3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren
AU1783201A (en)	1999-11-23	2001-06-04	Smithkline Beecham Corporation	3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
US6759410B1 (en)	1999-11-23	2004-07-06	Smithline Beecham Corporation	3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
IL144760A0 (en) *	1999-12-08	2002-06-30	Pharmacia Corp	Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect
US20020002169A1 (en) *	1999-12-08	2002-01-03	Griffin John H.	Protein kinase inhibitors
US7235551B2 (en) *	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US6525051B2 (en)	2000-03-27	2003-02-25	Schering Aktiengesellschaft	N-heterocyclic derivatives as NOS inhibitors
PE20020146A1 (es) *	2000-07-13	2002-03-31	Upjohn Co	Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2)
US20020128267A1 (en) *	2000-07-13	2002-09-12	Rebanta Bandyopadhyay	Method of using COX-2 inhibitors in the treatment and prevention of ocular COX-2 mediated disorders
PT1303265E (pt)	2000-07-20	2007-10-09	Lauras As	''utilização de inibidores da cox-2 como imuno-estimulantes, no tratamento do vih ou da sida''
IL155367A0 (en) *	2000-10-23	2003-12-23	Smithkline Beecham Corp	NOVEL 2,4,8-TRISUBSTITUTED-8h-PYRIDO[2,3,-d]PYRIMIDIN-7-ONE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, PROCESSES FOR THE PREPARATION THEREOF, AND USE THEREOF IN THE PREPARATION OF MEDICAMENTS FOR TREATING CSBP/p38 KINASE MEDIATED DISEASES
US7115565B2 (en) *	2001-01-18	2006-10-03	Pharmacia & Upjohn Company	Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
ES2296910T3 (es) *	2001-01-22	2008-05-01	Sankyo Company, Limited	Compuestos sustituidos con grupo amino biciclicos.
BR0208462A (pt)	2001-03-26	2004-03-02	Ortho Mcneil Pharm Inc	Processo para a preparação de derivados imidazólicos e novas estruturas cristalinas dos mesmos
US7695736B2 (en)	2001-04-03	2010-04-13	Pfizer Inc.	Reconstitutable parenteral composition
WO2002094267A1 (fr) *	2001-05-24	2002-11-28	Sankyo Company, Limited	Preparation pharmaceutique pour prevenir ou traiter l'arthrite
UA80682C2 (en) *	2001-08-06	2007-10-25	Pharmacia Corp	Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
MY147948A (en) *	2001-10-22	2013-02-15	Mitsubishi Tanabe Pharma Corp	4- imidazolin-2-one compounds
AR039241A1 (es) *	2002-04-04	2005-02-16	Biogen Inc	Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
US6982259B2 (en) *	2002-04-30	2006-01-03	Schering Aktiengesellschaft	N-heterocyclic derivatives as NOS inhibitors
DE60310730T2 (de)	2002-07-09	2007-05-16	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege
AU2003262911A1 (en)	2002-08-29	2004-03-19	Scios Inc.	Methods of promoting osteogenesis
UA80295C2 (en) *	2002-09-06	2007-09-10	Biogen Inc	Pyrazolopyridines and using the same
UA80296C2 (en) *	2002-09-06	2007-09-10	Biogen Inc	Imidazolopyridines and methods of making and using the same
JP4654035B2 (ja)	2002-11-05	2011-03-16	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー	抗菌剤
BR0317313A (pt) *	2002-12-16	2005-11-08	Astrazeneca Uk Ltd	Processo para a preparação de um composto, e, composto
CL2004000234A1 (es) *	2003-02-12	2005-04-15	Biogen Idec Inc	Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid
CL2004000366A1 (es) *	2003-02-26	2005-01-07	Pharmacia Corp Sa Organizada B	USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.
US7244441B2 (en)	2003-09-25	2007-07-17	Scios, Inc.	Stents and intra-luminal prostheses containing map kinase inhibitors
SV2005001973A (es) *	2003-12-12	2005-11-04	Wyeth Corp	Quinolinas utiles en el tratamiento de enfermedades cardiovasculares ref. wyth0090-504 (am101500)
JP2007514730A (ja) *	2003-12-18	2007-06-07	ファイザー・プロダクツ・インク	ｐ３８ＭＡＰキナーゼ阻害剤による、動物における急性の炎症の治療方法
RU2401265C2 (ru) *	2004-06-10	2010-10-10	Айрм Ллк	Соединения и композиции в качестве ингибиторов протеинкиназы
US20060035893A1 (en)	2004-08-07	2006-02-16	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
WO2006025373A1 (fr) *	2004-08-31	2006-03-09	Sanyo Chemical Industries, Ltd.	Agent tensioactif
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP1676574A3 (fr)	2004-12-30	2006-07-26	Johnson & Johnson Vision Care, Inc.	Procédé favorisant la survie des tissus ou cellules griffées
JP2008537937A (ja) *	2005-03-25	2008-10-02	グラクソグループリミテッド	ピリド［２，３−ｄ］ピリミジン−７−オンおよび３，４−ジヒドロピリミド［４，５−ｄ］ピリミジン−２（１Ｈ）−オン誘導体の製造方法
PE20100737A1 (es) *	2005-03-25	2010-11-27	Glaxo Group Ltd	Nuevos compuestos
US20060252807A1 (en) *	2005-04-22	2006-11-09	Kalypsys, Inc.	Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders
US20060281788A1 (en)	2005-06-10	2006-12-14	Baumann Christian A	Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
US8697716B2 (en)	2006-04-20	2014-04-15	Janssen Pharmaceutica Nv	Method of inhibiting C-KIT kinase
PL2021335T3 (pl)	2006-04-20	2011-10-31	Janssen Pharmaceutica Nv	Związki heterocykliczne jako inhibitory kinazy C-FMS
WO2007124322A1 (fr)	2006-04-20	2007-11-01	Janssen Pharmaceutica N.V.	Inhibiteurs de la kinase de c-fms
EP1992344A1 (fr)	2007-05-18	2008-11-19	Institut Curie	P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3
WO2008151307A2 (fr) *	2007-06-05	2008-12-11	The Regents Of The University Of Colorado	Molécules de surface induisant la cytokine de cellule t et procédés d'utilisation
JO3240B1 (ar)	2007-10-17	2018-03-08	Janssen Pharmaceutica Nv	c-fms مثبطات كيناز
WO2010091324A1 (fr) *	2009-02-06	2010-08-12	Western States Biopharmaceuticals, Inc.	Double inhibition de membres de la famille des immunophilines/cyclophilines et de membres de la superfamille des récepteurs d'immunoglobulines emmprin
RU2418582C1 (ru) *	2010-04-08	2011-05-20	Аверин Константин Михайлович	1,3-диалкилбензимидазолия галогениды - средства для лечения рассеянного склероза
JOP20180012A1 (ar)	2012-08-07	2019-01-30	Janssen Pharmaceutica Nv	عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد
JP6359537B2 (ja)	2012-08-07	2018-07-18	ヤンセンファーマシューティカエヌ．ベー．	複素環エステル誘導体の調製プロセス
EA201590380A1 (ru) *	2012-08-16	2015-07-30	Янссен Фармацевтика Нв	Замещенные пиразолы, используемые в качестве блокаторов кальциевых каналов n-типа
US9453002B2 (en)	2013-08-16	2016-09-27	Janssen Pharmaceutica Nv	Substituted imidazoles as N-type calcium channel blockers
CN104402823B (zh) *	2014-11-05	2016-03-23	上海浩登材料科技有限公司	一种1，2-二甲基咪唑的制备方法
CN104496906B (zh) *	2014-11-05	2016-03-23	上海浩登材料科技有限公司	一种咪唑的制备方法
EP4591936A3 (fr)	2015-03-23	2025-10-15	Tianli Biotech Pty Ltd	Traitement de maladies respiratoires
US20200079757A1 (en) *	2017-05-03	2020-03-12	The University Of Melbourne	Compounds for the treatment of respiratory diseases
US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
PT3691620T (pt)	2017-10-05	2022-10-06	Fulcrum Therapeutics Inc	Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd
WO2020093098A1 (fr) *	2018-11-07	2020-05-14	The University Of Melbourne	Nouveaux composés pour le traitement de maladies respiratoires
EP3725768A1 (fr) *	2019-04-17	2020-10-21	Newron Pharmaceuticals S.p.A.	Procédé de production de dérivés de 2-[2-(phényl)éthylamino]alkanéamide
FR3097222B1 (fr) *	2019-06-11	2021-05-28	Michelin & Cie	Nouveaux composes 1,3-dipolaires comprenant un heterocycle aromatique et un cycle imidazole
MX2022002017A (es)	2019-08-23	2022-03-11	Mochida Pharm Co Ltd	Metodo para producir derivado de heterociclideno acetamida.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES377330A1 (es) *	1969-03-11	1972-06-16	Glaxo Lab Ltd	Procedimiento para preparar esteres de acido 7 beta-acila- mido-3-metilcef3-em-4-carboxilico.
US3707475A (en) *	1970-11-16	1972-12-26	Pfizer	Antiinflammatory imidazoles
US3929807A (en) *	1971-05-10	1975-12-30	Ciba Geigy Corp	2-Substituted-4(5)-(aryl)-5(4)-(2,3 or -4-pyridyl)-imidazoles
US3940486A (en) *	1971-05-10	1976-02-24	Ciba-Geigy Corporation	Imidazole derivatives in the treatment of pain
US4058614A (en) *	1973-12-04	1977-11-15	Merck & Co., Inc.	Substituted imidazole compounds and therapeutic compositions therewith
CY1302A (en) *	1978-04-11	1985-12-06	Ciba Geigy Ag	Mercapto-imidazole derivatives,their preparation,their pharmaceutical compositions and applications
US4199592A (en) *	1978-08-29	1980-04-22	E. I. Du Pont De Nemours And Company	Antiinflammatory 4,5-diaryl-2-nitroimidazoles
DD201677A5 (de) *	1980-07-25	1983-08-03	Ciba Geigy	Verfahren zur herstellung von trisubstituierten imidazolderivaten
US4503065A (en) *	1982-08-03	1985-03-05	E. I. Du Pont De Nemours And Company	Antiinflammatory 4,5-diaryl 1-2-halo imidazoles
US4565875A (en) *	1984-06-27	1986-01-21	Fmc Corporation	Imidazole plant growth regulators
US4686231A (en) *	1985-12-12	1987-08-11	Smithkline Beckman Corporation	Inhibition of 5-lipoxygenase products
IE59893B1 (en) *	1986-04-16	1994-04-20	Roussel Uclaf	Process for the manufacture of n-(sulfonylmethyl) formamides
IL83467A0 (en) *	1986-08-15	1988-01-31	Fujisawa Pharmaceutical Co	Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same
US5166400A (en) *	1989-01-19	1992-11-24	Pfizer Inc.	Intermediates for isopropyl 3S-amino-2R-hydroxy-alkanoates
AU9137591A (en) *	1990-12-13	1992-07-08	Smithkline Beecham Corporation	Novel csaids
WO1992010498A1 (fr) *	1990-12-13	1992-06-25	Smithkline Beecham Corporation	Nouveaux medicaments anti-inflammatoires suppresseurs de cytokine
AU3592493A (en) *	1992-01-13	1993-08-03	Smithkline Beecham Corporation	Pyridyl substituted imidazoles
IL104369A0 (en) *	1992-01-13	1993-05-13	Smithkline Beecham Corp	Novel compounds and compositions
IL110296A (en) *	1993-07-16	1999-12-31	Smithkline Beecham Corp	Imidazole compounds process for their preparation and pharmaceutical compositions containing them
AU7629594A (en) *	1993-07-21	1995-02-20	Smithkline Beecham Corporation	Imidazoles for treating cytokine mediated disease
IL114483A0 (en) *	1994-07-12	1995-11-27	Yissum Res Dev Co	Glycinamide derivatives pharmaceutical compositions containing the same and methods utilizing the same
EP0802908A4 (fr) *	1995-01-12	2001-04-11	Smithkline Beecham Corp	Nouveaux composes

1995
- 1995-06-07 US US08/472,366 patent/US5593992A/en not_active Expired - Lifetime
- 1995-12-19 IL IL13432295A patent/IL134322A/en not_active IP Right Cessation
- 1995-12-19 IL IL13432395A patent/IL134323A/en not_active IP Right Cessation
- 1995-12-19 IL IL11645595A patent/IL116455A/en not_active IP Right Cessation
- 1995-12-19 IL IL13432495A patent/IL134324A/xx unknown
1996
- 1996-01-03 IN IN11DE1996 patent/IN184957B/en unknown
- 1996-01-05 MA MA24125A patent/MA23770A1/fr unknown
- 1996-01-05 AR ARP960100903A patent/AR002267A1/es unknown
- 1996-01-06 DZ DZ960002A patent/DZ1961A1/fr active
- 1996-01-09 ID IDP990850D patent/ID23273A/id unknown
- 1996-01-09 ID IDP990849D patent/ID23597A/id unknown
- 1996-01-09 ID IDP990848D patent/ID23599A/id unknown
- 1996-01-11 CN CNB961922982A patent/CN1138546C/zh not_active Expired - Fee Related
- 1996-01-11 WO PCT/US1996/000546 patent/WO1996021452A1/fr not_active Ceased
- 1996-01-11 RU RU97113753/04A patent/RU2196139C2/ru not_active IP Right Cessation
- 1996-01-11 PT PT96902151T patent/PT809499E/pt unknown
- 1996-01-11 BR BR9606904A patent/BR9606904A/pt active Search and Examination
- 1996-01-11 AP APAP/P/1997/001021A patent/AP1270A/en active
- 1996-01-11 FI FI972901A patent/FI972901L/fi not_active IP Right Cessation
- 1996-01-11 AT AT96902151T patent/ATE254613T1/de not_active IP Right Cessation
- 1996-01-11 PL PL96322249A patent/PL322249A1/xx unknown
- 1996-01-11 CZ CZ972158A patent/CZ215897A3/cs unknown
- 1996-01-11 JP JP52186296A patent/JP3330952B2/ja not_active Expired - Fee Related
- 1996-01-11 DK DK96902151T patent/DK0809499T3/da active
- 1996-01-11 HU HU9702409A patent/HUP9702409A3/hu unknown
- 1996-01-11 SK SK902-97A patent/SK90297A3/sk unknown
- 1996-01-11 CA CA002209938A patent/CA2209938A1/fr not_active Abandoned
- 1996-01-11 SI SI9630660T patent/SI0809499T1/xx unknown
- 1996-01-11 ES ES96902151T patent/ES2210348T3/es not_active Expired - Lifetime
- 1996-01-11 EP EP02078189A patent/EP1264827A1/fr not_active Withdrawn
- 1996-01-11 MX MX9705142A patent/MX9705142A/es unknown
- 1996-01-11 DE DE69630777T patent/DE69630777T2/de not_active Expired - Fee Related
- 1996-01-11 NZ NZ301204A patent/NZ301204A/xx unknown
- 1996-01-11 EP EP96902151A patent/EP0809499B1/fr not_active Expired - Lifetime
- 1996-01-11 AU AU46572/96A patent/AU705207C/en not_active Ceased
- 1996-03-18 TW TW085103208A patent/TW523511B/zh not_active IP Right Cessation
- 1996-08-21 US US08/702,250 patent/US5663334A/en not_active Expired - Lifetime
1997
- 1997-03-17 US US08/819,619 patent/US6103936A/en not_active Expired - Fee Related
- 1997-07-02 BG BG101727A patent/BG63769B1/bg unknown
- 1997-07-08 NO NO973167A patent/NO973167L/no unknown
- 1997-07-09 OA OA70045A patent/OA10738A/en unknown
2000
- 2000-01-27 IN IN60DE2000 patent/IN188338B/en unknown
- 2000-01-27 IN IN61DE2000 patent/IN188339B/en unknown
- 2000-02-01 IL IL13432400A patent/IL134324A0/xx unknown
- 2000-02-01 IL IL13432300A patent/IL134323A0/xx unknown
- 2000-02-01 IL IL13432200A patent/IL134322A0/xx unknown
- 2000-02-11 US US09/502,763 patent/US6222036B1/en not_active Expired - Fee Related
2001
- 2001-02-27 US US09/795,009 patent/US20020188122A1/en not_active Abandoned
- 2001-07-16 JP JP2001215404A patent/JP2002105047A/ja active Pending
- 2001-12-19 NO NO20016225A patent/NO20016225D0/no not_active Application Discontinuation
- 2001-12-19 NO NO20016226A patent/NO20016226D0/no not_active Application Discontinuation
2002
- 2002-08-15 RU RU2002122174/14A patent/RU2002122174A/ru not_active Application Discontinuation

Also Published As

Publication number	Publication date
HK1003623A1 (en)	1999-02-12
NZ301204A (en)	1999-05-28
TW523511B (en)	2003-03-11
IL134324A0 (en)	2001-04-30
IN188339B (fr)	2002-09-07
IL116455A0 (en)	1996-03-31
MA23770A1 (fr)	1996-10-01
FI972901A0 (fi)	1997-07-08
IL134323A0 (en)	2001-04-30
PT809499E (pt)	2004-04-30
CA2209938A1 (fr)	1996-07-18
JP3330952B2 (ja)	2002-10-07
RU2196139C2 (ru)	2003-01-10
US5663334A (en)	1997-09-02
MX9705142A (es)	1997-10-31
BR9606904A (pt)	1997-10-21
ES2210348T3 (es)	2004-07-01
WO1996021452A1 (fr)	1996-07-18
FI972901A7 (fi)	1997-09-08
US20020188122A1 (en)	2002-12-12
HUP9702409A2 (hu)	1999-05-28
IL134322A0 (en)	2001-04-30
ATE254613T1 (de)	2003-12-15
US6103936A (en)	2000-08-15
ID23597A (id)	1996-10-10
EP0809499A1 (fr)	1997-12-03
IN188338B (fr)	2002-09-07
IL134323A (en)	2001-11-25
HUP9702409A3 (en)	1999-06-28
JPH10512555A (ja)	1998-12-02
NO973167D0 (no)	1997-07-08
JP2002105047A (ja)	2002-04-10
IN184957B (fr)	2000-10-07
IL134322A (en)	2001-09-13
IL134324A (en)	2001-08-26
EP0809499B1 (fr)	2003-11-19
CN1138546C (zh)	2004-02-18
EP1264827A1 (fr)	2002-12-11
DE69630777D1 (de)	2003-12-24
AR002267A1 (es)	1998-03-11
AP1270A (en)	2004-04-16
SK90297A3 (en)	1998-01-14
NO973167L (no)	1997-09-08
NO20016225D0 (no)	2001-12-19
AP9701021A0 (en)	1997-07-31
PL322249A1 (en)	1998-01-19
AU4657296A (en)	1996-07-31
CZ215897A3 (cs)	1998-04-15
FI972901L (fi)	1997-09-08
IL116455A (en)	2001-07-24
ID23599A (id)	1996-10-10
DE69630777T2 (de)	2004-07-29
BG101727A (bg)	1998-03-31
NO20016226D0 (no)	2001-12-19
US6222036B1 (en)	2001-04-24
US5593992A (en)	1997-01-14
NO20016226L (no)	1997-09-08
EP0809499A4 (fr)	1998-10-14
DZ1961A1 (fr)	2002-02-17
NO20016225L (no)	1997-09-08
RU2002122174A (ru)	2004-02-27
AU705207C (en)	2002-09-19
SI0809499T1 (en)	2004-04-30
ID23273A (id)	1996-10-10
CN1177299A (zh)	1998-03-25
BG63769B1 (bg)	2002-12-29
AU705207B2 (en)	1999-05-20
OA10738A (en)	2002-12-11

Publication	Publication Date	Title
DK0809499T3 (da)	2004-03-29	Visse 1,4,5-trisubstituerede imidazolforbindelser, der er egnede som cytokin
FI934109L (fi)	1994-03-23	Bensoylguanidiner, foerfarande foer framstaellning av dessa, deras anvaendning som laekemedel och laekemedel innehaollande dessa
FI932961L (fi)	1993-12-28	Metallocener med arylsubsituerade indenylderivat som ligander, foerfarande foer framstaellning av dessa och anvaendning av dessa som katalysatorer
FI932659L (fi)	1993-12-13	Gallsyraderivat, foerfaranden foer deras framstaellning och anvaendning avdessa foereningar som laekemedel
DE59511103D1 (de)	2009-11-19	1-h-3-aryl-pyrrolidin-2,4-dion-derivate als schädlingsbekämpfungsmittel
FI932565L (fi)	1993-06-04	Shampookompositioner, som innehaoller konditioneringsmedel pao basis av silikoner och katjoniska organiska polymerer
FI931250L (fi)	1993-09-25	Sulfonamido- och sulfonamidokarbonyl-pyridin-2-karboxylsyraamider och deras pyridin-n-oxider, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
FI924709L (fi)	1993-04-19	Pao hartsemulsion baserat ytlimningsmedel, ett daermed limmat papper ochett limningsfoerfarande foer utnyttjande daerav
FI925926L (fi)	1993-09-20	Sammansaettning som innehaoller hydrerade sackarider med laog kariesframkallande effekt, foerfarande foer framstaellning av dessa och tillaempningen av denna sammansaettning
FI945042A7 (fi)	1994-10-26	1-piperatsino-1,2-dihydroindeenijohdannaiset
FI932660L (fi)	1993-12-14	Vaermefoerseglingsbara, antistatiska belagda folier och folielaminat, foerfarande foer framstaellning av dessa och anvaendning av dessa
FI932625A0 (fi)	1993-06-09	Anordning och foerfarande foer detektering av ytfel i laonga, i roerelse befintliga metallprodukter
FI932527L (fi)	1993-12-05	Anvaendning av polypropylenglykol saosom tillsatsaemne, som reducerar krympningens storlek i dispersionspulversammansaettningar avsedda foer byggmaterialer
FI921638L (fi)	1992-10-18	Vispbar, icke-mjoelkbaserad graedde pao basis av vaetskeformig olja (ii)
FI933903A7 (fi)	1994-03-10	Substituerade cyklohexanderivat, foerfarande foer framstaellning daerav och anvaendning av foereningar foer behandling av sjukdomar
FI931490L (fi)	1993-05-31	Detergentkompositioner, vilka med avseende pao sura komponenter av endoglukanastyp innehaoller anrikade cellulaskompositioner
FI930974L (fi)	1993-09-06	Substituerade aminofosfonatderivat, foerfarande foer framstaellning av desamma och farmaceutiska kompositioner innehaollande desamma
FI922163L (fi)	1993-01-17	Foerfarande och anordning foer kompensering av vaexelelfaelt, som foerekommer pao framutan av ett katodbildroer
FI931291A0 (fi)	1993-03-23	Indol- och indazolderivat foer behandling och foerebyggande av hjaernsjukdomar, deras framstaellning och anvaendning
FI923550A7 (fi)	1993-02-17	Anordning foer bildning av en fibermatta, saerskilt en mineraluddfibermatta, pao ett stoedband
FI935829A0 (fi)	1993-12-23	Anlaeggning och foerfarande foer uttnyttjning av braennbara aemnen, speciellt industri- och hushaollsavfall
FI930717A7 (fi)	1993-08-23	4-amino-2-ureido-pyrimidin-5-karboxylsyraamider, foerfarande foer framstaellning av dessa, laekemedel innehaollande dessa och deras anvaendning
FI930130L (fi)	1993-07-16	Bundet fiberknippe, foerfarande foer framstaellning av detta och daerav erhaollna textilytstrukturer
FI932951L (fi)	1993-12-28	Tillsatskonsentrat innehaollande sulfurerat jordalkalimetallhydrokarbylfenat, foerfarande foer framstaellning av detta och anvaendning av detta
EE03615B1 (et)	2002-02-15	Pürasool-4-üülhetaroüülderivaadid herbitsiididena