DK0543942T4 - Homogent assaysystem - Google Patents

Homogent assaysystem

Info

Publication number: DK0543942T4
Authority: DK; Denmark
Prior art keywords: assay system; nucleic acid; homogeneous assay; sequence variants; identify
Prior art date: 1990-08-06

Application number

DK91917050T

Other languages

Danish (da)

English (en)

Other versions

DK0543942T3 (da

Inventor

David H Gelfand

Randall K Saiki

Pamela M Holland

Robert M Watson

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-06

Filing date

1991-08-06

Publication date

2007-02-19

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24251781&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0543942(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-08-06 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2001-06-18 Application granted granted Critical

2001-06-18 Publication of DK0543942T3 publication Critical patent/DK0543942T3/da

2007-02-19 Publication of DK0543942T4 publication Critical patent/DK0543942T4/da

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Microbiology (AREA)
Virology (AREA)
Chemical Kinetics & Catalysis (AREA)
AIDS & HIV (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Materials By Optical Means (AREA)
Separation Using Semi-Permeable Membranes (AREA)
Physical Or Chemical Processes And Apparatus (AREA)
Saccharide Compounds (AREA)
Automatic Analysis And Handling Materials Therefor (AREA)
Measurement Of Radiation (AREA)
Auxiliary Devices For Music (AREA)
Analysing Materials By The Use Of Radiation (AREA)

DK91917050T 1990-08-06 1991-08-06 Homogent assaysystem DK0543942T4 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/563,758 US5210015A (en)	1990-08-06	1990-08-06	Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
PCT/US1991/005571 WO1992002638A1 (en)	1990-08-06	1991-08-06	Homogeneous assay system

Publications (2)

Publication Number	Publication Date
DK0543942T3 DK0543942T3 (da)	2001-06-18
DK0543942T4 true DK0543942T4 (da)	2007-02-19

Family

ID=24251781

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DK91917050T DK0543942T4 (da)	1990-08-06	1991-08-06	Homogent assaysystem
DK98119974T DK0919565T4 (da)	1990-08-06	1991-08-06	Mærkede oligonukleotider
DK03000776T DK1302549T3 (da)	1990-08-06	1991-08-06	Fremgangsmåde til at skelne mellem sekvensvarianter

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
DK98119974T DK0919565T4 (da)	1990-08-06	1991-08-06	Mærkede oligonukleotider
DK03000776T DK1302549T3 (da)	1990-08-06	1991-08-06	Fremgangsmåde til at skelne mellem sekvensvarianter

Country Status (10)

Country	Link
US (6)	US5210015A (es)
EP (3)	EP1302549B1 (es)
JP (1)	JP2825976B2 (es)
AT (3)	ATE198912T1 (es)
AU (1)	AU666837B2 (es)
CA (1)	CA2088683C (es)
DE (3)	DE69132521T3 (es)
DK (3)	DK0543942T4 (es)
ES (3)	ES2155058T5 (es)
WO (1)	WO1992002638A1 (es)

Families Citing this family (1420)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5635347A (en) *	1986-04-30	1997-06-03	Igen, Inc.	Rapid assays for amplification products
US5795762A (en) *	1986-08-22	1998-08-18	Roche Molecular Systems, Inc.	5' to 3' exonuclease mutations of thermostable DNA polymerases
US5466591A (en) *	1986-08-22	1995-11-14	Hoffmann-La Roche Inc.	5' to 3' exonuclease mutations of thermostable DNA polymerases
US6589734B1 (en)	1989-07-11	2003-07-08	Gen-Probe Incorporated	Detection of HIV
US5856088A (en) *	1989-07-11	1999-01-05	Gen-Probe Incorporated	Detection of human immunodeficiency virus type 1
US7273749B1 (en)	1990-06-04	2007-09-25	University Of Utah Research Foundation	Container for carrying out and monitoring biological processes
US7081226B1 (en)	1996-06-04	2006-07-25	University Of Utah Research Foundation	System and method for fluorescence monitoring
US5210015A (en) *	1990-08-06	1993-05-11	Hoffman-La Roche Inc.	Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5994056A (en)	1991-05-02	1999-11-30	Roche Molecular Systems, Inc.	Homogeneous methods for nucleic acid amplification and detection
US6872816B1 (en) *	1996-01-24	2005-03-29	Third Wave Technologies, Inc.	Nucleic acid detection kits
US5846717A (en) *	1996-01-24	1998-12-08	Third Wave Technologies, Inc.	Detection of nucleic acid sequences by invader-directed cleavage
US5994069A (en) *	1996-01-24	1999-11-30	Third Wave Technologies, Inc.	Detection of nucleic acids by multiple sequential invasive cleavages
US5565322A (en) *	1991-11-07	1996-10-15	Nanogen, Inc.	Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to donor energy transfer system
US5567583A (en) *	1991-12-16	1996-10-22	Biotronics Corporation	Methods for reducing non-specific priming in DNA detection
US6033854A (en) *	1991-12-16	2000-03-07	Biotronics Corporation	Quantitative PCR using blocking oligonucleotides
FI115214B (fi) *	1992-01-22	2005-03-31	Hoechst Ag	Menetelmä oligonukleotidianalogien valmistamiseksi ja niiden käyttö
US6033909A (en) *	1992-01-22	2000-03-07	Hoechst Aktiengesellschaft	Oligonucleotide analogs, their preparation and use
US5646261A (en) *	1992-01-22	1997-07-08	Hoechst Aktiengesellschaft	3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use
ES2154648T3 (es) *	1992-08-03	2001-04-16	Abbott Lab	Deteccion y amplificacion de acidos nucleicos blanco con actividad exonucleolitica.
DE4239531A1 (de) *	1992-11-25	1994-05-26	Gabor Dr Igloi	Reagenz zur Kupplung verschiedener Substanzen an Nukleinsäuren sowie Verfahren zu dessen Herstellung
US5541311A (en) *	1992-12-07	1996-07-30	Third Wave Technologies, Inc.	Nucleic acid encoding synthesis-deficient thermostable DNA polymerase
US5843654A (en) *	1992-12-07	1998-12-01	Third Wave Technologies, Inc.	Rapid detection of mutations in the p53 gene
US6372424B1 (en) *	1995-08-30	2002-04-16	Third Wave Technologies, Inc	Rapid detection and identification of pathogens
US5614402A (en) *	1992-12-07	1997-03-25	Third Wave Technologies, Inc.	5' nucleases derived from thermostable DNA polymerase
US7785852B2 (en) *	1992-12-07	2010-08-31	Third Wave Technologies, Inc.	Cleavage of nucleic acids
US6673616B1 (en) *	1992-12-07	2004-01-06	Third Wave Technologies, Inc.	Methods and compositions for characterizing nucleic acids
US5422253A (en) *	1992-12-07	1995-06-06	Wisconsin Alumni Research Foundation	Method of site specific nucleic acid cleavage
US5888780A (en) *	1992-12-07	1999-03-30	Third Wave Technologies, Inc.	Rapid detection and identification of nucleic acid variants
US5719028A (en) *	1992-12-07	1998-02-17	Third Wave Technologies Inc.	Cleavase fragment length polymorphism
US20060078914A1 (en) *	1993-01-05	2006-04-13	Gelfand David H	Homogeneous assay system
JP3099853B2 (ja) *	1993-02-19	2000-10-16	株式会社日立製作所	核酸の測定試薬及び測定方法
WO1994023069A1 (en)	1993-03-26	1994-10-13	Gen-Probe Incorporated	Detection of human immunodeficiency virus type 1
US5491086A (en) *	1993-05-14	1996-02-13	Hoffmann-La Roche Inc.	Purified thermostable nucleic acid polymerase and DNA coding sequences from pyrodictium species
DE4344742A1 (de) *	1993-06-09	1994-12-15	Boehringer Mannheim Gmbh	Verfahren zur Immobilisierung von Nukleinsäuren
JPH0723800A (ja) *	1993-07-08	1995-01-27	Tanabe Seiyaku Co Ltd	核酸の検出方法
US6576419B1 (en) *	1993-07-23	2003-06-10	University Of Utah Research Foundation	Assay procedure using fluorogenic tracers
ATE208658T1 (de) *	1993-07-28	2001-11-15	Pe Corp Ny	Vorrichtung und verfahren zur nukleinsäurevervielfältigung
WO1995011437A1 (en) *	1993-10-21	1995-04-27	Abbott Laboratories	Apparatus and method for transfer of a fluid sample
US5645801A (en) *	1993-10-21	1997-07-08	Abbott Laboratories	Device and method for amplifying and detecting target nucleic acids
US5925517A (en) *	1993-11-12	1999-07-20	The Public Health Research Institute Of The City Of New York, Inc.	Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) *	1994-11-16	1996-07-23	Applied Biosystems Division, Perkin-Elmer Corp.	Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US6821727B1 (en)	1993-11-15	2004-11-23	Applera Corporation	Hybridization assay using self-quenching fluorescence probe
WO1995014106A2 (en) *	1993-11-17	1995-05-26	Id Biomedical Corporation	Cycling probe cleavage detection of nucleic acid sequences
DE69432919T2 (de) *	1993-12-28	2004-05-27	Tanabe Seiyaku Co., Ltd.	Verfahren für den Nachweis spezifischer Polynukleotiden
US5869255A (en)	1994-02-01	1999-02-09	The Regents Of The University Of California	Probes labeled with energy transfer couples dyes exemplified with DNA fragment analysis
US6028190A (en)	1994-02-01	2000-02-22	The Regents Of The University Of California	Probes labeled with energy transfer coupled dyes
US5547861A (en) *	1994-04-18	1996-08-20	Becton, Dickinson And Company	Detection of nucleic acid amplification
JP2909216B2 (ja) *	1994-04-29	1999-06-23	パーキン‐エルマーコーポレイション	核酸増幅生成物のリアルタイム検出装置
JPH10500572A (ja) *	1994-05-23	1998-01-20	バイオトロニクスコーポレーション	標的核酸を検出する方法
AU707391B2 (en) *	1994-05-28	1999-07-08	Tepnel Medical Limited	Producing copies of nucleic acids
US5773213A (en) *	1994-06-06	1998-06-30	Brigham & Women's Hospital	Method for conducting sequential nucleic acid hybridization steps
US20070269799A9 (en) *	1994-06-22	2007-11-22	Zhang David Y	Nucleic acid amplification methods
US5580730A (en) *	1994-08-19	1996-12-03	Olympus America, Inc.	Enzyme digestion method for the detection of amplified DNA
US5491063A (en) *	1994-09-01	1996-02-13	Hoffmann-La Roche Inc.	Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
CA2203627C (en) *	1994-11-09	2000-06-06	James E. Dahlberg	Rapid detection and identification of nucleic acid variants and pathogens
US5512441A (en) *	1994-11-15	1996-04-30	American Health Foundation	Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method
US5571673A (en) *	1994-11-23	1996-11-05	Hoffmann-La Roche Inc.	Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5786139A (en) *	1994-12-09	1998-07-28	Panvera Corporation	Method and kit for detecting nucleic acid cleavage utilizing a covalently attached fluorescent tag
DE69528670T2 (de) *	1994-12-23	2004-03-11	Dade Behring Inc., Deerfield	Nachweis von nukleinsäuren durch nuklease-katalysierte produktbildung
US6787304B1 (en)	1994-12-28	2004-09-07	Georgetown University	Fluorometric assay for detecting nucleic acid cleavage
US20030165908A1 (en) *	1994-12-30	2003-09-04	Georgetown University	Fluorometric assay for detecting nucleic acid cleavage
DE69535882D1 (de) *	1994-12-30	2008-12-18	Univ Georgetown	Fluoreszenztest zum nachweis der spaltung einer nukleinsäure
WO1996024044A1 (en) *	1995-02-02	1996-08-08	Chugai Seiyaku Kabushiki Kaisha	Method of assaying specimen substance by controlling dose of chemiluminescence
US6312894B1 (en)	1995-04-03	2001-11-06	Epoch Pharmaceuticals, Inc.	Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
US5801155A (en) *	1995-04-03	1998-09-01	Epoch Pharmaceuticals, Inc.	Covalently linked oligonucleotide minor grove binder conjugates
DE69610304T2 (de) *	1995-05-05	2001-04-05	Perkin-Elmer Corp., Foster City	Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay
KR100463475B1 (ko)	1995-06-08	2005-06-22	로셰 디아그노스틱스 게엠베하	자기성피그먼트
DE19520398B4 (de) *	1995-06-08	2009-04-16	Roche Diagnostics Gmbh	Magnetisches Pigment
US5994063A (en) *	1995-06-23	1999-11-30	Metzker; Michael L.	Substituted 4,4-difluoro-4-bora-3A,4A-diaza-s-indacene compounds for homogenous amplification/detection assays
US6027879A (en) *	1995-08-09	2000-02-22	The Regents Of The University Of California	Detection and isolation of nucleic acid sequences using a bifunctional hybridization probe
KR970706902A (ko) *	1995-09-12	1997-12-01	로드릭 리차드 제이	Dna 증폭 및 검정 방법 및 장치(device and method for dna amplification and assay)
US5837442A (en)	1995-11-29	1998-11-17	Roche Molecular Systems, Inc.	Oligonucleotide primers for amplifying HCV nucleic acid
DE19548680A1 (de) *	1995-12-23	1997-06-26	Boehringer Mannheim Gmbh	Verfahren zum quantitativen Nachweis von spezifischen Nukleinsäuresequenzen
US6312893B1 (en)	1996-01-23	2001-11-06	Qiagen Genomics, Inc.	Methods and compositions for determining the sequence of nucleic acid molecules
US6027890A (en)	1996-01-23	2000-02-22	Rapigene, Inc.	Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
PT850320E (pt) *	1996-01-23	2000-05-31	Rapigene Inc	Metodos para a deteccao da ligacao num par de ligantes com sensibilidade aumentada
US6613508B1 (en)	1996-01-23	2003-09-02	Qiagen Genomics, Inc.	Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US7122364B1 (en) *	1998-03-24	2006-10-17	Third Wave Technologies, Inc.	FEN endonucleases
AU731062B2 (en) *	1996-01-24	2001-03-22	Third Wave Technologies, Inc.	Invasive cleavage of nucleic acids
US7432048B2 (en) *	1996-11-29	2008-10-07	Third Wave Technologies, Inc.	Reactions on a solid surface
US5985557A (en)	1996-01-24	1999-11-16	Third Wave Technologies, Inc.	Invasive cleavage of nucleic acids
US6706471B1 (en) *	1996-01-24	2004-03-16	Third Wave Technologies, Inc.	Detection of nucleic acid sequences by invader-directed cleavage
US6875572B2 (en)	1996-01-24	2005-04-05	Third Wave Technologies, Inc.	Nucleic acid detection assays
US7527928B2 (en) *	1996-11-29	2009-05-05	Third Wave Technologies, Inc.	Reactions on a solid surface
US7195871B2 (en) *	1996-01-24	2007-03-27	Third Wave Technologies, Inc	Methods and compositions for detecting target sequences
US7256020B2 (en) *	1996-11-29	2007-08-14	Third Wave Technologies, Inc.	Methods and compositions for detecting target sequences
US20080160524A1 (en) *	1996-01-24	2008-07-03	Third Wave Technologies, Inc.	Methods and Compositions for Detecting Target Sequences
US6090606A (en) *	1996-01-24	2000-07-18	Third Wave Technologies, Inc.	Cleavage agents
US6913881B1 (en)	1996-01-24	2005-07-05	Third Wave Technologies, Inc.	Methods and compositions for detecting target sequences
US5763184A (en)	1996-01-30	1998-06-09	Roche Molecular Systems, Inc.	Nucleotide sequence variation in the ABO glycosyltransferase gene
US5716784A (en) *	1996-02-05	1998-02-10	The Perkin-Elmer Corporation	Fluorescence detection assay for homogeneous PCR hybridization systems
US5874216A (en) *	1996-02-23	1999-02-23	Ensys Environmental Products, Inc.	Indirect label assay device for detecting small molecules and method of use thereof
CA2246238A1 (en) *	1996-03-01	1997-09-04	E.I. Du Pont De Nemours And Company	A method for the amplification and detection of a nucleic acid fragment of interest
CA2199213C (en)	1996-03-11	2007-04-17	John Wesley Backus	Amplifying and detecting target nucleic acids using a post amplification incubation step
US7244622B2 (en)	1996-04-03	2007-07-17	Applera Corporation	Device and method for multiple analyte detection
WO1998010096A1 (en) *	1996-04-12	1998-03-12	The Public Health Research Institute Of The City Of New York, Inc.	Detection probes, kits and assays
WO1997039008A1 (en) *	1996-04-12	1997-10-23	The Public Health Research Institute Of The City Of New York, Inc.	Detection probes, kits and assays
US5955268A (en) *	1996-04-26	1999-09-21	Abbott Laboratories	Method and reagent for detecting multiple nucleic acid sequences in a test sample
US5887385A (en)	1996-05-28	1999-03-30	Rite-Hite Holding Corporation	Release mechanism for industrial doors
JP4278712B2 (ja) *	1996-06-04	2009-06-17	ユニバーシティオブユタリサーチファウンデーション	Ｄｎａ増幅を蛍光でモニタリングするためのシステムと方法
US5736333A (en) *	1996-06-04	1998-04-07	The Perkin-Elmer Corporation	Passive internal references for the detection of nucleic acid amplification products
ATE318327T1 (de)	1996-06-04	2006-03-15	Univ Utah Res Found	Fluoreszenz-donor-akzeptor paar
US6780982B2 (en)	1996-07-12	2004-08-24	Third Wave Technologies, Inc.	Charge tags and the separation of nucleic acid molecules
US7070925B1 (en)	1996-07-16	2006-07-04	Gen-Probe Incorporated	Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
US6117635A (en) *	1996-07-16	2000-09-12	Intergen Company	Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5866336A (en) *	1996-07-16	1999-02-02	Oncor, Inc.	Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
DE69736667T2 (de) *	1996-07-16	2007-09-06	Gen-Probe Inc., San Diego	Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm)
US5853990A (en)	1996-07-26	1998-12-29	Edward E. Winger	Real time homogeneous nucleotide assay
US6361940B1 (en)	1996-09-24	2002-03-26	Qiagen Genomics, Inc.	Compositions and methods for enhancing hybridization and priming specificity
US20050153373A1 (en) *	1996-10-31	2005-07-14	Billing-Medel Patricia A.	Reagents and methods useful for detecting diseases of the breast
US20030165971A1 (en) *	1996-10-31	2003-09-04	Billing-Medel Patricia A.	Reagents and methods useful for detecting diseases of the breast
US20050202499A1 (en)	1996-10-31	2005-09-15	Billing-Medel Patricia A.	Reagents and methods useful for detecting diseases of the breast
ATE530652T1 (de)	1996-11-29	2011-11-15	Third Wave Tech Inc	Fen-1-endonucleasen, mischungen und spaltungsverfahren
US5840879A (en) *	1996-12-06	1998-11-24	Wang; Edge R.	Reagents and solid supports for improved synthesis and labeling of polynucleotides
US20020137904A1 (en) *	1998-03-27	2002-09-26	Patricia A. Billing-Medel	Reagents and methods useful for detecting diseases of the gastrointestinal tract
US20050208567A1 (en) *	1997-04-25	2005-09-22	Billing-Medel Patricia A	Reagents and methods useful for detecting diseases of the prostate
JP3948503B2 (ja) *	1997-08-01	2007-07-25	誠鶴岡	蛍光偏光法による核酸の測定方法およびＶｅｒｏ毒素生産菌の検出方法
JP3174751B2 (ja) *	1997-09-30	2001-06-11	財団法人東京都医学研究機構	リアルタイム検出ｐｃｒ法によるｈｃｖ遺伝子の測定方法並びにそれに用いられるプライマー及びプローブ
DE19743518A1 (de) *	1997-10-01	1999-04-15	Roche Diagnostics Gmbh	Automatisierbare universell anwendbare Probenvorbereitungsmethode
AU1366299A (en)	1997-10-27	1999-05-17	Boston Probes, Inc.	Methods, kits and compositions pertaining to pna molecular beacons
US6485901B1 (en)	1997-10-27	2002-11-26	Boston Probes, Inc.	Methods, kits and compositions pertaining to linear beacons
WO1999023250A2 (de)	1997-11-04	1999-05-14	Roche Diagnostics Gmbh	Spezifisches und sensitives nukleinsäurenachweisverfahren
US6077669A (en) *	1997-11-04	2000-06-20	Becton Dickinson And Company	Kit and method for fluorescence based detection assay
US6294326B1 (en)	1997-11-07	2001-09-25	Abbott Laboratories	Analyte detection process using dual labeled probes
US6583168B1 (en)	1997-11-25	2003-06-24	Applera Corporation	Sulfonated diarylrhodamine dyes
US8182991B1 (en)	1997-11-26	2012-05-22	Third Wave Technologies, Inc.	FEN-1 endonucleases, mixtures and cleavage methods
DE19752898A1 (de) *	1997-11-28	1999-08-05	Centeon Pharma Gmbh	Verfahren zum Nachweis hoher Vierenkonzentrationen im Blutplasma und/oder Blutserum mittels der Polymerasekettenreaktion
ES2290979T3 (es)	1997-12-15	2008-02-16	Csl Behring Gmbh	Cebador marcado para uso en la deteccion de acidos nucleicos diana.
DE19755642B4 (de) *	1997-12-15	2005-03-10	Zlb Behring Gmbh	Markierter Primer für die Polymerasekettenreaktion
ATE469982T1 (de) *	1998-02-04	2010-06-15	Life Technologies Corp	Bestimmung des genotyps eines amplifikationsproduktes an mehreren allelen stellen
WO1999040219A1 (en) *	1998-02-05	1999-08-12	Bavarian Nordic Research Institute A/S	Quantification by inhibition of amplification
GB9803382D0 (en) *	1998-02-19	1998-04-15	Secr Defence	Detection system
WO1999049293A2 (en)	1998-03-24	1999-09-30	Boston Probes, Inc.	Methods, kits and compositions pertaining to detection complexes
US5952202A (en) *	1998-03-26	1999-09-14	The Perkin Elmer Corporation	Methods using exogenous, internal controls and analogue blocks during nucleic acid amplification
US7045610B2 (en) *	1998-04-03	2006-05-16	Epoch Biosciences, Inc.	Modified oligonucleotides for mismatch discrimination
US6127121A (en) *	1998-04-03	2000-10-03	Epoch Pharmaceuticals, Inc.	Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
US6683173B2 (en)	1998-04-03	2004-01-27	Epoch Biosciences, Inc.	Tm leveling methods
US6949367B1 (en)	1998-04-03	2005-09-27	Epoch Pharmaceuticals, Inc.	Modified oligonucleotides for mismatch discrimination
US7715989B2 (en) *	1998-04-03	2010-05-11	Elitech Holding B.V.	Systems and methods for predicting oligonucleotide melting temperature (TmS)
GB9808145D0 (en) *	1998-04-17	1998-06-17	Zeneca Ltd	Assay
US20030203394A1 (en) *	1998-05-04	2003-10-30	Yoav Eichen	Detection of a target in a sample
DE19822108A1 (de) *	1998-05-12	2000-02-03	Schering Ag	Verfahren zur Detektion von Mikroorganismen in Produkten, insbesondere in Arzneimitteln und Kosmetika
US6468743B1 (en)	1998-05-18	2002-10-22	Conagra Grocery Products Company	PCR techniques for detecting microbial contaminants in foodstuffs
DE19824535A1 (de)	1998-06-03	1999-12-09	Roche Diagnostics Gmbh	Neue Rhodamin-Derivate und deren Verwendung
GB9812768D0 (en) *	1998-06-13	1998-08-12	Zeneca Ltd	Methods
CA2330735C (en)	1998-06-17	2010-05-11	Amersham Pharmacia Biotech Inc.	Fy7 polymerase
ATE440963T1 (de) *	1998-07-02	2009-09-15	Gen Probe Inc	Molekulare fackeln
JP3437094B2 (ja) *	1998-07-03	2003-08-18	松下電器産業株式会社	多波長蛍光偏光法
US20040203078A1 (en) *	1998-07-22	2004-10-14	National Institute Of Advanced Industrial Science And Technology	Labeled complex, process for producing same and process for utilizing same
US6037130A (en) *	1998-07-28	2000-03-14	The Public Health Institute Of The City Of New York, Inc.	Wavelength-shifting probes and primers and their use in assays and kits
IL126776A (en) *	1998-10-27	2001-04-30	Technion Res & Dev Foundation	A method of investing gold
US6492111B1 (en) *	1998-11-25	2002-12-10	Isis Pharmaceuticals, Inc.	In situ binary synthesis of biologically effective molecules
WO2000034521A1 (en) *	1998-12-08	2000-06-15	Boston Probes, Inc.	Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
EP1013775A1 (en) *	1998-12-21	2000-06-28	LUTZ, Hans	Quantitative polymerase chain reaction using a fluorogenic real-time detection system
US6432642B1 (en) *	1999-01-15	2002-08-13	Pe Corporation (Ny)	Binary probe and clamp composition and methods for a target hybridization detection
DE19906169A1 (de) *	1999-02-08	2000-08-10	Bioinside Ges Fuer Biodiagnost	Testkit und Verfahren zum quantitativen Nachweis von gentechnisch veränderter DNS in Lebensmitteln mittels fluoreszenzgekoppelter PCR
US7141417B1 (en) *	1999-02-25	2006-11-28	Thomas Jefferson University	Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
US20040248150A1 (en) *	1999-04-02	2004-12-09	Sharat Singh	Methods employing oligonucleotide-binding e-tag probes
US6514700B1 (en) *	1999-04-30	2003-02-04	Aclara Biosciences, Inc.	Nucleic acid detection using degradation of a tagged sequence
US6322980B1 (en)	1999-04-30	2001-11-27	Aclara Biosciences, Inc.	Single nucleotide detection using degradation of a fluorescent sequence
GB9908437D0 (en) *	1999-04-13	1999-06-09	Minton Treharne & Davies Limit	Methods of marking materials
US6573047B1 (en)	1999-04-13	2003-06-03	Dna Sciences, Inc.	Detection of nucleotide sequence variation through fluorescence resonance energy transfer label generation
DE29906582U1 (de) *	1999-04-14	2000-09-21	Langenbach, Guido, 37191 Katlenburg-Lindau	Crashschutzvorrichtung
US20030235832A1 (en) *	2000-06-21	2003-12-25	Ahmed Chenna	Multiplexed analysis by chromatographic separation of molecular tags
US6331393B1 (en) *	1999-05-14	2001-12-18	University Of Southern California	Process for high-throughput DNA methylation analysis
US6180349B1 (en)	1999-05-18	2001-01-30	The Regents Of The University Of California	Quantitative PCR method to enumerate DNA copy number
DE19923168A1 (de)	1999-05-20	2000-11-23	Roche Diagnostics Gmbh	Neue Fluoreszenzfarbstoffe und ihre Verwendung als Fluoreszenzmarker
ATE415409T1 (de)	1999-05-24	2008-12-15	Invitrogen Corp	Ein verfahren zum entschützen markierter oligonukleotide
US6277607B1 (en)	1999-05-24	2001-08-21	Sanjay Tyagi	High specificity primers, amplification methods and kits
US7097973B1 (en)	1999-06-14	2006-08-29	Alpha Mos	Method for monitoring molecular species within a medium
EP1190097A2 (en)	1999-06-22	2002-03-27	Invitrogen Corporation	Improved primers and methods for the detection and discrimination of nucleic acids
EP1194535A4 (en) *	1999-06-23	2004-03-10	Genesource Inc	NON-DESTRUCTIVE, CELL-BASED TEST PROCEDURE
US6750357B1 (en)	1999-06-25	2004-06-15	Syngen, Inc.	Rhodamine-based fluorophores useful as labeling reagents
US6692834B1 (en) *	1999-06-28	2004-02-17	Medtronic, Inc.	Method for coating implantable devices
US6830902B1 (en) *	1999-07-02	2004-12-14	Invitrogen Corporation	Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US6339147B1 (en)	1999-07-29	2002-01-15	Epoch Biosciences, Inc.	Attachment of oligonucleotides to solid supports through Schiff base type linkages for capture and detection of nucleic acids
ATE342271T1 (de)	1999-08-30	2006-11-15	Roche Diagnostics Gmbh	2-azapurine verbindungen und ihre verwendung
DE50001774D1 (de)	1999-09-29	2003-05-22	Tecan Trading Ag Maennedorf	Thermocycler sowie Hebeelement für Mikrotiterplatte
GB9923144D0 (en) *	1999-09-30	1999-12-01	Socrates Biotech International	Methods
US6272939B1 (en)	1999-10-15	2001-08-14	Applera Corporation	System and method for filling a substrate with a liquid sample
US20030082616A1 (en) *	1999-10-15	2003-05-01	Hitachi, Ltd.	Apparatus and method for analyzing nucleic acids and related genetic abnormality
JP4919568B2 (ja) *	1999-10-22	2012-04-18	ピーエイチアールアイプロパティーズ，インコーポレイテッド	短い配列の変異体を検出するためのアッセイ
US6528254B1 (en)	1999-10-29	2003-03-04	Stratagene	Methods for detection of a target nucleic acid sequence
US7381532B2 (en) *	1999-10-29	2008-06-03	Stratagene California	Compositions and methods for the detection of a nucleic acid using a cleavage reaction
US7534568B2 (en)	1999-10-29	2009-05-19	Hologic Inc.	Methods for detection of a target nucleic acid by forming a cleavage structure with a cleavage resistant probe
US7118860B2 (en) *	1999-10-29	2006-10-10	Stratagene California	Methods for detection of a target nucleic acid by capture
US7838225B2 (en) *	1999-10-29	2010-11-23	Hologic, Inc.	Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
US7824859B2 (en) *	1999-10-29	2010-11-02	Cytyc Corporation	Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
US6893819B1 (en) *	2000-11-21	2005-05-17	Stratagene California	Methods for detection of a nucleic acid by sequential amplification
JP2003514383A (ja) *	1999-11-17	2003-04-15	ロシュダイアグノスティクスゲゼルシャフトミットベシュレンクテルハフツング	磁性ガラス粒子、それらの製造方法、及びそれらの使用
EP1233976A4 (en) *	1999-11-17	2003-06-11	Jiuping Ji	SIMULTANEOUS DETECTION OF HBV, HCV AND HIV IN PLASMA SAMPLES WITH THE AID OF A MULTIPLEX FIXING TEST
US6660845B1 (en)	1999-11-23	2003-12-09	Epoch Biosciences, Inc.	Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
WO2001038585A2 (en) *	1999-11-24	2001-05-31	The Regents Of The University Of California	Polymer arrays and methods of using labeled probe molecules to identify and quantify target molecule expression
EP1250452A1 (en)	1999-12-02	2002-10-23	DNA Sciences, Inc.	Methods for determining single nucleotide variations and genotyping
US6727356B1 (en)	1999-12-08	2004-04-27	Epoch Pharmaceuticals, Inc.	Fluorescent quenching detection reagents and methods
US7205105B2 (en) *	1999-12-08	2007-04-17	Epoch Biosciences, Inc.	Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
US20040081959A9 (en) *	1999-12-08	2004-04-29	Epoch Biosciences, Inc.	Fluorescent quenching detection reagents and methods
US7250252B2 (en) *	1999-12-30	2007-07-31	David Aaron Katz	Amplification based polymorphism detection
AU2001234595A1 (en)	2000-01-26	2001-08-07	University Of Cincinnati	Detection of nucleic acid target sequences by electron paramagnetic resonance spectroscopy
DE10004147A1 (de) *	2000-01-31	2001-08-09	Gsf Forschungszentrum Umwelt	Oligonukleotide zur spezifischen Amplifikation und zum spezifischen Nachweis von 16S-rRNA-Genen von Bakterien
US7169355B1 (en)	2000-02-02	2007-01-30	Applera Corporation	Apparatus and method for ejecting sample well trays
FI20000333A0 (fi) *	2000-02-16	2000-02-16	Jussi Nurmi	Homogeeninen menetelmä polynukleotidin havaitsemiseksi
ES2330408T3 (es) *	2000-02-23	2009-12-10	City Of Hope	Polimerizacion activada por pirofosforolisis (pap): aplicacion en la amplificacion de un alelo especifico y en la determinacion de secuencias de acidos nucleicos.
US7033763B2 (en) *	2000-02-23	2006-04-25	City Of Hope	Pyrophosphorolysis activated polymerization (PAP)
US20030117705A1 (en) *	2000-02-25	2003-06-26	Cambridge Research & Instrumentation Inc.	Fluorescence polarization assay system and method
WO2001064958A2 (en)	2000-03-01	2001-09-07	Epoch Bioscienecs, Inc.	Modified oligonucleotides for mismatch discrimination
EP1944310A3 (en)	2000-03-01	2008-08-06	Epoch Biosciences, Inc.	Modified oligonucleotides for mismatch discrimination
AU785111C (en) *	2000-03-23	2007-05-03	Lumigen, Inc.	Methods of detecting polynucleotide kinase and its use as a label
EP1950313A3 (en)	2000-03-27	2010-12-08	GlaxoSmithKline LLC	Detection of viable agents
US7998673B2 (en) *	2000-03-29	2011-08-16	Lgc Limited	Hybridisation beacon and method of rapid sequence detection and discrimination
US7211381B1 (en)	2000-04-04	2007-05-01	Abbott Laboratories	β2 andrenergic polymorphism detection
US6593092B2 (en)	2000-04-04	2003-07-15	Abbott Laboratories	Beta 2 adrenergic polymorphism detection
US7771929B2 (en) *	2000-04-28	2010-08-10	Monogram Biosciences, Inc.	Tag library compounds, compositions, kits and methods of use
US20040067498A1 (en) *	2000-04-28	2004-04-08	Ahmed Chenna	Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
CN1592792B (zh) *	2000-05-19	2010-12-01	伊拉根生物科学公司	检测核酸的材料和方法
US6355433B1 (en)	2000-06-02	2002-03-12	Dna Sciences, Inc.	Determination of nucleotide sequence variations through limited primer extension
US6887664B2 (en)	2000-06-06	2005-05-03	Applera Corporation	Asynchronous primed PCR
US6719949B1 (en)	2000-06-29	2004-04-13	Applera Corporation	Apparatus and method for transporting sample well trays
GB0016836D0 (en) *	2000-07-07	2000-08-30	Lee Helen	Improved dipstick assays (1)
WO2002004122A2 (en) *	2000-07-07	2002-01-17	Helen Lee	Improved stability of hybridisation interactions in dipstick assays
DE60132596T2 (de) *	2000-08-03	2009-02-19	Roche Diagnostics Gmbh	NUKLEINSÄUREBINDENDE VERBINDUNGEN MIT PYRAZOLOi3,4-D PYRIMIDINANALOGEN VON PURIN-2,6-DIAMIN UND IHRE VERWENDUNG
US6358679B1 (en) *	2000-08-24	2002-03-19	Pe Corporation (Ny)	Methods for external controls for nucleic acid amplification
AUPR050700A0 (en) *	2000-10-03	2000-10-26	Id+Plus Ltd	Detection method
AU2001291513B2 (en) *	2000-10-03	2007-06-07	Id+Plus Ltd	Nucleotide detection method
US6350580B1 (en)	2000-10-11	2002-02-26	Stratagene	Methods for detection of a target nucleic acid using a probe comprising secondary structure
JP2002369700A (ja) *	2000-10-11	2002-12-24	Internatl Reagents Corp	核酸分析方法
JP4499987B2 (ja)	2000-10-14	2010-07-14	エラジェンバイオサイエンシズインコーポレイテッド	非−標準塩基を使用する固体支持体アッセイ系及び方法
NZ525336A (en) *	2000-10-20	2006-03-31	Expression Diagnostics Inc	Leukocyte expression profiling
JP2002125687A (ja) *	2000-10-30	2002-05-08	Tosoh Corp	Ｈｉｖ−１検出のためのオリゴヌクレオチドおよび検出法
EP1341929A2 (en) *	2000-11-15	2003-09-10	Third Wave Technologies, Inc.	Fen endonucleases
US7309573B2 (en) *	2000-11-21	2007-12-18	Stratagene California	Methods for detection of a nucleic acid by sequential amplification
US20050267061A1 (en) *	2004-04-08	2005-12-01	Sangamo Biosciences, Inc.	Methods and compositions for treating neuropathic and neurodegenerative conditions
US7157232B2 (en) *	2000-12-13	2007-01-02	The Regents Of The University Of California	Method to detect the end-point for PCR DNA amplification using an ionically labeled probe and measuring impedance change
US20020142336A1 (en) *	2001-02-02	2002-10-03	Genome Therapeutics Corporation	Methods for determining a nucleotide at a specific location within a nucleic acid molecule
JP3681729B2 (ja) *	2001-02-15	2005-08-10	タカラバイオ株式会社	塩基置換の検出方法
EP1236804A1 (en)	2001-03-02	2002-09-04	Boehringer Mannheim Gmbh	A method for determination of a nucleic acid using a control
US6713620B2 (en) *	2001-03-28	2004-03-30	Council Of Scientific And Industrial Research	Oligonucleotide primers for phosphotidyl inositol in bacillus cereus
US7329223B1 (en) *	2001-05-31	2008-02-12	Abbott Cardiovascular Systems Inc.	Catheter with optical fiber sensor
US7532920B1 (en)	2001-05-31	2009-05-12	Advanced Cardiovascular Systems, Inc.	Guidewire with optical fiber
CA2348042A1 (en)	2001-06-04	2002-12-04	Ann Huletsky	Sequences for detection and identification of methicillin-resistant staphylococcus aureus
US7235358B2 (en)	2001-06-08	2007-06-26	Expression Diagnostics, Inc.	Methods and compositions for diagnosing and monitoring transplant rejection
US6905827B2 (en) *	2001-06-08	2005-06-14	Expression Diagnostics, Inc.	Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7026121B1 (en)	2001-06-08	2006-04-11	Expression Diagnostics, Inc.	Methods and compositions for diagnosing and monitoring transplant rejection
WO2003002959A1 (en) *	2001-06-15	2003-01-09	Mj Research, Inc.	Controller for a fluorometer
US9261460B2 (en)	2002-03-12	2016-02-16	Enzo Life Sciences, Inc.	Real-time nucleic acid detection processes and compositions
US6514750B2 (en) *	2001-07-03	2003-02-04	Pe Corporation (Ny)	PCR sample handling device
EP1275735A1 (en) *	2001-07-11	2003-01-15	Roche Diagnostics GmbH	Composition and method for hot start nucleic acid amplification
WO2003052116A2 (en) *	2001-07-17	2003-06-26	Stratagene	Methods for detection of a target nucleic acid using multi-subunit probes
US6852491B2 (en)	2001-09-04	2005-02-08	Abbott Laboratories	Amplification and detection reagents for HIV-1
US6593091B2 (en)	2001-09-24	2003-07-15	Beckman Coulter, Inc.	Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer
WO2003033741A1 (en) *	2001-10-16	2003-04-24	Aclara Biosciences, Inc.	Universal e-tag primer and probe compositions and methods
US6942836B2 (en) *	2001-10-16	2005-09-13	Applera Corporation	System for filling substrate chambers with liquid
AU2002366046A1 (en)	2001-10-19	2003-06-10	Proligo Llc	Nucleic acid probes and methods to detect and/or quantify nucleic acid analytes
US20030165859A1 (en) *	2001-10-23	2003-09-04	Invitrogen Corporation	Primers and methods for the detection and discrimination of nucleic acids
CN1166422C (zh) *	2001-11-05	2004-09-15	北京源德生物医学工程股份有限公司	用于体外高能聚焦超声波治疗机的坐位架
DE10153829A1 (de) *	2001-11-05	2003-05-28	Bayer Ag	Assay basierend auf dotierten Nanoteilchen
US20050053939A1 (en) *	2001-11-09	2005-03-10	Ahmed Chenna	Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
EP1456409B1 (en) *	2001-11-28	2010-02-24	Bio-Rad Laboratories, Inc.	Parallel polymorphism scoring by amplification and error correction
WO2003048295A1 (en)	2001-11-30	2003-06-12	Fluidigm Corporation	Microfluidic device and methods of using same
US7223538B2 (en) *	2001-12-14	2007-05-29	Ge Healthcare Bio-Sciences Ab	Post-synthesis labeling of nucleic acids, assays using nucleic acids that are labeled post-synthetically, single nucleotide polymorphism detection, and associated compounds and microarrays
US7198897B2 (en) *	2001-12-19	2007-04-03	Brandeis University	Late-PCR
ES2294287T5 (es)	2002-01-08	2015-10-27	F. Hoffmann-La Roche Ag	Empleo de un material de sílice en una reacción de amplificación
WO2003064679A2 (en) *	2002-01-30	2003-08-07	Id Biomedical Corporation	Methods for detecting vancomycin-resistant microorganisms and compositions therefor
AU2003225629A1 (en) *	2002-02-27	2003-09-09	University Of Delaware	Molecular markers for identification of fat and lean phenotypes in chickens
EP1340818A1 (en) *	2002-02-27	2003-09-03	Epigenomics AG	Method and nucleic acids for the analysis of a colon cell proliferative disorder
GB0205455D0 (en)	2002-03-07	2002-04-24	Molecular Sensing Plc	Nucleic acid probes, their synthesis and use
US7166478B2 (en) *	2002-03-12	2007-01-23	Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc.	Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US9353405B2 (en)	2002-03-12	2016-05-31	Enzo Life Sciences, Inc.	Optimized real time nucleic acid detection processes
HUP0200981A3 (en) *	2002-03-14	2004-06-28	Genoid Kft	Pcr reactions with hybridizing probes using primers with broad genotype-specificity for detection of human papilloma-viruses and typing amplificates by using specifically hybridizing oligonucleotides
WO2003083111A1 (fr) *	2002-03-29	2003-10-09	Precision System Science Co.,Ltd.	Bibliotheque d'acides nucleiques et bibliotheque de proteines
US7445893B2 (en) *	2002-04-12	2008-11-04	Primera Biosystems, Inc.	Sampling method for amplification reaction analysis
US7081339B2 (en) *	2002-04-12	2006-07-25	Primera Biosystems, Inc.	Methods for variation detection
US7745180B2 (en)	2002-04-24	2010-06-29	Hitachi Chemical Co., Ltd.	Device and method for high-throughput quantification of mRNA from whole blood
EP1500710A4 (en) *	2002-05-08	2006-10-04	Arkray Inc	METHOD FOR DETECTING TARGET NUCLEIC ACID
US20030219754A1 (en) *	2002-05-23	2003-11-27	Oleksy Jerome E.	Fluorescence polarization detection of nucleic acids
WO2004003136A2 (en) *	2002-06-28	2004-01-08	Sention, Inc.	Methods of detecting sequence differences
US6896727B2 (en) *	2002-06-28	2005-05-24	Seh America, Inc.	Method of determining nitrogen concentration within a wafer
US20040023220A1 (en) *	2002-07-23	2004-02-05	Lawrence Greenfield	Integrated method for PCR cleanup and oligonucleotide removal
FR2842827B1 (fr) *	2002-07-26	2004-10-22	Biocortech	NOUVELLE METHODE D'ANALYSE D'ACIDE NUCLEIQUE ET SON UTILISATION POUR EVALUER LE DEGRE D'EDITION DE L'ARNm DU RECEPTEUR 5-HT2c
EP2385138A1 (en)	2002-07-31	2011-11-09	University of Southern California	Polymorphisms for predicting disease and treatment outcome
AU2003236461B2 (en) *	2002-08-29	2009-05-28	Epigenomics Ag	Improved method for bisulfite treatment
JP4694201B2 (ja) *	2002-09-20	2011-06-08	インテグレイテッドディーエヌエイテクノロジーズインコーポレイテッド	アントラキノン消光色素、それらの製造方法及び使用
US7245789B2 (en) *	2002-10-07	2007-07-17	Vascular Imaging Corporation	Systems and methods for minimally-invasive optical-acoustic imaging
US7807802B2 (en)	2002-11-12	2010-10-05	Abbott Lab	Polynucleotides for the amplification and detection of Chlamydia trachomatis and Neisseria gonorrhoeae
US7824851B2 (en)	2002-11-15	2010-11-02	Idenix Pharmaceuticals, Inc.	2′-branched nucleosides and Flaviviridae mutation
FI113549B (fi) *	2002-11-19	2004-05-14	Mobidiag Oy	Diagnostinen menetelmä hengitystieinfektioita aiheuttavien bakteerien osoittamiseksi ja tunnistamiseksi ja menetelmässä käyttökelpoinen alukeseos
US20050089875A1 (en) *	2002-11-21	2005-04-28	Sention Inc.	Quantitative analysis of expression profiling information produced at various stages of an amplification process
JP4898119B2 (ja) *	2002-11-22	2012-03-14	エフ．ホフマン−ラロシュアーゲー	検出できるラベルされたヌクレオシド類似体及びその使用方法
US20040248085A1 (en) *	2002-11-29	2004-12-09	Sang-Wha Lee	General primers and process for detecting diverse genotypes of human papillomavirus by PCR
EP2194147B1 (en)	2002-12-04	2015-07-22	Applied Biosystems, LLC	Multiplex amplification of polynucleotides
US7718361B2 (en)	2002-12-06	2010-05-18	Roche Molecular Systems, Inc.	Quantitative test for bacterial pathogens
EP1426447A1 (en) *	2002-12-06	2004-06-09	Roche Diagnostics GmbH	Method for the detection of pathogenic gram positive bacteria selected from the genera Staphylococcus, Enterococcus and Streptococcus
DE60327462D1 (de) *	2002-12-06	2009-06-10	Roche Diagnostics Gmbh	Nachweis, identifizierung und differenzierung von eubakterien unter verwendung eines hybridisierungs-assays
WO2004053155A1 (en) *	2002-12-06	2004-06-24	Roche Diagniostics Gmbh	Multiplex assay detection of pathogenic organisms
US8206904B2 (en)	2002-12-18	2012-06-26	Third Wave Technologies, Inc.	Detection of nucleic acids
US7851150B2 (en) *	2002-12-18	2010-12-14	Third Wave Technologies, Inc.	Detection of small nucleic acids
ATE386141T1 (de) *	2002-12-20	2008-03-15	Stratagene Inc	Zusammensetzungen und verfahren für den nachweis von polynukleotiden
EP2500440B1 (en)	2002-12-20	2015-12-16	Celera Corporation	Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
US7560231B2 (en) *	2002-12-20	2009-07-14	Roche Molecular Systems, Inc.	Mannitol and glucitol derivatives
US7514212B2 (en) *	2003-01-17	2009-04-07	Eragen Biosciences, Inc.	Nucleic acid amplification using non-standard bases
ATE373673T1 (de) *	2003-01-29	2007-10-15	Hoffmann La Roche	Verbessertes verfahren zur behandlung durch bisulfit
EP1601955B1 (en) *	2003-03-07	2013-01-09	Luxcel Biosciences Limited	An oxygen sensitive probe and method for measuring oxygen uptake
WO2004085670A2 (en) *	2003-03-24	2004-10-07	Perkinelmer Las, Inc.	Polarization detection
WO2004092412A2 (en) *	2003-03-31	2004-10-28	Roche Diagnostics Gmbh	Compositions and methods for detecting certain flaviviruses, including members of the japanese encephalitis virus serogroup
EP1615942B1 (en)	2003-04-01	2016-03-16	Luminex Corporation	Polymerase inhibitor and method of using same
AU2004228678A1 (en)	2003-04-03	2004-10-21	Fluidigm Corp.	Microfluidic devices and methods of using same
CA2463719A1 (en) *	2003-04-05	2004-10-05	F. Hoffmann-La Roche Ag	Nucleotide analogs with six membered rings
WO2004094986A2 (en) *	2003-04-16	2004-11-04	Handylab, Inc.	System and method for electrochemical detection of biological compounds
US20040214176A1 (en) *	2003-04-22	2004-10-28	Osborne James C.	Multiplexed DNA assays using structure-specific endonucleases
US20060263813A1 (en) *	2005-05-11	2006-11-23	Expression Diagnostics, Inc.	Methods of monitoring functional status of transplants using gene panels
US7892745B2 (en) *	2003-04-24	2011-02-22	Xdx, Inc.	Methods and compositions for diagnosing and monitoring transplant rejection
US7148043B2 (en)	2003-05-08	2006-12-12	Bio-Rad Laboratories, Inc.	Systems and methods for fluorescence detection with a movable detection module
PL1626714T3 (pl)	2003-05-20	2007-12-31	Bayer Healthcare Llc	Diarylowe pochodne mocznika do schorzeń, w których pośredniczy PDGFR
DE10327756B4 (de) *	2003-06-18	2005-12-29	november Aktiengesellschaft Gesellschaft für Molekulare Medizin	Verfahren zum Echtzeit-Quantifizieren einer Nukleinsäure
WO2005003373A2 (en) *	2003-06-26	2005-01-13	Proligo, Llc	Fluorogenic nucleic acid probes including lna for methods to detect and/or quantify nucleic acid analytes
US20050233314A1 (en) *	2003-06-30	2005-10-20	National Health Research Institutes	Sensitive and quantitative detection of pathogens by real-time nested PCR
GB0317592D0 (en) *	2003-07-26	2003-08-27	Astrazeneca Ab	Method
EP1650300B1 (en)	2003-07-29	2012-02-08	Otsuka Pharmaceutical Co., Ltd.	Method of judging risk for drug-induced granulocytopenia
EP1502958A1 (en) *	2003-08-01	2005-02-02	Roche Diagnostics GmbH	New detection format for hot start real time polymerase chain reaction
EP1502961B1 (en) *	2003-08-01	2010-09-08	Roche Diagnostics GmbH	New detection format for hot start real time polymerase chain reaction
WO2005029041A2 (en) *	2003-09-19	2005-03-31	Applera Corporation	High density sequence detection methods and apparatus
EP1704246A4 (en) *	2003-09-30	2007-11-28	Perkinelmer Las Inc	COMPOSITIONS AND METHODS FOR GENOTYPING POLYMORPHISMS OF A SINGLE NUCLEOTIDE
US7348146B2 (en) *	2003-10-02	2008-03-25	Epoch Biosciences, Inc.	Single nucleotide polymorphism analysis of highly polymorphic target sequences
CA2482097C (en) *	2003-10-13	2012-02-21	F. Hoffmann-La Roche Ag	Methods for isolating nucleic acids
CA2542542C (en)	2003-10-21	2015-09-15	Orion Genomics Llc	Method of detecting a quantity of methylation at a locus
US20050130246A1 (en) *	2003-10-27	2005-06-16	Hossein Salimi-Moosavi	Detecting human anti-therapeutic antibodies
US7381818B2 (en) *	2003-10-28	2008-06-03	Epoch Biosciences, Inc.	Fluorescent probes containing 5′-minor groove binder, fluorophore and quenching moieties and methods of use thereof
EP1682898A2 (en) *	2003-11-04	2006-07-26	Roche Diagnostics GmbH	Method for distinguishing aml subtypes with recurring genetic aberrations
US20070128607A1 (en) *	2003-11-04	2007-06-07	Martin Dugas	Method for distinguishing aml subtypes with different gene dosages
EP1682901A2 (en) *	2003-11-04	2006-07-26	Roche Diagnostics GmbH	Method for distinguishing leukemia subtypes
WO2005045435A2 (en) *	2003-11-04	2005-05-19	Roche Diagnostics Gmbh	METHOD FOR DISTINGUISHING T(11q23)/MLL-POSITIVE LEUKEMIAS FROM T(11q23)MLL NEGATIVE LEUKEMIAS
EP1530046A1 (en) *	2003-11-04	2005-05-11	Ludwig-Maximilians-Universität München	Method for distinguishing AML subtypes with aberrant and prognostically intermediate karyotypes
EP1682897A2 (en) *	2003-11-04	2006-07-26	Roche Diagnostics GmbH	Method for distinguishing immunologically defined all subtypes
US20070212688A1 (en) *	2003-11-04	2007-09-13	Martin Dugas	Method For Distinguishing Cbf-Positive Aml Subtypes From Cbf-Negative Aml Subtypes
EP1682902A2 (en) *	2003-11-04	2006-07-26	Roche Diagnostics GmbH	Method for distinguishing mll-ptd-positive aml from other aml subtypes
WO2005043168A2 (en) *	2003-11-04	2005-05-12	Roche Diagnostics Gmbh	Method for distinguishing aml-specific flt3 length mutations from tkd mutations
EP1533618A1 (en) *	2003-11-04	2005-05-25	Ludwig-Maximilians-Universität München	Method for distinguishing prognostically definable AML
US20050261841A1 (en) *	2003-11-07	2005-11-24	Shepard Donald F	Physical geolocation system
JP4912151B2 (ja)	2003-11-12	2012-04-11	バイエル・ヘルスケア・エルエルシー	西ナイルウイルスを検出するためのオリゴヌクレオチドおよび方法
US7439341B2 (en) *	2003-11-14	2008-10-21	Integrated Dna Technologies, Inc.	Fluorescence quenching azo dyes, their methods of preparation and use
WO2005051967A2 (en) *	2003-11-19	2005-06-09	Allelogic Biosciences Corp.	Oligonucleotides labeled with a plurality of fluorophores
WO2005054435A2 (en) *	2003-11-26	2005-06-16	Eppendorf Ag	Methods and compositions for in vitro amplification of extrachromosomal nucleic acid
EP2386657B1 (en)	2003-11-26	2014-01-08	Celera Corporation	Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
CA2494571C (en) *	2003-12-02	2010-02-09	F.Hoffmann-La Roche Ag	Oligonucleotides containing molecular rods
WO2005054502A1 (en)	2003-12-02	2005-06-16	Roche Diagnostics Gmbh	Improved method for bisulfite treatment
US7985585B2 (en)	2004-07-09	2011-07-26	Viacyte, Inc.	Preprimitive streak and mesendoderm cells
US7625753B2 (en)	2003-12-23	2009-12-01	Cythera, Inc.	Expansion of definitive endoderm cells
US8647873B2 (en)	2004-04-27	2014-02-11	Viacyte, Inc.	PDX1 expressing endoderm
US20050266554A1 (en)	2004-04-27	2005-12-01	D Amour Kevin A	PDX1 expressing endoderm
US8586357B2 (en)	2003-12-23	2013-11-19	Viacyte, Inc.	Markers of definitive endoderm
WO2005063971A2 (en)	2003-12-23	2005-07-14	Cythera, Inc	Definitive endoderm
US7541185B2 (en)	2003-12-23	2009-06-02	Cythera, Inc.	Methods for identifying factors for differentiating definitive endoderm
EP1716249A2 (en) *	2003-12-31	2006-11-02	Applera Corporation, Applied Biosystems Group	Quantitative amplification and detection of small numbers of target polynucleotides
EP1713925B9 (en)	2004-01-07	2012-09-05	Hitachi Chemical Research Center, Inc.	Primers and probes for the detection of hiv
JP4969250B2 (ja) *	2004-02-06	2012-07-04	イノジェネティックス・ナムローゼ・フェンノートシャップ	スペーサー領域を使用するプロテウス種の検出、同定、および区別
EP1716257B8 (en) *	2004-02-10	2012-11-07	Roche Diagnostics GmbH	New primers and probes for the detection of parvovirus b19
WO2005080596A1 (en) *	2004-02-19	2005-09-01	University College Cork - National University Of Ireland, Cork	Detection of biologically active compounds
EP1721011A1 (en)	2004-03-01	2006-11-15	Applera Corporation	Methods, compositions and kits for use in polynucleotide amplification
US8679788B2 (en)	2004-03-22	2014-03-25	The Johns Hopkins University	Methods for the detection of nucleic acid differences
KR100906749B1 (ko) *	2004-03-25	2009-07-09	(주)바이오니아	인터컬레이팅 형광염료가 표지된 프로브를 이용한 핵산 증폭 측정 방법
JP4972541B2 (ja)	2004-04-01	2012-07-11	バイオ−ラッドラボラトリーズインコーポレーティッド	標識されたプローブおよび３’→５’エキソヌクレアーゼ活性を用いた定量的増幅方法
CA2561565C (en) *	2004-04-08	2013-11-26	Sangamo Biosciences, Inc.	Methods for repression of phospholamban gene and modulating cardiac contractility
US8044184B2 (en) *	2004-04-26	2011-10-25	Wako Pure Chemical Industries, Ltd.	Probe and primer for tubercle bacillus detection, and method of detecting human tubercle bacillus therewith
US7939251B2 (en)	2004-05-06	2011-05-10	Roche Molecular Systems, Inc.	SENP1 as a marker for cancer
EP2423326B1 (en)	2004-05-07	2014-01-08	Celera Corporation	Genetic polymorphism associated with liver fibrosis methods of detection and uses thereof
US20050255485A1 (en) *	2004-05-14	2005-11-17	Livak Kenneth J	Detection of gene duplications
CN100468683C (zh) *	2004-05-17	2009-03-11	株式会社日立国际电气	衬底处理装置
CN101426930A (zh) *	2004-05-25	2009-05-06	日立化成工业株式会社	检测癌症易感性的方法
US7833709B2 (en) *	2004-05-28	2010-11-16	Wafergen, Inc.	Thermo-controllable chips for multiplex analyses
US7575863B2 (en) *	2004-05-28	2009-08-18	Applied Biosystems, Llc	Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
US7307802B2 (en)	2004-06-07	2007-12-11	Fluidigm Corporation	Optical lens system and method for microfluidic devices
EP1609871A1 (en) *	2004-06-21	2005-12-28	Biolytix AG	Methods and kits for the detection, identification and quantification of bacteria and yeast in food and beverages
DK2453024T3 (en)	2004-06-21	2018-02-12	Univ Leland Stanford Junior	Genes and conduits that are differentially expressed in bipolar disorder and / or major depressive disorder
US20070154889A1 (en) *	2004-06-25	2007-07-05	Veridex, Llc	Methods and reagents for the detection of melanoma
US20060216715A1 (en) *	2004-06-28	2006-09-28	Jun Nakayama	Method of detecting cancer
US7745125B2 (en)	2004-06-28	2010-06-29	Roche Molecular Systems, Inc.	2′-terminator related pyrophosphorolysis activated polymerization
WO2006000647A1 (en) *	2004-06-29	2006-01-05	Wallac Oy	Integrated non-homogeneous nucleic acid amplification and detection
US7776530B2 (en) *	2004-06-29	2010-08-17	Wallac Oy	Integrated nucleic acid analysis
US7399614B2 (en) *	2004-06-30	2008-07-15	Applera Corporation	5-methylcytosine detection, compositions and methods therefor
EP1776482A2 (en) *	2004-06-30	2007-04-25	Applera Corporation	Log-linear amplification
AU2005267148A1 (en)	2004-07-01	2006-02-02	University Of Southern California	Genetic markers for predicting disease and treatment outcome
TWI334885B (en) *	2004-07-05	2010-12-21	Food And Drug Administration Dept Of Health	Primers, probes and reference plasmid for detection of meat
EP1767655A4 (en)	2004-07-13	2007-08-01	Takeda Pharmaceutical	METHOD FOR CONTROLLING CELL FUCTIONS
EP1627921B1 (de) *	2004-08-18	2008-08-27	Roche Diagnostics GmbH	Verfahren zur Messung einer Nukleinsäureamplifikation in Real Time beinhaltend die Positionierung eines Reaktionsgefässes relativ zu einer Detektionseinheit
EP1632578A1 (en) *	2004-09-03	2006-03-08	Roche Diagnostics GmbH	DNA decontamination method
WO2006029184A2 (en) *	2004-09-08	2006-03-16	Expression Diagnostics, Inc.	Genes useful for diagnosing and monitoring inflammation related disorders
EP1634965B1 (en)	2004-09-09	2010-01-20	Roche Diagnostics GmbH	Real time PCR with the addition of pyrophosphatase
US20060051796A1 (en) *	2004-09-09	2006-03-09	Inga Boell	Real time PCR with the addition of pyrophosphatase
JP4834553B2 (ja)	2004-09-17	2011-12-14	エーザイ・アール・アンド・ディー・マネジメント株式会社	医薬組成物
ATE494392T1 (de) *	2004-09-21	2011-01-15	Life Technologies Corp	Zweifarbige echtzeit/endpunkt-quantifizierung von mikro-rnas (mirnas)
WO2006035062A1 (en) *	2004-09-30	2006-04-06	Innogenetics N.V.	Detection, identification and differentiation of serratia species using the spacer region
US7166680B2 (en) *	2004-10-06	2007-01-23	Advanced Cardiovascular Systems, Inc.	Blends of poly(ester amide) polymers
JP5543065B2 (ja) *	2004-10-18	2014-07-09	ブランデイズユニバーシティー	核酸増幅のためのプライマー、プローブおよび方法
BRPI0516619B1 (pt) *	2004-10-18	2016-02-10	Univ Brandeis	reagentes, kit de reagentes e conjunto de oligonucleotídeos para realização de uma amplificação por reação em cadeia de polimerase
US20060147954A1 (en) *	2004-10-19	2006-07-06	Wallac Oy	Novel probe and its use in bioaffinity assays
CN101044249B (zh) *	2004-10-20	2012-09-05	日立化成工业株式会社	通过定量mRNA定制给药的方法
EP2316927B1 (en)	2004-10-21	2014-11-05	Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)	Kaspp (lrrk2) gene, its production and use for the detection and treatment of neurodegenerative disorders
CN100441696C (zh) *	2004-10-22	2008-12-10	中国疾病预防控制中心传染病预防控制所	肠出血性大肠杆菌o157：h7菌株的检测方法
CN101068932B (zh)	2004-10-27	2013-02-13	塞弗德公司	封闭系统多阶段核酸扩增反应
CN101048504B (zh)	2004-10-28	2011-06-29	大塚制药株式会社	对干扰素治疗肾细胞癌反应的鉴定标记
EP2280085A3 (en)	2004-11-01	2011-02-23	George Mason University	Compositions and methods for diagnosing colon disorders
WO2006048262A2 (en) *	2004-11-04	2006-05-11	Roche Diagnostics Gmbh	Classification of acute myeloid leukemia
US20060105348A1 (en) *	2004-11-15	2006-05-18	Lee Jun E	Compositions and methods for the detection and discrimination of nucleic acids
US20060275792A1 (en) *	2004-11-15	2006-12-07	Lee Jun E	Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
EP1666150B1 (en)	2004-11-20	2015-01-07	Roche Diagnostics GmbH	Nucleic acid preparation
CA2589746A1 (en) *	2004-12-08	2006-06-15	Cedars-Sinai Medical Center	Methods for diagnosis and treatment of crohn's disease
US20080213762A1 (en) *	2004-12-08	2008-09-04	Takeshi Yamamoto	Method of Gene Sequence Examination
US7842794B2 (en)	2004-12-17	2010-11-30	Roche Molecular Systems, Inc.	Reagents and methods for detecting Neisseria gonorrhoeae
US20060178507A1 (en) *	2004-12-30	2006-08-10	Berry & Associates, Inc.	Fluorous oligonucleotide reagents and affinity purification of oligonucleotides
US20060252032A1 (en) *	2005-01-28	2006-11-09	Third Wave Technologies, Inc.	Detection of human herpesviruses
US7393665B2 (en)	2005-02-10	2008-07-01	Population Genetics Technologies Ltd	Methods and compositions for tagging and identifying polynucleotides
JP4988606B2 (ja) *	2005-02-28	2012-08-01	サンガモバイオサイエンシズインコーポレイテッド	抗血管新生方法及び組成物
US7521188B2 (en) *	2005-03-02	2009-04-21	The Regents Of The University Of Michigan	Optical monitoring of cleaving enzyme activity
EP1930730B1 (en)	2005-03-10	2019-08-14	Gen-Probe Incorporated	Systems and methods to perform assays for detecting or quantifying analytes
CA2967430C (en)	2005-03-10	2018-05-08	Gen-Probe Incorporated	Systems and methods to perform assays for detecting or quantifying analytes within samples
EP2113572B1 (en)	2005-03-11	2012-12-05	Celera Corporation	Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
US20070026423A1 (en) *	2005-03-16	2007-02-01	Thomas Koehler	Method and test kit for the detection of target nucleic acids
US7601498B2 (en) *	2005-03-17	2009-10-13	Biotium, Inc.	Methods of using dyes in association with nucleic acid staining or detection and associated technology
US7776567B2 (en) *	2005-03-17	2010-08-17	Biotium, Inc.	Dimeric and trimeric nucleic acid dyes, and associated systems and methods
WO2006101913A2 (en) *	2005-03-18	2006-09-28	Eragen Biosciences, Inc.	Methods for detecting multiple species and subspecies of neiserria
EP2518161A1 (en)	2005-03-18	2012-10-31	Fluidigm Corporation	Method for detection of mutant alleles
EP2415524A2 (en)	2005-03-30	2012-02-08	F. Hoffmann-La Roche AG	Sealed Device
US20060275798A1 (en) *	2005-04-04	2006-12-07	Steichen John C	Detection of organisms using a media sachet and primer directed nucleic acid amplification
GB2424886A (en)	2005-04-04	2006-10-11	Dxs Ltd	Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
CN101166537B (zh) *	2005-04-28	2013-01-23	日立化成研究中心公司	全血中基因的体外表达作为评定对饮食补充物个体差异的模型
US20070015180A1 (en) *	2005-05-02	2007-01-18	Stratagene California	Oligonucleotide probe/primer compositions and methods for polynucleotide detection
US8242249B2 (en)	2005-05-13	2012-08-14	Wako Pure Chemical Industries, Ltd.	Primer and probe for use in detection of Mycobacterium kansasii and method for detection of Mycobacterium kansasii using the same
CA2601554A1 (en) *	2005-05-20	2006-11-30	Integrated Dna Technologies, Inc.	Compounds and methods for labeling oligonucleotides
US7737281B2 (en) *	2005-05-24	2010-06-15	Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc.	Purine based fluorescent dyes
US8362250B2 (en)	2005-05-24	2013-01-29	Enzo Biochem, Inc.	Fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest
US8357801B2 (en)	2005-05-24	2013-01-22	Enzo Life Sciences, Inc.	Labeling of target molecules, identification of organelles and other applications, novel compositions, methods and kits
US7569695B2 (en) *	2005-05-24	2009-08-04	Enzo Life Sciences, Inc.	Dyes for the detection or quantification of desirable target molecules
EP1893777B1 (en)	2005-06-07	2014-10-01	Luminex Corporation	Methods for detection and typing of nucleic acids
ATE493515T1 (de) *	2005-06-08	2011-01-15	Hitachi Chemical Res Ct Inc	Verfahren zur vorhersage der immunreaktion auf neoplastische krankheiten auf der grundlage des mrna-ausdrucksprofil in neoplastischen zellen und stimulierten leukozyten
EP1896602A4 (en) *	2005-06-09	2009-08-12	Epoch Biosciences Inc	IMPROVED AMPLIFICATION PROCESSES ON PRIMER BASIS
US7884260B2 (en) *	2005-06-14	2011-02-08	University Of Chicago	Cell-based screen for agents useful for reducing neuronal demyelination or promoting neuronal remyelination
US7423194B2 (en) *	2005-06-14	2008-09-09	University Of Chicago	Animal models for demyelination disorders
US8053627B2 (en) *	2005-06-14	2011-11-08	University Of Chicago	Methods for treating demyelination disorders
EP2620510B2 (en)	2005-06-15	2020-02-19	Complete Genomics Inc.	Single molecule arrays for genetic and chemical analysis
US20060292577A1 (en) *	2005-06-27	2006-12-28	Purdue Research Foundation	Neoplasia-specific splice variants and methods
US20060292578A1 (en)	2005-06-28	2006-12-28	Weidong Zheng	DNA polymerase blends and mutant DNA polymerases
US8067208B2 (en)	2005-06-30	2011-11-29	Roche Molecular Systems, Inc.	Probes and methods for hepatitis C virus typing using multidimensional probe analysis
US9512483B2 (en) *	2005-07-09	2016-12-06	Lovelace Respiratory Research Institute	Gene methylation as a biomarker in sputum
US20070020671A1 (en) *	2005-07-12	2007-01-25	Radtkey Ray R	Method for detecting large mutations and duplications using control amplification comparisons to paralogous genes
US7977108B2 (en) *	2005-07-25	2011-07-12	Roche Molecular Systems, Inc.	Method for detecting a mutation in a repetitive nucleic acid sequence
BRPI0614445B8 (pt)	2005-07-26	2021-07-27	Merck & Co Inc	ensaio de ácido nucleico para resistência de fármaco de equinocandina em fungos suscetíveis aos fármacos de equinocandina e contendo o gene fks1 que corresponde a subunidade fks1p 1,3-?-d-glicano sintase, bem como conjunto de oligonucleotídeos e kit de reagentes de amplificação
US9006240B2 (en)	2005-08-02	2015-04-14	Eisai R&D Management Co., Ltd.	Method for assay on the effect of vascularization inhibitor
WO2007019410A2 (en) *	2005-08-05	2007-02-15	The Board Of Trustees Of The Leland Stanford Junior University	Mammalian obestatin receptors
ES2494922T3 (es) *	2005-09-01	2014-09-16	Ausdiagnostics Pty Ltd.	Métodos para la amplificación, cuantificación e identificación de ácidos nucleicos
ATE472100T1 (de)	2005-09-06	2010-07-15	Hoffmann La Roche	Vorrichtung mit komprimierbarer matrix und homogenem strömungsprofil
US7799530B2 (en)	2005-09-23	2010-09-21	Celera Corporation	Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
CA2624917C (en) *	2005-10-05	2013-07-09	F. Hoffmann-La Roche Ag	Non-fluorescent energy transfer
EP2546360A1 (en)	2005-10-07	2013-01-16	Callida Genomics, Inc.	Self-assembled single molecule arrays and uses thereof
US11834720B2 (en)	2005-10-11	2023-12-05	Geneohm Sciences, Inc.	Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx
US7838221B2 (en)	2005-10-11	2010-11-23	Geneohm Sciences, Inc.	Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA)
WO2007044974A2 (en) *	2005-10-12	2007-04-19	The Research Foundation Of State University Of New York	Absolute pcr quantification
US20070084706A1 (en) *	2005-10-18	2007-04-19	Shuichi Takayama	Microfluidic cell culture device and method for using same
US20070092904A1 (en) *	2005-10-19	2007-04-26	Biogen Idec Ma Inc.	Method for preparing limiting quantities of nucleic acids
US7781165B2 (en)	2005-10-19	2010-08-24	Roche Diagnostics Operations, Inc.	Benzimidazolium compounds and salts of benzimidazolium compounds for nucleic acid amplification
NZ598088A (en)	2005-10-21	2013-09-27	Univ California	C-kit oncogene mutations in melanoma
CA2528222A1 (en) *	2005-10-31	2007-04-30	Centre For Addiction And Mental Health	Slc1a1 marker for anxiety disorder
US20100248220A1 (en) *	2005-11-07	2010-09-30	Siemens Healthcare Diagnostics Inc.	Chlamydia Trachomatis Specific Oligonucleotide Sequences
US20090233842A1 (en)	2005-11-12	2009-09-17	Prtzker Neuropsychiatric Research Fund Llc	Fgf2-related methods for diagnosing and treating depression
WO2007120208A2 (en) *	2005-11-14	2007-10-25	President And Fellows Of Harvard College	Nanogrid rolling circle dna sequencing
ATE443072T1 (de)	2005-11-23	2009-10-15	Roche Diagnostics Gmbh	Polynukleotid mit phosphatmimetikum
DK2463388T3 (en)	2005-11-29	2018-02-26	Cambridge Entpr Ltd	Markers for breast cancer
EP1798542A1 (en)	2005-12-19	2007-06-20	Roche Diagnostics GmbH	Analytical method and instrument
EP1798650A1 (en)	2005-12-19	2007-06-20	Roche Diagnostics GmbH	Analytical method and instrument
KR100652903B1 (ko) *	2005-12-21	2006-12-04	한국과학기술연구원	초흡수성 고분자를 함유한 제습제의 제조 방법 및 그 제조장치
US7981606B2 (en) *	2005-12-21	2011-07-19	Roche Molecular Systems, Inc.	Control for nucleic acid testing
US20070166740A1 (en)	2006-01-17	2007-07-19	Somalogic, Incorporated	Multiplexed analyses of test samples
CA2677522A1 (en) *	2006-02-06	2007-08-16	Kvaegavlsforeningen Dansire	Qtls for udder health characteristics in cattle
WO2007092538A2 (en)	2006-02-07	2007-08-16	President And Fellows Of Harvard College	Methods for making nucleotide probes for sequencing and synthesis
WO2007090401A2 (en) *	2006-02-08	2007-08-16	Aarhus Universitet	Calving characteristics
EP1989324B1 (en) *	2006-02-27	2011-05-18	Roche Diagnostics GmbH	Pcr hot start by magnesium sequestration
BRPI0708439A2 (pt) *	2006-03-01	2011-05-31	Perlegen Sciences Inc	marcadores para vìcio
EP1992703B1 (en)	2006-03-13	2012-04-11	Wako Pure Chemical Industries, Ltd.	Method for detection of mutant gene
RU2394915C2 (ru) *	2006-03-24	2010-07-20	Александр Борисович Четверин	Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления
US20070264694A1 (en) *	2006-04-07	2007-11-15	Eragen Biosciences, Inc.	Use of non-standard bases and proximity effects for gene assembly and conversion of non-standard bases to standard bases during dna synthesis
US20090311684A1 (en) *	2006-04-07	2009-12-17	Hitachi Chemical Co., Ltd	Enhanced fc receptor-mediated tumor necrosis factor superfamily and chemokine mrna expression in peripheral blood leukocytes in patients with rheumatoid arthritis
WO2008051290A2 (en) *	2006-04-07	2008-05-02	Xdx, Inc.	Steroid responsive nucleic acid expression and prediction of disease activity
AU2007235282A1 (en) *	2006-04-07	2007-10-18	Siemens Healthcare Diagnostics Inc.	Neisseria gonorrhoeae specific oligonucleotide sequences
JP5027209B2 (ja) *	2006-04-07	2012-09-19	日立化成工業株式会社	クローン病患者の末梢血白血球におけるＴ細胞受容体介在性腫瘍壊死因子スーパーファミリー及びケモカインのｍＲＮＡ発現の増強
WO2007123553A1 (en) *	2006-04-24	2007-11-01	Xiyu Jia	Methods for detection of methylated dna
JP2009535033A (ja) *	2006-04-28	2009-10-01	バイオジェン・アイデック・エムエイ・インコーポレイテッド	Ｃｒｉｐｔｏ−３の検出のための組成物および方法
WO2007127454A2 (en)	2006-04-28	2007-11-08	Cythera, Inc.	Hepatocyte lineage cells
US8349556B2 (en)	2006-04-28	2013-01-08	Igor Kutyavin	Use of base-modified deoxynucleoside triphosphates to improve nucleic acid detection
US9121056B2 (en) *	2006-04-28	2015-09-01	Igor Kutyavin	Use of products of PCR amplification carrying elements of secondary structure to improve PCR-based nucleic acid detection
US8900828B2 (en)	2006-05-01	2014-12-02	Cepheid	Methods and apparatus for sequential amplification reactions
US8188256B2 (en)	2006-05-02	2012-05-29	Wako Pure Chemical Industries, Ltd.	Primer and probe for detection of Mycobacterium intracellulare
EP2015783A4 (en) *	2006-05-08	2010-07-21	Hitachi Chemical Co Ltd	METHOD FOR TESTING THE SENSITIVITY OF A MEDICINAL PRODUCT IN SOLID TUMORS BY QUANTIFYING THE EXPRESSION OF mRNA IN THIN CUTS OF TUMOR TISSUE
US20070264638A1 (en) *	2006-05-10	2007-11-15	Sigma-Aldrich Co.	Identification of ginseng and its imposters using genetic variations
US20070264639A1 (en) *	2006-05-10	2007-11-15	Sigma Aldrich, Co.	Identification of Echinacea and its imposters using genetic variations
US8232091B2 (en) *	2006-05-17	2012-07-31	California Institute Of Technology	Thermal cycling system
EP2027251A4 (en)	2006-05-17	2010-05-05	California Inst Of Techn	Thermal cycling system
RU2448708C3 (ru)	2006-05-18	2017-09-28	Эйсай Ар Энд Ди Менеджмент Ко., Лтд.	Противоопухолевое средство против рака щитовидной железы
US7674924B2 (en) *	2006-05-22	2010-03-09	Third Wave Technologies, Inc.	Compositions, probes, and conjugates and uses thereof
CA2653321A1 (en)	2006-05-26	2007-12-06	Althea Technologies, Inc.	Biochemical analysis of partitioned cells
US11001881B2 (en)	2006-08-24	2021-05-11	California Institute Of Technology	Methods for detecting analytes
DE602007012045D1 (de)	2006-06-06	2011-03-03	Gen Probe Inc	Markierte oligonukleotide und ihre verwendung in nukleinsäureverstärkungsverfahren
US7759062B2 (en) *	2006-06-09	2010-07-20	Third Wave Technologies, Inc.	T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
US8119352B2 (en) *	2006-06-20	2012-02-21	Cepheld	Multi-stage amplification reactions by control of sequence replication times
EP1886727A1 (en)	2006-07-14	2008-02-13	Roche Diagnostics GmbH	Analytical device
EP2046989B1 (en)	2006-07-17	2013-03-20	Brandeis University	Specialized oligonucleotides and their use in nucleic acid amplification and detection
US7772390B1 (en)	2006-07-18	2010-08-10	The Regents Of The University Of California	Lipid mediated nucleic acid synthesis
US11525156B2 (en)	2006-07-28	2022-12-13	California Institute Of Technology	Multiplex Q-PCR arrays
US8048626B2 (en)	2006-07-28	2011-11-01	California Institute Of Technology	Multiplex Q-PCR arrays
US20080213824A1 (en) *	2006-08-04	2008-09-04	Ikonisys, Inc.	Synthesis of Labeled Probes
WO2008021431A2 (en) *	2006-08-14	2008-02-21	Xdx, Inc.	Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
US8076067B2 (en) *	2006-08-15	2011-12-13	Genetag Technology, Inc.	Probe-antiprobe compositions and methods for DNA or RNA detection
US11560588B2 (en)	2006-08-24	2023-01-24	California Institute Of Technology	Multiplex Q-PCR arrays
CN101511793B (zh)	2006-08-28	2011-08-03	卫材R&D管理有限公司	针对未分化型胃癌的抗肿瘤剂
EP1900824A1 (en) *	2006-09-14	2008-03-19	Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts	Gene expression signature for the prognosis, diagnosis and therapy of prostate cancer and uses thereof
WO2008063758A2 (en)	2006-10-05	2008-05-29	Massachussetts Institute Of Technology	Multifunctional encoded particles for high-throughput analysis
EP1914303A1 (en) *	2006-10-09	2008-04-23	Qiagen GmbH	Thermus eggertssonii DNA polymerases
EP2431483B1 (en)	2006-10-20	2015-04-01	Celera Corporation	Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
GB0621864D0 (en)	2006-11-02	2006-12-13	Univ Manchester	Assay for fungal infection
US8148067B2 (en) *	2006-11-09	2012-04-03	Xdx, Inc.	Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US20080131880A1 (en) *	2006-11-22	2008-06-05	Bortolin Laura T	PNA-DNA oligomers and methods of use thereof
US8133701B2 (en) *	2006-12-05	2012-03-13	Sequenom, Inc.	Detection and quantification of biomolecules using mass spectrometry
US7902345B2 (en) *	2006-12-05	2011-03-08	Sequenom, Inc.	Detection and quantification of biomolecules using mass spectrometry
EP1932913B1 (en)	2006-12-11	2013-01-16	Roche Diagnostics GmbH	Nucleic acid isolation using polidocanol and derivatives
CA2614069C (en)	2006-12-11	2016-05-03	F. Hoffmann-La Roche Ag	Nucleic acid isolation using polidocanol and derivatives
WO2008076375A2 (en) *	2006-12-13	2008-06-26	Autogenomics, Inc.	Concurrent analysis of multiple patient samples using solid phase addressable multiplex test with high signal-to-noise ratio
KR101433208B1 (ko)	2006-12-13	2014-08-22	루미넥스 코포레이션	실시간으로 ｐｃｒ의 다중 분석을 위한 시스템과 방법
US9938641B2 (en) *	2006-12-18	2018-04-10	Fluidigm Corporation	Selection of aptamers based on geometry
CN103397024B (zh)	2006-12-18	2015-11-25	和光纯药工业株式会社	鸟分枝杆菌检测用引物和探针、以及使用它们检测鸟分枝杆菌的方法
WO2008140612A2 (en)	2006-12-19	2008-11-20	Geneohm Sciences, Inc.	Detection of staphylococcus aureus and identification of methicillin-resistant staphylococcus aureus
WO2008079972A2 (en)	2006-12-20	2008-07-03	Bayer Healthcare Llc	4-{4- [ ({3-tert-butyl-1- [3- (hydroxymethyl) phenyl] - 1h- pyrazol- 5 -yl } carbamoyl) -amin o] -3-chlorophenoxy} -n-methylpyridine-2-carboxamide as an inhibitor of the vegfr kinase for the treatment of cancer
CA2674012A1 (en) *	2006-12-29	2008-07-10	Applera Corporation	Systems and methods for detecting nucleic acids
EP2118310B1 (en) *	2006-12-29	2013-03-06	Applied Biosystems, LLC	Systems and methods for detecting nucleic acids
EP2126117A2 (en) *	2007-01-18	2009-12-02	University Of Southern California	Gene polymorphisms predictive for dual tki therapy
KR20100019409A (ko)	2007-01-22	2010-02-18	웨이퍼젠, 인크.	고효율 화학 반응을 위한 장치 및 방법
EP2119707B1 (en)	2007-01-29	2015-01-14	Eisai R&D Management Co., Ltd.	Composition for treatment of undifferentiated-type of gastric cancer
EP2129789B1 (en)	2007-01-31	2013-03-06	Celera Corporation	Method of determining risk associated with breast cancer metastasis by the determination of a molecular prognostic signature.
AU2008210279B2 (en)	2007-02-02	2013-10-31	Genera Biosystems Limited	Generation of nucleic acid molecules
WO2008098142A2 (en) *	2007-02-08	2008-08-14	Sequenom, Inc.	Nucleic acid-based tests for rhd typing, gender determination and nucleic acid quantification
US20100021917A1 (en) *	2007-02-14	2010-01-28	Cedars-Sinai Medical Center	Methods of using genes and genetic variants to predict or diagnose inflammatory bowel disease
US20100190162A1 (en) *	2007-02-26	2010-07-29	Cedars-Sinai Medical Center	Methods of using single nucleotide polymorphisms in the tl1a gene to predict or diagnose inflammatory bowel disease
GB0703997D0 (en) *	2007-03-01	2007-04-11	Oxitec Ltd	Methods for detecting nucleic sequences
GB0703996D0 (en) *	2007-03-01	2007-04-11	Oxitec Ltd	Nucleic acid detection
DE102007013099A1 (de)	2007-03-14	2008-09-18	Aj Innuscreen Gmbh	Verfahren und Testkit zum schnellen Nachweis spezifischer Nukleinsäuresequenzen, insbesondere zum Nachweis von Mutationen oder SNP's
WO2008116150A2 (en)	2007-03-21	2008-09-25	Cedars-Sinai Medical Center	Ileal pouch-anal anastomosis (ipaa) factors in the treatment of inflammatory bowel disease
WO2008118988A1 (en)	2007-03-26	2008-10-02	Sequenom, Inc.	Restriction endonuclease enhanced polymorphic sequence detection
CN103952470B (zh)	2007-03-28	2017-11-10	信号诊断公司	高解析度分析核酸以检测序列变异的系统和方法
JP5191041B2 (ja) *	2007-04-05	2013-04-24	エフ．ホフマン−ラロシュアーゲー	急速ワンステップｒｔ−ｐｃｒ
EP2147101A2 (en)	2007-04-06	2010-01-27	Virco BVBA	Respiratory syncytial virus (rsv) viral load detection assay
US9290803B2 (en) *	2007-04-12	2016-03-22	University Of Southern California	DNA methylation analysis by digital bisulfite genomic sequencing and digital methylight
ES2659145T3 (es) *	2007-04-13	2018-03-14	Abbott Molecular Inc.	Secuencia de cebador y sonda para detectar Chlamydia trachomatis
EP2150625B1 (en)	2007-04-19	2013-03-20	Molecular Detection Inc.	Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria
US20100184050A1 (en) *	2007-04-26	2010-07-22	Cedars-Sinai Medical Center	Diagnosis and treatment of inflammatory bowel disease in the puerto rican population
US20100144903A1 (en) *	2007-05-04	2010-06-10	Cedars-Sinai Medical Center	Methods of diagnosis and treatment of crohn's disease
ES2373496T3 (es) *	2007-05-04	2012-02-06	Myconostica Limited	Detección de la resistencia a triazol en aspergillus.
BRPI0811271A2 (pt) *	2007-05-31	2015-01-20	Monsanto Technology Llc	Polimorfismos da soja e processos de genotipagem
US20120115131A1 (en)	2007-05-31	2012-05-10	Yale University	Genetic lesion associated with cancer
BRPI0812461A2 (pt)	2007-06-08	2017-06-13	Biogen Idec Inc	método de prever a resposta de um indivíduo a uma terapia, método de tratamento de um distúrbio imunológico, composição e kit
CA2691364C (en)	2007-06-19	2020-06-16	Stratos Genomics, Inc.	High throughput nucleic acid sequencing by expansion
WO2008157801A2 (en)	2007-06-21	2008-12-24	Gen-Probe Incorporated	Instrument and receptacles for performing processes
DE102007029772B4 (de)	2007-06-22	2011-12-08	Aj Innuscreen Gmbh	Verfahren und Schnelltest zum Nachweis spezifischer Nukleinsäuresequenzen
US7635566B2 (en)	2007-06-29	2009-12-22	Population Genetics Technologies Ltd.	Methods and compositions for isolating nucleic acid sequence variants
US9689031B2 (en) *	2007-07-14	2017-06-27	Ionian Technologies, Inc.	Nicking and extension amplification reaction for the exponential amplification of nucleic acids
CA3022666C (en)	2007-07-17	2022-04-19	Somalogic, Inc.	Multiplexed analyses of test samples
US20090023138A1 (en) *	2007-07-17	2009-01-22	Zila Biotechnology, Inc.	Oral cancer markers and their detection
US20090181366A1 (en) *	2007-07-30	2009-07-16	Quest Diagnostics Investments Incorporated	Internal positive control for nucleic acid assays
ES2453108T3 (es)	2007-08-06	2014-04-04	Orion Genomics, Llc	Nuevos polimorfismos de un único nucleótido y combinaciones de polimorfismos nuevos y conocidos para determinar la expresión específica de alelo del gen IGF2
JP2010537637A (ja)	2007-08-27	2010-12-09	アプライドバイオシステムズインコーポレイテッド	Ｐｃｒのための方法および組成物
ATE549419T1 (de)	2007-08-29	2012-03-15	Sequenom Inc	Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
CN101821409B (zh)	2007-08-29	2014-08-27	孟山都技术公司	用于优选性状育种的方法和组合物
DE102007041864B4 (de)	2007-09-04	2012-05-03	Sirs-Lab Gmbh	Verfahren zum Nachweis von Bakterien und Pilzen
CA2698545C (en)	2007-09-07	2014-07-08	Fluidigm Corporation	Copy number variation determination, methods and systems
CA2639416C (en)	2007-09-11	2019-12-31	F. Hoffmann-La Roche Ag	Diagnostic test for susceptibility to b-raf kinase inhibitors
US7695963B2 (en)	2007-09-24	2010-04-13	Cythera, Inc.	Methods for increasing definitive endoderm production
GB2453173A (en) *	2007-09-28	2009-04-01	Dxs Ltd	Polynucleotide primers
CA2703227C (en) *	2007-10-22	2017-02-28	Lgc Limited	Oligonucleotides and uses thereof
US9382585B2 (en) *	2007-10-30	2016-07-05	Complete Genomics, Inc.	Apparatus for high throughput sequencing of nucleic acids
CA2866649A1 (en)	2007-11-01	2009-05-07	University Of Iowa Research Foundation	Rca locus analysis to assess susceptibility to amd and mpgnii
US8039212B2 (en)	2007-11-05	2011-10-18	Celera Corporation	Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
WO2009061640A2 (en) *	2007-11-06	2009-05-14	Siemens Healthcare Diagnostics Inc.	Hepatitis b virus (hbv) specific oligonucleotide sequences
JP5404638B2 (ja) *	2007-11-07	2014-02-05	ザユニヴァーシティオブブリティッシュコロンビア	マイクロ流体デバイスおよびその使用方法
WO2009060945A1 (ja)	2007-11-09	2009-05-14	Eisai R & D Management Co., Ltd.	血管新生阻害物質と抗腫瘍性白金錯体との併用
MX2010005111A (es)	2007-11-16	2010-05-27	Du Pont	Metodo para la deteccion y/o analisis de levaduras y moho en liquidos filtrables.
NZ628598A (en)	2007-11-30	2016-09-30	Genentech Inc	Vegf polymorphisms and anti-angiogenesis therapy
US9551026B2 (en)	2007-12-03	2017-01-24	Complete Genomincs, Inc.	Method for nucleic acid detection using voltage enhancement
US20090197254A1 (en) *	2007-12-14	2009-08-06	Ming-Chou Lee	Variant scorpion primers for nucleic acid amplification and detection
CA3046259C (en)	2007-12-21	2022-09-27	Biomerieux Sa	Detection of methicillin-resistant staphylococcus aureus
US20090186344A1 (en) *	2008-01-23	2009-07-23	Caliper Life Sciences, Inc.	Devices and methods for detecting and quantitating nucleic acids using size separation of amplicons
EP2546344A3 (en)	2008-02-08	2013-04-03	Wako Pure Chemical Industries, Ltd.	Primer and probe for detecting chlamydophilia caviae, as well as chlamydophilia caviae detection method using the same
WO2009103003A2 (en) *	2008-02-15	2009-08-20	Bio-Rad Laboratories, Inc.	Scanning fluorescent reader with diffuser system
US20090221620A1 (en)	2008-02-20	2009-09-03	Celera Corporation	Gentic polymorphisms associated with stroke, methods of detection and uses thereof
JP2011512160A (ja) *	2008-02-20	2011-04-21	アイエムテクノロジーズ，インコーポレイテッド	ポリオーマウイルスの検出
US20090215064A1 (en) *	2008-02-27	2009-08-27	Hitachi Chemical Co., Ltd.	Quantitative assessment of individual cancer susceptibility by measuring dna damage-induced mrna in whole blood
EP2271772B1 (en) *	2008-03-11	2014-07-16	Sequenom, Inc.	Nucleic acid-based tests for prenatal gender determination
KR101419980B1 (ko)	2008-03-15	2014-07-15	홀로직, 인크.	증폭 반응 도중에 핵산 분자를 분석하기 위한 조성물 및 방법
CA2658520C (en) *	2008-03-19	2016-11-08	F. Hoffmann-La Roche Ag	Nucleic acid amplification in the presence of modified randomers
WO2009120808A2 (en)	2008-03-26	2009-10-01	Sequenom, Inc.	Restriction endonuclease enhanced polymorphic sequence detection
EP2108699B1 (en)	2008-04-08	2014-06-25	F.Hoffmann-La Roche Ag	Analytical processing and detection device
US8206925B2 (en) *	2008-04-14	2012-06-26	Medical Diagnostic Laboratories, Llc	Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases
US9249455B2 (en) *	2008-04-18	2016-02-02	Luminex Corporation	Methods for detection and quantification of small RNA
CN102098909B (zh)	2008-04-24	2014-12-31	孟山都技术有限公司	鉴定大豆中亚洲大豆锈病抗性数量性状基因座的方法和其组合物
US9434988B2 (en)	2008-04-30	2016-09-06	Integrated Dna Technologies, Inc.	RNase H-based assays utilizing modified RNA monomers
US8911948B2 (en) *	2008-04-30	2014-12-16	Integrated Dna Technologies, Inc.	RNase H-based assays utilizing modified RNA monomers
DK2644707T3 (en)	2008-04-30	2015-06-29	Integrated Dna Tech Inc	RNase-H-based assays using modified RNA monomers.
CA2723726C (en)	2008-05-13	2017-09-12	Michael M. Becker	Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
EP2123360A1 (en)	2008-05-20	2009-11-25	F.Hoffmann-La Roche Ag	Thermocycling device having a thermocycler module with a thermal switch, method of cooling a heating block in a thermocycler module of a thermocycling device and analytical apparatus
WO2009145181A1 (ja)	2008-05-28	2009-12-03	和光純薬工業株式会社	マイコバクテリウム・イントラセルラー検出用プライマー及びプローブ、並びにこれを用いたマイコバクテリウム・イントラセルラーの検出方法
US8208909B2 (en)	2008-06-02	2012-06-26	West Corporation	System, apparatus and method for availing a mobile call of address information
EP2133434A1 (en)	2008-06-12	2009-12-16	Institut National de la Santé et de la Recherche Médicale (INSERM)	Method for the detection of target nucleic acid
JP2011522552A (ja) *	2008-06-13	2011-08-04	リボックス・ゲーエムベーハー	化学的に修飾されたｒｎａの酵素的合成のための方法
IES20090467A2 (en) *	2008-06-13	2010-03-31	Nat Univ Ireland	Ace2 as a target gene for the molecular identification of yeast and fungal species.
EP2141246A1 (en)	2008-07-01	2010-01-06	Koninklijke Philips Electronics N.V.	Separation-free methods of PCR detection using SERRS
EP2878680B1 (en)	2008-07-09	2016-06-08	Celera Corporation	Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof
EP2147981A1 (en)	2008-07-25	2010-01-27	Biotype AG	Kit and method for evaluating detection properties in amplification reactions
CA2638458A1 (en) *	2008-07-31	2010-01-31	Spartan Bioscience Inc.	Thermal recycling by positioning relative to fixed-temperature source
GB0909333D0 (en)	2009-06-01	2009-07-15	Fu Guoliang	Multiplex amplification and detection
WO2010012464A1 (en)	2008-08-01	2010-02-04	Roche Diagnostics Gmbh	Improved lysis and reverse transcription for mrna quantification
ES2574137T3 (es) *	2008-09-03	2016-06-15	Quantumdx Group Limited	Estrategias y métodos de detección de ácidos nucleicos mediante biosensores
EP3216874A1 (en)	2008-09-05	2017-09-13	TOMA Biosciences, Inc.	Methods for stratifying and annotating cancer drug treatment options
US9250249B2 (en)	2008-09-08	2016-02-02	Enzo Biochem, Inc.	Autophagy and phospholipidosis pathway assays
US9334281B2 (en) *	2008-09-08	2016-05-10	Enzo Life Sciences, Inc.	Fluorochromes for organelle tracing and multi-color imaging
US7910720B2 (en)	2008-09-09	2011-03-22	Roche Diagnostics Operations, Inc.	Polyanion for improved nucleic acid amplification
US20110171649A1 (en) *	2008-09-10	2011-07-14	Igor Kutyavin	Detection of nucleic acids by oligonucleotide probes cleaved in presence of endonuclease v
US8476013B2 (en) *	2008-09-16	2013-07-02	Sequenom, Inc.	Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en)	2008-09-16	2015-02-24	Sequenom, Inc.	Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US9090948B2 (en)	2008-09-30	2015-07-28	Abbott Molecular Inc.	Primers and probes for detecting human papillomavirus and human beta globin sequences in test samples
US20110177969A1 (en) *	2008-10-01	2011-07-21	Cedars-Sinai Medical Center	The role of il17rd and the il23-1l17 pathway in crohn's disease
CA2682439A1 (en)	2008-10-17	2010-04-17	F. Hoffmann-La Roche Ag	Cell monitoring and molecular analysis
ES2527653T3 (es)	2008-10-20	2015-01-28	F. Hoffmann-La Roche Ag	Amplificación específica de alelo usando un cebador con un nucleótido modificado
US20100301398A1 (en)	2009-05-29	2010-12-02	Ion Torrent Systems Incorporated	Methods and apparatus for measuring analytes
US20110189685A1 (en) *	2008-10-22	2011-08-04	Cedars-Sinai Medical Center	Methods of using jak3 genetic variants to diagnose and predict crohn's disease
US8278041B2 (en) *	2008-10-27	2012-10-02	Infraegis, Inc.	Compositions and methods for detecting food-borne pathogens
US7897356B2 (en)	2008-11-12	2011-03-01	Caris Life Sciences	Methods and systems of using exosomes for determining phenotypes
EP2540843B1 (en)	2008-11-05	2014-07-02	Genentech, Inc.	Genetic polymorphisms in age-related macular degeneration
US9365901B2 (en)	2008-11-07	2016-06-14	Adaptive Biotechnologies Corp.	Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
GB2483810B (en)	2008-11-07	2012-09-05	Sequenta Inc	Methods for correlating clonotypes with diseases in a population
US8748103B2 (en)	2008-11-07	2014-06-10	Sequenta, Inc.	Monitoring health and disease status using clonotype profiles
US9394567B2 (en)	2008-11-07	2016-07-19	Adaptive Biotechnologies Corporation	Detection and quantification of sample contamination in immune repertoire analysis
US9506119B2 (en)	2008-11-07	2016-11-29	Adaptive Biotechnologies Corp.	Method of sequence determination using sequence tags
US9528160B2 (en)	2008-11-07	2016-12-27	Adaptive Biotechnolgies Corp.	Rare clonotypes and uses thereof
US8628927B2 (en)	2008-11-07	2014-01-14	Sequenta, Inc.	Monitoring health and disease status using clonotype profiles
EP2352846B1 (en)	2008-11-13	2015-01-07	Riboxx GmbH	Rna detection method
US10669574B2 (en)	2008-11-18	2020-06-02	XCR Diagnostics, Inc.	DNA amplification technology
US20110229471A1 (en) *	2008-11-26	2011-09-22	Cedars-Sinai Medical Center	Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
WO2010067055A1 (en)	2008-12-09	2010-06-17	Oxitec Ltd.	Enhanced taqman probe based amplification
EP2367954B1 (en)	2008-12-19	2015-02-18	Life Technologies Corporation	Proteinase k inhibitors, methods and compositions therefor
CA2688174C (en)	2008-12-19	2018-08-07	F. Hoffmann-La Roche Ag	Dry composition of reaction compounds with stabilized polymerase
WO2010075579A2 (en)	2008-12-24	2010-07-01	Cedars-Sinai Medical Center	Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy
IT1397110B1 (it) *	2008-12-29	2012-12-28	St Microelectronics Rousset	Microreattore autosigillante e metodo per eseguire una reazione
US8206929B2 (en)	2009-01-07	2012-06-26	Roche Molecular Systems, Inc.	Nucleic acid amplification with allele-specific suppression of sequence variants
SG183029A1 (en)	2009-01-13	2012-08-30	Fluidigm Corp	Single-cell nucleic acid analysis
EP2387627B1 (en)	2009-01-15	2016-03-30	Adaptive Biotechnologies Corporation	Adaptive immunity profiling and methods for generation of monoclonal antibodies
WO2010088273A1 (en)	2009-01-27	2010-08-05	Qiagen Gaithersburg	Thermophilic helicase dependent amplification technology with endpoint homogenous fluorescent detection
EP2393939B1 (en)	2009-02-06	2014-09-17	Yale University	A snp marker of breast and ovarian cancer risk
EP2955234A1 (en)	2009-02-11	2015-12-16	Orion Genomics, LLC	Combinations of polymorphisms for determining allele-specific expression of igf2
JP5457222B2 (ja)	2009-02-25	2014-04-02	エフ．ホフマン−ラロシュアーゲー	小型化ハイスループット核酸分析
US9347092B2 (en) *	2009-02-25	2016-05-24	Roche Molecular System, Inc.	Solid support for high-throughput nucleic acid analysis
US8039215B2 (en)	2009-03-10	2011-10-18	Roche Molecular Systems, Inc.	Multiplex quantitative nucleic acid amplification and melting assay
AU2010224100B2 (en)	2009-03-12	2015-10-22	Brandeis University	Reagents and methods for PCR
US20100279295A1 (en) *	2009-03-18	2010-11-04	Sequenom, Inc.	Use of thermostable endonucleases for generating reporter molecules
WO2010112033A2 (en)	2009-03-31	2010-10-07	Østjysk Innovation A/S	Method for estimating the risk of having or developing multiple sclerosis using sequence polymorphisms in a specific region of chromosome x
EP2789694A1 (en)	2009-04-02	2014-10-15	Fluidigm Corporation	Microfluidic device with reaction product recovery system
EP2414504A4 (en) *	2009-04-03	2013-08-28	Illumina Inc	DEVICES AND METHOD FOR HEATING BIOLOGICAL SAMPLES
WO2010116290A1 (en)	2009-04-07	2010-10-14	Koninklijke Philips Electronics N.V.	Method for the detection and characterization of a toxinogenic clostridium difficile strain
RU2011147195A (ru)	2009-04-22	2013-05-27	Вертекс Фармасьютикалз Инкорпорейтед	Набор зондов для идентификации нуклеотидной мутации и способ идентификации нуклеотидной мутации
US20120100997A1 (en)	2009-04-24	2012-04-26	University Of Southern California	Cd133 polymorphisms and expression predict clinical outcome in patients with cancer
WO2010126614A2 (en)	2009-04-30	2010-11-04	Good Start Genetics, Inc.	Methods and compositions for evaluating genetic markers
US12129514B2 (en)	2009-04-30	2024-10-29	Molecular Loop Biosolutions, Llc	Methods and compositions for evaluating genetic markers
EP2256215A1 (en)	2009-04-30	2010-12-01	Steffen Mergemeier	Assay system using a nuclease activity of a nucleic acid polymerase
EP2248915B1 (en) *	2009-05-05	2013-09-18	Qiagen GmbH	Detection of multiple nucleic acid sequences in a reaction cartridge
US20100299773A1 (en) *	2009-05-20	2010-11-25	Monsanto Technology Llc	Methods and compositions for selecting an improved plant
US20120122161A1 (en)	2009-05-22	2012-05-17	Esther Musgrave-Brown	Sorting Asymmetrically Tagged Nucleic Acids by Selective Primer Extension
EP2267153A1 (en)	2009-05-26	2010-12-29	Université Claude Bernard Lyon 1	Identification of netrin-1 receptor unc5c gene mutation in solid cancers
US20110237537A1 (en) *	2009-05-29	2011-09-29	Lombard Jay L	Methods for assessment and treatment of mood disorders via single nucleotide polymorphisms analysis
US20100304391A1 (en) *	2009-05-29	2010-12-02	Lombard Jay L	Methods for assessment and treatment of depression via utilization of single nucleotide polymorphisms analysis
US8776573B2 (en)	2009-05-29	2014-07-15	Life Technologies Corporation	Methods and apparatus for measuring analytes
US8355927B2 (en)	2010-11-05	2013-01-15	Genomind, Llc	Neuropsychiatric test reports
EP3301104B1 (en)	2009-05-29	2019-10-30	Life Technologies Corporation	Scaffolded nucleic acid polymer particles and methods of making and using
US20120261274A1 (en)	2009-05-29	2012-10-18	Life Technologies Corporation	Methods and apparatus for measuring analytes
US20100330571A1 (en)	2009-06-25	2010-12-30	Robins Harlan S	Method of measuring adaptive immunity
US20120156676A1 (en)	2009-06-25	2012-06-21	Weidhaas Joanne B	Single nucleotide polymorphisms in brca1 and cancer risk
IL206810A (en)	2009-07-08	2015-07-30	Janssen Diagnostics Llc	Methods for identifying melanoma and kits for using these methods
CA2767616A1 (en)	2009-07-09	2011-01-13	The Scripps Research Institute	Gene expression profiles associated with chronic allograft nephropathy
WO2011008640A1 (en)	2009-07-14	2011-01-20	Beth Israel Deaconess Medical Center, Inc.	Methods of increasing liver proliferation
BR112012001411A2 (pt)	2009-07-22	2019-09-24	Du Pont	sequencias e seu uso para detecção e caracterização de e. coli 0157:h7
WO2011020075A2 (en)	2009-08-13	2011-02-17	Life Technologies Corporation	Amelogenin snp on chromosome x
WO2011021102A2 (en)	2009-08-20	2011-02-24	Population Genetics Technologies Ltd	Compositions and methods for intramolecular nucleic acid rearrangement
JP2013503352A (ja) *	2009-08-31	2013-01-31	エムバイオダイアグノスティクス，インコーポレイティド	統合されたサンプル調製及び検体検出
US8987685B2 (en) *	2009-09-09	2015-03-24	Pcr Max Limited	Optical system for multiple reactions
WO2011030091A1 (en)	2009-09-11	2011-03-17	Myconostica Limited	Assay for candida species
KR101590175B1 (ko) *	2009-09-24	2016-01-29	주식회사 씨젠	반복적 엑소핵산 절단 반응에 의한 타겟 핵산서열의 검출
US9914963B2 (en)	2009-09-28	2018-03-13	Igor Kutyavin	Methods and compositions for detection of nucleic acids based on stabilized oligonucleotide probe complexes
MX2012004306A (es)	2009-10-21	2012-04-30	Genentech Inc	Polimorfismos geneticos en degeneracion macular relacionada con la edad.
EP2491146B1 (en) *	2009-10-23	2017-09-20	Luminex Corporation	Amplification primers with non-standard bases for increased reaction specificity
WO2011050938A1 (de)	2009-10-26	2011-05-05	Genovoxx Gmbh	Konjugate von nukleotiden und methoden zu deren anwendung
US20110129832A1 (en) *	2009-10-27	2011-06-02	Swift Biosciences, Inc.	Polynucleotide Primers and Probes
WO2011053845A2 (en)	2009-10-30	2011-05-05	Illumina, Inc.	Microvessels, microparticles, and methods of manufacturing and using the same
BR112012010251A2 (pt)	2009-10-30	2018-03-20	The Board Of Trustes Of The Leland Stanford Junior Univ	mutações de gna11 em melanoma
US20120245041A1 (en)	2009-11-04	2012-09-27	Sydney Brenner	Base-by-base mutation screening
KR20110050327A (ko)	2009-11-07	2011-05-13	주식회사 씨젠	Ｔｈｄ 프라이머 타겟 검출
BR112012011262A2 (pt)	2009-11-13	2019-09-24	Beckman Coulter Inc	sistemas e métodos para detectar a presença de um estado biológico usando aglomeração
BR112012011280A2 (pt)	2009-11-13	2019-09-24	Beckman Coulter Inc	sistemas e metodos para detectar a presenca de um status biologico usando grafico
US20110117546A1 (en) *	2009-11-18	2011-05-19	Microfluidic Systems, Inc.	Increase of signal sensitivity using dual probes in pcr reactions
US9133343B2 (en) *	2009-11-30	2015-09-15	Enzo Biochem, Inc.	Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
AU2010324594B2 (en)	2009-11-30	2016-09-15	Caris Life Sciences Switzerland Holdings Gmbh	Methods and systems for isolating, storing, and analyzing vesicles
EP3321380B1 (en)	2009-12-03	2023-09-06	Quest Diagnostics Investments Incorporated	Methods for the diagnosis of bacterial vaginosis
US8614071B2 (en)	2009-12-11	2013-12-24	Roche Molecular Systems, Inc.	Preferential amplification of mRNA over DNA using chemically modified primers
US9238832B2 (en)	2009-12-11	2016-01-19	Roche Molecular Systems, Inc.	Allele-specific amplification of nucleic acids
EP2516679B1 (en)	2009-12-21	2017-08-23	Seegene, Inc.	Tsg primer target detection
WO2011084757A1 (en)	2009-12-21	2011-07-14	University Of Southern California	Germline polymorphisms in the sparc gene associated with clinical outcome in gastric cancer
DK2516680T3 (en)	2009-12-22	2016-05-02	Sequenom Inc	Method and kits to identify aneuploidy
US8877437B1 (en)	2009-12-23	2014-11-04	Biotium, Inc.	Methods of using dyes in association with nucleic acid staining or detection
WO2011085334A1 (en)	2010-01-11	2011-07-14	University Of Southern California	Cd44 polymorphisms predict clinical outcome in patients with gastric cancer
AU2011205230A1 (en)	2010-01-13	2012-08-02	Caris Life Sciences Switzerland Holdings Gmbh	Detection of gastrointestinal disorders
EP2534263B1 (en)	2010-02-09	2020-08-05	Unitaq Bio	Methods and compositions for universal detection of nucleic acids
US20130053253A1 (en)	2010-02-22	2013-02-28	Population Genetics Technologies Ltd	Region of Interest Extraction and Normalization Methods
KR20130056855A (ko)	2010-03-01	2013-05-30	카리스 라이프 사이언스 룩셈부르크 홀딩스	치료진단용 생물학적 지표들
WO2011107887A2 (en)	2010-03-02	2011-09-09	Population Genetic Technologies Ltd.	Methods for replicating polynucleotides with secondary structure
US9458513B2 (en)	2010-03-23	2016-10-04	Wako Pure Chemical Industries, Ltd.	Primer and probe for detecting chlamydia trachomatis, and method for detecting chlamydia trachomatis using same
US9506057B2 (en)	2010-03-26	2016-11-29	Integrated Dna Technologies, Inc.	Modifications for antisense compounds
EP2553123B1 (en)	2010-03-26	2016-08-24	Integrated DNA Technologies, Inc.	Methods for enhancing nucleic acid hybridization
US10787701B2 (en)	2010-04-05	2020-09-29	Prognosys Biosciences, Inc.	Spatially encoded biological assays
KR20130043104A (ko)	2010-04-06	2013-04-29	카리스 라이프 사이언스 룩셈부르크 홀딩스	질병용 순환 생물학적 지표들
DE102010003781B4 (de)	2010-04-08	2012-08-16	Aj Innuscreen Gmbh	Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen
US20110250598A1 (en)	2010-04-12	2011-10-13	Ulrike Fischer	Detergent free polymerases
WO2011128096A1 (en)	2010-04-16	2011-10-20	Roche Diagnostics Gmbh	Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
CA2796744A1 (en)	2010-04-17	2011-10-20	Bayer Healthcare Llc	Synthetic metabolites of fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
US20110269735A1 (en)	2010-04-19	2011-11-03	Celera Corporation	Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
AU2011244228B2 (en)	2010-04-21	2015-07-30	Jan Astermark	Genetic factors associated with inhibitor development in hemophilia A
US8774494B2 (en)	2010-04-30	2014-07-08	Complete Genomics, Inc.	Method and system for accurate alignment and registration of array for DNA sequencing
WO2011139371A1 (en)	2010-05-06	2011-11-10	Sequenta, Inc.	Monitoring health and disease status using clonotype profiles
EP2569452B1 (en)	2010-05-14	2020-03-25	Life Technologies Corporation	Karyotyping assay
US8618253B2 (en)	2010-05-25	2013-12-31	Samsung Techwin Co., Ltd.	Modified RNAse H and detection of nucleic acid amplification
US8628914B2 (en) *	2010-05-26	2014-01-14	Qiagen Gaithersburg, Inc.	Quantitative helicase assay
US8828688B2 (en)	2010-05-27	2014-09-09	Affymetrix, Inc.	Multiplex amplification methods
DK2576577T3 (en)	2010-05-28	2015-04-20	Life Technologies Corp	Synthesis of 2 ', 3'-dideoxynucleosides for automated DNA synthesis and PYROPHOSPHOROLYSIS ACTIVATED POLYMERIZATION
WO2011156434A2 (en)	2010-06-07	2011-12-15	Firefly Bioworks, Inc.	Nucleic acid detection and quantification by post-hybridization labeling and universal encoding
US20120009177A1 (en)	2010-06-07	2012-01-12	Roche Molecular Systems, Inc.	Gene expression markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
WO2011156707A2 (en)	2010-06-11	2011-12-15	Life Technologies Corporation	Alternative nucleotide flows in sequencing-by-synthesis methods
WO2011157432A1 (en)	2010-06-18	2011-12-22	Roche Diagnostics Gmbh	Dna polymerases with increased 3'-mismatch discrimination
US8715991B2 (en)	2010-06-18	2014-05-06	Roche Molecular Systems, Inc.	DNA polymerases with increased 3'-mismatch discrimination
JP5876477B2 (ja)	2010-06-18	2016-03-02	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
JP5841136B2 (ja)	2010-06-18	2016-01-13	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
MX2012013959A (es)	2010-06-18	2013-01-24	Hoffmann La Roche	Adn polimerasas con dicriminacion incrementada de apareamiento erroneo en el extremo 3'.
CA2802239C (en)	2010-06-18	2016-08-23	F. Hoffmann-La Roche Ag	Dna polymerases with increased 3'-mismatch discrimination
EP2582808B1 (en)	2010-06-18	2015-04-22	Roche Diagniostics GmbH	Dna polymerases with increased 3'-mismatch discrimination
EP2582804B1 (en)	2010-06-18	2015-02-25	Roche Diagnostics GmbH	Dna polymerases with increased 3'-mismatch discrimination
EP2585593B1 (en)	2010-06-24	2017-03-01	Population Genetics Technologies Ltd.	Methods for polynucleotide library production, immortalization and region of interest extraction
AU2011270165B2 (en)	2010-06-25	2015-12-24	Eisai R&D Management Co., Ltd.	Antitumor agent using compounds having kinase inhibitory effect in combination
EP2588628A1 (en)	2010-06-30	2013-05-08	Life Technologies Corporation	Detection of listeria species in food and environmental samples, methods and compositions thereof
US20120009575A1 (en)	2010-06-30	2012-01-12	Life Technologies Corporation	Inducible nucleic acid targets for detection of pathogens, methods and compositions thereof
US9650629B2 (en)	2010-07-07	2017-05-16	Roche Molecular Systems, Inc.	Clonal pre-amplification in emulsion
DE102010033107A1 (de)	2010-08-02	2012-02-02	Aj Innuscreen Gmbh	Nachweis spezifischer Nukleinsäuresequenzen mittels Fluoreszenzlöschung
WO2012016936A1 (de)	2010-07-31	2012-02-09	Aj Innuscreen Gmbh	Nachweis spezifischer nukleinsäuresequenzen mittels fluoreszenz - quenching
US9175354B2 (en)	2010-08-03	2015-11-03	Life Technologies Corporation	Detection of Salmonella enterica subspecies enterica serovar Enteritidis in food and environmental samples, methods and compositions therefor
EP2606343A4 (en)	2010-08-18	2017-08-16	Life Technologies Corporation	Chemical coating of microwell for electrochemical detection device
US8557532B2 (en)	2010-08-30	2013-10-15	The University Of Utah Research Foundation	Diagnosis and treatment of drug-resistant Ewing'S sarcoma
WO2012030856A2 (en)	2010-08-30	2012-03-08	Gen-Probe Incorporated	Compositions, methods and reaction mixtures for the detection of xenotropic murine leukemia virus-related virus
CA2809457C (en)	2010-09-07	2019-07-30	Integrated Dna Technologies, Inc.	Modifications for antisense compounds
CA2810520C (en)	2010-09-10	2019-03-12	Bio-Rad Laboratories, Inc.	Size selection of dna for chromatin analysis
US9051606B2 (en)	2010-09-10	2015-06-09	Qiagen Gaithersburg, Inc.	Methods and compositions for nucleic acid detection
JP5916732B2 (ja) *	2010-09-20	2016-05-11	シージーンアイエヌシー	単一標識固定化プローブ及びエキソ核酸切断活性を利用した固相におけるターゲット核酸配列検出
US8481292B2 (en)	2010-09-21	2013-07-09	Population Genetics Technologies Litd.	Increasing confidence of allele calls with molecular counting
US9090946B2 (en)	2010-09-21	2015-07-28	Life Technologies Corporation	SE33 mutations impacting genotype concordance
WO2012038049A2 (en)	2010-09-22	2012-03-29	Roche Diagnostics Gmbh	Amplification of distant nucleic acid targets using engineered primers
KR20130113447A (ko)	2010-09-24	2013-10-15	더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티	고정된 프라이머들을 이용하여 표적 dna의 직접적인 캡쳐, 증폭 및 서열화
WO2012040619A2 (en)	2010-09-24	2012-03-29	Massachusetts Eye And Ear Infirmary	Methods and compositions for prognosing and/or detecting age-related macular degeneration
CN103124796B (zh)	2010-10-04	2016-08-03	霍夫曼-拉罗奇有限公司	用于pcr反应缓冲液中的细胞裂解的方法
EP2625284B1 (en)	2010-10-04	2015-01-28	Roche Diagniostics GmbH	Method for cell lysis in a rt-pcr reaction buffer
CA2810316A1 (en)	2010-10-04	2012-04-12	F. Hoffmann-La Roche Ag	Method for cell lysis and pcr within the same reaction vessel
DK2625295T3 (da)	2010-10-08	2019-06-11	Harvard College	High-throughput-immunsekvensering
ES2966040T3 (es)	2010-10-08	2024-04-18	Harvard College	Alto rendimiento de células individuales con código de barra
US8725422B2 (en)	2010-10-13	2014-05-13	Complete Genomics, Inc.	Methods for estimating genome-wide copy number variations
AR083497A1 (es) *	2010-10-21	2013-02-27	Riken	Kit para detectar el virus de la leucemia bovina (blv), y uso del mismo
CA3155334A1 (en)	2010-10-22	2012-04-26	T2 Biosystems, Inc.	NMR SYSTEMS AND METHODS FOR RAPID ANALYTE DETECTION
KR20120042100A (ko)	2010-10-22	2012-05-03	주식회사 씨젠	이중표지 고정화 프로브를 이용한 고상에서의 타겟 핵산서열 검출
WO2012052758A1 (en)	2010-10-22	2012-04-26	Astrazeneca Ab	Response biomarkers for iap antagonists in human cancers
US8409807B2 (en)	2010-10-22	2013-04-02	T2 Biosystems, Inc.	NMR systems and methods for the rapid detection of analytes
US8563298B2 (en)	2010-10-22	2013-10-22	T2 Biosystems, Inc.	NMR systems and methods for the rapid detection of analytes
GB201017978D0 (en)	2010-10-25	2010-12-08	Oxitec Ltd	Multiplex amplification and detection
US20120108651A1 (en)	2010-11-02	2012-05-03	Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL)	Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
DE102010052524A1 (de)	2010-11-22	2012-05-24	Aj Innuscreen Gmbh	Verfahren zum qualitativen und quantitativen Nachweis von spezifischen Nukleinsäuresequenzen in Echtzeit
EP2646569A1 (en)	2010-11-30	2013-10-09	Diagon Kft.	Procedure for nucleic acid-based molecular diagnostic determination of bacterial germ counts and kit for this purpose
WO2012075231A1 (en)	2010-12-03	2012-06-07	Brandeis University	Methods and kits for detecting nucleic acid mutants in wild-type populations
WO2012087135A1 (en)	2010-12-22	2012-06-28	Academisch Ziekenhuis Leiden H.O.D.N. Lumc	Genetic markers specific for clostridium difficile ribotypes 027 (nap01/b1; rt 027) and 078 (nap7/8; rt 078) and their use
US9163281B2 (en)	2010-12-23	2015-10-20	Good Start Genetics, Inc.	Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
EP3181704B1 (en)	2010-12-27	2021-01-27	Abbott Molecular Inc.	Quantitating high titer samples by digital pcr
WO2012089240A1 (en)	2010-12-28	2012-07-05	Qiagen Hamburg Gmbh	Oligonucleotide probe for the detection of adenovirus
EP2659408B1 (en)	2010-12-29	2019-03-27	Life Technologies Corporation	Time-warped background signal for sequencing-by-synthesis operations
US20120174246A1 (en)	2010-12-30	2012-07-05	Chaky Julian M	Methods of identifying aphid resistant soybeans
WO2012092455A2 (en)	2010-12-30	2012-07-05	Life Technologies Corporation	Models for analyzing data from sequencing-by-synthesis operations
US20130060482A1 (en)	2010-12-30	2013-03-07	Life Technologies Corporation	Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
WO2013025998A1 (en)	2011-08-18	2013-02-21	Life Technologies Corporation	Methods, systems, and computer readable media for making base calls in nucleic acid sequencing
US10241075B2 (en)	2010-12-30	2019-03-26	Life Technologies Corporation	Methods, systems, and computer readable media for nucleic acid sequencing
MX340258B (es)	2011-01-11	2016-07-01	Seegene Inc	Detección de secuencias de ácido nucleico objetivo mediante ensayo de escisión y extensión del pto.
US20120208189A1 (en)	2011-01-14	2012-08-16	Life Technologies Corporation	Methods for isolation, identification, and quantification of mirnas
ES2728743T3 (es)	2011-01-17	2019-10-28	Life Technologies Corp	Flujo de trabajo para la detección de ligandos utilizando ácidos nucleicos
US9127309B2 (en)	2011-01-31	2015-09-08	Qiagen Mansfield, Inc.	Methods of nucleic acid quantification and detection using anomalous migration
WO2012108864A1 (en)	2011-02-08	2012-08-16	Illumina, Inc.	Selective enrichment of nucleic acids
EP2673376A1 (en)	2011-02-09	2013-12-18	RiboxX GmbH	Method for the detection of polynucleotide sequences
JP5847201B2 (ja)	2011-02-15	2016-01-20	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	増大した３’末端ミスマッチ識別能を有するｄｎａポリメラーゼ
US20120208193A1 (en)	2011-02-15	2012-08-16	Bio-Rad Laboratories, Inc.	Detecting methylation in a subpopulation of genomic dna
WO2012112883A1 (en)	2011-02-18	2012-08-23	Yale University	The kras-variant and endometriosis
EP3498864B1 (en)	2011-03-10	2024-10-09	Gen-Probe Incorporated	Methods for the selection and optimization of oligonucleotide tag sequences
AU2012203968A1 (en)	2011-03-21	2012-10-11	Yale University	The KRAS variant and tumor biology
CN103534358B (zh)	2011-03-29	2015-03-25	Seegene株式会社	基于pto切割以及延伸-依赖性切割的靶核酸序列的检测
EP2508625A1 (en)	2011-04-05	2012-10-10	Université de Franche-Comté	Real-time duplex PCR for HPV16 and HPV18 simultaneous viral load quantification
EP3878975A1 (en)	2011-04-08	2021-09-15	Life Technologies Corporation	Phase-protecting reagent flow orderings for use in sequencing-by-synthesis
WO2012139748A1 (en)	2011-04-11	2012-10-18	Roche Diagnostics Gmbh	Dna polymerases with improved activity
JP6021805B2 (ja)	2011-04-18	2016-11-09	エーザイ・アール・アンド・ディー・マネジメント株式会社	腫瘍治療剤
EP2702171A1 (de)	2011-04-27	2014-03-05	Cherkasov, Dmitry	Methoden und komponenten zur detektion von nukleinsäureketten
US9957558B2 (en)	2011-04-28	2018-05-01	Life Technologies Corporation	Methods and compositions for multiplex PCR
EP2702168B1 (en)	2011-04-29	2018-01-17	Sequenom, Inc.	Quantification of a minority nucleic acid species
WO2012149193A2 (en)	2011-04-29	2012-11-01	Monsanto Technology Llc	Diagnostic molecular markers for seed lot purity traits in soybeans
WO2012151254A1 (en)	2011-05-02	2012-11-08	Board Of Regents Of The University Of Nebraska	Plants with useful traits and related methods
MX342067B (es) *	2011-05-04	2016-09-09	Seegene Inc	Detección de secuencias de ácido nucleico objetivo por desdoblamiento e hibridización de oligonucleótido de sonda.
US9850524B2 (en)	2011-05-04	2017-12-26	Seegene, Inc.	Detection of target nucleic acid sequences by PO cleavage and hybridization
WO2012153153A1 (en)	2011-05-11	2012-11-15	Diagon Kft.	Procedure for rapid determination of viruses using nucleic acid-based molecular diagnostics, and a kit for this purpose
US9034581B2 (en)	2011-05-26	2015-05-19	Roche Molecular Systems, Inc.	Compositions and methods for detection of Staphylococcus aureus
EP3444363B1 (en)	2011-06-03	2020-11-25	Eisai R&D Management Co., Ltd.	Biomarkers for prediciting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
US9567628B2 (en)	2011-06-08	2017-02-14	Life Technologies Corporation	Polymerization of nucleic acids using proteins having low isoelectric points
FI3461807T3 (fi)	2011-06-08	2023-09-07	Life Technologies Corp	Uudenlaisten detergenttien suunnittelu ja kehitys pcr-järjestelmissä käyttöä varten
US20140186845A1 (en)	2011-06-14	2014-07-03	Universite Paul Sabatier - Toulouse Iii	Methods for determining the expression level of a gene of interest including correction of rt-qpcr data for genomic dna-derived signals
WO2012178210A1 (en)	2011-06-23	2012-12-27	Anitoa Systems, Llc	Apparatus for amplification of nucleic acids
US9487824B2 (en)	2011-06-28	2016-11-08	Igor Kutyavin	Methods and compositions for enrichment of nucleic acids in mixtures of highly homologous sequences
DE102011078342A1 (de)	2011-06-29	2013-01-03	Aj Innuscreen Gmbh	Rehybridisierendes Sondensystem zur qualitativen und quantitativen Messung von spezifischen Nukleinsäuren in Echtzeit
EP2737061B1 (en)	2011-07-28	2015-09-16	Roche Diagnostics GmbH	Dna polymerases with improved activity
US9758837B2 (en)	2011-08-02	2017-09-12	The United States Of America, As Represented By The Secretary Of Agriculture	Sensitive and rapid method for Candidatus Liberibacter species detection
US8778843B1 (en)	2011-08-03	2014-07-15	Fry Laboratories, L.L.C.	Semi-pan-protozoal by quantitative PCR
US8592156B2 (en)	2011-08-08	2013-11-26	Roche Molecular Systems, Inc.	Predicting response to anti-CD20 therapy in DLBCL patients
US10704164B2 (en)	2011-08-31	2020-07-07	Life Technologies Corporation	Methods, systems, computer readable media, and kits for sample identification
US20150087537A1 (en)	2011-08-31	2015-03-26	Life Technologies Corporation	Methods, Systems, Computer Readable Media, and Kits for Sample Identification
BR112014004763A2 (pt)	2011-08-31	2017-03-21	Hoffmann La Roche	método de determinação da susceptibilidade de pacientes ao desenvolvimento da hipertensão, composição farmacêutica, kit de condução, método de redução e método de tratamento de pacientes
CN104024431A (zh)	2011-08-31	2014-09-03	霍夫曼-拉罗奇有限公司	对血管发生抑制剂的响应
ES2727672T3 (es)	2011-08-31	2019-10-17	Seminis Vegetable Seeds Inc	Procedimientos y composiciones para la firmeza de la sandía
US10385475B2 (en)	2011-09-12	2019-08-20	Adaptive Biotechnologies Corp.	Random array sequencing of low-complexity libraries
EP2756101B1 (en)	2011-09-15	2018-05-23	David A. Shafer	Probe: antiprobe compositions for high specificity dna or rna detection
KR102087062B1 (ko)	2011-09-16	2020-03-11	렉소겐 게엠베하	핵산 전사 방법
CA2840242C (en)	2011-09-16	2019-03-26	Gilead Sciences, Inc.	Methods for treating hcv
EP2570487A1 (en)	2011-09-16	2013-03-20	Lexogen GmbH	Nucleic acid transcription method
KR20140064971A (ko)	2011-09-19	2014-05-28	제넨테크, 인크.	c-met 길항제 및 B-raf 길항제를 포함하는 조합 치료
WO2013041577A1 (en)	2011-09-20	2013-03-28	Vib Vzw	Methods for the diagnosis of amyotrophic lateral sclerosis and frontotemporal lobar degeneration
AU2012312169B2 (en)	2011-09-21	2016-01-14	Gen-Probe Incorporated	Methods for amplifying nucleic acid using tag-mediated displacement
US9352312B2 (en)	2011-09-23	2016-05-31	Alere Switzerland Gmbh	System and apparatus for reactions
EP2758546B1 (en)	2011-09-23	2017-11-22	Roche Diagnostics GmbH	Use of g-clamp for improved allele-specific pcr
CN103890192A (zh)	2011-09-28	2014-06-25	纳幕尔杜邦公司	用于stec细菌的检测和鉴定的序列以及它们的使用
WO2013049613A1 (en) *	2011-09-29	2013-04-04	Luminex Corporation	Hydrolysis probes
US9416153B2 (en)	2011-10-11	2016-08-16	Enzo Life Sciences, Inc.	Fluorescent dyes
JP2014531908A (ja)	2011-10-14	2014-12-04	プレジデントアンドフェローズオブハーバードカレッジ	構造アッセンブリによる配列決定
US9228233B2 (en)	2011-10-17	2016-01-05	Good Start Genetics, Inc.	Analysis methods
AU2012325791B2 (en)	2011-10-21	2018-04-05	Adaptive Biotechnologies Corporation	Quantification of adaptive immune cell genomes in a complex mixture of cells
US20140242590A1 (en)	2011-10-28	2014-08-28	The Regents Of The University Of California	Flt3 mutations associated with drug resistance in aml patients having activating mutations in flt3
US10876160B2 (en)	2011-10-31	2020-12-29	Eiken Kagaku Kabushiki Kaisha	Method for detecting target nucleic acid
US10837879B2 (en)	2011-11-02	2020-11-17	Complete Genomics, Inc.	Treatment for stabilizing nucleic acid arrays
WO2013070662A1 (en)	2011-11-09	2013-05-16	E.I. Du Pont De Nemours And Company	Sequences and their use for detection of salmonella
SG11201402554SA (en)	2011-11-23	2014-06-27	Hoffmann La Roche	Responsiveness to angiogenesis inhibitors
CN104053786B (zh)	2011-11-29	2017-06-06	生命技术公司	用于多重pcr的方法和组合物
WO2013081864A1 (en)	2011-11-29	2013-06-06	Life Technologies Corporation	Methods and compositions for multiplex pcr
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
US9260714B2 (en)	2011-12-02	2016-02-16	Roche Molecular Systems, Inc.	Suppression of non-specific amplification with high-homology oligonucleotides
CN103987844B (zh)	2011-12-08	2016-01-20	霍夫曼-拉罗奇有限公司	具有改进活性的dna聚合酶
CN103998603B (zh)	2011-12-08	2016-05-25	霍夫曼-拉罗奇有限公司	具有改进活性的dna聚合酶
JP6144697B2 (ja)	2011-12-08	2017-06-07	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	改善された活性を有するｄｎａポリメラーゼ
EP3904536B1 (en)	2011-12-09	2025-10-29	Adaptive Biotechnologies Corporation	Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en)	2011-12-13	2016-11-22	Adaptive Biotechnologies Corp.	Detection and measurement of tissue-infiltrating lymphocytes
US9115394B2 (en)	2011-12-22	2015-08-25	Roche Molecular Systems, Inc.	Methods and reagents for reducing non-specific amplification
BR112014015401A8 (pt)	2011-12-23	2017-07-04	Biomerieux Sa	detecção de cepas da variante de meca de staphylococcus aureus resistente à meticilina
WO2013101750A1 (en)	2011-12-29	2013-07-04	Pioneer Hi-Bred International, Inc.	Methods of improving aphid resistance in soybeans
CA2863121A1 (en)	2011-12-30	2013-07-04	Abbott Molecular Inc.	Microorganism nucleic acid purification from host samples
US9194840B2 (en)	2012-01-19	2015-11-24	Life Technologies Corporation	Sensor arrays and methods for making same
US9515676B2 (en)	2012-01-31	2016-12-06	Life Technologies Corporation	Methods and computer program products for compression of sequencing data
US9864846B2 (en)	2012-01-31	2018-01-09	Life Technologies Corporation	Methods and computer program products for compression of sequencing data
KR20130101952A (ko)	2012-02-02	2013-09-16	주식회사 씨젠	Ｐｔｏ 절단과 연장-의존적 혼성화를 이용한 타겟 핵산서열의 검출
CN107326085B (zh)	2012-02-03	2022-05-03	加州理工学院	多路生化测定中信号的编码和解码
WO2013123125A1 (en)	2012-02-17	2013-08-22	President And Fellows Of Harvard College	Assembly of nucleic acid sequences in emulsions
WO2013124743A1 (en)	2012-02-22	2013-08-29	Population Genetics Technologies Ltd.	Compositions and methods for intramolecular nucleic acid rearrangement ii
ES2741099T3 (es)	2012-02-28	2020-02-10	Agilent Technologies Inc	Método de fijación de una secuencia de recuento para una muestra de ácido nucleico
US9045803B2 (en)	2012-02-29	2015-06-02	Abbott Molecular Inc.	Hepatitis B virus typing and resistance assay
US9605313B2 (en)	2012-03-02	2017-03-28	Sequenom, Inc.	Methods and processes for non-invasive assessment of genetic variations
US9127317B2 (en)	2012-03-02	2015-09-08	Winthrop-University Hospital	Method for using probe based PCR detection to measure the levels of circulating demethylated β cell derived DNA as a measure of β cell loss in diabetes
EP2823060B1 (en)	2012-03-05	2018-02-14	Adaptive Biotechnologies Corporation	Determining paired immune receptor chains from frequency matched subunits
JP5976849B2 (ja)	2012-03-05	2016-08-24	シージーンアイエヌシー	ＰＴＯ切断及び伸長アッセイによるターゲット核酸配列でのヌクレオチド変異検出｛ＤｅｔｅｃｔｉｏｎｏｆＮｕｃｌｅｏｔｉｄｅＶａｒｉａｔｉｏｎｏｎＴａｒｇｅｔＮｕｃｌｅｉｃＡｃｉｄＳｅｑｕｅｎｃｅｂｙＰＴＯＣｌｅａｖａｇｅａｎｄＥｘｔｅｎｓｉｏｎＡｓｓａｙ｝
EP2828400B1 (en)	2012-03-21	2018-09-19	Roche Diagniostics GmbH	Methods for assessing rna quality
US9803239B2 (en)	2012-03-29	2017-10-31	Complete Genomics, Inc.	Flow cells for high density array chips
US8209130B1 (en)	2012-04-04	2012-06-26	Good Start Genetics, Inc.	Sequence assembly
EP2834371B1 (en)	2012-04-05	2019-01-09	The Regents of The University of California	Gene expression panel for breast cancer prognosis
US10633707B2 (en)	2012-04-10	2020-04-28	Vib Vzw	Markers for detecting microsatellite instability in cancer and determining synthetic lethality with inhibition of the DNA base excision repair pathway
US10294529B2 (en)	2012-04-10	2019-05-21	Life Sciences Research Partners Vzw	Microsatellite instability markers in detection of cancer
US10227635B2 (en)	2012-04-16	2019-03-12	Molecular Loop Biosolutions, Llc	Capture reactions
JPWO2013157215A1 (ja)	2012-04-17	2015-12-21	国立大学法人山口大学	子宮体がん発症感受性の判定方法
EP2653558B1 (en)	2012-04-18	2015-10-07	Roche Diagniostics GmbH	A method of detecting nucleic acid targets using a statistical classifier
WO2013158281A1 (en)	2012-04-20	2013-10-24	T2 Biosystems, Inc.	Compositions and methods for detection of candida species
BR112014027309A2 (pt)	2012-05-08	2017-07-11	Adaptive Biotechnologies Corp	composições e métodos para medir e calibrar a tendên-cia de amplificação em reações de pcr multiplexadas
US9646132B2 (en)	2012-05-11	2017-05-09	Life Technologies Corporation	Models for analyzing data from sequencing-by-synthesis operations
US9920361B2 (en)	2012-05-21	2018-03-20	Sequenom, Inc.	Methods and compositions for analyzing nucleic acid
US10504613B2 (en)	2012-12-20	2019-12-10	Sequenom, Inc.	Methods and processes for non-invasive assessment of genetic variations
US10077474B2 (en)	2012-05-29	2018-09-18	Abbott Molecular, Inc.	Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
US9914967B2 (en)	2012-06-05	2018-03-13	President And Fellows Of Harvard College	Spatial sequencing of nucleic acids using DNA origami probes
US9628676B2 (en)	2012-06-07	2017-04-18	Complete Genomics, Inc.	Imaging systems with movable scan mirrors
US9488823B2 (en)	2012-06-07	2016-11-08	Complete Genomics, Inc.	Techniques for scanned illumination
WO2013188839A1 (en)	2012-06-14	2013-12-19	Life Technologies Corporation	Novel compositions, methods and kits for real time polymerase chain reaction (pcr)
US20130337442A1 (en)	2012-06-15	2013-12-19	Pioneer Hi-Bred International, Inc.	Genetic loci associated with soybean cyst nematode resistance and methods of use
WO2013192100A1 (en)	2012-06-18	2013-12-27	The United States Of America, As Represented By The Secretary, Department Of Health & Human Services	Methods and compositions for detecting jc virus
US20150167068A1 (en)	2012-07-13	2015-06-18	Life Technologies Corporation	HUMAN IDENTIFICATION USING A PANEL OF SNPs
HK1206792A1 (en)	2012-07-13	2016-01-15	Sequenom, Inc.	Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US9384320B2 (en)	2012-07-19	2016-07-05	President And Fellows Of Harvard College	Methods of storing information using nucleic acids
EP2880184B1 (en)	2012-08-03	2021-03-31	California Institute of Technology	Multiplexing and quantification in pcr with reduced hardware and requirements
US9957557B2 (en)	2012-08-13	2018-05-01	Life Genetics Lab, Llc	Development of a highly sensitive quantification system for assessing DNA degradation and quality in forensic samples
US10993418B2 (en)	2012-08-13	2021-05-04	Life Genetics Lab, Llc	Method for measuring tumor burden in patient derived xenograft (PDX) mice
US9982313B2 (en)	2012-08-17	2018-05-29	Roche Molecular Systems, Inc.	Compositions and methods for detection of herpes simplex virus 1 and 2
DK2890814T3 (da)	2012-08-30	2019-12-16	Gen Probe Inc	Flerfaset nukleinsyreamplificering
US9914968B2 (en)	2012-09-26	2018-03-13	Cepheid	Honeycomb tube
ES2701235T3 (es)	2012-09-28	2019-02-21	Bna Inc	Método de abrazadera de BNA
CN105189779B (zh)	2012-10-01	2018-05-11	适应生物技术公司	通过适应性免疫受体多样性和克隆性表征进行的免疫能力评估
US10329608B2 (en)	2012-10-10	2019-06-25	Life Technologies Corporation	Methods, systems, and computer readable media for repeat sequencing
EP2722399A1 (en)	2012-10-18	2014-04-23	Roche Diagniostics GmbH	Method for preventing high molecular weight products during amplification
ES2659747T3 (es)	2012-10-18	2018-03-19	F. Hoffmann-La Roche Ag	Ensayo de doble sonda para la detección de poblaciones heterogéneas de amplicón
EP2722398B1 (en)	2012-10-18	2017-07-12	F. Hoffmann-La Roche AG	Dual probe assay for the detection of HCV
US9476089B2 (en)	2012-10-18	2016-10-25	President And Fellows Of Harvard College	Methods of making oligonucleotide probes
WO2014068072A1 (en)	2012-10-31	2014-05-08	Institut Gustave-Roussy	Identification, assessment and therapy of essential thrombocythemia with resistance to jak2 inhibitors
ES2749463T3 (es)	2012-11-02	2020-03-20	Life Technologies Corp	Captura, detección y cuantificación de ARN pequeño
US10314253B2 (en)	2012-12-04	2019-06-11	Seminis Vegetable Seeds, Inc.	Methods and compositions for watermelon sex expression
IL239317B (en)	2012-12-12	2022-07-01	Broad Inst Inc	Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
WO2014093709A1 (en)	2012-12-12	2014-06-19	The Broad Institute, Inc.	Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
EP2896697B1 (en)	2012-12-12	2015-09-02	The Broad Institute, Inc.	Engineering of systems, methods and optimized guide compositions for sequence manipulation
EP2931898B1 (en)	2012-12-12	2016-03-09	The Broad Institute, Inc.	Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
EP2931899A1 (en)	2012-12-12	2015-10-21	The Broad Institute, Inc.	Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
US20140186919A1 (en)	2012-12-12	2014-07-03	Feng Zhang	Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
US9427737B2 (en)	2012-12-14	2016-08-30	Bio-Rad Laboratories, Inc.	Methods and compositions for using oils for analysis and detection of molecules
JPWO2014098176A1 (ja)	2012-12-21	2017-01-12	エーザイ・アール・アンド・ディー・マネジメント株式会社	キノリン誘導体のアモルファス及びその製造方法
JP6178430B2 (ja)	2012-12-27	2017-08-09	シージーンアイエヌシー	Ｐｔｏ切断及び延長依存的非ハイブリダイゼーションアッセイによるターゲット核酸配列の検出
EP3650013A1 (en)	2013-01-31	2020-05-13	Gilead Pharmasset LLC	Combination formulation of two antiviral compounds
US9850515B2 (en)	2013-02-08	2017-12-26	Bio-Rad Laboratories, Inc.	Affinity-based partition assay for detection of target molecules
US10000819B2 (en)	2013-02-21	2018-06-19	Qualicon Diagnostics Llc	Sequences and their use for detection and characterization of E. coli O157:H7
EP2770065B1 (en)	2013-02-25	2017-12-13	Seegene, Inc.	Detection of nucleotide variation on target nucleic acid sequence
US20140249037A1 (en)	2013-03-04	2014-09-04	Fry Laboratories, LLC	Method and kit for characterizing microorganisms
CA2902099C (en)	2013-03-08	2020-06-02	F. Hoffmann-La Roche Ag	Egfr mutation blood testing
US20140287417A1 (en)	2013-03-08	2014-09-25	Roche Molecular Systems, Inc.	EGFR Blood Monitoring
EP3640347A3 (en)	2013-03-12	2020-07-29	Life Technologies Corporation	Universal reporter-based genotyping methods and materials
WO2014142575A1 (en)	2013-03-13	2014-09-18	Seegene, Inc.	Quantification of target nucleic acid using melting peak analysis
EP3597774A1 (en)	2013-03-13	2020-01-22	Sequenom, Inc.	Primers for dna methylation analysis
US20140296080A1 (en)	2013-03-14	2014-10-02	Life Technologies Corporation	Methods, Systems, and Computer Readable Media for Evaluating Variant Likelihood
WO2014152421A1 (en)	2013-03-14	2014-09-25	Good Start Genetics, Inc.	Methods for analyzing nucleic acids
EP3486328B1 (en)	2013-03-15	2020-11-11	Avellino Lab USA, Inc.	Methods for improved isolation of genomic dna templates for allele detection
US9828629B2 (en)	2013-03-15	2017-11-28	Roche Molecular Systems, Inc.	Nucleic acid target identification by structure based probe cleavage
US10294489B2 (en)	2013-03-15	2019-05-21	Board Of Trustees Of Southern Illinois University	Soybean resistant to cyst nematodes
WO2014144495A1 (en)	2013-03-15	2014-09-18	Abvitro, Inc.	Single cell bar-coding for antibody discovery
US20140272956A1 (en)	2013-03-15	2014-09-18	Abbott Molecular Inc.	Method for amplification and assay of rna fusion gene variants, method of distinguishing same and related primers, probes, and kits
JP6441893B2 (ja)	2013-03-19	2018-12-19	ディレクティド・ジェノミクス・エル・エル・シー	標的配列の濃縮
WO2014160797A1 (en)	2013-03-26	2014-10-02	Genetag Technology, Inc.	Dual probe:antiprobe compositions for dna and rna detection
WO2014160883A1 (en)	2013-03-27	2014-10-02	Cedars-Sinai Medical Center	Treating fibrosis and inflammation by inhibiting tl1a
ES2693133T3 (es) *	2013-04-01	2018-12-07	Genomictree, Inc.	Método de amplificación de ácidos nucleicos usando cebador reactivo específico de alelo
WO2014172434A1 (en)	2013-04-16	2014-10-23	The Johns Hopkins University	Diagnostic and prognostic test for sturge-weber syndrome, klippel-trenaunay-weber syndrome, and port-wine stains (pwss)
WO2014176259A1 (en)	2013-04-22	2014-10-30	Icahn School Of Medicine At Mount Sinai	Mutations in pdgfrb and notch3 as causes of autosomal dominant infantile myofibromatosis
CN105431575B (zh)	2013-05-09	2017-08-29	生物辐射实验室股份有限公司	磁性免疫数字pcr试验
CN105264380B (zh)	2013-05-14	2017-09-05	卫材R&D管理有限公司	用于预测和评价子宫内膜癌受试者对乐伐替尼化合物响应性的生物标志
US10059999B2 (en)	2013-06-10	2018-08-28	Monsanto Technology Llc	Molecular markers associated with soybean tolerance to low iron growth conditions
AU2014281028B2 (en)	2013-06-17	2020-09-10	Massachusetts Institute Of Technology	Delivery and use of the CRISPR-Cas systems, vectors and compositions for hepatic targeting and therapy
CN105793425B (zh)	2013-06-17	2021-10-26	布罗德研究所有限公司	使用病毒组分靶向障碍和疾病的crispr-cas系统和组合物的递送、用途和治疗应用
CN106062197A (zh)	2013-06-17	2016-10-26	布罗德研究所有限公司	用于序列操纵的串联指导系统、方法和组合物的递送、工程化和优化
WO2014204725A1 (en)	2013-06-17	2014-12-24	The Broad Institute Inc.	Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
EP3620524A1 (en)	2013-06-17	2020-03-11	The Broad Institute, Inc.	Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells
EP3957743A1 (en) *	2013-06-19	2022-02-23	Luminex Corporation	Real-time multiplexed hydrolysis probe assay
US9708657B2 (en)	2013-07-01	2017-07-18	Adaptive Biotechnologies Corp.	Method for generating clonotype profiles using sequence tags
DE102013213279B4 (de)	2013-07-06	2024-03-28	Ist Innuscreen Gmbh	Universelles Verfahren zur Detektion von diversen Analyten in Form von Nukleinsäuresequenzen
JP6050555B2 (ja)	2013-07-15	2016-12-21	シージーンアイエヌシー	Ｐｔｏの切断及び延長−依存的固定化オリゴヌクレオチドハイブリダイゼーションを用いたターゲット核酸配列の検出
US10316083B2 (en)	2013-07-19	2019-06-11	Cedars-Sinai Medical Center	Signature of TL1A (TNFSF15) signaling pathway
SG11201600550WA (en)	2013-07-25	2016-02-26	Dch Molecular Diagnostics Inc	Methods and compositions for detecting bacterial contamination
US9926597B2 (en)	2013-07-26	2018-03-27	Life Technologies Corporation	Control nucleic acid sequences for use in sequencing-by-synthesis and methods for designing the same
KR20180021234A (ko)	2013-08-12	2018-02-28	제넨테크, 인크.	보체-연관 상태의 치료를 위한 조성물 및 방법
AU2014309047A1 (en)	2013-08-20	2016-02-11	Qualicon Diagnostics, Llc	Sequences and their use for detection of Salmonella enteritidis and/or Salmonella typhimurium
US10767188B2 (en)	2013-09-25	2020-09-08	Nutech Ventures	Methods and compositions for obtaining useful plant traits
CN105683980B (zh)	2013-10-04	2018-08-24	生命科技股份有限公司	在使用终止化学物质的测序中建立分阶段效应模型的方法和系统
NZ630628A (en)	2013-10-08	2015-04-24	Seminis Vegetable Seeds Inc	Methods and compositions for peronospora resistance in spinach
ES2925313T3 (es)	2013-10-09	2022-10-14	Fluoresentric Inc	Método para la detección de secuencias de ácido nucleico diana
JP6524073B2 (ja)	2013-10-17	2019-06-05	センターフォーアディクションアンドメンタルヘルス	抗精神病薬誘導体重増加に関連する遺伝子マーカーおよびその使用のための方法
US10655173B2 (en)	2013-10-18	2020-05-19	The Broad Institute, Inc.	Spatial and cellular mapping of biomolecules in situ by high-throughput sequencing
US10851414B2 (en)	2013-10-18	2020-12-01	Good Start Genetics, Inc.	Methods for determining carrier status
JP6295322B2 (ja)	2013-10-18	2018-03-14	シージーンアイエヌシー	ｈＣＴＯを利用するＰＴＯ切断及び延長分析による固相におけるターゲット核酸配列の検出
WO2015056243A1 (en)	2013-10-18	2015-04-23	Institut De Cardiologie De Montreal	Genotyping tests and methods for evaluating plasma creatine kinase levels
CN106458885B (zh)	2013-10-25	2019-12-10	生命技术公司	用于聚合酶链式反应系统的新颖化合物及其应用
CA2923296A1 (en)	2013-10-25	2015-04-30	Pioneer Hi-Bred International, Inc.	Stem canker tolerant soybeans and methods of use
JP6672147B2 (ja)	2013-11-15	2020-03-25	アベリノラボユーエスエーインコーポレイテッドＡｖｅｌｌｉｎｏＬａｂＵＳＡ，Ｉｎｃ．	眼疾患に関連したアレルのマルチプレックス検出方法
AU2014351800B2 (en)	2013-11-22	2021-04-08	Orion Diagnostica Oy	Detection of nucleic acids by strand invasion based amplification
NZ630717A (en)	2013-11-27	2016-04-29	Seminis Vegetable Seeds Inc	Disease resistance loci in onion
DK3077539T3 (en)	2013-12-02	2018-11-19	Personal Genome Diagnostics Inc	Procedure for evaluating minority variations in a sample
ES2964927T3 (es)	2013-12-04	2024-04-10	Newleaf Symbiotics Inc	Composiciones para el tratamiento de plantas
US9840697B2 (en)	2013-12-06	2017-12-12	Bio-Rad Laboratories, Inc.	Fusion polymerases
US9476853B2 (en)	2013-12-10	2016-10-25	Life Technologies Corporation	System and method for forming microwells
WO2015089419A2 (en)	2013-12-12	2015-06-18	The Broad Institute Inc.	Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
US9637791B2 (en)	2013-12-20	2017-05-02	Roche Molecular Systems, Inc.	Multiplexed nucleic acid target identification by strucutre based probe cleavage
US20150176060A1 (en)	2013-12-20	2015-06-25	Roche Molecular Systems, Inc.	Method For Coding Of Multiple PCR Reactions For Assay Recognition
US9243289B2 (en)	2013-12-23	2016-01-26	Roche Molecular Systems, Inc.	Method for screening reagents used in PCR assays
CN106659716B (zh)	2014-01-24	2021-03-12	人工智能治疗公司	阿吡莫德组合物及其使用方法
SG11201606490YA (en)	2014-02-08	2016-09-29	Genentech Inc	Methods of treating alzheimer's disease
US9822396B2 (en)	2014-02-13	2017-11-21	Bio-Rad Laboratories, Inc.	Chromosome conformation capture in partitions
CN106232827A (zh)	2014-02-21	2016-12-14	哈佛学院董事及会员团体	变构蛋白的从头设计
EA202091497A3 (ru)	2014-02-21	2020-12-30	Зингента Партисипейшнс Аг	Генетические локусы, связанные с повышенной фертильностью у маиса
NZ630710A (en)	2014-02-27	2016-03-31	Seminis Vegetable Seeds Inc	Compositions and methods for peronospora resistance in spinach
CN106462668A (zh)	2014-02-28	2017-02-22	戒毒及精神卫生中心	用于治疗和预防抗精神病药物诱导的增重的组合物和方法
ES2741740T3 (es)	2014-03-05	2020-02-12	Adaptive Biotechnologies Corp	Métodos que usan moléculas sintéticas que contienen segmentos de nucleótidos aleatorios
KR102207922B1 (ko)	2014-03-06	2021-01-26	삼성전자주식회사	반코마이신 저항성 엔테로코커스 특이적인 프라이머 세트, 그를 포함하는 조성물 및 시료 중 반코마이신 저항성 엔테로코커스 속 미생물을 검출하는 방법
WO2015138774A1 (en)	2014-03-13	2015-09-17	Sequenom, Inc.	Methods and processes for non-invasive assessment of genetic variations
EP3119204B1 (en)	2014-03-17	2020-02-26	Newleaf Symbiotics, Inc.	Compositions and methods for improving tomato production
WO2015147370A1 (en)	2014-03-28	2015-10-01	Seegene, Inc.	Detection of target nucleic acid sequences using different detection temperatures
EP3125907A4 (en)	2014-04-01	2017-11-29	Cornell University	Use of double-stranded dna in exosomes: a novel biomarker in cancer detection
US11390921B2 (en)	2014-04-01	2022-07-19	Adaptive Biotechnologies Corporation	Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en)	2014-04-01	2018-09-04	Adaptive Biotechnologies Corp.	Determining antigen-specific t-cells
EP3126524B1 (en)	2014-04-04	2020-07-22	Affymetrix, Inc.	Improved compositions and methods for molecular inversion probe assays
ES2777529T3 (es)	2014-04-17	2020-08-05	Adaptive Biotechnologies Corp	Cuantificación de genomas de células inmunitarias adaptativas en una mezcla compleja de células
US20160053302A1 (en)	2014-04-22	2016-02-25	Roche Molecular Systems, Inc.	Method for visual identification of pcr solutions for accurate reaction setup
EP2942400A1 (en)	2014-05-09	2015-11-11	Lifecodexx AG	Multiplex detection of DNA that originates from a specific cell-type
WO2015169947A1 (en)	2014-05-09	2015-11-12	Lifecodexx Ag	Detection of dna that originates from a specific cell-type and related methods
EP2942401A1 (en)	2014-05-09	2015-11-11	Lifecodexx AG	Detection of DNA that originates from a specific cell-type
WO2015175530A1 (en)	2014-05-12	2015-11-19	Gore Athurva	Methods for detecting aneuploidy
EP3146455A4 (en)	2014-05-22	2018-05-02	The Scripps Research Institute	Molecular signatures for distinguishing liver transplant rejections or injuries
EP3825416A3 (en)	2014-05-22	2021-09-15	The Scripps Research Institute	Gene expression profiles associated with sub-clinical kidney transplant rejection
US11104951B2 (en)	2014-05-22	2021-08-31	The Scripps Research Institute	Molecular signatures for distinguishing liver transplant rejections or injuries
EP3825417A3 (en)	2014-05-22	2021-09-15	The Scripps Research Institute	Tissue molecular signatures of kidney transplant rejections
US10443100B2 (en)	2014-05-22	2019-10-15	The Scripps Research Institute	Gene expression profiles associated with sub-clinical kidney transplant rejection
JP6442534B2 (ja) *	2014-06-02	2018-12-19	ベース４イノベーションリミテッド	ヌクレオチド多型の検出方法
WO2015200855A1 (en)	2014-06-26	2015-12-30	University Of Florida Research Foundation, Inc.	Rapid detection of infectious agents
US10316369B2 (en)	2014-06-27	2019-06-11	Seminis Vegetable Seeds, Inc.	Methods and assays for male sterile watermelon
CN107209188A (zh)	2014-06-27	2017-09-26	雅培制药有限公司	用于检测人Pegivirus 2 (HPgV‑2)的组合物和方法
KR102295290B1 (ko)	2014-07-10	2021-08-30	플루어레센트릭 인코포레이티드	Dna 증폭 기술
US10131898B2 (en)	2014-07-22	2018-11-20	Bio-Rad Laboratories, Inc.	Buffers for use with polymerases
US10072306B2 (en)	2014-07-24	2018-09-11	Abbott Molecular Inc.	Compositions and methods for the detection and analysis of mycobacterium tuberculosis
CN114381512A (zh)	2014-07-30	2022-04-22	豪夫迈·罗氏有限公司	预测对hdl升高剂或hdl模拟剂疗法的应答性的遗传标记
US20160048608A1 (en)	2014-08-15	2016-02-18	Good Start Genetics, Inc.	Systems and methods for genetic analysis
EP3686279B1 (en)	2014-08-17	2023-01-04	The Broad Institute, Inc.	Genome editing using cas9 nickases
US10175239B2 (en)	2014-08-18	2019-01-08	The Texas A&M University System	Beta lactamase as biomarker for the specific detection of tuberculosis-complex bacteria
SMT202200367T1 (it)	2014-08-28	2022-11-18	Eisai R&D Man Co Ltd	Derivato di chinolina a elevata purezza e metodo per la produzione dello stesso
WO2016040446A1 (en)	2014-09-10	2016-03-17	Good Start Genetics, Inc.	Methods for selectively suppressing non-target sequences
SG10201911069WA (en)	2014-09-15	2020-01-30	Abvitro Llc	High-throughput nucleotide library sequencing
US10429399B2 (en)	2014-09-24	2019-10-01	Good Start Genetics, Inc.	Process control for increased robustness of genetic assays
CN113016623A (zh)	2014-09-26	2021-06-25	谱赛科美国股份有限公司	用于甜菊的单核苷酸多态性(snp)标志物
SG11201702416YA (en)	2014-09-30	2017-04-27	Genetic Technologies Ltd	Methods for assessing risk of developing breast cancer
GB201417500D0 (en)	2014-10-03	2014-11-19	Convergence Pharmaceuticals	Novel use
GB201417497D0 (en)	2014-10-03	2014-11-19	Convergence Pharmaceuticals	Novel use
GB201417499D0 (en)	2014-10-03	2014-11-19	Convergence Pharmaceuticals	Novel use
EP3005862A1 (en)	2014-10-10	2016-04-13	Seminis Vegetable Seeds, Inc.	Melon plants with improved disease tolerance
EP3207156A1 (en)	2014-10-13	2017-08-23	Life Technologies Corporation	Methods, kits & compositions for determining gene copy numbers
US10676787B2 (en)	2014-10-13	2020-06-09	Life Technologies Corporation	Methods, systems, and computer-readable media for accelerated base calling
EP3207472B1 (en)	2014-10-16	2024-11-27	Cepheid	Biosecurity screening system and method
JP6767374B2 (ja)	2014-10-20	2020-10-14	ジェン−プローブ・インコーポレーテッド	赤血球溶解溶液
US10392663B2 (en)	2014-10-29	2019-08-27	Adaptive Biotechnologies Corp.	Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from a large number of samples
KR102287811B1 (ko)	2014-10-31	2021-08-09	삼성전자주식회사	2개 표면을 결합시키는 방법 및 그에 의하여 제조된 구조체, 및 상기 구조체를 포함하는 미세유동 장치
RU2727802C2 (ru)	2014-11-07	2020-07-24	ЭйАй ТЕРАПЬЮТИКС, ИНК.	Апилимод для применения в лечении рака почек
EP3218515B1 (en)	2014-11-10	2023-04-26	F. Hoffmann-La Roche AG	Therapeutic and diagnostic methods for il-33-mediated disorders
WO2016077763A1 (en)	2014-11-13	2016-05-19	The Board Of Trustees Of The University Of Illinois	Bio-engineered hyper-functional "super" helicases
US10246701B2 (en)	2014-11-14	2019-04-02	Adaptive Biotechnologies Corp.	Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
US9745618B2 (en)	2014-11-19	2017-08-29	Roche Molecular Systems, Inc.	Photoblocked probes and methods for sequential detection of nucleic acids
US9920381B2 (en)	2014-12-02	2018-03-20	Roche Molecular Systems, Inc.	Compositions and methods for detecting MECC-containing methicillin-resistant Staphylococcus aureus
JP2017537657A (ja)	2014-12-11	2017-12-21	ニユー・イングランド・バイオレイブス・インコーポレイテツド	標的配列の濃縮
EP3889260A1 (en)	2014-12-12	2021-10-06	The Broad Institute, Inc.	Protected guide rnas (pgrnas)
WO2016094874A1 (en)	2014-12-12	2016-06-16	The Broad Institute Inc.	Escorted and functionalized guides for crispr-cas systems
US9909169B2 (en)	2014-12-17	2018-03-06	Roche Molecular Systems, Inc.	Allele-specific amplification of nucleic acids using blocking oligonucleotides for wild type suppression
AU2015369725A1 (en)	2014-12-24	2017-06-29	Massachusetts Institute Of Technology	CRISPR having or associated with destabilization domains
EP4095261B1 (en)	2015-01-06	2025-05-28	Molecular Loop Biosciences, Inc.	Screening for structural variants
US10337072B2 (en)	2015-01-08	2019-07-02	The Board Of Trustees Of The University Of Illinois	Copy number detection and methods
EP3248011A4 (en)	2015-01-21	2018-11-14	T2 Biosystems, Inc.	Nmr methods and systems for the rapid detection of tick-borne pathogens
CN107428818A (zh)	2015-01-29	2017-12-01	密西根州立大学校董会	隐藏多肽及其用途
US10421993B2 (en)	2015-02-11	2019-09-24	Paragon Genomics, Inc.	Methods and compositions for reducing non-specific amplification products
EP3259602B9 (en)	2015-02-20	2021-05-19	Takara Bio USA, Inc.	Method for rapid accurate dispensing, visualization and analysis of single cells
CA2976325C (en)	2015-02-25	2023-07-04	Eisai R&D Management Co., Ltd.	Method for suppressing bitterness of quinoline derivative
KR102662228B1 (ko)	2015-03-04	2024-05-02	머크 샤프 앤드 돔 코포레이션	암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
CN105936930A (zh)	2015-03-04	2016-09-14	松下知识产权经营株式会社	Dna检测方法和dna检测装置
CN105969655A (zh)	2015-03-10	2016-09-28	松下知识产权经营株式会社	多个核酸靶标的分析方法
EP3929291A1 (en)	2015-03-17	2021-12-29	Bio-Rad Laboratories, Inc.	Detection of genome editing
US9708647B2 (en)	2015-03-23	2017-07-18	Insilixa, Inc.	Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
US9957393B2 (en)	2015-03-30	2018-05-01	Enzo Biochem, Inc.	Monoazo dyes with cyclic amine as fluorescence quenchers
AU2016242967B2 (en)	2015-04-01	2021-07-01	Adaptive Biotechnologies Corp.	Method of identifying human compatible T cell receptors specific for an antigenic target
WO2016168174A1 (en)	2015-04-13	2016-10-20	The Translational Genomics Research Institute	Predicting the occurrence of metastatic cancer using epigenomic biomarkers and non-invasive methodologies
CN104845967B (zh)	2015-04-15	2020-12-11	苏州新海生物科技股份有限公司	寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用
RU2745987C2 (ru)	2015-04-28	2021-04-05	Монсанто Текнолоджи Ллс	Способы и композиции для получения укороченных растений кукурузы
US10415101B2 (en)	2015-04-30	2019-09-17	Monsanto Technology Llc	Methods for producing canola plants with clubroot resistance and compositions thereof
EP4220645A3 (en)	2015-05-14	2023-11-08	Life Technologies Corporation	Barcode sequences, and related systems and methods
WO2016193070A1 (en)	2015-05-29	2016-12-08	Roche Diagnostics Gmbh	A method of inactivating microbes by citraconic anhydride
BR112017026193B1 (pt)	2015-06-05	2021-09-14	W.R. Grace & Co-Conn	Adsorventes, método de produção dos adsorventes e uso dos adsorventes
CN108271342B (zh)	2015-06-10	2021-12-07	新叶共生有限公司	抗真菌甲基杆菌组合物及使用方法
EP3307885B1 (en)	2015-06-15	2020-10-21	Cepheid	Integrated purification and measurement of dna methylation and co-measurement of mutations and/or mrna expression levels in an automated reaction cartridge
CN107801379B (zh)	2015-06-16	2021-05-25	卫材R&D管理有限公司	抗癌剂
US9790490B2 (en)	2015-06-18	2017-10-17	The Broad Institute Inc.	CRISPR enzymes and systems
CA3012631A1 (en)	2015-06-18	2016-12-22	The Broad Institute Inc.	Novel crispr enzymes and systems
WO2016205749A1 (en)	2015-06-18	2016-12-22	The Broad Institute Inc.	Novel crispr enzymes and systems
RU2600873C1 (ru) *	2015-06-24	2016-10-27	Закрытое акционерное общество "ЕВРОГЕН"	Способ идентификации нативных пар фрагментов днк или рнк, присутствующих в одних и тех же живых клетках
US10526664B2 (en)	2015-07-14	2020-01-07	Abbott Molecular Inc.	Compositions and methods for identifying drug resistant tuberculosis
EP3124619B1 (en)	2015-07-31	2019-03-06	Menicon Co., Ltd	Reagents, method and kit for across and within dog breed glaucoma diagnosis
US10471055B2 (en)	2015-08-17	2019-11-12	Kura Oncology, Inc.	Methods of treating cancer patients with farnesyltransferase inhibitors
BR112018000541B1 (pt)	2015-08-18	2023-11-28	Monsanto Technology Llc	Métodos para selecionar uma população de plantas ou sementes de algodão staygreen (stg), para selecionar uma planta ou semente de algodão e para avaliar uma coleção de germoplasma de algodão
AU2016309356B2 (en)	2015-08-20	2021-06-24	Eisai R&D Management Co., Ltd.	Tumor therapeutic agent
WO2017040520A1 (en)	2015-08-31	2017-03-09	Hitachi Chemical Co., Ltd.	Molecular methods for assessing urothelial disease
US10448595B2 (en)	2015-09-03	2019-10-22	Seminis Vegetable Seeds, Inc.	Downy mildew resistant lettuce plants
WO2022269023A1 (en)	2021-06-25	2022-12-29	F. Hoffmann-La Roche Ag	Methods for performing temperature multiplexed pcr with increased sensitivity
WO2017044744A2 (en)	2015-09-10	2017-03-16	Monsanto Technology Llc	Methods for producing corn plants with downy mildew resistance and compositions thereof
US9499861B1 (en)	2015-09-10	2016-11-22	Insilixa, Inc.	Methods and systems for multiplex quantitative nucleic acid amplification
JP6869233B2 (ja)	2015-09-24	2021-05-12	アブビトロ，エルエルシー	親和性−オリゴヌクレオチドコンジュゲートおよびその使用
US10928392B2 (en)	2015-09-25	2021-02-23	Abvitro Llc	High throughput process for T cell receptor target identification of natively-paired T cell receptor sequences
US11266730B2 (en)	2015-09-29	2022-03-08	The General Hospital Corporation	Methods of treating and diagnosing disease using biomarkers for BCG therapy
US20190062841A1 (en)	2015-10-08	2019-02-28	Urology Diagnostics, Inc.	Diagnostic assay for urine monitoring of bladder cancer
CN109153980B (zh)	2015-10-22	2023-04-14	布罗德研究所有限公司	Vi-b型crispr酶和系统
WO2017075294A1 (en)	2015-10-28	2017-05-04	The Board Institute Inc.	Assays for massively combinatorial perturbation profiling and cellular circuit reconstruction
US11996168B2 (en)	2015-10-28	2024-05-28	The Broad Institute, Inc.	Systems and methods for determining relative abundances of biomolecules
EP3371211B1 (en)	2015-11-04	2025-01-01	Icahn School of Medicine at Mount Sinai	Rho-associated protein kinase ("rock") inhibitor for treating tumors and cancer, and identifying candidate subjects for such treatment
HUE050491T2 (hu)	2015-11-10	2020-12-28	Eurofins Lifecodexx Gmbh	Magzati kromoszomális aneuploidiák kimutatása olyan DNS régiókat alkalmazva, amelyek különbözõképpen vannak metilezve a magzat és a terhes nõstény között
WO2017083852A1 (en)	2015-11-13	2017-05-18	MOORE, Tara	Methods for the treatment of corneal dystrophies
KR102270771B1 (ko)	2015-11-20	2021-06-29	주식회사 씨젠	표적 분석물질에 대한 데이터 세트의 보정 방법
CN108350407B (zh)	2015-12-11	2022-07-08	杰诺玛迪克斯公司	用于核酸扩增的管密封系统和方法
EP3390665B1 (en)	2015-12-15	2023-12-06	Seegene, Inc.	Signal extraction for a target nucleic acid sequence
US11319599B2 (en)	2015-12-18	2022-05-03	Pioneer Hi-Bred International, Inc.	Genetic loci associated with reproductive growth phenotypes in soybean and methods of use
WO2017106657A1 (en)	2015-12-18	2017-06-22	The Broad Institute Inc.	Novel crispr enzymes and systems
WO2017106731A1 (en)	2015-12-18	2017-06-22	Monsanto Technology Llc	Methods for producing corn plants with northern leaf blight resistance and compositions thereof
US10689689B2 (en) *	2015-12-28	2020-06-23	Roche Molecular Systems, Inc.	Generic method for the stabilization of specific RNA
CA3011363A1 (en)	2016-01-12	2017-07-20	Interleukin Genetics, Inc.	Methods for predicting response to treatment
US20190032104A1 (en)	2016-01-21	2019-01-31	T2 Biosystems, Inc.	Rapid antimicrobial susceptibility testing using high-sensitivity direct detection methods
CA3011901A1 (en)	2016-01-21	2017-07-27	T2 Biosystems, Inc.	Nmr methods and systems for the rapid detection of bacteria
EP3408403A1 (en)	2016-01-25	2018-12-05	Bio-Rad Europe GmbH	Digital microbiology
ES2976360T3 (es)	2016-01-28	2024-07-30	Univ Melbourne	Métodos para evaluar el riesgo de desarrollar cáncer colorrectal
WO2017136204A1 (en)	2016-02-05	2017-08-10	Pioneer Hi-Bred International, Inc.	Genetic loci associated with brown stem rot resistance in soybean and methods of use
WO2017135756A1 (en)	2016-02-05	2017-08-10	Seegene, Inc.	Method for reducing noise level of data set for a target analyte
EP3783108B1 (en)	2016-02-09	2025-01-29	Eiken Kagaku Kabushiki Kaisha	Method for detecting target nucleic acid
WO2017155858A1 (en)	2016-03-07	2017-09-14	Insilixa, Inc.	Nucleic acid sequence identification using solid-phase cyclic single base extension
CN108779500B (zh)	2016-03-11	2022-12-13	豪夫迈·罗氏有限公司	用于检测寨卡病毒的组合物和方法
KR20240095481A (ko)	2016-03-17	2024-06-25	세다르스-신나이 메디칼 센터	Rnaset2를 통한 염증성 장 질환의 진단 방법
EP3440221B1 (en)	2016-04-06	2025-08-27	Life Technologies Corporation	Methods for synthesis and detection of nucleic acids
CA3020581A1 (en)	2016-04-14	2017-10-19	T2 Biosystems, Inc.	Methods and systems for amplification in complex samples
KR102424476B1 (ko)	2016-04-19	2022-07-25	더 브로드 인스티튜트, 인코퍼레이티드	신규한 crispr 효소 및 시스템
US11286478B2 (en)	2016-04-19	2022-03-29	The Broad Institute, Inc.	Cpf1 complexes with reduced indel activity
EP3445856A1 (en)	2016-04-19	2019-02-27	The Broad Institute Inc.	Novel crispr enzymes and systems
US20190119758A1 (en)	2016-04-22	2019-04-25	Kura Oncology, Inc.	Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
US11246868B2 (en)	2016-04-26	2022-02-15	Icahn School Of Medicine At Mount Sinai	Treatment of hippo pathway mutant tumors and methods of identifying subjects as candidates for treatment
AU2017257978B2 (en)	2016-04-27	2022-12-22	Gen-Probe Incorporated	Blood cell lysis reagent
WO2017189906A1 (en)	2016-04-27	2017-11-02	Mira Dx, Inc.	Immune-based treatment of kras-variant cancer patients
US10619205B2 (en)	2016-05-06	2020-04-14	Life Technologies Corporation	Combinatorial barcode sequences, and related systems and methods
MX390872B (es)	2016-05-12	2025-03-21	Pioneer Hi Bred Int	Metodos para determinacion genotipica simultanea y combinada.
EP3458597B1 (en)	2016-05-18	2022-09-07	Roche Diagnostics GmbH	Quantitative real time pcr amplification using an electrowetting-based device
US10612101B2 (en)	2016-05-27	2020-04-07	Roche Molecular Systems, Inc.	Compositions and methods for detection of Mycoplasma genitalium
CN109154023B (zh)	2016-05-27	2022-09-20	豪夫迈·罗氏有限公司	用于检测阴道毛滴虫的组合物和方法
US20170351807A1 (en)	2016-06-01	2017-12-07	Life Technologies Corporation	Methods and systems for designing gene panels
WO2017213458A1 (en)	2016-06-10	2017-12-14	Seegene, Inc.	Methods for preparing tagging oligonucleotides
EP3472349A1 (en)	2016-06-16	2019-04-24	Life Technologies Corporation	Novel compositions, methods and kits for microorganism detection
CN109642252A (zh)	2016-06-17	2019-04-16	加州理工学院	核酸反应及相关方法和组合物
CN109642231A (zh)	2016-06-17	2019-04-16	博德研究所	Vi型crispr直向同源物和系统
EP3478702A4 (en)	2016-06-27	2020-03-18	Dana-Farber Cancer Institute, Inc.	METHODS FOR MEASURING RNA TRANSLATION RATES
WO2018005873A1 (en)	2016-06-29	2018-01-04	The Broad Institute Inc.	Crispr-cas systems having destabilization domain
KR102301305B1 (ko)	2016-06-30	2021-09-13	주식회사 씨젠	핵산 증폭용 튜브 및 핵산 증폭용 반응 용기
EP3487616B1 (en)	2016-07-21	2023-08-09	Takara Bio USA, Inc.	Multi-z imaging of wells of multi-well devices and liquid dispensing into the wells
US10626454B2 (en)	2016-07-27	2020-04-21	SeqMatic, LLC	Compositions and methods for nucleic acid amplification and analysis
ES2926513T3 (es)	2016-07-29	2022-10-26	Juno Therapeutics Inc	Métodos para evaluar la presencia o ausencia de virus competente en replicación
WO2018024562A1 (en)	2016-08-02	2018-02-08	Roche Diagnostics Gmbh	Helper oligonucleotide for improving efficiency of amplification and detection/quantitation of nucleic acids
WO2018031874A1 (en)	2016-08-11	2018-02-15	Monsanto Technology Llc	Methods and compositions for producing corn plants with resistance to late wilt
CN118207299A (zh)	2016-08-26	2024-06-18	生命技术公司	核酸提取和扩增对照及其使用方法
JP7221199B2 (ja)	2016-09-15	2023-02-20	エフ．ホフマン－ラロシュエージー．	マルチプレックスｐｃｒの実施方法
US10487358B2 (en)	2016-09-23	2019-11-26	Grail, Inc.	Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
WO2018057971A1 (en)	2016-09-23	2018-03-29	Life Technologies Corporation	Compositions and methods for assessing immune response
BR112019005748A2 (pt)	2016-09-24	2019-06-18	Abvitro Llc	afinidade-conjugados de oligonucleotídeo e usos destes
AU2017232187B2 (en)	2016-09-30	2023-11-09	Seminis Vegetable Seeds, Inc.	Xanthomonas resistant brassica oleracea plants
KR102239375B1 (ko)	2016-10-06	2021-04-13	주식회사 씨젠	시료 내 타겟 핵산분자의 검출에 이용되는 올리고뉴클레오타이드의 제공방법
DE102016120124B8 (de)	2016-10-21	2018-08-23	Gna Biosolutions Gmbh	Verfahren zum Durchführen einer Polymerase-Kettenreaktion und Vorrichtung zum Ausführen des Verfahrens
EP3838275A1 (en)	2016-11-03	2021-06-23	Kura Oncology, Inc.	Farnesyltransferase inhibitors for use in methods of treating cancer
CA3040930A1 (en)	2016-11-07	2018-05-11	Grail, Inc.	Methods of identifying somatic mutational signatures for early cancer detection
US10793923B2 (en)	2016-11-09	2020-10-06	Roche Molecular Systems, Inc.	Compositions and methods for detection of BK virus
US11031099B2 (en)	2016-11-09	2021-06-08	Roche Molecular Systems, Inc.	Detection of sequence variants
WO2018107103A1 (en)	2016-12-09	2018-06-14	The Broad Institute, Inc.	Crispr-systems for modifying a trait of interest in a plant
CN110291205A (zh)	2016-12-12	2019-09-27	塞弗德公司	自动反应盒中的整合的免疫pcr和核酸分析
EP3551768B1 (en)	2016-12-12	2024-03-06	Grail, LLC	Methods for tagging and amplifying rna template molecules for preparing sequencing libraries
MX2019006628A (es)	2016-12-12	2019-11-12	Cepheid	Purificacion y medicion integradas de metilacion de adn y co-medicion de mutaciones y/o niveles de expresion de arnm en un cartucho de reaccion automatizado.
US20190211377A1 (en)	2016-12-22	2019-07-11	Roche Molecular Systems, Inc.	Cobra probes to detect a marker for epidemic ribotypes of clostridium difficile
WO2018119399A1 (en)	2016-12-23	2018-06-28	Grail, Inc.	Methods for high efficiency library preparation using double-stranded adapters
CA3046303A1 (en)	2016-12-29	2018-07-05	Seegene, Inc.	Method for reducing primer dimer formation and increasing amplification efficiency
KR102349259B1 (ko)	2017-01-04	2022-01-07	엠쥐아이 테크 컴퍼니 엘티디.	친화성 시약을 이용한 핵산 시퀀싱
CN110382716A (zh)	2017-01-10	2019-10-25	佰隆基因公司	用于减少引物延伸反应中产生的冗余分子条形码的方法和组合物
US10329620B2 (en)	2017-01-12	2019-06-25	Cardioforecast Ltd.	Methods and kits for treating cardiovascular disease
ES2971448T3 (es)	2017-02-08	2024-06-05	Eisai R&D Man Co Ltd	Composición farmacéutica para el tratamiento de tumores
US9956215B1 (en)	2017-02-21	2018-05-01	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
EP3542800B1 (en)	2017-02-21	2022-06-01	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
JP2018139520A (ja) *	2017-02-27	2018-09-13	パナソニックＩｐマネジメント株式会社	核酸検出用オリゴヌクレオチド
US11248261B2 (en)	2017-03-08	2022-02-15	Etablissement Francais Du Sang	RhD gene allele associated with a weak D phenotype and its uses
WO2018170436A1 (en)	2017-03-16	2018-09-20	Jacobs Farm Del Cabo	Basil with high tolerance to downy mildew
CN110475871B (zh)	2017-03-28	2024-04-12	Seegene株式会社	用于确定靶核酸序列的存在的分析信号
US11459618B2 (en)	2017-03-29	2022-10-04	Crown Bioscience, Inc. (Taicang)	System and method for determining Cetuximab sensitivity on gastric cancer
US11274344B2 (en)	2017-03-30	2022-03-15	Grail, Inc.	Enhanced ligation in sequencing library preparation
US11584958B2 (en)	2017-03-31	2023-02-21	Grail, Llc	Library preparation and use thereof for sequencing based error correction and/or variant identification
WO2018183897A1 (en)	2017-03-31	2018-10-04	Grail, Inc.	Higher target capture efficiency using probe extension
US11572591B2 (en)	2017-04-26	2023-02-07	The Translational Genomics Research Institute	Methods and assays for subtyping Staphylococcus aureus clonal complex 8 strains
CN108823287B (zh)	2017-04-28	2019-04-12	厦门大学	一种检测靶核酸序列的方法
CN110997940A (zh)	2017-04-28	2020-04-10	阿维利诺美国实验室股份有限公司	用于检测与圆锥角膜相关的等位基因的方法
CA3061888A1 (en)	2017-05-16	2018-11-22	Eisai R&D Management Co., Ltd.	Treatment of hepatocellular carcinoma
WO2018213803A1 (en)	2017-05-19	2018-11-22	Neon Therapeutics, Inc.	Immunogenic neoantigen identification
US20190093155A1 (en)	2017-05-25	2019-03-28	Roche Molecular Systems, Inc.	Multiplex Nucleic Acid Amplification Assay
MA49352A (fr)	2017-05-26	2020-04-08	Abvitro Llc	Séquençage de bibliothèque de polynucléotides à haut rendement et analyse de transcriptome
US10011849B1 (en)	2017-06-23	2018-07-03	Inscripta, Inc.	Nucleic acid-guided nucleases
JP7136816B2 (ja)	2017-06-23	2022-09-13	インスクリプタ，インコーポレイテッド	核酸誘導型ヌクレアーゼ
US9982279B1 (en)	2017-06-23	2018-05-29	Inscripta, Inc.	Nucleic acid-guided nucleases
US10760137B2 (en)	2017-07-18	2020-09-01	Roche Molecular Systems, Inc.	Compositions and methods for detection of Babesia
US11655504B2 (en)	2017-07-24	2023-05-23	Quantum-Si Incorporated	High intensity labeled reactant compositions and methods for sequencing
US10806730B2 (en)	2017-08-07	2020-10-20	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
AU2018313738B2 (en)	2017-08-07	2024-07-04	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
EP3676400A4 (en)	2017-08-31	2021-06-02	Seegene, Inc.	EVALUATING THE PERFORMANCE OF COMPONENTS USING A PAIR OF DIMERING PRIMERS
US20200263170A1 (en)	2017-09-14	2020-08-20	Grail, Inc.	Methods for preparing a sequencing library from single-stranded dna
EP3628058B1 (en)	2017-09-27	2022-05-11	Abbott Molecular Inc.	Assay for detecting hepatitis b virus (hbv)
TW201919634A (zh)	2017-09-27	2019-06-01	美商藍治療公司	Hsp90抑制劑相關的治療方法
ES2993027T3 (en)	2017-09-28	2024-12-20	Seegene Inc	Method and device for analyzing target analyte in sample
EP4269583B1 (en)	2017-09-28	2025-12-31	Grail, Inc.	ENRICHEMENT OF SHORT NUCLEIC ACID FRAGMENTS IN SEQUENCING BANK PREPARATION
WO2019063661A1 (en)	2017-09-29	2019-04-04	Roche Diagnostics Gmbh	COMPOSITIONS AND METHODS FOR THE DETECTION OF TRICHOMONAS VAGINALIS
US11401546B2 (en)	2017-09-29	2022-08-02	Seegene, Inc.	Detection of target nucleic acid sequences by PTO cleavage and extension-dependent extension assay
ES3035799T3 (en)	2017-10-03	2025-09-09	Abbott Molecular Inc	Assay for detecting hepatitis c virus (hcv)
WO2019070731A1 (en)	2017-10-03	2019-04-11	Abbott Molecular Inc.	ASSAY FOR DETECTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV)
WO2019084055A1 (en)	2017-10-23	2019-05-02	Massachusetts Institute Of Technology	CLASSIFICATION OF GENETIC VARIATION FROM UNICELLULAR TRANSCRIPTOMS
US20200340041A1 (en)	2017-11-13	2020-10-29	Life Technologies Corporation	Novel compositions, methods and kits for urinary tract microorganism detection
WO2021130199A2 (en)	2019-12-27	2021-07-01	F. Hoffmann-La Roche Ag	Compositions and methods for detecting methicillin-resistant staphylococcus aureus
US11332736B2 (en)	2017-12-07	2022-05-17	The Broad Institute, Inc.	Methods and compositions for multiplexing single cell and single nuclei sequencing
WO2019118652A1 (en)	2017-12-12	2019-06-20	Essenlix Corporation	Sample manipulation and assay with rapid temperature change
WO2019118925A1 (en)	2017-12-15	2019-06-20	Grail, Inc.	Methods for enriching for duplex reads in sequencing and error correction
WO2019126803A1 (en)	2017-12-22	2019-06-27	Grail, Inc.	Error removal using improved library preparation methods
US11242568B2 (en)	2017-12-29	2022-02-08	City Of Hope	DNA methylation diagnostic test for breast cancer
WO2019135567A1 (en)	2018-01-05	2019-07-11	Seegene, Inc. .	Method for determining the presence or absence of m. tuberculosis, m. bovis and m. bovis bcg in a sample
US11015228B2 (en)	2018-01-09	2021-05-25	Abbott Molecular Inc.	Assay for detecting Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium
MX2020007852A (es)	2018-01-25	2021-01-29	Biogen Ma Inc	Metodos para el tratamiento de la atrofia muscular espinal.
CN111670072B (zh)	2018-01-30	2023-10-27	生命技术公司	用于智能分子分析系统的工作流中的仪器、装置和消耗品
WO2019152747A1 (en)	2018-01-31	2019-08-08	Juno Therapeutics, Inc.	Methods and reagents for assessing the presence or absence of replication competent virus
KR102417088B1 (ko)	2018-02-09	2022-07-07	제넨테크, 인크.	비만 세포 매개 염증성 질환에 대한 치료 및 진단 방법
CN112074612A (zh)	2018-02-26	2020-12-11	Agct有限公司	一种具有更高特异性的核酸扩增方法
DE102018001586A1 (de)	2018-02-28	2019-10-17	Agct Gmbh	Verfahren zur Detektion der Amplifikation einer Nukleinsäure mit verbesserter Spezifität
CN121006394A (zh)	2018-03-02	2025-11-25	量子细胞公司	从组织中分离和表达分析感兴趣的区域的方法、组成和装置
US20190284609A1 (en)	2018-03-14	2019-09-19	Luminex Corporation	Fast, multiplex amplification of nucleic acids
ES2969883T3 (es)	2018-03-21	2024-05-23	Hoffmann La Roche	ADN polimerasas para la incorporación eficiente y eficaz de dNTP metilados
WO2019191679A1 (en)	2018-03-30	2019-10-03	Incyte Corporation	Biomarkers for inflammatory skin disease
CN112424377A (zh)	2018-04-17	2021-02-26	克罗玛科德公司	用于多重分析的方法和系统
EP3781708B1 (en)	2018-04-20	2025-01-15	Seegene, Inc.	Method for detecting a plurality of target nucleic acid sequences in sample
WO2019213619A1 (en)	2018-05-04	2019-11-07	Abbott Laboratories	Hbv diagnostic, prognostic, and therapeutic methods and products
US11268102B2 (en)	2018-05-16	2022-03-08	University Of Florida Research Foundation, Incorporated	Compositions and methods for identifying and selecting brachytic locus in solanaceae
GB2590210B (en)	2018-06-13	2023-01-25	Gen Probe Inc	Compositions and methods for detecting group B Streptococcus nucleic acid
US12203129B2 (en)	2018-07-03	2025-01-21	ChromaCode, Inc.	Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays
CN112423883A (zh)	2018-07-12	2021-02-26	卢米耐克斯公司	用于进行可变样品制备和分析过程的系统和方法
AU2019300169A1 (en)	2018-07-13	2021-01-28	Quantum-Si Incorporated	Biconjugatable labels and methods of use
GB201812192D0 (en)	2018-07-26	2018-09-12	Ttp Plc	Variable temperature reactor, heater and control circuit for the same
SG11202101934SA (en)	2018-07-30	2021-03-30	Readcoor Llc	Methods and systems for sample processing or analysis
US12227812B2 (en)	2018-08-01	2025-02-18	Gen-Probe Incorporated	Compositions and methods for detecting nucleic acids of Epstein-Barr virus
US12421507B2 (en)	2018-08-20	2025-09-23	The Broad Institute, Inc.	Methods and compositions for optochemical control of CRISPR-CAS9
US20210324452A1 (en)	2018-09-06	2021-10-21	Hygiena, Llc	Sequences and their use for detection and characterization of escherichia coli serotype o157:h7
EP3850086A1 (en)	2018-09-13	2021-07-21	F. Hoffmann-La Roche AG	Mutant dna polymerase(s) with improved strand displacement ability
WO2020069085A2 (en)	2018-09-27	2020-04-02	Gen-Probe Incorporated	Compositions and methods for detecting bordetella pertussis and bordetella parapertussis nucleic acid
KR102220701B1 (ko)	2018-09-28	2021-03-03	(주)나노헬릭스	형광기반의 다중 융해 분석을 이용한 증폭 산물의 다중 분석방법
US12168794B2 (en) *	2018-10-02	2024-12-17	Osler Diagnostics Limited	Methods for immunoassays using electrochemical measurement
JP7564097B2 (ja)	2018-10-05	2024-10-08	エーザイ・アール・アンド・ディー・マネジメント株式会社	ソラフェニブ化合物を含む療法のためのバイオマーカー
EP3861347B1 (en)	2018-10-05	2022-12-21	Eisai R&D Management Co., Ltd.	Biomarkers for a combination therapy comprising lenvatinib and everolimus
US20220401460A1 (en)	2018-10-10	2022-12-22	Dana-Farber Cancer Institute, Inc.	Modulating resistance to bcl-2 inhibitors
US11066404B2 (en)	2018-10-11	2021-07-20	Incyte Corporation	Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
US20220195515A1 (en)	2018-10-29	2022-06-23	Koninklijke Nederlandse Akademie Van Wetenschappen	Single cell full length RNA sequencing
AU2019372141A1 (en)	2018-11-01	2021-05-27	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
US12344905B2 (en)	2018-12-03	2025-07-01	Roche Molecular Systems, Inc.	Compositions and methods for detection of Candida auris
KR20210104779A (ko)	2018-12-13	2021-08-25	디엔에이 스크립트	세포 및 생체분자 상의 직접 올리고뉴클레오타이드 합성
KR102699175B1 (ko)	2018-12-14	2024-08-26	주식회사 씨젠	기울기 데이터 세트에 대한 s자 형태의 함수를 사용하여 샘플 내 타겟 분석물질을 검출하는 방법
CN113544266A (zh)	2018-12-17	2021-10-22	博德研究所	Crispr相关转座酶系统和其使用方法
WO2020132090A1 (en)	2018-12-18	2020-06-25	Abbott Molecular Inc.	Assay for detecting human papilloma virus (hpv)
US11512349B2 (en)	2018-12-18	2022-11-29	Grail, Llc	Methods for detecting disease using analysis of RNA
CN113195734B (zh)	2018-12-20	2024-12-24	豪夫迈·罗氏有限公司	通过固相分子成像检测靶核酸
CA3124763A1 (en)	2019-01-03	2020-07-09	Dna Script	One pot synthesis of sets of oligonucleotides
CA3145881A1 (en)	2019-01-15	2020-07-23	Seminis Vegetable Seeds, Inc.	Green bean plants with improved resistance to sclerotinia sclerotiorum and genetic markers therefor
WO2020154546A1 (en)	2019-01-23	2020-07-30	Quantum-Si Incorporated	High intensity labeled reactant compositions and methods for sequencing
KR102097721B1 (ko)	2019-01-24	2020-04-06	주식회사 시선바이오머티리얼스	태그서열 snp를 이용한 단일 검출 프로브 기반 다중 표적 검출방법
MA54949A (fr)	2019-02-12	2021-12-22	Biogen Ma Inc	Biomarqueurs de la leucoencéphalopathie multifocale progressive
MA54947A (fr)	2019-02-15	2021-12-22	Incyte Corp	Biomarqueurs de kinase 2 dépendant de la cycline et leurs utilisations
WO2020168197A1 (en)	2019-02-15	2020-08-20	Incyte Corporation	Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
WO2020180663A1 (en)	2019-03-01	2020-09-10	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2020180959A1 (en)	2019-03-05	2020-09-10	Incyte Corporation	Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors
CN113924041B (zh)	2019-03-14	2024-12-03	因斯利克萨公司	基于时间门控的荧光检测的方法和系统
WO2020191102A1 (en)	2019-03-18	2020-09-24	The Broad Institute, Inc.	Type vii crispr proteins and systems
US11634782B2 (en)	2019-03-20	2023-04-25	Hygiena, Llc	Quantification of microorganisms in samples and methods of determining quantification conditions thereof
JP7641232B2 (ja)	2019-03-29	2025-03-06	クラオンコロジー，インコーポレイテッド	ファルネシルトランスフェラーゼ阻害剤による扁平上皮癌の治療方法
WO2020205560A1 (en)	2019-03-29	2020-10-08	Incyte Corporation	Sulfonylamide compounds as cdk2 inhibitors
US20220168296A1 (en)	2019-04-01	2022-06-02	Kura Oncology, Inc.	Methods of treating cancer with farnesyltransferase inhibitors
WO2020206046A1 (en)	2019-04-01	2020-10-08	The Broad Institute, Inc.	Methods and compositions for cell therapy
EP4600650A3 (en)	2019-04-05	2025-11-26	Earli Inc.	Improved methods and compositions for synthetic biomarkers
WO2020205491A1 (en)	2019-04-05	2020-10-08	Hygiena, Llc	Sequences and their use for detection and characterization of genus cronobacter
US11440914B2 (en)	2019-05-01	2022-09-13	Incyte Corporation	Tricyclic amine compounds as CDK2 inhibitors
US11447494B2 (en)	2019-05-01	2022-09-20	Incyte Corporation	Tricyclic amine compounds as CDK2 inhibitors
WO2020223583A1 (en)	2019-05-02	2020-11-05	Kura Oncology, Inc.	Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors
WO2020221915A1 (en)	2019-05-02	2020-11-05	F. Hoffmann-La Roche Ag	UTILIZATION OF dITP FOR PREFERENTIAL/SELECTIVE AMPLIFICATION OF RNA VERSUS DNA TARGETS BASED ON STRAND-SEPARATION TEMPERATURE
JP7592027B2 (ja)	2019-05-07	2024-11-29	エフ．ホフマン－ラロシュアーゲー	ナイセリア・ゴノレア（ＮｅｉｓｓｅｒｉａＧｏｎｏｒｒｏｈｅａｅ）を検出するための組成物および方法
US20220235340A1 (en)	2019-05-20	2022-07-28	The Broad Institute, Inc.	Novel crispr-cas systems and uses thereof
EP3980561A1 (en)	2019-06-06	2022-04-13	Sitokine Limited	Compositions and methods for treating lung, colorectal and breast cancer
CN113966535A (zh)	2019-06-14	2022-01-21	Seegene 株式会社	用于协同开发用于检测靶核酸的试剂的计算机实施的方法
ES2988562T3 (es)	2019-07-25	2024-11-20	Hoffmann La Roche	Composiciones y procedimientos para la detección del virus de Epstein-Barr (VEB)
US12496305B2 (en)	2019-07-30	2025-12-16	The Cleveland Clinic Foundation	Detection for determining corticosteroid responsiveness
CA3147009A1 (en)	2019-08-07	2021-02-11	Joe G.N. Garcia	Single nucleotide polymorphisms and uses thereof
WO2021028469A1 (en)	2019-08-12	2021-02-18	Sitokine Limited	Compositions and methods for treating cytokine release syndrome and neurotoxicity
EP4019634A4 (en)	2019-08-13	2024-04-03	Universidade de Santiago de Compostela	COMPOUNDS AND METHODS FOR TREATING CANCER
PH12022550361A1 (en)	2019-08-14	2023-02-27	Incyte Corp	Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
EP4022086B1 (en)	2019-08-27	2025-08-06	F. Hoffmann-La Roche AG	Compositions and methods for amplification and detection of hepatitis b virus rna, including hbv rna transcribed from cccdna
EP3569717A3 (en)	2019-08-28	2020-04-08	Boehringer Ingelheim Vetmedica GmbH	Diagnostic method for the detection of dna and rna viruses by carrying out a polymerase chain reaction in a heated reaction volume
US20220298501A1 (en)	2019-08-30	2022-09-22	The Broad Institute, Inc.	Crispr-associated mu transposase systems
US20210077500A1 (en)	2019-09-12	2021-03-18	Al Therapeutics, Inc.	Pikfyve inhibitors for cancer therapy
NZ786111A (en)	2019-09-23	2025-10-31	Univ Gent	Probe and method for str-genotyping
SG10202008262UA (en)	2019-09-26	2021-04-29	Seminis Vegetable Seeds Inc	Lettuce plants having resistance to nasonovia ribisnigri biotype nr:1
MX2022004390A (es)	2019-10-11	2022-08-08	Incyte Corp	Aminas biciclicas como inhibidores de la cinasa dependiente de ciclina 2 (cdk2).
WO2021072439A1 (en)	2019-10-11	2021-04-15	Life Technologies Corporation	Compositions and methods for assessing microbial populations
US11441167B2 (en)	2019-11-20	2022-09-13	Roche Molecular Systems, Inc.	Compositions and methods for rapid identification and phenotypic antimicrobial susceptibility testing of bacteria and fungi
EP4073175A1 (en)	2019-12-09	2022-10-19	F. Hoffmann-La Roche AG	Dicationic fluorescent dyes
CN115175922A (zh)	2019-12-23	2022-10-11	雅培实验室	用于检测小双核糖核酸病毒的组合物和方法
US11060141B1 (en)	2019-12-23	2021-07-13	Stilla Technologies	Multiplex drop-off digital polymerase chain reaction methods
WO2021138325A1 (en)	2019-12-30	2021-07-08	Abbott Laboratories	Compositions and methods for detecting bunyavirus
WO2021136752A1 (en)	2019-12-31	2021-07-08	F. Hoffmann-La Roche Ag	Quantitative pcr screening of inducible prophage from bacterial isolates
US12365942B2 (en)	2020-01-13	2025-07-22	10X Genomics, Inc.	Methods of decreasing background on a spatial array
US20210292856A1 (en)	2020-02-18	2021-09-23	Life Technologies Corporation	Compositions, kits and methods for detection of viral sequences
US20230117369A1 (en)	2020-03-04	2023-04-20	Gen-Probe Incorporated	Compositions and methods for detecting sars-cov-2 nucleaic acid
US20210332448A1 (en)	2020-03-09	2021-10-28	Janssen Pharmaceutica Nv	Compositions and methods for quantifying integration of recombinant vector nucleic acid
CN116171333A (zh)	2020-03-09	2023-05-26	豪夫迈·罗氏有限公司	用于检测严重急性呼吸综合征冠状病毒2(sars-cov-2)、甲型流感和乙型流感的组合物和方法
JP2023516497A (ja)	2020-03-13	2023-04-19	メドイミューン・リミテッド	Ｉｌ３３にリスクアレルを有する対象を治療するための治療方法
WO2021185320A1 (en)	2020-03-18	2021-09-23	Mgi Tech Co., Ltd.	Restoring phase in massively parallel sequencing
WO2021205013A1 (en)	2020-04-09	2021-10-14	Sitokine Limited	Compositions and methods for treating covid-19
US20230242971A1 (en)	2020-05-08	2023-08-03	Roche Sequencing Solutions, Inc.	Removal of excess oligonucleotides from a reation mixture
US10941453B1 (en)	2020-05-20	2021-03-09	Paragon Genomics, Inc.	High throughput detection of pathogen RNA in clinical specimens
CA3179313A1 (en)	2020-05-27	2021-12-02	Gillian Sue Dite	Methods of assessing risk of developing a severe response to coronavirus infection
KR20230007464A (ko)	2020-06-05	2023-01-12	주식회사 씨젠	호흡기 병원체 검출을 위한 검체수송 키트 및 이를 이용한 호흡기 병원체 검출방법
AU2021204717A1 (en)	2020-07-15	2022-02-03	Seminis Vegetable Seeds, Inc.	Green Bean Plants with Improved Disease Resistance
WO2022020359A1 (en)	2020-07-24	2022-01-27	The Regents Of The University Of Michigan	Compositions and methods for detecting and treating high grade subtypes of uterine cancer
US20220042117A1 (en)	2020-08-06	2022-02-10	Roche Molecular Systems, Inc.	COMPOSITIONS AND METHODS FOR THE SIMULTANEOUS DETECTION OF INFLUENZA A, INFLUENZA B, AND SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-CoV-2)
EP4204546A1 (en)	2020-08-31	2023-07-05	City of Hope	Novel cell lines, methods of producing natural killer cells and uses thereof
US20230371453A1 (en)	2020-10-12	2023-11-23	Nunhems B.V.	Parthenocarpic watermelon plants
EP4237573A1 (en)	2020-10-29	2023-09-06	DNA Script	Enzymatic synthesis of polynucleotide probes
EP4240143A1 (en)	2020-11-09	2023-09-13	Nunhems B.V.	Parthenocarpic watermelon plants
CA3203308A1 (en)	2020-11-30	2022-06-02	Enigma Biointelligence, Inc.	Non-invasive assessment of alzheimer's disease
EP4256089A1 (en)	2020-12-04	2023-10-11	F. Hoffmann-La Roche AG	Compositions and methods for detection of malaria
JP7209980B2 (ja)	2020-12-11	2023-01-23	東洋紡株式会社	Ｄｎａポリメラーゼの５’→３’エキソヌクレアーゼ活性ドメインに特異的に結合する抗体
JP2024500169A (ja)	2020-12-22	2024-01-04	エフ．ホフマン－ラロシュアーゲー	大ストークスシフト蛍光色素を使用して多重化リアルタイムｐｃｒを行うための方法
US20220205020A1 (en)	2020-12-30	2022-06-30	Roche Molecular Systems, Inc.	Compositions and methods for detection of bacteria and fungi associated with bacterial and candida vaginosis
EP4274907A4 (en)	2021-01-08	2025-01-15	Cellanome, Inc.	DEVICES AND METHODS FOR THE ANALYSIS OF BIOLOGICAL SAMPLES
WO2022155588A2 (en)	2021-01-18	2022-07-21	Life Technologies Corporation	Compositions, kits and methods for direct amplification from crude biological samples
US20240392394A1 (en)	2021-01-25	2024-11-28	Life Technologies Corporation	Compositions, kits and methods for detection of viral variant sequences
JP2024505686A (ja)	2021-02-05	2024-02-07	エフ．ホフマン－ラロシュアーゲー	ヒトパラインフルエンザウイルス１－４（ｈｐｉｖ１－４）の検出のための組成物及び方法
US20220290221A1 (en)	2021-03-15	2022-09-15	Roche Molecular Systems, Inc.	Compositions and methods for detecting severe acute respiratory syndrome coronavirus 2 (sars-cov-2) variants having spike protein mutations
EP4314350A1 (en)	2021-03-23	2024-02-07	Life Technologies Corporation	Compositions, kits, and methods for variant-resistant detection of target viral sequences
WO2022233930A1 (en)	2021-05-06	2022-11-10	F. Hoffmann-La Roche Ag	Compositions and methods for detecting hepatitis delta virus by a dual-target assay
AU2022273052A1 (en)	2021-05-14	2023-11-30	Gen-Probe Incorporated	Compositions and methods for detecting human adenovirus nucleic acid
US11981671B2 (en)	2021-06-21	2024-05-14	Incyte Corporation	Bicyclic pyrazolyl amines as CDK2 inhibitors
WO2023275048A1 (en)	2021-06-30	2023-01-05	Nunhems B.V.	Methods for selecting watermelon plants and plant parts comprising a modified dwarf14 gene
EP4613873A3 (en)	2021-07-01	2025-10-22	Gen-Probe Incorporated	Enzyme formulations and reaction mixtures for nucleic acid amplification
WO2023283452A2 (en)	2021-07-09	2023-01-12	Cepheid	High-level multiplexing reaction vessel, reagent spotting device and associated methods
FR3125824B1 (fr)	2021-07-30	2025-07-11	Bforcure	Dispositif et procédé de détection multiplexée de séquences d’acides nucléiques
US20240352544A1 (en)	2021-08-02	2024-10-24	Life Technologies Corporation	Compositions, kits, and methods for detection of nucleic acid sequence loads
WO2023020938A1 (en)	2021-08-16	2023-02-23	Nunhems B.V.	Lettuce plant having delayed bolting
WO2023043280A1 (ko)	2021-09-17	2023-03-23	주식회사 씨젠	합성 비자연 염기를 포함하는 태그 올리고뉴클레오타이드를 이용한 타겟 핵산 서열의 검출
KR20240056605A (ko)	2021-09-30	2024-04-30	주식회사 씨젠	분자진단 시스템의 샘플 처리 및 분석 방법
US20230121442A1 (en)	2021-10-06	2023-04-20	Johnson & Johnson Consumer Inc.	Method of Quantifying Product Impact on Human Microbiome
WO2023069604A1 (en)	2021-10-20	2023-04-27	Life Technologies Corporation	Compositions, kits, and methods for quantification of nucleic acid sequences using an internal quantitative standard
KR20240093623A (ko)	2021-10-21	2024-06-24	주식회사 씨젠	시료 내 표적 분석물질에 대한 양음성 판독 장치 및 방법
KR20240099319A (ko)	2021-10-26	2024-06-28	카리부 바이오사이언시스 인코포레이티드	엑소뉴클레아제-커플링된 실시간 엔도뉴클레아제 활성 검정
US20240398393A1 (en)	2021-10-29	2024-12-05	Seegene, Inc.	Sample collecting swab tool and method for detection of respiratory pathogen
WO2023079032A1 (en)	2021-11-05	2023-05-11	F. Hoffmann-La Roche Ag	Compositions and methods for detection of malaria
WO2023089186A1 (en)	2021-11-22	2023-05-25	F. Hoffmann-La Roche Ag	Compositions and methods for detecting vana and/or vanb genes associated with multidrug resistance
WO2023104812A1 (en)	2021-12-09	2023-06-15	F. Hoffmann-La Roche Ag	Mass based detection of pcr amplicons
US11976073B2 (en)	2021-12-10	2024-05-07	Incyte Corporation	Bicyclic amines as CDK2 inhibitors
US20230193310A1 (en)	2021-12-10	2023-06-22	Seminis Vegetabe Seeds, Inc.	Lettuce plants having resistance to downy mildew
WO2023122723A1 (en)	2021-12-23	2023-06-29	The Broad Institute, Inc.	Panels and methods for diagnosing and treating lung cancer
EP4453249A1 (en)	2021-12-24	2024-10-30	F. Hoffmann-La Roche AG	Improved detection of lamp amplification products
EP4471162A4 (en)	2022-01-26	2025-12-17	Seegene Inc	METHOD FOR THE DETECTION OF TARGET NUCLEAN ACIDS IN A SAMPLE
AU2023232823A1 (en)	2022-03-07	2024-09-12	Incyte Corporation	Solid forms, salts, and processes of preparation of a cdk2 inhibitor
US20230348985A1 (en)	2022-03-21	2023-11-02	CarexDx, Inc.	Methods for non-invasively monitoring organ health in cross-species transplantation
US12091715B2 (en)	2022-04-21	2024-09-17	Paragon Genomics, Inc.	Methods and compositions for reducing base errors of massive parallel sequencing using triseq sequencing
US11680293B1 (en)	2022-04-21	2023-06-20	Paragon Genomics, Inc.	Methods and compositions for amplifying DNA and generating DNA sequencing results from target-enriched DNA molecules
WO2023214843A1 (ko)	2022-05-06	2023-11-09	주식회사 씨젠	핵산 검출 카트리지
EP4542552A1 (en)	2022-06-15	2025-04-23	Seegene, Inc.	Method and device for creating technical construction file
WO2023250288A2 (en)	2022-06-21	2023-12-28	Seminis Vegetable Seeds, Inc.	Novel qtls conferring resistance to cucumber mosaic virus
EP4544289A1 (en)	2022-06-24	2025-04-30	Gen-Probe Incorporated	Compact detection system
CN119487130A (zh)	2022-06-28	2025-02-18	豪夫迈·罗氏有限公司	具有大斯托克斯位移的荧光染料
CA3260523A1 (en)	2022-06-29	2024-01-04	Actome Gmbh	DETECTION OF BIOMOLECULES IN SINGLE CELLS
CN119731337A (zh)	2022-06-29	2025-03-28	生命科技公司	用于从多重测定检测分析物的系统和方法
EP4547861A1 (en)	2022-06-29	2025-05-07	Life Technologies Corporation	Compositions, kits, and methods for detecting nucleic acids using intra-channel multiplexing
US20250368983A1 (en)	2022-06-30	2025-12-04	Kapa Biosystems, Inc.	Controlling for tagmentation sequencing library insert size using archaeal histone-like proteins
JP2025521750A (ja)	2022-06-30	2025-07-10	エフ．ホフマン－ラロシュアーゲー	クラミジア・トラコマチス（ｃｈｌａｍｙｄｉａｔｒａｃｈｏｍａｔｉｓ）の鼠径リンパ肉芽腫症（ｌｇｖ）血清型を検出するための組成物および方法
KR20250020611A (ko)	2022-07-05	2025-02-11	주식회사 씨젠	복수의 표적 분석물 각각에 대한 근사 신호의 획득 방법 및 이를 수행하는 컴퓨터 장치
CN119968468A (zh)	2022-07-12	2025-05-09	拓扑基因股份有限公司	Dna芯片亚微米精度大规模复制方法
KR20250037769A (ko)	2022-07-29	2025-03-18	주식회사 씨젠	파라미터의 임계값 설정용 인터페이스 제공 장치 및 방법
EP4565720A1 (en)	2022-08-04	2025-06-11	Abbott Laboratories	Assays for detecting monkeypox virus
EP4577674A1 (en)	2022-08-24	2025-07-02	F. Hoffmann-La Roche AG	Compositions and methods for detecting monkeypox virus
EP4577672A1 (en)	2022-08-26	2025-07-02	The General Hospital Corporation	Methods and compositions for prognosis and treatment of dilated cardiomyopathy and heart failure
WO2024054925A1 (en)	2022-09-09	2024-03-14	Life Technologies Corporation	Compositions, kits and methods for detection of viral variant sequences
WO2024081776A1 (en)	2022-10-13	2024-04-18	Gen-Probe Incorporated	Cellularity control for nucleic acid assays
KR20250086619A (ko)	2022-10-14	2025-06-13	주식회사 씨젠	상이한 tm 값을 가지는 2개의 프로브를 이용하여 샘플 내 타겟 핵산을 검출하는 방법
EP4607520A1 (en)	2022-10-20	2025-08-27	Seegene, Inc.	Method of guiding multiple detailed performance experiments required for developing reagent for detecting target nucleic acid molecule, and organizing experiment result record sheets
EP4611533A1 (en)	2022-11-04	2025-09-10	Nunhems B.V.	Melon plants producing seedless fruit
WO2024102839A1 (en)	2022-11-10	2024-05-16	Life Technologies Corporation	Compositions, kits, and methods for detection of viral sequences
KR20250110818A (ko)	2022-11-16	2025-07-21	주식회사 씨젠	퀀칭-pto 절단 및 연장(quenching-pto cleavage and extension；q-ptoce) 어세이에 의한 타겟 핵산의 검출
GB202217984D0 (en)	2022-11-30	2023-01-11	Qbiotix Ltd	Assays
EP4630587A1 (en)	2022-12-07	2025-10-15	Université de Lille	Blastocystis sp. as a predictive biomarker of high productive longevity in dairy heifers
GB202218575D0 (en)	2022-12-09	2023-01-25	Qbiotix Ltd	Affinity probes
IL321497A (en)	2022-12-15	2025-08-01	Seegene Inc	Device and method for displaying performance comparison results with respect to a fluorescence data analysis algorithm
WO2024137379A2 (en)	2022-12-19	2024-06-27	Gen-Probe Incorporated	Compositions and methods for detecting gastrointestinal pathogens
EP4389911A1 (en)	2022-12-21	2024-06-26	Mobidiag Oy	Methods and systems for isolating an analyte
EP4389887A1 (en)	2022-12-21	2024-06-26	Mobidiag Oy	Isolating and lysing cells
EP4638791A1 (en)	2022-12-25	2025-10-29	F. Hoffmann-La Roche AG	Compositions and methods for detecting carbapenem resistant acinetobacter calcoaceticus- baumannii(crab)
CN120457216A (zh)	2022-12-28	2025-08-08	豪夫迈·罗氏有限公司	针对多个乙型肝炎病毒基因靶标的数字pcr测定设计及用于其的不可延伸的阻断剂寡核苷酸
WO2024145445A1 (en) *	2022-12-30	2024-07-04	10X Genomics, Inc.	Methods of capturing target analytes
WO2024148013A1 (en)	2023-01-02	2024-07-11	Life Technologies Corporation	Compositions, kits and methods for detection of viral sequences
EP4655411A2 (en)	2023-01-26	2025-12-03	DNA Script	Enzymatic synthesis of polynucleotide probes
US20240254568A1 (en)	2023-01-27	2024-08-01	Life Technologies Corporation	Compositions, kits, and methods for detecting sti pathogen sequences
WO2024175749A1 (en)	2023-02-25	2024-08-29	F. Hoffmann-La Roche Ag	Compositions and methods for candida species detection
WO2024182219A1 (en)	2023-02-27	2024-09-06	Adaptive Biotechnologies Corp.	Therapeutic t cell receptors targeting kras g12d
WO2024184165A1 (en)	2023-03-03	2024-09-12	F. Hoffmann-La Roche Ag	Compositions and methods for the detection of group b streptococcus ( streptococcus agalactiae) and clindamycin resistance gene determinants
WO2024192338A1 (en)	2023-03-16	2024-09-19	Gen-Probe Incorporated	Compositions and methods for detecting gastrointestinal parasites
AU2024202284B2 (en)	2023-04-14	2025-08-14	Seminis Vegetable Seeds, Inc.	Methods and compositions for Peronospora resistance in spinach
WO2024238460A2 (en)	2023-05-12	2024-11-21	Life Technologies Corporation	Systems and methods for multiplexed polymerase chain reaction processes and data analysis
WO2024235904A1 (en)	2023-05-16	2024-11-21	Roche Molecular Systems, Inc.	Detection of target analytes using multimodal signal probes
WO2024254245A1 (en)	2023-06-09	2024-12-12	Incyte Corporation	Bicyclic amines as cdk2 inhibitors
FI20235652A1 (en)	2023-06-12	2024-12-13	Mobidiag Oy	Methods for isolating microbial analyte
WO2025024676A1 (en)	2023-07-26	2025-01-30	Caribou Biosciences, Inc.	In vitro validation methods for cd19-targeting cell therapies
WO2025027080A1 (en)	2023-08-03	2025-02-06	F. Hoffmann-La Roche Ag	Use of 5'-tailed long primers to improve amplification performance when targeting short primer-binding sites
WO2025034736A1 (en)	2023-08-08	2025-02-13	Life Technologies Corporation	Sample preparation for nucleic acids
WO2025072571A1 (en)	2023-09-27	2025-04-03	Cellanome, Inc.	Cell culture within microfluidic structures
WO2025106804A1 (en)	2023-11-16	2025-05-22	Massachusetts Institute Of Technology	Compositions and methods for characterizing hepatocyte stress
WO2025117544A1 (en)	2023-11-29	2025-06-05	The Broad Institute, Inc.	Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof
WO2025151807A1 (en)	2024-01-11	2025-07-17	Life Technologies Corporation	Crude lysate sample extraction for digital pcr
WO2025153541A1 (en)	2024-01-19	2025-07-24	Nunhems Netherlands B.V.	Cucumber fruits with increased sugar content
WO2025175243A1 (en)	2024-02-15	2025-08-21	Life Technologies Corporation	Amplification and data collection protocol for rapid genotyping
WO2025175212A1 (en)	2024-02-15	2025-08-21	Life Technologies Corporation	Methods for rapid extraction-free genotyping
WO2025172110A1 (en)	2024-02-16	2025-08-21	Nunhems Netherlands B.V.	Modified plant architecture in cucumber
WO2025184318A1 (en)	2024-02-28	2025-09-04	The General Hospital Corporation	Methods and compositions for prognosis and treatment of peripartum cardiomyopathy
WO2025184324A1 (en)	2024-02-28	2025-09-04	The General Hospital Corporation	Methods and compositions for prognosis and treatment of cancer therapy-related cardiac dysfunction
WO2025237806A1 (en)	2024-05-13	2025-11-20	Nunhems Netherlands B.V.	Lettuce plant having delayed bolting and shade tolerance
WO2025240660A1 (en)	2024-05-15	2025-11-20	Foresite Labs, Llc	Drug development and drug activity determination for coronary artery disease (cad)

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4318981A (en)	1980-04-24	1982-03-09	Miles Laboratories, Inc.	Homogeneous specific binding assay employing an intramolecularly modulated photogenic enzyme substrate label
US4358535A (en) *	1980-12-08	1982-11-09	Board Of Regents Of The University Of Washington	Specific DNA probes in diagnostic microbiology
CA1219824A (en) †	1981-04-17	1987-03-31	David C. Ward	Modified nucleotides and methods of preparing and using same
US4711955A (en) *	1981-04-17	1987-12-08	Yale University	Modified nucleotides and methods of preparing and using same
CA1185177A (en) *	1981-07-17	1985-04-09	Larry E. Morrison	Non-radiative energy transfer immunochemical technique
CA1190838A (en) *	1981-07-17	1985-07-23	Cavit Akin	Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
CA1180647A (en) *	1981-07-17	1985-01-08	Cavit Akin	Light-emitting polynucleotide hybridization diagnostic method
FR2540122B1 (fr)	1983-01-27	1985-11-29	Centre Nat Rech Scient	Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application
GB8311018D0 (en) *	1983-04-22	1983-05-25	Amersham Int Plc	Detecting mutations in dna
US4743535A (en)	1984-11-07	1988-05-10	Miles Inc.	Hybridization assay employing labeled probe and anti-hybrid
US4683194A (en) *	1984-05-29	1987-07-28	Cetus Corporation	Method for detection of polymorphic restriction sites and nucleic acid sequences
US4820630A (en) *	1984-11-23	1989-04-11	Digene Diagnostics, Incorporated	Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
US4883750A (en) *	1984-12-13	1989-11-28	Applied Biosystems, Inc.	Detection of specific sequences in nucleic acids
DK150841C (da)	1984-12-19	1988-07-11	Medicotest Systemer As	Forbindelsesled til etablering af elektrisk forbindelse med en engangshudelektrode
ES8706823A1 (es)	1985-03-28	1987-06-16	Cetus Corp	Un procedimiento para detectar la presencia o ausencia de al menos una secuencia especifica de acidos nucleicos en una muestra
US4683195A (en) *	1986-01-30	1987-07-28	Cetus Corporation	Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en)	1985-03-28	1987-07-28	Cetus Corporation	Process for amplifying nucleic acid sequences
US4780405A (en) †	1985-06-25	1988-10-25	Siska Diagnostics, Inc.	Carbonic anhydrase inhibitor-tagged nucleic acid probes
SE450813B (sv) †	1985-07-23	1987-08-03	Volcano Int Medical Ab	Kneskydd med festbara stoddelar
FR2586704B1 (fr)	1985-09-04	1987-12-18	Centre Nat Rech Scient	Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation et a un groupe chimique activable, leur synthese et leurs applications a titre de nucleases artificielles specifiques de sequences. centre national de la recherche scientifique (cnrs)
US5011769A (en) *	1985-12-05	1991-04-30	Meiogenics U.S. Limited Partnership	Methods for detecting nucleic acid sequences
US4996143A (en) *	1985-12-23	1991-02-26	Syngene, Inc.	Fluorescent stokes shift probes for polynucleotide hybridization
CA1273552A (en) *	1985-12-23	1990-09-04	Michael J. Heller	Fluorescent stokes shift probes for polynucleotide hybridization assays
ATE88761T1 (de)	1986-01-10	1993-05-15	Amoco Corp	Kompetitiver homogener test.
US4868103A (en) *	1986-02-19	1989-09-19	Enzo Biochem, Inc.	Analyte detection by means of energy transfer
CA1284931C (en) *	1986-03-13	1991-06-18	Henry A. Erlich	Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids
US4851331A (en) *	1986-05-16	1989-07-25	Allied Corporation	Method and kit for polynucleotide assay including primer-dependant DNA polymerase
GB8612087D0 (en) *	1986-05-19	1986-06-25	Ici Plc	Hybridisation probes
JPS638396A (ja)	1986-06-30	1988-01-14	Wakunaga Pharmaceut Co Ltd	ポリ標識化オリゴヌクレオチド誘導体
CA1340806C (en) *	1986-07-02	1999-11-02	James Merrill Prober	Method, system and reagents for dna sequencing
US4889818A (en) *	1986-08-22	1989-12-26	Cetus Corporation	Purified thermostable enzyme
CA1338457C (en) *	1986-08-22	1996-07-16	Henry A. Erlich	Purified thermostable enzyme
US4914210A (en) *	1987-10-02	1990-04-03	Cetus Corporation	Oligonucleotide functionalizing reagents
CA1323293C (en) *	1987-12-11	1993-10-19	Keith C. Backman	Assay using template-dependent nucleic acid probe reorganization
FR2627590A1 (fr) *	1988-02-24	1989-08-25	Ire Celltarg Sa	Sonde d'acides nucleiques comportant un nucleotide terminal modifie chimiquement en 5(prime) (oh) en vue de son marquage non radioactif et procedes de preparation
US5082830A (en)	1988-02-26	1992-01-21	Enzo Biochem, Inc.	End labeled nucleotide probe
WO1989009284A1 (en) *	1988-03-24	1989-10-05	University Of Iowa Research Foundation	Catalytic hybridization systems for the detection of nucleic acid sequences based on their activity as cofactors in catalytic reactions in which a complementary labeled nucleic acid probe is cleaved
ATE114726T1 (de) *	1988-05-10	1994-12-15	Du Pont	Verfahren zum schnellen nachweis von nukleinsäuren.
AU632494B2 (en) †	1988-05-20	1993-01-07	F. Hoffmann-La Roche Ag	Immobilized sequence-specific probes
AU629845B2 (en) *	1988-08-30	1992-10-15	Abbott Laboratories	Detection and amplification of target nucleic acid sequences
US4997928A (en) *	1988-09-15	1991-03-05	E. I. Du Pont De Nemours And Company	Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
US5118801A (en) *	1988-09-30	1992-06-02	The Public Health Research Institute	Nucleic acid process containing improved molecular switch
WO1990012115A1 (en) *	1989-03-21	1990-10-18	Collaborative Research, Inc.	A dna diagnostic test using an exonuclease activity
US5108892A (en) *	1989-08-03	1992-04-28	Promega Corporation	Method of using a taq dna polymerase without 5'-3'-exonuclease activity
EP0439182B1 (en) *	1990-01-26	1996-04-24	Abbott Laboratories	Improved method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions
CA2037673A1 (en) *	1990-03-07	1991-09-08	Nanibhushan Dattagupta	Ribonuclease scission chain reaction
US5210015A (en) *	1990-08-06	1993-05-11	Hoffman-La Roche Inc.	Homogeneous assay system using the nuclease activity of a nucleic acid polymerase

1990
- 1990-08-06 US US07/563,758 patent/US5210015A/en not_active Expired - Lifetime
1991
- 1991-08-06 EP EP03000776A patent/EP1302549B1/en not_active Expired - Lifetime
- 1991-08-06 DK DK91917050T patent/DK0543942T4/da active
- 1991-08-06 ES ES91917050T patent/ES2155058T5/es not_active Expired - Lifetime
- 1991-08-06 DE DE69132521T patent/DE69132521T3/de not_active Expired - Lifetime
- 1991-08-06 DK DK98119974T patent/DK0919565T4/da active
- 1991-08-06 AT AT91917050T patent/ATE198912T1/de not_active IP Right Cessation
- 1991-08-06 AT AT98119974T patent/ATE252110T1/de not_active IP Right Cessation
- 1991-08-06 AT AT03000776T patent/ATE365812T1/de not_active IP Right Cessation
- 1991-08-06 ES ES98119974T patent/ES2209033T5/es not_active Expired - Lifetime
- 1991-08-06 AU AU86510/91A patent/AU666837B2/en not_active Expired
- 1991-08-06 WO PCT/US1991/005571 patent/WO1992002638A1/en not_active Ceased
- 1991-08-06 ES ES03000776T patent/ES2289190T3/es not_active Expired - Lifetime
- 1991-08-06 CA CA002088683A patent/CA2088683C/en not_active Expired - Lifetime
- 1991-08-06 JP JP3517497A patent/JP2825976B2/ja not_active Expired - Lifetime
- 1991-08-06 DK DK03000776T patent/DK1302549T3/da active
- 1991-08-06 DE DE69133329T patent/DE69133329T3/de not_active Expired - Lifetime
- 1991-08-06 DE DE69133574T patent/DE69133574T2/de not_active Expired - Lifetime
- 1991-08-06 EP EP91917050A patent/EP0543942B2/en not_active Expired - Lifetime
- 1991-08-06 EP EP98119974A patent/EP0919565B2/en not_active Expired - Lifetime
1993
- 1993-01-05 US US07/961,884 patent/US5487972A/en not_active Expired - Lifetime
1995
- 1995-04-25 US US08/428,941 patent/US5804375A/en not_active Expired - Lifetime
1997
- 1997-09-19 US US08/934,378 patent/US6214979B1/en not_active Expired - Fee Related
2005
- 2005-01-27 US US11/043,099 patent/US7141377B2/en not_active Expired - Fee Related
- 2005-08-11 US US11/203,461 patent/US7445900B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1302549A3 (en)	2004-01-14
DE69132521T2 (de)	2001-09-06
EP0919565A3 (en)	2000-11-15
DE69133329T3 (de)	2009-07-09
EP0919565B2 (en)	2008-11-12
CA2088683A1 (en)	1992-02-07
ATE365812T1 (de)	2007-07-15
AU666837B2 (en)	1996-02-29
EP0543942A1 (en)	1993-06-02
ES2289190T3 (es)	2008-02-01
DK1302549T3 (da)	2007-10-01
US7141377B2 (en)	2006-11-28
DE69133574D1 (de)	2007-08-09
EP0919565B1 (en)	2003-10-15
DK0919565T4 (da)	2009-01-12
US5210015A (en)	1993-05-11
US20050255499A1 (en)	2005-11-17
EP0543942B2 (en)	2006-11-15
US6214979B1 (en)	2001-04-10
ES2209033T3 (es)	2004-06-16
JP2825976B2 (ja)	1998-11-18
US5804375A (en)	1998-09-08
DE69132521D1 (de)	2001-03-01
ES2155058T3 (es)	2001-05-01
AU8651091A (en)	1992-03-02
ES2209033T5 (es)	2009-04-16
DE69133329D1 (de)	2003-11-20
WO1992002638A1 (en)	1992-02-20
US5487972A (en)	1996-01-30
EP0543942B1 (en)	2001-01-24
EP1302549B1 (en)	2007-06-27
DK0919565T3 (da)	2004-02-16
EP0919565A2 (en)	1999-06-02
DE69133574T2 (de)	2008-03-06
ES2155058T5 (es)	2007-06-16
ATE252110T1 (de)	2003-11-15
US20080171315A1 (en)	2008-07-17
DE69132521T3 (de)	2007-07-05
CA2088683C (en)	2000-03-28
DE69133329T2 (de)	2004-08-05
DK0543942T3 (da)	2001-06-18
JPH06500021A (ja)	1994-01-06
EP1302549A2 (en)	2003-04-16
ATE198912T1 (de)	2001-02-15
US7445900B2 (en)	2008-11-04

Publication	Publication Date	Title
DK0543942T3 (da)	2001-06-18	Homogent assaysystem
AU6180190A (en)	1991-03-11	Fast process for detecting and/or identifying a single base on a nucleic acid sequence and its applications
ATE324464T1 (de)	2006-05-15	Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren
AU577776B2 (en)	1988-10-06	Methods and structures employing non-radioactive chemically labelled polynucleotide probes
EP0173339A3 (en)	1987-12-23	Composition and method for the dectection of the presence of a polynucleotide sequence of interest
DE69031237D1 (de)	1997-09-18	Verfahren zur Reinigung von Nukleinsäuren
DE69028257D1 (de)	1996-10-02	Verfahren zur Vervielfältigung von Nukleinsäuresequenzen
DE69114353D1 (de)	1995-12-14	Vorbereitung und Isolierung von einzel-strängigen Nukleinsäuren mit Avidin-Biotintrennung.
DE3650679D1 (de)	1998-06-10	Oligonukleotide zur Amplifizierung von Nukleinsäuresequenzen und zur Anknüpfung einer Promotersequenz
ATE167231T1 (de)	1998-06-15	Vorrichtung zur behandlung biologischer proben für die analyse von nukleinsäuren
DE3750774D1 (de)	1995-01-05	Chaotropisches verfahren zur schätzung von nukleinen säuren in einer biologischen probe.
EP0417842A3 (en)	1991-08-28	Diagnostic and amplification methods overcoming a primer-target mismatch at the primer 3'end
ATE174926T1 (de)	1999-01-15	Hydrophobe nukleinsäure-sonde
DE3876108D1 (de)	1993-01-07	Diagnostischer test unter verwendung von nucleinsaeure-sonden.
ATE137807T1 (de)	1996-05-15	Systeme für amplifikation/nachweis von nukleinsäuren
ES2072864T3 (es)	1995-08-01	Procedimiento rapido para la identificacion de una secuencia especifica de acidos nucleicos.