DK0789568T3 - Antineoplastiske kakaoekstrakter, fremgangsmåder til fremstilling og anvendelse - Google Patents
Antineoplastiske kakaoekstrakter, fremgangsmåder til fremstilling og anvendelseInfo
- Publication number
- DK0789568T3 DK0789568T3 DK95938189T DK95938189T DK0789568T3 DK 0789568 T3 DK0789568 T3 DK 0789568T3 DK 95938189 T DK95938189 T DK 95938189T DK 95938189 T DK95938189 T DK 95938189T DK 0789568 T3 DK0789568 T3 DK 0789568T3
- Authority
- DK
- Denmark
- Prior art keywords
- antineoplastic
- preparation
- methods
- cocoa extracts
- cocoa
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/577—Malvaceae (Mallow family)
- A61K36/5777—Theobroma, e.g. cocao or cocoa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
- C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/317,226 US5554645A (en) | 1994-10-03 | 1994-10-03 | Antineoplastic cocoa extracts and methods for making and using the same |
| PCT/US1995/012963 WO1996010404A1 (fr) | 1994-10-03 | 1995-10-03 | Extraits antineoplasiques de cacao et leurs procedes de preparation et d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0789568T3 true DK0789568T3 (da) | 2007-04-10 |
Family
ID=23232689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95938189T DK0789568T3 (da) | 1994-10-03 | 1995-10-03 | Antineoplastiske kakaoekstrakter, fremgangsmåder til fremstilling og anvendelse |
Country Status (26)
| Country | Link |
|---|---|
| US (13) | US5554645A (fr) |
| EP (2) | EP1759696A1 (fr) |
| JP (2) | JPH10506903A (fr) |
| CN (2) | CN1134255C (fr) |
| AP (1) | AP9700952A0 (fr) |
| AT (1) | ATE346599T1 (fr) |
| AU (1) | AU696050B2 (fr) |
| BG (1) | BG101446A (fr) |
| CA (1) | CA2201310C (fr) |
| CZ (1) | CZ99197A3 (fr) |
| DE (1) | DE69535318T2 (fr) |
| DK (1) | DK0789568T3 (fr) |
| EE (1) | EE9700074A (fr) |
| FI (1) | FI971354L (fr) |
| HU (1) | HUT77366A (fr) |
| IS (1) | IS4456A (fr) |
| LT (1) | LT4322B (fr) |
| LV (1) | LV11819B (fr) |
| MD (1) | MD970165A (fr) |
| MX (1) | MX9702415A (fr) |
| NO (1) | NO971485L (fr) |
| OA (1) | OA10604A (fr) |
| PL (1) | PL187819B1 (fr) |
| RU (1) | RU2220719C2 (fr) |
| SK (1) | SK43497A3 (fr) |
| WO (1) | WO1996010404A1 (fr) |
Families Citing this family (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5554645A (en) * | 1994-10-03 | 1996-09-10 | Mars, Incorporated | Antineoplastic cocoa extracts and methods for making and using the same |
| US6777005B1 (en) * | 1994-10-03 | 2004-08-17 | Mars, Incorporated | Foods containing a cocoa polyphenol additive |
| US6187315B1 (en) | 1995-03-03 | 2001-02-13 | Atajje, Inc. | Compositions and methods of treating cancer with tannin complexes |
| US6261565B1 (en) | 1996-03-13 | 2001-07-17 | Archer Daniels Midland Company | Method of preparing and using isoflavones |
| US6391310B1 (en) | 1996-03-13 | 2002-05-21 | Archer Daniels Midland Company | Method of preparing and using isoflavones for the treatment of neurological symptoms |
| CN1159019C (zh) * | 1996-04-02 | 2004-07-28 | 火星有限公司 | 可提取物化合物以及其制备方法和用途 |
| US6297273B1 (en) * | 1996-04-02 | 2001-10-02 | Mars, Inc. | Use of cocoa solids having high cocoa polyphenol content in tabletting compositions and capsule filling compositions |
| US6696485B1 (en) | 1996-04-02 | 2004-02-24 | Mars, Incorporated | Procyanidin and cyclo-oxygenase modulator compositions |
| US6469053B1 (en) * | 1996-04-02 | 2002-10-22 | Mars Incorporated | Use of procyanidins in the maintenance of vascular health and modulation of the inflammatory response |
| US6423743B1 (en) | 1996-04-02 | 2002-07-23 | Mars Incorporated | Cocoa extract compounds and methods for making and using the same |
| US7968140B2 (en) | 1997-09-08 | 2011-06-28 | Mars, Incorporated | Chocolates and chocolate liquor having an enhanced polyphenol content |
| US6015913A (en) * | 1996-09-06 | 2000-01-18 | Mars, Incorporated | Method for producing fat and/or solids from cocoa beans |
| US6737088B1 (en) | 1996-09-06 | 2004-05-18 | Mars, Incorporated | Cocoa extracts prepared from cocoa solids having high cocoa polyphenol contents |
| US6558713B2 (en) * | 1996-09-06 | 2003-05-06 | Mars, Incorporated | Health of a mammal by administering a composition containing at least one cocoa polyphenol ingredient |
| US6312753B1 (en) * | 1996-09-06 | 2001-11-06 | Mars, Incorporated | Cocoa components, edible products having enriched polyphenol content, methods of making same and medical uses |
| US6905715B1 (en) | 1996-09-06 | 2005-06-14 | Mars, Incorporated | Cocoa solids having a high cocoa procyanidin content |
| US6569446B1 (en) | 1996-09-20 | 2003-05-27 | The Howard Foundation | Solubilization of flavonols |
| US6238673B1 (en) | 1996-09-20 | 2001-05-29 | The Howard Foundation | Method of producing high flavonol content polyphenol compositions |
| TR199900626T2 (xx) * | 1996-09-20 | 1999-07-21 | The Howard Foundation | Flavonol i�eren besinler. |
| US6066350A (en) * | 1997-02-07 | 2000-05-23 | Cargill Incorporated | Method and arrangement for processing cocoa mass |
| JP2001513505A (ja) * | 1997-08-08 | 2001-09-04 | エイティーエイジェイジェイイー インコーポレーテッド | タンニン酸及びタンニン複合体により癌を治療する組成物及び方法 |
| US6207842B1 (en) | 1997-10-09 | 2001-03-27 | Mars Incorporated | Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives |
| US8507018B2 (en) | 1998-03-12 | 2013-08-13 | Mars, Incorporated | Products containing polyphenol(s) and L-arginine and methods of use thereof |
| EP1894566A1 (fr) * | 1998-03-12 | 2008-03-05 | Mars, Incorporated | Produits contenant du ou des polyphénol(s) et de la L-arginine pour stimuler la production d'oxyde nitrique |
| US6805883B2 (en) | 1998-03-12 | 2004-10-19 | Mars, Incorporated | Food products containing polyphenol(s) and L-arginine to stimulate nitric oxide |
| EP1106073B1 (fr) * | 1998-06-18 | 2008-08-20 | Meiji Seika Kaisha, Ltd. | Cacao en poudre riche en polyphenols, son procede de fabrication, et cacao modifie le contenant |
| US7011856B2 (en) * | 1998-08-05 | 2006-03-14 | Amino Up Chemical Co., Ltd. | Composition for the treatment of symptoms and conditions associated with aging |
| US6576275B1 (en) * | 1999-02-02 | 2003-06-10 | Archer-Daniels-Midland Company | Process for extracting polyphenolic antioxidants from purine-containing plants |
| US6190716B1 (en) * | 1999-02-17 | 2001-02-20 | Scott O. Galbreath, Jr. | Method for preparing a grape derived product |
| US6156912A (en) * | 1999-04-09 | 2000-12-05 | Mars, Incorporated | 88, 66, and 68 catechin and epicatechin dimers and methods for their preparation |
| US7015338B1 (en) | 1999-04-15 | 2006-03-21 | Mars Incorporated | Synthetic methods for preparing procyanidin oligomers |
| CN1238350C (zh) * | 1999-04-23 | 2006-01-25 | 协和发酵工业株式会社 | 原花色素低聚物的提纯方法 |
| KR100319251B1 (ko) * | 1999-06-30 | 2002-01-05 | 한수길 | 충치 억제 효능을 지닌 카카오 콩껍질 분획물의 제조방법 |
| KR100509119B1 (ko) * | 1999-07-16 | 2005-08-18 | 주식회사 엘지생활건강 | 프로시아니딘 올리고머를 유효성분으로 하는 약제 |
| AU2289601A (en) * | 1999-12-21 | 2001-07-03 | Mars, Incorporated | The use of procyanidins in the modulation of cytokine gene expression and protein secretion |
| MXPA02008819A (es) * | 2000-03-10 | 2003-02-12 | Yakult Honsha Kk | Inhibidor de actividad de alfa amilasa. |
| AU2001261004B2 (en) | 2000-03-22 | 2006-07-13 | Mars, Incorporated | The use of cocoa procyanidins combined with acetylsalicyclic acid as an anti-platelet therapy |
| WO2001078529A2 (fr) | 2000-04-14 | 2001-10-25 | Mars, Incorporated | Compositions et methodes permettant d'ameliorer la sante vasculaire |
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| FR2808192A1 (fr) * | 2000-04-28 | 2001-11-02 | Oreal | Epichatechine comme inhibiteur de no-synthase et utilisations |
| US6627232B1 (en) | 2000-06-09 | 2003-09-30 | Mars Incorporated | Method for extracting cocoa procyanidins |
| FR2810242B1 (fr) * | 2000-06-16 | 2003-01-17 | Nuxe Lab | Composition cosmetique et/ou dermatologique a base d'extraits de cacao |
| FR2812873B1 (fr) * | 2000-08-11 | 2003-08-01 | Barry Callebaut France | Procede de production de polyphenols a partir de feves de cacao |
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| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
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| US7514107B2 (en) * | 2002-03-21 | 2009-04-07 | Mars, Incorporated | Treatment of diseases involving defective gap junctional communication |
| EP1575519A2 (fr) * | 2002-05-17 | 2005-09-21 | Board Of Regents, The University Of Texas System | Therapies a base de cd26 destinees aux cancers et a une maladie immunitaire |
| US7067679B2 (en) * | 2002-10-02 | 2006-06-27 | Mars, Inc. | Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest |
| US20040071848A1 (en) * | 2002-10-15 | 2004-04-15 | Cargill Inc. | Process for producing cocoa butter and cocoa powder by liquefied gas extraction |
| US7201934B2 (en) * | 2002-10-15 | 2007-04-10 | Cargill, Incorporated | Dispersible cocoa products |
| US20040071847A1 (en) * | 2002-10-15 | 2004-04-15 | Cargill, Inc. | Producing cocoa powders with different cocoa butter contents by liquefied gas extraction on substantially the same production line |
| US6936644B2 (en) * | 2002-10-16 | 2005-08-30 | Cookson Electronics, Inc. | Releasable microcapsule and adhesive curing system using the same |
| US20040254357A1 (en) * | 2002-12-19 | 2004-12-16 | Zaloga Gary P. | Fatty acid phenolic conjugates |
| US20070270504A1 (en) * | 2003-06-20 | 2007-11-22 | Avalon Pharmaceuticals, Inc. | Identification of Therapeutic Agents Using Genetic Fingerprinting |
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| CA2564443C (fr) | 2004-05-10 | 2016-04-26 | Instituto Tecnologico Y De Estudios Superiores De Monterrey (Itesm) | Inhibition de la croissance de cellules cancereuses a l'aide d'extraits d'haricot noir (phaseolus vulgaris l) |
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| EP2522347A1 (fr) | 2005-06-29 | 2012-11-14 | Mars Incorporated | Induction de la vasodilatation d'un vaisseau sanguin périphérique |
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1994
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-
1995
- 1995-10-03 CA CA002201310A patent/CA2201310C/fr not_active Expired - Lifetime
- 1995-10-03 FI FI971354A patent/FI971354L/fi not_active Application Discontinuation
- 1995-10-03 HU HU9702279A patent/HUT77366A/hu unknown
- 1995-10-03 MX MX9702415A patent/MX9702415A/es not_active Application Discontinuation
- 1995-10-03 WO PCT/US1995/012963 patent/WO1996010404A1/fr not_active Ceased
- 1995-10-03 AT AT95938189T patent/ATE346599T1/de active
- 1995-10-03 EP EP06024499A patent/EP1759696A1/fr not_active Withdrawn
- 1995-10-03 CN CNB951965956A patent/CN1134255C/zh not_active Expired - Lifetime
- 1995-10-03 EE EE9700074A patent/EE9700074A/xx unknown
- 1995-10-03 PL PL95319756A patent/PL187819B1/pl unknown
- 1995-10-03 CN CNB2003101015256A patent/CN100357287C/zh not_active Expired - Lifetime
- 1995-10-03 AP APAP/P/1997/000952A patent/AP9700952A0/en unknown
- 1995-10-03 MD MD97-0165A patent/MD970165A/ro unknown
- 1995-10-03 DE DE69535318T patent/DE69535318T2/de not_active Expired - Lifetime
- 1995-10-03 CZ CZ97991A patent/CZ99197A3/cs unknown
- 1995-10-03 RU RU97106832/15A patent/RU2220719C2/ru active
- 1995-10-03 EP EP95938189A patent/EP0789568B1/fr not_active Revoked
- 1995-10-03 DK DK95938189T patent/DK0789568T3/da active
- 1995-10-03 SK SK434-97A patent/SK43497A3/sk unknown
- 1995-10-03 AU AU38916/95A patent/AU696050B2/en not_active Ceased
- 1995-10-03 JP JP8512152A patent/JPH10506903A/ja active Pending
-
1996
- 1996-07-26 US US08/687,885 patent/US5712305A/en not_active Expired - Lifetime
-
1997
- 1997-04-02 NO NO971485A patent/NO971485L/no unknown
- 1997-04-02 IS IS4456A patent/IS4456A/is unknown
- 1997-04-03 OA OA60986A patent/OA10604A/en unknown
- 1997-04-14 US US08/839,446 patent/US5891905A/en not_active Expired - Lifetime
- 1997-04-14 US US08/834,637 patent/US5877206A/en not_active Expired - Lifetime
- 1997-04-22 US US08/837,803 patent/US6479539B1/en not_active Expired - Lifetime
- 1997-04-25 BG BG101446A patent/BG101446A/xx unknown
- 1997-04-29 LT LT97-077A patent/LT4322B/lt not_active IP Right Cessation
- 1997-05-02 LV LVP-97-85A patent/LV11819B/xx unknown
-
1998
- 1998-10-15 US US09/172,873 patent/US6225338B1/en not_active Expired - Lifetime
- 1998-11-23 US US09/198,551 patent/US6156791A/en not_active Expired - Fee Related
-
2001
- 2001-01-24 US US09/768,473 patent/US6562863B2/en not_active Expired - Lifetime
- 2001-10-11 US US09/975,242 patent/US6517841B2/en not_active Expired - Lifetime
-
2003
- 2003-01-15 US US10/342,772 patent/US6790966B2/en not_active Expired - Fee Related
-
2004
- 2004-03-01 US US10/790,268 patent/US20040175448A1/en not_active Abandoned
-
2007
- 2007-05-08 US US11/745,698 patent/US7820713B2/en not_active Expired - Fee Related
- 2007-10-29 US US11/926,919 patent/US20080269320A1/en not_active Abandoned
-
2009
- 2009-09-03 JP JP2009203541A patent/JP2009286796A/ja active Pending
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