DK0646115T3 - Heterocykliske/cykliske aminderivater - Google Patents

Heterocykliske/cykliske aminderivater

Info

Publication number: DK0646115T3
Authority: DK; Denmark
Prior art keywords: heterocyclic; cyclic amine; amine derivatives; compounds; formula
Prior art date: 1991-03-28

Application number

DK92921695T

Other languages

Danish (da)

English (en)

Inventor

Anabella Villalobos

Arthur Adam Nagel

Yuhpyng Liang Chen

Original Assignee

Eisai Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-28

Filing date

1992-03-09

Publication date

2003-04-22

1992-03-09 Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd

2003-04-22 Application granted granted Critical

2003-04-22 Publication of DK0646115T3 publication Critical patent/DK0646115T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Thiazole And Isothizaole Compounds (AREA)
Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)

DK92921695T 1991-03-28 1992-03-09 Heterocykliske/cykliske aminderivater DK0646115T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US67691891A	1991-03-28	1991-03-28
PCT/US1992/001605 WO1992017475A1 (fr)	1991-03-28	1992-03-09	Derives d'amines heterocycliques-cycliques

Publications (1)

Publication Number	Publication Date
DK0646115T3 true DK0646115T3 (da)	2003-04-22

Family

ID=24716559

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92921695T DK0646115T3 (da)	1991-03-28	1992-03-09	Heterocykliske/cykliske aminderivater

Country Status (29)

Country	Link
EP (1)	EP0646115B1 (fr)
JP (3)	JP2659107B2 (fr)
KR (1)	KR0179054B1 (fr)
CN (1)	CN1044242C (fr)
AT (1)	ATE231505T1 (fr)
AU (2)	AU658194B2 (fr)
BR (1)	BR9205811A (fr)
CA (2)	CA2107105C (fr)
CZ (1)	CZ289756B6 (fr)
DE (1)	DE69232907T2 (fr)
DK (1)	DK0646115T3 (fr)
EG (1)	EG20281A (fr)
ES (1)	ES2188584T3 (fr)
FI (1)	FI934223L (fr)
HU (1)	HU225047B1 (fr)
IE (1)	IE920980A1 (fr)
IL (3)	IL101327A (fr)
MX (1)	MX9201419A (fr)
MY (1)	MY108885A (fr)
NO (1)	NO304071B1 (fr)
NZ (3)	NZ242151A (fr)
PL (3)	PL171915B1 (fr)
PT (1)	PT100300B (fr)
RU (1)	RU2119920C1 (fr)
SG (1)	SG49055A1 (fr)
UA (1)	UA45944C2 (fr)
WO (1)	WO1992017475A1 (fr)
YU (1)	YU31392A (fr)
ZA (1)	ZA922239B (fr)

Families Citing this family (50)

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WO1993004063A1 (fr) *	1991-08-22	1993-03-04	Yoshitomi Pharmaceutical Industries, Ltd.	Compose de benzisoxazole et son utilisation
EP0535496A1 (fr) *	1991-09-25	1993-04-07	Hoechst-Roussel Pharmaceuticals Incorporated	(1-Indanon-2-yl)méthylpipéridines, produits intermédiaires et procédé pour leur préparation et leur utilisation comme médicaments
US5494908A (en) *	1992-11-23	1996-02-27	Hoechst-Roussel Pharmaceutical Incorporated	Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
DK0669920T3 (da) *	1992-11-23	2003-05-26	Aventis Pharma Inc	Substituerede 3-(aminoalkylamino)-1,2-benzisoxazoler og beslægtede forbindelser
GB9305623D0 (en) *	1993-03-18	1993-05-05	Merck Sharp & Dohme	Therapeutic agents
DE69532641T2 (de) *	1994-10-26	2004-08-05	Pfizer Inc.	Verfahren und zwischenprodukte zur herstellung von 5,7-dihydro-3-(2 1-benzylpiperidin-4-yl ethyl)-6h-pyrrolo-(4,5-f)-1,2-benzisoxazol-6-on
AU4859596A (en) *	1995-02-15	1996-09-04	Pharmacia & Upjohn Company	Imidazo{1,2-a}pyridines for the treatment of cns and cardiac diseases
EP0816362A4 (fr) *	1995-03-22	1998-07-08	Taisho Pharmaceutical Co Ltd	Derives de la thiazole
PT833820E (pt) *	1995-06-06	2001-07-31	Aventis Pharmaceuticals Inc Av	Derivados de benzisoxazol e indazol uteis como agentes antipsicoticos
JPH09124643A (ja) *	1995-08-14	1997-05-13	Bristol Myers Squibb Co	抗うつ作用を有する１−アリールアルキル−４−（アルコキシピリジニル）−又は４−（アルコキシピリミジニル）ピペラジン誘導体
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EP0976404A3 (fr) *	1998-07-30	2001-06-27	Pfizer Products Inc.	Compositions pharmaceutiques pour la prévention et la therapie de troubles cognitifes chez les mammifères
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EP1050303A3 (fr) *	1999-04-27	2003-01-15	Pfizer Products Inc.	Methodes et compositions pour le traitement des troubles du comportement liées à l'age des animaux de compagnie
US6951873B1 (en)	1999-04-27	2005-10-04	Pfizer Inc.	Methods for treating age-related behavioral disorders in companion animals
EP1048302A3 (fr) *	1999-04-30	2002-07-17	Pfizer Products Inc.	Traceurs radioactifs pour étude de l'acétylcholinesterase et la maladie de Alzheimer
GB9914486D0 (en)	1999-06-21	1999-08-18	Smithkline Beecham Plc	Medicaments
GB9917408D0 (en)	1999-07-23	1999-09-22	Smithkline Beecham Plc	Compounds
GB9917406D0 (en)	1999-07-23	1999-09-22	Smithkline Beecham Plc	Compounds
ATE360612T1 (de)	1999-09-01	2007-05-15	Eisai R&D Man Co Ltd	In 4-stellung substituierte piperidinderivate
US6906083B2 (en)	2000-06-21	2005-06-14	Eisai Co., Ltd.	4-substituted piperidine compound
RU2332419C2 (ru) *	2001-10-17	2008-08-27	Циба Спешиалти Кемикэлз Холдинг Инк.	Фотоактивируемые азотистые основания, фотополимеризующиеся композиции и применение
US7226915B2 (en) *	2003-05-15	2007-06-05	Hoffmann-La Roche Inc.	Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors
US7396833B2 (en) *	2003-12-22	2008-07-08	Memory Pharmaceuticals Corporation	Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
EP1609783A1 (fr) *	2004-06-17	2005-12-28	Neuropharma S.A.U.	Composes marines bloquant les canaux calciques pur le traitement de la maladie de alzheimer
DE102005038947A1 (de) *	2005-05-18	2006-11-30	Grünenthal GmbH	Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
JP2008545008A (ja) *	2005-06-30	2008-12-11	プロシディオン・リミテッド	Ｇｐｃｒアゴニスト
GB0519879D0 (en)	2005-09-30	2005-11-09	Astrazeneca Ab	Chemical process
US20090318690A1 (en)	2006-04-28	2009-12-24	Eisai R&D Management Co., Ltd.	Benzisoxazole Compound
EP2164852A2 (fr)	2007-06-01	2010-03-24	Schering Corporation	Modulateurs de sécrétase gamma
CA2722923C (fr)	2008-04-29	2016-08-02	Boehringer Ingelheim International Gmbh	Composes indazole comme antagonistes des recepteurs ccr1
EP2297112B1 (fr)	2008-05-06	2013-04-03	Boehringer Ingelheim International GmbH	Composés de pyrazole comme antagonistes de ccr1
AP2739A (en)	2008-09-26	2013-09-30	Boehringer Ingelheim Int	Azaindazole compounds as CCRI receptor antagonists
CN102232078B (zh) *	2008-12-12	2014-07-16	埃科特莱茵药品有限公司	5-氨基-2-(1-羟基-乙基)-四氢吡喃衍生物
PL2491028T3 (pl)	2009-10-21	2014-05-30	Boehringer Ingelheim Int	Związki indazolowe i pirazolopirydynowe jako antagoniści receptora CCR1
EP2493875B1 (fr)	2009-10-27	2014-08-06	Boehringer Ingelheim International GmbH	Composés hétérocycliques utilisés en tant qu'antagonistes des récepteurs ccr1
EA037187B1 (ru)	2010-02-09	2021-02-17	Дзе Джонс Хопкинс Юниверсити	Способ и композиция для лечения когнитивного расстройства
US8871786B2 (en)	2010-04-30	2014-10-28	Boehringer Ingelheim International Gmbh	Azaindazole amide compounds as CCR1 receptor antagonists
US8546442B2 (en)	2010-12-23	2013-10-01	Boehringer Ingelheim International Gmbh	Pyrazolopiperidine compounds as CCR1 receptor antagonists
US10154988B2 (en)	2012-11-14	2018-12-18	The Johns Hopkins University	Methods and compositions for treating schizophrenia
EP2922849B1 (fr)	2012-11-21	2017-07-12	RaQualia Pharma Inc.	Polymorphes du 4-{[4-({[4-(2,2,2-trifluoroéthoxy)-1,2-benzisoxazol-3-yl]oxy}méthyl)pipéridin-1-yl]méthyl}-tetrahydro-2h-pyran-4-acide carboxilique en tant qu'agonistes du recepteur 5-hydroxytryptamine-4 (5-ht4) pour le traitement de maladies gastrointestinales
JP6433482B2 (ja)	2013-03-15	2018-12-05	エージンバイオ，インコーポレイテッド	認知機能を改善するための方法および組成物
US10806717B2 (en)	2013-03-15	2020-10-20	The Johns Hopkins University	Methods and compositions for improving cognitive function
AU2016268096B2 (en)	2015-05-22	2021-04-01	Agenebio, Inc.	Extended release pharmaceutical compositions of levetiracetam
RU2638155C1 (ru) *	2016-02-29	2017-12-12	Общество С Ограниченной Ответственностью "Сай Фарма"	Производные бензо[d]изоксазола и их применение
KR20240046530A (ko) *	2021-08-10	2024-04-09	지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드	설폰아미드 유도체, 이의 제조 방법 및 이의 의학적 용도

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1992
- 1992-03-09 RU RU93055137A patent/RU2119920C1/ru not_active IP Right Cessation
- 1992-03-09 BR BR9205811A patent/BR9205811A/pt not_active Application Discontinuation
- 1992-03-09 DE DE69232907T patent/DE69232907T2/de not_active Expired - Fee Related
- 1992-03-09 HU HU9302733A patent/HU225047B1/hu not_active IP Right Cessation
- 1992-03-09 AT AT92921695T patent/ATE231505T1/de not_active IP Right Cessation
- 1992-03-09 CZ CS19923958A patent/CZ289756B6/cs not_active IP Right Cessation
- 1992-03-09 PL PL92313811A patent/PL171915B1/pl not_active IP Right Cessation
- 1992-03-09 WO PCT/US1992/001605 patent/WO1992017475A1/fr not_active Ceased
- 1992-03-09 DK DK92921695T patent/DK0646115T3/da active
- 1992-03-09 UA UA93004393A patent/UA45944C2/uk unknown
- 1992-03-09 PL PL92313812A patent/PL171914B1/pl not_active IP Right Cessation
- 1992-03-09 PL PL92300711A patent/PL170567B1/pl not_active IP Right Cessation
- 1992-03-09 SG SG1996005572A patent/SG49055A1/en unknown
- 1992-03-09 CA CA002107105A patent/CA2107105C/fr not_active Expired - Fee Related
- 1992-03-09 AU AU18782/92A patent/AU658194B2/en not_active Ceased
- 1992-03-09 ES ES92921695T patent/ES2188584T3/es not_active Expired - Lifetime
- 1992-03-09 EP EP92921695A patent/EP0646115B1/fr not_active Expired - Lifetime
- 1992-03-09 FI FI934223A patent/FI934223L/fi not_active Application Discontinuation
- 1992-03-09 CA CA002195129A patent/CA2195129C/fr not_active Expired - Fee Related
- 1992-03-09 JP JP4510182A patent/JP2659107B2/ja not_active Expired - Fee Related
- 1992-03-22 IL IL101327A patent/IL101327A/en active IP Right Grant
- 1992-03-22 IL IL11612292A patent/IL116122A/en active IP Right Grant
- 1992-03-22 IL IL11612295A patent/IL116122A0/xx unknown
- 1992-03-26 EG EG15592A patent/EG20281A/xx active
- 1992-03-26 PT PT100300A patent/PT100300B/pt not_active IP Right Cessation
- 1992-03-27 IE IE098092A patent/IE920980A1/en not_active IP Right Cessation
- 1992-03-27 NZ NZ242151A patent/NZ242151A/en not_active IP Right Cessation
- 1992-03-27 ZA ZA922239A patent/ZA922239B/xx unknown
- 1992-03-27 YU YU31392A patent/YU31392A/sh unknown
- 1992-03-27 NZ NZ250987A patent/NZ250987A/en not_active IP Right Cessation
- 1992-03-27 MY MYPI92000531A patent/MY108885A/en unknown
- 1992-03-27 NZ NZ248946A patent/NZ248946A/en not_active IP Right Cessation
- 1992-03-27 CN CN92102178A patent/CN1044242C/zh not_active Expired - Fee Related
- 1992-03-30 MX MX9201419A patent/MX9201419A/es not_active IP Right Cessation
1993
- 1993-09-27 NO NO933445A patent/NO304071B1/no unknown
- 1993-09-27 KR KR1019930702929A patent/KR0179054B1/ko not_active Expired - Fee Related
1995
- 1995-06-20 AU AU21788/95A patent/AU674477B2/en not_active Ceased
1997
- 1997-03-06 JP JP9052097A patent/JP3051076B2/ja not_active Expired - Fee Related
1999
- 1999-12-24 JP JP11368302A patent/JP2000154185A/ja active Pending

Also Published As

Publication number	Publication date
AU674477B2 (en)	1996-12-19
CN1065267A (zh)	1992-10-14
HU9302733D0 (en)	1993-12-28
JP3051076B2 (ja)	2000-06-12
PT100300A (pt)	1993-08-31
IL116122A (en)	1998-10-30
HU225047B1 (en)	2006-05-29
FI934223A0 (fi)	1993-09-27
ATE231505T1 (de)	2003-02-15
EP0646115A1 (fr)	1995-04-05
IL101327A (en)	1998-06-15
HUT68357A (en)	1995-06-28
JPH06500794A (ja)	1994-01-27
AU1878292A (en)	1992-11-02
NO933445D0 (no)	1993-09-27
EP0646115B1 (fr)	2003-01-22
NO933445L (no)	1993-09-27
NZ242151A (en)	1994-10-26
CA2107105A1 (fr)	1992-09-29
PL171914B1 (pl)	1997-06-30
CA2195129A1 (fr)	1992-09-29
CA2195129C (fr)	2002-09-10
WO1992017475A1 (fr)	1992-10-15
JP2659107B2 (ja)	1997-09-30
ZA922239B (en)	1993-09-27
MX9201419A (es)	1992-10-01
FI934223A7 (fi)	1993-09-27
UA45944C2 (uk)	2002-05-15
PL171915B1 (pl)	1997-06-30
JP2000154185A (ja)	2000-06-06
NO304071B1 (no)	1998-10-19
DE69232907D1 (de)	2003-02-27
FI934223L (fi)	1993-09-27
DE69232907T2 (de)	2003-05-15
CZ289756B6 (cs)	2002-04-17
CA2107105C (fr)	2003-10-07
SG49055A1 (en)	1998-05-18
NZ250987A (en)	1997-06-24
AU658194B2 (en)	1995-04-06
CZ395892A3 (en)	1994-04-13
RU2119920C1 (ru)	1998-10-10
EG20281A (en)	1998-07-30
AU2178895A (en)	1995-09-07
KR0179054B1 (en)	1999-03-20
BR9205811A (pt)	1994-06-28
IL101327A0 (en)	1992-11-15
ES2188584T3 (es)	2003-07-01
YU31392A (sh)	1994-12-28
IL116122A0 (en)	1996-01-31
NZ248946A (en)	1995-04-27
PT100300B (pt)	1999-09-30
JPH10158264A (ja)	1998-06-16
CN1044242C (zh)	1999-07-21
IE920980A1 (en)	1992-10-07
PL170567B1 (pl)	1997-01-31
MY108885A (en)	1996-11-30

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DK0646115T3 (da)	2003-04-22	Heterocykliske/cykliske aminderivater
FI893433A0 (fi)	1989-07-14	Menetelmä terapeuttisesti käyttökelpoisten heterosyklisten yhdisteiden valmistamiseksi
ES2111639T3 (es)	1998-03-16	Derivados de 3-aminopiperidina y heterociclos relacionados que contienen nitrogeno.
MX9700557A (es)	1997-12-31	Dihidrobenzofuranos.
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DE59401924D1 (de)	1997-04-10	Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
TR199800011T1 (xx)	1998-04-21	Benzo$g] kuinolin t�revleri
FI915920A0 (fi)	1991-12-16	Serotoninantagonister.
NO180083C (no)	1997-02-12	Fremstilling av substituerte piperidiner
ATE123024T1 (de)	1995-06-15	4-aminopyridinderivate.
DE60108626D1 (de)	2005-03-03	Verwendung von 5-thio, sulfinyl- und sulfonylpyrazolo 3,4-b] pyridinen als cyclin-abhängige kinase-hemmer
NO930205D0 (no)	1993-01-21	Benzimidazoler, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling
ATE63309T1 (de)	1991-05-15	2,3-dihydro-2-oxo-3-benzofuranylessigs\|urederivate und diese enthaltende arzneimittel.
ATE283269T1 (de)	2004-12-15	5-(heteroaryl)alkyl)-3-oxo-pyrido(1,2- a)benzimidazol-4-carboxamid (pbi) derivate zur behandlung von störungen des zentralen nervensystems
ATE53839T1 (de)	1990-06-15	2,3-dihydro-3-phenyl-benzofuran-2-onacetamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
DK1105388T3 (da)	2003-08-18	N-substituerede azabicycloheptan-derivater, fremstilling og anvendelse heraf