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DK0467954T3 - Fremstilling af liposom- og lipidkomplekssammensætninger - Google Patents

Fremstilling af liposom- og lipidkomplekssammensætninger

Info

Publication number
DK0467954T3
DK0467954T3 DK90906530.2T DK90906530T DK0467954T3 DK 0467954 T3 DK0467954 T3 DK 0467954T3 DK 90906530 T DK90906530 T DK 90906530T DK 0467954 T3 DK0467954 T3 DK 0467954T3
Authority
DK
Denmark
Prior art keywords
liposome
compounds
aprotic solvent
preparation
lipid complex
Prior art date
Application number
DK90906530.2T
Other languages
Danish (da)
English (en)
Inventor
Francis C Szoka Jr
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of DK0467954T3 publication Critical patent/DK0467954T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK90906530.2T 1989-03-31 1990-03-28 Fremstilling af liposom- og lipidkomplekssammensætninger DK0467954T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33260989A 1989-03-31 1989-03-31
US33405589A 1989-04-05 1989-04-05

Publications (1)

Publication Number Publication Date
DK0467954T3 true DK0467954T3 (da) 1996-05-28

Family

ID=26988293

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90906530.2T DK0467954T3 (da) 1989-03-31 1990-03-28 Fremstilling af liposom- og lipidkomplekssammensætninger

Country Status (11)

Country Link
EP (1) EP0467954B1 (fr)
JP (1) JP2798302B2 (fr)
AT (1) ATE137403T1 (fr)
AU (1) AU638245B2 (fr)
CA (1) CA2050679C (fr)
DE (1) DE69026820T2 (fr)
DK (1) DK0467954T3 (fr)
ES (1) ES2087151T3 (fr)
HU (1) HU208070B (fr)
NO (1) NO303205B1 (fr)
WO (1) WO1990011780A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
JPH0363298A (ja) * 1989-07-31 1991-03-19 Green Cross Corp:The コロニー形成刺激因子・脂質複合体
FR2653015B1 (fr) * 1989-10-12 1993-10-29 Oreal Composition cosmetique ou pharmaceutique pour application topique contenant au moins un derive retinouide et au moins un derive de pyrimidine, son utilisation comme medicament et procede de traitement correspondant.
WO1992008467A1 (fr) 1990-11-16 1992-05-29 Nippon Shinyaku Co., Ltd. Preparattion de dispersion
DE4238779A1 (de) * 1992-11-12 1994-05-19 Max Delbrueck Centrum Lyotrophe Mesophasen und ihre Anwendung in der Pharmazie, der Kosmetik und der Dermatologie
EP0707472B1 (fr) 1993-07-08 2001-03-14 The Liposome Company, Inc. Procede de maitrise de la taille des liposomes
ATE311748T1 (de) * 1993-09-29 2005-12-15 Dsm Ip Assets Bv Modifizierte formen des natamycins, verfahren zu ihrer herstellung und sie enthaltende antifungale zusammensetzungen
AU705549B2 (en) * 1995-06-07 1999-05-27 Promega Biosciences, Inc. Phosphonic acid-based cationic lipids
DE69924004T2 (de) * 1998-12-22 2006-02-09 United States Of America Represented By The Secretary, Department Of Health & Human Services Verabreichungssystem für wasserunlösliche arzneistoffe
US6511676B1 (en) * 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
AU2001292287A1 (en) * 2000-10-26 2002-05-06 Senju Pharmaceutical Co. Ltd. Drug composition comprising dipeptydyl aldehyde derivative
EP1343476B1 (fr) * 2000-12-01 2008-05-28 Biomira Inc. Preparation de liposomes de grande taille par perfusion dans du peg
IS6389A (is) * 2001-08-31 2003-03-03 Heraeus Kulzer Gmbh & Co. Kg Reynsla af sýklalyfjahúðun skrokka, sem í eru örholrými, og einnig af þannig húðuðum skrokkum og notkun þeirra
WO2008114274A1 (fr) * 2007-03-19 2008-09-25 Fresenius Kabi Onclology Ltd. Compositions proliposomales et liposomales
AU2008321174A1 (en) * 2007-11-14 2009-05-22 The Regents Of The University Of California Sterol-modified amphiphilic lipids
WO2010036947A2 (fr) 2008-09-27 2010-04-01 Jina Pharmaceuticals, Inc. Préparations pharmaceutiques à base de lipide(s) à usage oral et topique, leurs compositions, procédés et utilisations
CN104001159B (zh) * 2010-07-14 2016-08-24 中国医学科学院药物研究所 一种胰岛素的脂质复合物及其制备方法和制剂
US10004759B2 (en) 2014-08-04 2018-06-26 Zoneone Pharma, Inc. Remote loading of sparingly water-soluble drugs into lipid vesicles
CN113616798A (zh) * 2021-09-06 2021-11-09 天津农学院 一种甲苯咪唑脂质复合物、制备方法和应用
CN115177590A (zh) * 2022-04-20 2022-10-14 南昌大学抚州医学院 一种甲苯达唑类脂质体的制备方法及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588578A (en) * 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
JPS60240634A (ja) 1984-05-08 1985-11-29 関　則雄 飲み干し容易なコツプ
US4619913A (en) * 1984-05-29 1986-10-28 Matrix Pharmaceuticals, Inc. Treatments employing drug-containing matrices for introduction into cellular lesion areas
AU598002B2 (en) * 1986-07-15 1990-06-14 Cilag Ltd. Method of preparing single bilayered liposomes
US4839175A (en) * 1986-07-28 1989-06-13 Liposome Technology, Inc. Liposomes with enhanced retention on mucosal tissue
US4804539A (en) 1986-07-28 1989-02-14 Liposome Technology, Inc. Ophthalmic liposomes
US4812312A (en) * 1987-03-03 1989-03-14 Board Of Regents Of The University Of Texas System Liposome-incorporated nystatin
NZ223660A (en) * 1987-03-05 1990-11-27 Liposome Co Inc Low toxicity drug-lipid complexes; methods of making them; and method of determining their toxicity

Also Published As

Publication number Publication date
DE69026820T2 (de) 1996-11-28
NO303205B1 (no) 1998-06-15
HU208070B (en) 1993-08-30
ES2087151T3 (es) 1996-07-16
EP0467954A1 (fr) 1992-01-29
NO913816D0 (no) 1991-09-27
ATE137403T1 (de) 1996-05-15
NO913816L (no) 1991-11-26
EP0467954B1 (fr) 1996-05-01
AU638245B2 (en) 1993-06-24
CA2050679C (fr) 1998-09-22
HK1000912A1 (en) 1998-05-08
HUT59818A (en) 1992-07-28
HU903559D0 (en) 1991-12-30
JP2798302B2 (ja) 1998-09-17
JPH04506207A (ja) 1992-10-29
CA2050679A1 (fr) 1990-10-01
AU5434590A (en) 1990-11-05
EP0467954A4 (en) 1992-06-03
WO1990011780A1 (fr) 1990-10-18
DE69026820D1 (de) 1996-06-05

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