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DE69937076D1 - Zwischenprodukte für die Herstellung von Imidazo-Pyridin-Derivate - Google Patents

Zwischenprodukte für die Herstellung von Imidazo-Pyridin-Derivate

Info

Publication number
DE69937076D1
DE69937076D1 DE69937076T DE69937076T DE69937076D1 DE 69937076 D1 DE69937076 D1 DE 69937076D1 DE 69937076 T DE69937076 T DE 69937076T DE 69937076 T DE69937076 T DE 69937076T DE 69937076 D1 DE69937076 D1 DE 69937076D1
Authority
DE
Germany
Prior art keywords
imidazo
intermediates
preparation
pyridine derivatives
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69937076T
Other languages
English (en)
Other versions
DE69937076T2 (de
Inventor
Kosrat Amin
Mikael Dahlstroem
Peter Nordberg
Ingemar Starke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE69937076D1 publication Critical patent/DE69937076D1/de
Publication of DE69937076T2 publication Critical patent/DE69937076T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69937076T 1998-04-29 1999-04-23 Zwischenprodukte für die Herstellung von Imidazo-Pyridin-Derivate Expired - Lifetime DE69937076T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9801526 1998-04-29
SE9801526A SE9801526D0 (sv) 1998-04-29 1998-04-29 New compounds

Publications (2)

Publication Number Publication Date
DE69937076D1 true DE69937076D1 (de) 2007-10-18
DE69937076T2 DE69937076T2 (de) 2008-05-29

Family

ID=20411154

Family Applications (4)

Application Number Title Priority Date Filing Date
DE69927803T Expired - Lifetime DE69927803T2 (de) 1998-04-29 1999-04-23 Imidazo-pyridin verbindungen, die die sekretion von magensäure hemmen.
DE69928792T Expired - Lifetime DE69928792T2 (de) 1998-04-29 1999-04-23 Imidazo-pyridin verbindungen, die die sekretion von magensäure hemmen
DE69937077T Expired - Lifetime DE69937077T2 (de) 1998-04-29 1999-04-23 Zwischenprodukte für die Herstellung von Imidazo-Pyridin-Derivate
DE69937076T Expired - Lifetime DE69937076T2 (de) 1998-04-29 1999-04-23 Zwischenprodukte für die Herstellung von Imidazo-Pyridin-Derivate

Family Applications Before (3)

Application Number Title Priority Date Filing Date
DE69927803T Expired - Lifetime DE69927803T2 (de) 1998-04-29 1999-04-23 Imidazo-pyridin verbindungen, die die sekretion von magensäure hemmen.
DE69928792T Expired - Lifetime DE69928792T2 (de) 1998-04-29 1999-04-23 Imidazo-pyridin verbindungen, die die sekretion von magensäure hemmen
DE69937077T Expired - Lifetime DE69937077T2 (de) 1998-04-29 1999-04-23 Zwischenprodukte für die Herstellung von Imidazo-Pyridin-Derivate

Country Status (33)

Country Link
US (2) US6313137B1 (de)
EP (4) EP1073657B1 (de)
JP (2) JP3883383B2 (de)
KR (3) KR100595805B1 (de)
CN (2) CN1174980C (de)
AR (2) AR015769A1 (de)
AT (4) ATE312101T1 (de)
AU (2) AU769108B2 (de)
BR (2) BR9909995B1 (de)
CA (2) CA2329921A1 (de)
CZ (2) CZ293977B6 (de)
DE (4) DE69927803T2 (de)
DK (2) DK1073657T3 (de)
EE (2) EE04676B1 (de)
ES (2) ES2252975T3 (de)
HU (2) HUP0102425A3 (de)
ID (2) ID26819A (de)
IL (4) IL139200A0 (de)
IS (2) IS5683A (de)
MY (2) MY121379A (de)
NO (2) NO317262B1 (de)
NZ (2) NZ507639A (de)
PL (2) PL343797A1 (de)
RU (2) RU2238271C2 (de)
SA (2) SA99200065B1 (de)
SE (1) SE9801526D0 (de)
SI (1) SI1073656T1 (de)
SK (2) SK285768B6 (de)
TR (4) TR200102728T2 (de)
TW (2) TW490466B (de)
UA (2) UA67769C2 (de)
WO (2) WO1999055705A1 (de)
ZA (2) ZA200005796B (de)

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US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE9802794D0 (sv) * 1998-08-21 1998-08-21 Astra Ab New compounds
US6900324B2 (en) 2000-09-07 2005-05-31 Astrazeneca Ab Process for preparing a substituted imidazopyridine compound
SE0003186D0 (sv) * 2000-09-07 2000-09-07 Astrazeneca Ab New process
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
SE0100297D0 (sv) * 2001-02-01 2001-02-01 Astrazeneca Ab New compounds
SE0100295D0 (sv) * 2001-02-01 2001-02-01 Astrazeneca Ab New compounds
SE0100296D0 (sv) * 2001-02-01 2001-02-01 Astrazeneca Ab New compounds
CN1491105A (zh) * 2001-02-13 2004-04-21 新的改进释放的制剂
KR100904599B1 (ko) * 2001-03-08 2009-06-25 아스트라제네카 아베 신규 용도
SE0102808D0 (sv) * 2001-08-22 2001-08-22 Astrazeneca Ab New compounds
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
SE0201939D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination
SE0201940D0 (sv) * 2002-06-20 2002-06-20 Astrazeneca Ab New combination II
JP4845379B2 (ja) 2002-09-19 2011-12-28 シェーリング コーポレイション サイクリン依存性キナーゼインヒビターとしてのイミダゾピリジン
EA008304B1 (ru) 2002-11-19 2007-04-27 Алтана Фарма Аг 8-замещённые имидазопиридины
AR043002A1 (es) * 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
US7230098B2 (en) 2003-02-26 2007-06-12 Sugen, Inc. Aminoheteroaryl compounds as protein kinase inhibitors
DE602004023921D1 (de) 2003-03-10 2009-12-17 Nycomed Gmbh Neues verfahren zur herstellung vonroflumilast
SE525349C2 (sv) * 2003-06-23 2005-02-08 Volvo Penta Ab Utombordsdrev för båtar
SE0301904D0 (sv) * 2003-06-26 2003-06-26 Astrazeneca Ab Novel imidazopyridine compound II with therapeutic effect
SE0301905D0 (sv) * 2003-06-26 2003-06-26 Astrazeneca Ab Novel imidazopyridine compound I with therapeutic effect
SE0301903D0 (sv) * 2003-06-26 2003-06-26 Astrazeneca Ab Novel imidazopyridine compound III with therapeutic effect
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20080280944A1 (en) * 2003-11-03 2008-11-13 Paula Fernstrom Imidazo[1,2-A]Pyridine Derivatives For The Treatment Of Silent Gastro-Esophageal Reflux
SE0303451D0 (sv) * 2003-12-18 2003-12-18 Astrazeneca Ab New compounds
US20080033006A1 (en) * 2004-01-26 2008-02-07 Altana Pharma Ag 1,2,4-Triazolo[ 1,5-A] Pyridines as Gastric Acid Secretion Inhibitors
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20090291977A1 (en) * 2004-12-17 2009-11-26 Madoka Jinno Chromane Derivatives Useful As Acid Pump Antagonists
US8663694B2 (en) 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast
US7666880B2 (en) 2005-03-21 2010-02-23 S*Bio Pte Ltd. Imidazo[1,2-A]pyridine derivatives: preparation and pharmaceutical applications
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WO2006100119A1 (en) * 2005-03-24 2006-09-28 Glaxo Group Limited Derivatives of imidazo (1,2-a) pyridine useful as medicaments for treating gastrointestinal diseases
GB0513423D0 (en) * 2005-06-30 2005-08-03 Glaxo Group Ltd Novel compounds
US8217057B2 (en) * 2005-12-05 2012-07-10 Pfizer Inc. Polymorphs of a c-MET/HGFR inhibitor
BRPI0619424B1 (pt) * 2005-12-05 2022-02-08 Pfizer Products Inc Uso de inibidores c-met/hgfrs para a fabricação de medicamentos
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FI20086158A0 (fi) 2008-12-03 2008-12-03 Mikael Dahlstroem Imidatsopyridiinijohdannaiset
AU2014201644B2 (en) * 2008-12-03 2015-05-21 Cinclus Pharma Holding AB (publ) Imidazopyridine derivatives which inhibit the secretion of gastric acid
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CN105358151B (zh) * 2013-06-25 2019-04-12 豪夫迈·罗氏有限公司 用于治疗脊髓性肌萎缩的化合物
US9944637B2 (en) 2013-12-16 2018-04-17 Asana Biosciences, Llc P2X3 and/or P2X2/3 compounds and methods
AU2015236273B2 (en) * 2014-03-24 2019-03-28 Arqule Inc. Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo(4,5-b)pyridin-2-yl)pyridin-2-amine
CN106279151A (zh) * 2015-06-26 2017-01-04 江苏太瑞生诺生物医药科技有限公司 5-(2-(8-((2,6-二甲基苄基)氨基)-2,3-二甲基咪唑并[1,2-a]吡啶-6-甲酰胺基)乙氧基)-5-氧代戊酸的固体形式及其制备方法
KR101777971B1 (ko) * 2016-07-05 2017-09-12 제일약품주식회사 이미다조[1,2-a]피리딘 유도체, 이의 제조방법 및 이의 용도
KR20190057569A (ko) 2017-11-20 2019-05-29 제일약품주식회사 7-아미노-1h-인돌-5-카르복사미드 유도체 및 이의 용도
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EP0068378B1 (de) * 1981-06-26 1986-03-05 Schering Corporation Imidazo(1,2-a)pyridine und -pyrazine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
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GB9107513D0 (en) * 1991-04-10 1991-05-29 Fujisawa Pharmaceutical Co Pyrazolopyridine compound and processes for preparation thereof

Also Published As

Publication number Publication date
HK1033457A1 (en) 2001-08-31
ATE307130T1 (de) 2005-11-15
JP3883383B2 (ja) 2007-02-21
KR20010043133A (ko) 2001-05-25
JP2002513024A (ja) 2002-05-08
NZ507638A (en) 2003-10-31
US6313136B1 (en) 2001-11-06
NO20005451D0 (no) 2000-10-27
DK1073656T3 (da) 2006-01-16
ATE372340T1 (de) 2007-09-15
JP3692034B2 (ja) 2005-09-07
NO20005450D0 (no) 2000-10-27
RU2238271C2 (ru) 2004-10-20
DE69937076T2 (de) 2008-05-29
AU4300699A (en) 1999-11-16
NZ507639A (en) 2004-01-30
TR200102728T2 (tr) 2002-06-21
BR9909996A (pt) 2000-12-26
ATE372339T1 (de) 2007-09-15
EP1491543B1 (de) 2007-09-05
EE200000664A (et) 2002-04-15
EP1491542B1 (de) 2007-09-05
TWI250159B (en) 2006-03-01
RU2235725C2 (ru) 2004-09-10
BR9909995B1 (pt) 2010-07-13
CN1306533A (zh) 2001-08-01
US6313137B1 (en) 2001-11-06
UA66846C2 (uk) 2004-06-15
DE69937077D1 (de) 2007-10-18
IS5684A (is) 2000-10-25
KR100595806B1 (ko) 2006-07-03
EE04916B1 (et) 2007-10-15
DK1073657T3 (da) 2006-03-13
TR200003149T2 (tr) 2001-03-21
ZA200005796B (en) 2002-01-18
IL139297A0 (en) 2001-11-25
UA67769C2 (uk) 2004-07-15
BR9909996B1 (pt) 2010-08-24
NO20005451L (no) 2000-12-27
TR200003176T2 (tr) 2001-03-21
EP1073657B1 (de) 2005-12-07
CN1174980C (zh) 2004-11-10
ID27530A (id) 2001-04-12
CA2329921A1 (en) 1999-11-04
DE69927803T2 (de) 2006-07-06
HK1071139A1 (en) 2005-07-08
PL343801A1 (en) 2001-09-10
DE69937077T2 (de) 2008-05-29
ID26819A (id) 2001-02-15
DE69928792D1 (de) 2006-01-12
AR015769A1 (es) 2001-05-16
CZ20003981A3 (cs) 2001-03-14
NO317262B1 (no) 2004-09-27
HUP0102425A3 (en) 2002-12-28
SK14912000A3 (sk) 2001-06-11
CZ20003982A3 (cs) 2001-02-14
AU769108B2 (en) 2004-01-15
EE04676B1 (et) 2006-08-15
SK14922000A3 (sk) 2001-06-11
HUP0102313A3 (en) 2002-10-28
MY121379A (en) 2006-01-28
IL139200A0 (en) 2001-11-25
CZ292567B6 (cs) 2003-10-15
SE9801526D0 (sv) 1998-04-29
SA99200065A (ar) 2005-12-03
ZA200005797B (en) 2002-01-18
KR20010043134A (ko) 2001-05-25
CA2329922C (en) 2006-04-11
PL343797A1 (en) 2001-09-10
EE200000626A (et) 2002-04-15
IL139200A (en) 2010-04-29
MY121389A (en) 2006-01-28
TR200102612T2 (tr) 2002-06-21
NO20005450L (no) 2000-12-22
CA2329922A1 (en) 1999-11-04
AU769190B2 (en) 2004-01-22
EP1491542A2 (de) 2004-12-29
AR015768A1 (es) 2001-05-16
HK1036981A1 (en) 2002-01-25
IL139297A (en) 2007-06-03
SA99200064B1 (ar) 2006-10-11
CN1165535C (zh) 2004-09-08
EP1491542A3 (de) 2005-01-05
CZ293977B6 (cs) 2004-09-15
EP1073656B1 (de) 2005-10-19
HUP0102313A2 (hu) 2001-12-28
KR20050121760A (ko) 2005-12-27
EP1073656A1 (de) 2001-02-07
WO1999055705A1 (en) 1999-11-04
EP1491543A1 (de) 2004-12-29
HUP0102425A2 (hu) 2001-11-28
NO318203B1 (no) 2005-02-14
KR100650472B1 (ko) 2006-11-28
AU4300799A (en) 1999-11-16
HK1033317A1 (en) 2001-08-24
SI1073656T1 (sl) 2006-02-28
WO1999055706A1 (en) 1999-11-04
DE69927803D1 (de) 2006-03-02
TW490466B (en) 2002-06-11
JP2002513025A (ja) 2002-05-08
EP1073657A1 (de) 2001-02-07
CN1307577A (zh) 2001-08-08
SK285768B6 (sk) 2007-07-06
KR100595805B1 (ko) 2006-07-03
DE69928792T2 (de) 2006-07-20
PL195000B1 (pl) 2007-07-31
ES2249913T3 (es) 2006-04-01
ES2252975T3 (es) 2006-05-16
IS5683A (is) 2000-10-25
ATE312101T1 (de) 2005-12-15
WO1999055706A9 (en) 2000-03-16
BR9909995A (pt) 2000-12-26
HK1036984A1 (en) 2002-01-25
SA99200065B1 (ar) 2006-11-07

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