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PT100300B - Derivados de aminas heterociclicas-ciclicas, nomeadamente derivados de benzisoxazole-piperidina - Google Patents

Derivados de aminas heterociclicas-ciclicas, nomeadamente derivados de benzisoxazole-piperidina

Info

Publication number
PT100300B
PT100300B PT100300A PT10030092A PT100300B PT 100300 B PT100300 B PT 100300B PT 100300 A PT100300 A PT 100300A PT 10030092 A PT10030092 A PT 10030092A PT 100300 B PT100300 B PT 100300B
Authority
PT
Portugal
Prior art keywords
derivatives
benzisoxazole
heterocyclic
namely
cyclic amines
Prior art date
Application number
PT100300A
Other languages
English (en)
Other versions
PT100300A (pt
Inventor
Yuhpyng L Chen
Arthur Adam Nagel
Anabella Villalobos
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of PT100300A publication Critical patent/PT100300A/pt
Publication of PT100300B publication Critical patent/PT100300B/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
PT100300A 1991-03-28 1992-03-26 Derivados de aminas heterociclicas-ciclicas, nomeadamente derivados de benzisoxazole-piperidina PT100300B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67691891A 1991-03-28 1991-03-28

Publications (2)

Publication Number Publication Date
PT100300A PT100300A (pt) 1993-08-31
PT100300B true PT100300B (pt) 1999-09-30

Family

ID=24716559

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100300A PT100300B (pt) 1991-03-28 1992-03-26 Derivados de aminas heterociclicas-ciclicas, nomeadamente derivados de benzisoxazole-piperidina

Country Status (29)

Country Link
EP (1) EP0646115B1 (pt)
JP (3) JP2659107B2 (pt)
KR (1) KR0179054B1 (pt)
CN (1) CN1044242C (pt)
AT (1) ATE231505T1 (pt)
AU (2) AU658194B2 (pt)
BR (1) BR9205811A (pt)
CA (2) CA2107105C (pt)
CZ (1) CZ289756B6 (pt)
DE (1) DE69232907T2 (pt)
DK (1) DK0646115T3 (pt)
EG (1) EG20281A (pt)
ES (1) ES2188584T3 (pt)
FI (1) FI934223L (pt)
HU (1) HU225047B1 (pt)
IE (1) IE920980A1 (pt)
IL (3) IL116122A (pt)
MX (1) MX9201419A (pt)
MY (1) MY108885A (pt)
NO (1) NO304071B1 (pt)
NZ (3) NZ248946A (pt)
PL (3) PL170567B1 (pt)
PT (1) PT100300B (pt)
RU (1) RU2119920C1 (pt)
SG (1) SG49055A1 (pt)
UA (1) UA45944C2 (pt)
WO (1) WO1992017475A1 (pt)
YU (1) YU31392A (pt)
ZA (1) ZA922239B (pt)

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US5494908A (en) * 1992-11-23 1996-02-27 Hoechst-Roussel Pharmaceutical Incorporated Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
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US5916902A (en) * 1995-09-13 1999-06-29 Pfizer Inc. Processes and intermediates for preparing 5, 7-dihydro-3- 2-(1-benzylpiperidin-4-yl)ethyl-!6H-pyrrolo- 4, 5-F!-1, 2-benzisoxazol-6-one
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ES2284519T3 (es) 1999-09-01 2007-11-16 EISAI R&D MANAGEMENT CO., LTD. Derivados de piperidina 4-sustituida.
DE60139781D1 (de) 2000-06-21 2009-10-15 Eisai R&D Man Co Ltd 4-substituierte piperidinverbindung
CA2459374C (en) * 2001-10-17 2011-02-08 Ciba Specialty Chemicals Holding Inc. Photoactivable nitrogen bases
US7226915B2 (en) * 2003-05-15 2007-06-05 Hoffmann-La Roche Inc. Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors
JP4824578B2 (ja) * 2003-12-22 2011-11-30 メモリー・ファーマシューティカルズ・コーポレイション インドール類、1,2−ベンズイソオキサゾール類、および1,2−ベンゾイソチアゾール類、ならびにそれらの製造と使用
EP1609783A1 (en) * 2004-06-17 2005-12-28 Neuropharma S.A.U. Marine compounds with calcium channel blocking properties for Alzheimer's disease treatment
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WO2009137338A1 (en) 2008-05-06 2009-11-12 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
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Also Published As

Publication number Publication date
EG20281A (en) 1998-07-30
RU2119920C1 (ru) 1998-10-10
UA45944C2 (uk) 2002-05-15
SG49055A1 (en) 1998-05-18
JP2000154185A (ja) 2000-06-06
HUT68357A (en) 1995-06-28
HU225047B1 (en) 2006-05-29
AU674477B2 (en) 1996-12-19
CN1065267A (zh) 1992-10-14
BR9205811A (pt) 1994-06-28
CA2195129C (en) 2002-09-10
FI934223A7 (fi) 1993-09-27
WO1992017475A1 (en) 1992-10-15
KR0179054B1 (en) 1999-03-20
ZA922239B (en) 1993-09-27
IL116122A0 (en) 1996-01-31
CA2107105C (en) 2003-10-07
DE69232907T2 (de) 2003-05-15
NZ250987A (en) 1997-06-24
CZ395892A3 (en) 1994-04-13
PL171915B1 (pl) 1997-06-30
PT100300A (pt) 1993-08-31
MY108885A (en) 1996-11-30
ATE231505T1 (de) 2003-02-15
NO304071B1 (no) 1998-10-19
NO933445D0 (no) 1993-09-27
PL171914B1 (pl) 1997-06-30
DK0646115T3 (da) 2003-04-22
EP0646115A1 (en) 1995-04-05
YU31392A (sh) 1994-12-28
IL101327A (en) 1998-06-15
MX9201419A (es) 1992-10-01
EP0646115B1 (en) 2003-01-22
IL116122A (en) 1998-10-30
CZ289756B6 (cs) 2002-04-17
NZ248946A (en) 1995-04-27
ES2188584T3 (es) 2003-07-01
JPH10158264A (ja) 1998-06-16
HU9302733D0 (en) 1993-12-28
AU2178895A (en) 1995-09-07
JPH06500794A (ja) 1994-01-27
FI934223A0 (fi) 1993-09-27
AU658194B2 (en) 1995-04-06
CN1044242C (zh) 1999-07-21
JP2659107B2 (ja) 1997-09-30
PL170567B1 (pl) 1997-01-31
CA2195129A1 (en) 1992-09-29
NO933445L (no) 1993-09-27
NZ242151A (en) 1994-10-26
AU1878292A (en) 1992-11-02
DE69232907D1 (de) 2003-02-27
FI934223L (fi) 1993-09-27
IL101327A0 (en) 1992-11-15
JP3051076B2 (ja) 2000-06-12
IE920980A1 (en) 1992-10-07
CA2107105A1 (en) 1992-09-29

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