DK0580817T3 - Farmaceutisk præparat og fremgangsmåde til fremstilling deraf - Google Patents

Farmaceutisk præparat og fremgangsmåde til fremstilling deraf

Info

Publication number: DK0580817T3
Authority: DK; Denmark
Prior art keywords: preparation; pharmaceutical composition; solid phase; cyclosporin; solution
Prior art date: 1991-04-19

Application number

DK92922779.1T

Other languages

English (en)

Inventor

Jill P Adler-Moore

William A Ernst

Original Assignee

Nexstar Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-19

Filing date

1992-04-20

Publication date

1996-08-05

1992-04-20 Application filed by Nexstar Pharmaceuticals Inc filed Critical Nexstar Pharmaceuticals Inc

1996-08-05 Application granted granted Critical

1996-08-05 Publication of DK0580817T3 publication Critical patent/DK0580817T3/da

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 2
229930105110 Cyclosporin A Natural products 0.000 abstract 2
108010036949 Cyclosporine Proteins 0.000 abstract 2
229960001265 ciclosporin Drugs 0.000 abstract 2
229930182912 cyclosporin Natural products 0.000 abstract 2
239000007790 solid phase Substances 0.000 abstract 2
239000007864 aqueous solution Substances 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000000887 hydrating effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Dispersion Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK92922779.1T 1991-04-19 1992-04-20 Farmaceutisk præparat og fremgangsmåde til fremstilling deraf DK0580817T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US68781291A	1991-04-19	1991-04-19

Publications (1)

Publication Number	Publication Date
DK0580817T3 true DK0580817T3 (da)	1996-08-05

Family

ID=24761958

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92922779.1T DK0580817T3 (da)	1991-04-19	1992-04-20	Farmaceutisk præparat og fremgangsmåde til fremstilling deraf

Country Status (11)

Country	Link
US (3)	US5688525A (da)
EP (1)	EP0580817B1 (da)
JP (1)	JP2721041B2 (da)
AT (1)	ATE139439T1 (da)
AU (1)	AU657961B2 (da)
CA (1)	CA2108288C (da)
DE (1)	DE69211691T2 (da)
DK (1)	DK0580817T3 (da)
ES (1)	ES2088160T3 (da)
GR (1)	GR3020396T3 (da)
WO (1)	WO1992018104A1 (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0697214A1 (en) *	1994-07-19	1996-02-21	Vestar, Inc.	Liposomal cyclosporin pharmaceutical formulations
EP0789584B1 (de) *	1994-11-04	2001-09-19	Polymun Scientific Immunbiologische Forschung GmbH	Applikation von sod in liposomen
AU6047996A (en) *	1995-06-07	1996-12-30	Nexstar Pharmaceuticals, Inc.	Liposomal cyclosporin formulations as agents for immunosuppr ession and multiple drug resistant indications
US5693336A (en) *	1995-06-07	1997-12-02	Nexstar Pharmaceuticals, Inc.	Blood stable liposomal cyclosporin formulations
CA2202103C (en)	1996-04-11	2007-01-09	Toshiaki Tagawa	Method for preparing closed vesicles
US6979456B1 (en)	1998-04-01	2005-12-27	Jagotec Ag	Anticancer compositions
JP2002534370A (ja)	1998-12-30	2002-10-15	デクセルリミテッド	サイクロスポリンを送達するための分散可能な濃縮物
US6613352B2 (en)	1999-04-13	2003-09-02	Universite De Montreal	Low-rigidity liposomal formulation
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
ES2220724T3 (es) *	2000-01-20	2004-12-16	Basilea Pharmaceutica Ag	Composiciones de peptidos ciclicos administrables por via nasal.
US7125568B2 (en) *	2001-08-23	2006-10-24	Sung Michael T	Lipophilic drug compositions
US7060672B2 (en)	2001-10-19	2006-06-13	Isotechnika, Inc.	Cyclosporin analog formulations
RU2217128C1 (ru) *	2002-07-16	2003-11-27	Закрытое акционерное общество "АИП-Наука"	Препарат для местного применения при лечении туберкулеза легких и гнойно-воспалительных заболеваний
AU2003287526A1 (en) *	2002-11-06	2004-06-03		Protein-stabilized liposomal formulations of pharmaceutical agents
WO2006014035A1 (en) *	2004-08-06	2006-02-09	Biospectrum, Inc.	Multiple layered liposome and preparation method thereof
US20060165641A1 (en) *	2005-01-18	2006-07-27	Kumar Pillai	Cosmetic compositions containing combinations of hydroxamate derivatives and antioxidants in a liposomal delivery system
US20070026061A1 (en) *	2005-05-25	2007-02-01	Nahid Ali	Liposomal formulation and use thereof
TWI435729B (zh)	2005-11-09	2014-05-01	Combinatorx Inc	治療病症之方法，組合物及套組
EP2457589A1 (en) *	2006-08-31	2012-05-30	Astellas Pharma Inc.	Reverse targeting lipid vesicle
RU2015109165A (ru)	2008-03-06	2015-11-10	Анакор Фармасьютикалз, Инк.	Борсодержащие малые молекулы в качестве противовоспалительных агентов
US8218847B2 (en)	2008-06-06	2012-07-10	Superdimension, Ltd.	Hybrid registration method
JP6205133B2 (ja)	2009-07-10	2017-09-27	プレジデントアンドフェローズオブハーバードカレッジ	抗炎症剤としての恒久的に荷電したナトリウムおよびカルシウムチャンネルブロッカー
JP6200648B2 (ja)	2009-12-18	2017-09-20	アケリオスセラピューティクス，インコーポレーテッド	三叉神経・自律神経性頭痛、片頭痛、および血管症状の治療および予防のための組成物
WO2011094450A1 (en)	2010-01-27	2011-08-04	Anacor Pharmaceuticals, Inc	Boron-containing small molecules
CN107001479B (zh)	2014-09-12	2021-09-28	基因泰克公司	抗her2抗体和免疫缀合物
JP2017536421A (ja)	2014-12-01	2017-12-07	アケリオスセラピューティクス，インコーポレーテッド	片頭痛及び疼痛に関連する状態を処置するための方法及び組成物
RU2018107695A (ru)	2015-08-03	2019-09-05	Президент Энд Феллоуз Оф Гарвард Колледж	Заряженные блокаторы ионных каналов и способы их применения
KR20190058477A (ko)	2016-08-17	2019-05-29	솔스티스 바이올로직스, 리미티드	폴리뉴클레오티드 구축물
WO2019006455A1 (en)	2017-06-30	2019-01-03	Solstice Biologics, Ltd.	AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF
US20210244664A1 (en)	2018-06-27	2021-08-12	Breath Therapeutics Gmbh	Pharmaceutical compositions in lyophilized form
BR112021017772A2 (pt)	2019-03-11	2021-11-16	Nocion Therapeutics Inc	Bloqueadores de canais de íons carregados e métodos para uso
US10780083B1 (en)	2019-03-11	2020-09-22	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
US10786485B1 (en)	2019-03-11	2020-09-29	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
BR112021017809A2 (pt)	2019-03-11	2021-11-23	Nocion Therapeutics Inc	Bloqueadores de canais iônicos substituídos por éster e métodos para uso
JP7692834B2 (ja)	2019-03-11	2025-06-16	ノシオンセラピューティクス，インコーポレイテッド	荷電したイオンチャンネル遮断薬および使用方法
US12089902B2 (en)	2019-07-30	2024-09-17	Coviden Lp	Cone beam and 3D fluoroscope lung navigation
EP4021934A4 (en)	2019-08-30	2024-02-14	The Regents of the University of California	Gene fragment overexpression screening methodologies, and uses thereof
JP7513713B2 (ja)	2019-11-06	2024-07-09	ノシオンセラピューティクス，インコーポレイテッド	荷電したイオンチャンネル遮断薬および使用方法
AU2020380118A1 (en)	2019-11-06	2022-05-19	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
BR112022017801A2 (pt)	2020-03-11	2022-10-25	Nocion Therapeutics Inc	Bloqueadores de canais de íons carregados e métodos para uso
US12162851B2 (en)	2020-03-11	2024-12-10	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
WO2022243866A1 (en) *	2021-05-17	2022-11-24	Mahmoud Reza Jaafari	Method for producing liposomes entrapping cyclosporine a

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4663167A (en) *	1984-04-16	1987-05-05	The Board Of Regents Of The University Of Texas System	Composition and method for treatment of disseminated fungal infections in mammals
US4797285A (en) *	1985-12-06	1989-01-10	Yissum Research And Development Company Of The Hebrew University Of Jerusalem	Lipsome/anthraquinone drug composition and method
US5023087A (en) *	1986-02-10	1991-06-11	Liposome Technology, Inc.	Efficient method for preparation of prolonged release liposome-based drug delivery system
US4963362A (en) *	1987-08-07	1990-10-16	Regents Of The University Of Minnesota	Freeze-dried liposome mixture containing cyclosporin
US5000887A (en) *	1988-05-17	1991-03-19	Liposome Technology, Inc.	Preparation of uniform-size liposomes
US4952405A (en) *	1988-10-20	1990-08-28	Liposome Technology, Inc.	Method of treating M. avium infection
WO1991004019A1 (en) *	1989-09-12	1991-04-04	The Regents Of The University Of California	Therapeutic peptides and proteins

1992
- 1992-04-20 DE DE69211691T patent/DE69211691T2/de not_active Expired - Lifetime
- 1992-04-20 JP JP4510313A patent/JP2721041B2/ja not_active Expired - Lifetime
- 1992-04-20 AU AU17977/92A patent/AU657961B2/en not_active Expired
- 1992-04-20 WO PCT/US1992/003234 patent/WO1992018104A1/en not_active Ceased
- 1992-04-20 EP EP92922779A patent/EP0580817B1/en not_active Expired - Lifetime
- 1992-04-20 DK DK92922779.1T patent/DK0580817T3/da active
- 1992-04-20 AT AT92922779T patent/ATE139439T1/de active
- 1992-04-20 ES ES92922779T patent/ES2088160T3/es not_active Expired - Lifetime
- 1992-04-20 CA CA002108288A patent/CA2108288C/en not_active Expired - Lifetime
1993
- 1993-06-30 US US08/085,673 patent/US5688525A/en not_active Expired - Lifetime
1995
- 1995-05-05 US US08/435,909 patent/US5660856A/en not_active Expired - Lifetime
- 1995-06-06 US US08/468,956 patent/US5670166A/en not_active Expired - Lifetime
1996
- 1996-06-28 GR GR960401773T patent/GR3020396T3/el unknown

Also Published As

Publication number	Publication date
US5660856A (en)	1997-08-26
WO1992018104A1 (en)	1992-10-29
US5688525A (en)	1997-11-18
DE69211691T2 (de)	1997-01-16
CA2108288C (en)	2003-09-16
AU1797792A (en)	1992-11-17
ES2088160T3 (es)	1996-08-01
EP0580817A1 (en)	1994-02-02
AU657961B2 (en)	1995-03-30
JP2721041B2 (ja)	1998-03-04
CA2108288A1 (en)	1992-10-20
US5670166A (en)	1997-09-23
ATE139439T1 (de)	1996-07-15
GR3020396T3 (en)	1996-09-30
EP0580817B1 (en)	1996-06-19
DE69211691D1 (de)	1996-07-25
JPH06510024A (ja)	1994-11-10

Publication	Publication Date	Title
DK0580817T3 (da)	1996-08-05	Farmaceutisk præparat og fremgangsmåde til fremstilling deraf
NO20005431D0 (no)	2000-10-27	Gelérbare farmasøytiske preparater
SE8201351L (sv)	1982-03-04	Sett att framstella liposomberedningar
ATE101340T1 (de)	1994-02-15	Neue arzneimittelformulierung sowie verfahren zu deren herstellung.
NO884989L (no)	1989-05-16	Fremgangsmaate for opploeseliggjoering av amfifile medisinske preparater/forbindelser.
ES2088385T3 (es)	1996-08-16	Formulaciones de liposomas con una elevada relacion agente antineoplasico/lipido.
DK653688D0 (da)	1988-11-23	Stabiliserede laegemiddelaktive forbindelser, fremgangsmaade til deres frmstilling samt stabile laegemiddelpraeparater
DE69517048D1 (de)	2000-06-21	Hilfsmittel zum löschmachen von hydrophylen makromolekülen
ATE63220T1 (de)	1991-05-15	Transdermal resorbierbare, wasserhaltige zubereitungen von arylpropionsaeurederivaten und verfahren zur herstellung derselben.
HUT54144A (en)	1991-01-28	Process for producing 3-desmethylmevalonic acid derivatives and pharmaceutical compositions comprising same as active ingredient
NO165626C (no)	1991-03-13	Fremgangsmaate for aa opploeseliggjoere en hydrofob, terapeutisk aktiv, organisk forbindelse, spesielt en n-acyl-indol.
BR9609332A (pt)	1999-05-25	Composição biologicamente ativa processo para a fabricação da mesma e uso de uma fase
RU94046093A (ru)	1996-09-27	Производные 7-(2-аминоэтил)бензотиазолона, способ их получения, промежуточные соединения, фармкомпозиция
ES2091019T3 (es)	1996-10-16	Formulaciones liposomicas de itraconazol.
PT95697A (pt)	1991-09-13	Processo para a preparacao de composicoes farmaceuticas contendo substancias antiandrogenicamente activas
ATE67406T1 (de)	1991-10-15	Nicorandil enthaltende zubereitung zum einspritzen.
MX9302327A (es)	1993-10-01	Aminoacidos ciclicos novedosos y derivados de los mismos.
BG60101B2 (bg)	1993-10-29	Метод за получаване на 4-флуор-2-(((4-метокси-2- пиридинил)метил)тионил)-1н-бензимидазол
NO172537C (no)	1993-08-04	Analogifremgangsmaate til fremstilling av terapeutisk aktive 3-desmetyl-4-fluor-mevalonsyrederivater
KR900701300A (ko)	1990-12-01	생물학적 활성 펩티드 및 특정음이온을 갖는 조성물 및 이것을 사용하는 방법
ES2133928T3 (es)	1999-09-16	Agente para el tratamiento del cabello en 2 fases.
ATE136783T1 (de)	1996-05-15	Arzneimittel mit antineoplastischer wirkung enthaltend als wirkstoff octadecyl-(2-(n- methylpiperidino)-ethyl>-phosphat und verfahren zu dessen herstellung
MY101266A (en)	1991-08-17	Pharmaceutical formulations
ATE112679T1 (de)	1994-10-15	Wässrige bereitung von liposomenzusammensetzungen.
ATE40687T1 (de)	1989-02-15	Neue pyridinderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.