DE69927694D1 - Orale bioadhäsive tablette mit verlängerter wirkstoffabgabe - Google Patents

Orale bioadhäsive tablette mit verlängerter wirkstoffabgabe

Info

Publication number: DE69927694D1
Authority: DE; Germany
Prior art keywords: active substance; extended active; bioadhesive tablet; oral bioadhesive; oral
Prior art date: 1998-08-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69927694T

Other languages

English (en)

Other versions

DE69927694T2 (de

Inventor

J Bologna

L Levine

Philippe Cartier

Ziegler Dominique De

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Columbia Laboratories Bermuda Ltd

Original Assignee

Columbia Laboratories Bermuda Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-25

Filing date

1999-08-24

Publication date

2005-11-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22265404&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69927694(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1999-08-24 Application filed by Columbia Laboratories Bermuda Ltd filed Critical Columbia Laboratories Bermuda Ltd

2005-11-17 Application granted granted Critical

2005-11-17 Publication of DE69927694D1 publication Critical patent/DE69927694D1/de

2006-08-10 Publication of DE69927694T2 publication Critical patent/DE69927694T2/de

2019-08-25 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physiology (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Nutrition Science (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE69927694T 1998-08-25 1999-08-24 Orale bioadhäsive tablette mit verlängerter wirkstoffabgabe Expired - Lifetime DE69927694T2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US9784398P	1998-08-25	1998-08-25
US97843P		1998-08-25
US09/379,310 US6248358B1 (en)	1998-08-25	1999-08-23	Bioadhesive progressive hydration tablets and methods of making and using the same
US379310		1999-08-23
PCT/US1999/019260 WO2000010536A1 (en)	1998-08-25	1999-08-24	Extended release buccal bioadhesive tablet

Publications (2)

Publication Number	Publication Date
DE69927694D1 true DE69927694D1 (de)	2005-11-17
DE69927694T2 DE69927694T2 (de)	2006-08-10

Family

ID=22265404

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69927694T Expired - Lifetime DE69927694T2 (de)	1998-08-25	1999-08-24	Orale bioadhäsive tablette mit verlängerter wirkstoffabgabe

Country Status (25)

Country	Link
US (1)	US6248358B1 (de)
EP (1)	EP1105104B1 (de)
JP (2)	JP5411398B2 (de)
KR (1)	KR100716702B1 (de)
CN (2)	CN1879608A (de)
AR (1)	AR036972A1 (de)
AT (1)	ATE306253T1 (de)
AU (1)	AU754880B2 (de)
BR (1)	BR9913239B1 (de)
CA (1)	CA2341375C (de)
DE (1)	DE69927694T2 (de)
DK (1)	DK1105104T3 (de)
ES (1)	ES2251220T3 (de)
HU (1)	HU226591B1 (de)
IL (1)	IL141445A (de)
MA (1)	MA24964A1 (de)
MX (1)	MXPA01002007A (de)
MY (2)	MY125919A (de)
NO (1)	NO331255B1 (de)
NZ (1)	NZ509963A (de)
PE (1)	PE20001036A1 (de)
RU (1)	RU2227022C2 (de)
UA (1)	UA78967C2 (de)
WO (1)	WO2000010536A1 (de)
ZA (1)	ZA995445B (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6624200B2 (en) *	1998-08-25	2003-09-23	Columbia Laboratories, Inc.	Bioadhesive progressive hydration tablets
AU2005203703B2 (en) *	1998-08-25	2007-05-24	Columbia Laboratories (Bermuda) Limited	Bioadhesive progressive hydration tablets
US7803392B2 (en)	2000-12-27	2010-09-28	University Of Kentucky Research Foundation	pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules
WO2002087552A2 (en) *	2001-05-01	2002-11-07	Mcgill University	Androgen-mediated neuroprotection and uses thereof
CN101327326A (zh) *	2001-10-29	2008-12-24	哥伦比亚实验室(百慕大群岛)有限公司	阴道给药治疗骨盆痛和不孕症的抗节律障碍剂
US20030114394A1 (en) *	2001-10-29	2003-06-19	Levine Howard L.	Vaginally administered anti-dysrhythmic agents for treating pelvic pain
US7709026B2 (en)	2001-10-29	2010-05-04	Columbia Laboratories, Inc.	Low concentration of peroxide for treating or preventing vaginal infections
US8425892B2 (en) *	2001-10-29	2013-04-23	Columbia Laboratories, Inc.	Extended, controlled-release pharmaceutical compositions using charged polymers
US7005138B2 (en) *	2001-12-21	2006-02-28	Duramed Pharmaceuticals, Inc.	Method of systematically delivering SSRIs
GB0210397D0 (en) *	2002-05-07	2002-06-12	Ferring Bv	Pharmaceutical formulations
US20050226926A1 (en)	2002-07-25	2005-10-13	Pfizer Inc	Sustained-release tablet composition of pramipexole
PE20040134A1 (es) *	2002-07-25	2004-03-06	Pharmacia Corp	Forma de dosificacion de una vez al dia de pramipexol
RU2005105945A (ru) *	2002-08-02	2005-07-10	Рэнбакси Лабораториз Лимитед (In)	Таблетки фозиноприла натрия, устойчивые при хранении
RU2213558C1 (ru) *	2002-09-30	2003-10-10	Нестерук Владимир Викторович	Антибактериальное средство
AU2003285189B2 (en) *	2002-11-14	2006-07-27	Shear/Kershman Laboratories, Inc.	Oral testosterone delivery system with improved sustained release
SE0302947D0 (sv)	2003-01-24	2003-11-07	Magle Ab	A composition material for transmucosal delivery
EP1617823B1 (de) *	2003-01-24	2019-01-09	Nicachet AB	Beutel mit nikotinhaltiger zusammensetzung zur transmukosalen abgabe
EP1750862B1 (de)	2004-06-04	2011-01-05	Teva Pharmaceutical Industries Ltd.	Irbesartan enthaltende pharmazeutische zusammensetzung
UA95993C2 (ru) *	2004-08-13	2011-09-26	Бёрингер Ингельхайм Интернациональ Гмбх	Композиция пеллеты пролонгированного высвобождения, которая содержит прамипексол или его фармацевтически приемлемую соль, способ ее изготовления и ее применение
UA86831C2 (uk) *	2004-08-13	2009-05-25	Бьорінгер Інгельхайм Інтернаціональ Гмбх	Композиція таблетки пролонгованого вивільнення, яка містить праміпексол або його фармацевтично прийнятну сіль, спосіб її виготовлення та її застосування
CA2610465A1 (en) *	2005-06-03	2006-12-14	Duramed Pharmaceuticals, Inc.	Pharmaceutical compositions comprising prostanoid-receptor agonists and methods of making and using the same
US20070048369A1 (en) *	2005-08-26	2007-03-01	National Starch And Chemical Investment Holding Corporation	Mucosal delivery tablet
EP1968539A2 (de)	2005-12-13	2008-09-17	Biodelivery Sciences International, Inc.	Transmukosales arzneiabgabegerät mit sicherheitsmerkmal
US20090041844A1 (en) *	2006-02-10	2009-02-12	Boehringer Ingelheim International Gmbh	Modified Release Formulation
WO2007090883A1 (en) *	2006-02-10	2007-08-16	Boehringer Ingelheim International Gmbh	Extended release formulation
WO2007096906A2 (en) *	2006-02-27	2007-08-30	Panacea Biotec Ltd.	Novel buccoadhesive compositions and process of preparation thereof
EP1837020A1 (de)	2006-03-24	2007-09-26	Bioalliance Pharma	Bioadhäsive Schleimhautträger zur langsamen Verabreichung von aktiven Substanzen
US20070248655A1 (en) *	2006-04-21	2007-10-25	Haley Jeffrey T	Lenticular shaped protective mouth sore discs
EP1872775A1 (de) *	2006-06-29	2008-01-02	Polichem S.A.	Verwendung einer hydrophilen Matrix, die ein Polyacrylsäurederivat, einen Celluloseether und ein Zerfallsmittel enthält, für die Herstellung eines Medikamentes zur Behandlung weiblicher Genitalstörungen
RS54764B1 (sr)	2006-07-21	2016-10-31	Biodelivery Sciences Int Inc	Sredstvo za transmukozalnu isporuku sa povećanim nakupljanjem
EP2112923A1 (de)	2007-01-22	2009-11-04	Targacept Inc.	Intranasale, orale und sublinguale verabreichung von metanikotin-analogen
EP2118123B1 (de)	2007-01-31	2015-10-14	Dana-Farber Cancer Institute, Inc.	Stabilisierte p53-peptide und deren verwendungen
US8828981B2 (en)	2007-02-06	2014-09-09	George Creasy	Progesterone for the treatment or prevention of spontaneous preterm birth
EP3159352B1 (de)	2007-03-28	2023-08-02	President and Fellows of Harvard College	Geheftete polypeptide
EP1987820A1 (de) *	2007-05-04	2008-11-05	Christian Fiala, Ph. D.	Langsame Freisetzung von Misoprostol für gynäkologische und/oder Geburtshilfeanwendungen
WO2009132208A1 (en) *	2008-04-24	2009-10-29	Evestra, Inc.	Oral contraceptive dosage forms comprising a progestogen dispersed in an enteric polymer and further comprising an estrogen
EP2163240A1 (de) *	2008-09-12	2010-03-17	Universita' Degli Studi Di Genova	Verfahren zur Herstellung von bioadhesiven Kompaktmatrizen
CN102647993A (zh)	2009-06-18	2012-08-22	阿勒根公司	安全的去氨加压素给药
KR102104762B1 (ko)	2010-08-13	2020-04-24	에일러론 테라퓨틱스 인코포레이티드	펩티도미메틱 거대고리
JP6158810B2 (ja)	2011-08-18	2017-07-05	バイオデリバリーサイエンシズインターナショナル，インコーポレーテッド	ブプレノルフィンの乱用抵抗性粘膜付着性送達デバイス
TW201806968A (zh)	2011-10-18	2018-03-01	艾利倫治療公司	擬肽巨環化合物
US9901539B2 (en)	2011-12-21	2018-02-27	Biodelivery Sciences International, Inc.	Transmucosal drug delivery devices for use in chronic pain relief
CA2864120A1 (en)	2012-02-15	2013-08-22	Aileron Therapeutics, Inc.	Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
NZ627528A (en)	2012-02-15	2016-05-27	Aileron Therapeutics Inc	Peptidomimetic macrocycles
BR112015009470A2 (pt)	2012-11-01	2019-12-17	Aileron Therapeutics Inc	aminoácidos dissubstituídos e seus métodos de preparação e uso
KR20170058424A (ko)	2014-09-24	2017-05-26	에일러론 테라퓨틱스 인코포레이티드	펩티드모방 거대고리 및 이의 용도
SG11201707750YA (en)	2015-03-20	2017-10-30	Aileron Therapeutics Inc	Peptidomimetic macrocycles and uses thereof
MY208388A (en) *	2019-04-05	2025-05-06	Gedea Biotech Ab	Vaginal tablet formulation

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3133862A (en)	1960-07-22	1964-05-19	Miles Lab	Buccal tablet containing vitamin a and sodium proteinate
GB2042888B (en)	1979-03-05	1983-09-28	Teijin Ltd	Preparation for administration to the mucosa of the oral or nasal cavity
CH653550A5 (de) *	1981-10-20	1986-01-15	Sandoz Ag	Pharmazeutische zusammensetzung zur verzoegerten freigabe eines medikamentes im mundbereich.
US4389393A (en)	1982-03-26	1983-06-21	Forest Laboratories, Inc.	Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose
CA1208558A (en)	1982-10-07	1986-07-29	Kazuo Kigasawa	Soft buccal
US5225196A (en) *	1983-11-14	1993-07-06	Columbia Laboratories, Inc.	Bioadhesive compositions and methods of treatment therewith
ATE151286T1 (de)	1983-11-14	1997-04-15	Columbia Lab Inc	Bioadhäsive mittel
US4540566A (en)	1984-04-02	1985-09-10	Forest Laboratories, Inc.	Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose
DE3580384D1 (de)	1984-04-09	1990-12-13	Toyo Boseki	Praeparat mit verzoegerter freigabe zum aufbringen auf die schleimhaeute der mundhoehle.
JPS60215622A (ja) *	1984-04-09	1985-10-29	Toyobo Co Ltd	口腔粘膜適用徐放性製剤
US4596795A (en)	1984-04-25	1986-06-24	The United States Of America As Represented By The Secretary, Dept. Of Health & Human Services	Administration of sex hormones in the form of hydrophilic cyclodextrin derivatives
US4764378A (en)	1986-02-10	1988-08-16	Zetachron, Inc.	Buccal drug dosage form
DE3776116D1 (de)	1986-12-30	1992-02-27	American Cyanamid Co	Zusammensetzung die ein polycarbophil enthaelt.
US4915948A (en)	1987-08-31	1990-04-10	Warner-Lambert Company	Tablets having improved bioadhesion to mucous membranes
US4900552A (en)	1988-03-30	1990-02-13	Watson Laboratories, Inc.	Mucoadhesive buccal dosage forms
US5252334A (en)	1989-09-08	1993-10-12	Cygnus Therapeutic Systems	Solid matrix system for transdermal drug delivery
WO1991006289A1 (en) *	1989-10-31	1991-05-16	Watson Laboratories, Inc.	Mucoadhesive carrier for delivery of therapeutical agent
US6017521A (en) *	1989-10-31	2000-01-25	Columbia Laboratories, Inc.	Use of polycarboxylic acid polymers to treat vaginal infections
US5750136A (en)	1989-11-03	1998-05-12	Riker Laboratories, Inc.	Bioadhesive composition and patch
US5750134A (en)	1989-11-03	1998-05-12	Riker Laboratories, Inc.	Bioadhesive composition and patch
EP0459373A3 (en) *	1990-05-31	1993-09-08	The B.F. Goodrich Company	Bioadhesive carboxylic polymer composition and method relating thereto
FR2665357B1 (fr)	1990-07-31	1995-03-31	Aiache Jean Marc	Procede de preparation d'une forme galenique bio-adhesive et forme galenique ainsi preparee.
US5110605A (en)	1990-08-21	1992-05-05	Oramed, Inc.	Calcium polycarbophil-alginate controlled release composition and method
US5686094A (en)	1991-04-01	1997-11-11	Theratech, Inc.	Controlled release formulations for the treatment of xerostomia
US5102666A (en)	1990-09-11	1992-04-07	Oramed, Inc.	Calcium polycarbophil controlled release composition and method
JP2609022B2 (ja)	1990-11-29	1997-05-14	北陸製薬株式会社	ポリカルボフィルカルシウム含有製剤
JPH06100466A (ja)	1992-02-14	1994-04-12	Tsumura & Co	ストレス性脳神経細胞器質障害防御剤
DE69312487T2 (de)	1992-05-18	1997-11-27	Minnesota Mining & Mfg	Einrichtung zur transmucosalen wirkstoffabgabe
GR1002418B (el) *	1992-07-29	1996-08-21	Johnson & Johnson Consumer Products Inc.	Βιοεπισυναπτομενες συνθεσεις θεραπειας και μεθοδοι χρησης.
US5458884A (en)	1992-09-10	1995-10-17	Britton; Peter	Bioerodible device for administering active ingredients
CA2105887C (en)	1992-09-10	2004-03-16	Peter Britton	Bioerodible device for administering active ingredients
US5298017A (en)	1992-12-29	1994-03-29	Alza Corporation	Layered electrotransport drug delivery system
US5460820B1 (en)	1993-08-03	1999-08-03	Theratech Inc	Method for providing testosterone and optionally estrogen replacement therapy to women
US5543150A (en) *	1993-09-15	1996-08-06	Columbia Laboratories, Inc.	Method of progesterone delivery and affect thereof
FR2712807B1 (fr)	1993-11-24	1996-02-23	Vetoquinol Sa	Composition solide mucoadhésive, thérapeutique ou hygiénique, pour administration par application sur la muqueuse buccale ou nasale .
US5578315A (en) *	1993-12-01	1996-11-26	Rutgers, The State University Of New Jersey	Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity
US5567439A (en)	1994-06-14	1996-10-22	Fuisz Technologies Ltd.	Delivery of controlled-release systems(s)
US5958458A (en) *	1994-06-15	1999-09-28	Dumex-Alpharma A/S	Pharmaceutical multiple unit particulate formulation in the form of coated cores
US5804209A (en)	1994-06-16	1998-09-08	Pharmacia S.P.A.	Bioadhesive starches and process for their preparation
US5554380A (en)	1994-08-04	1996-09-10	Kv Pharmaceutical Company	Bioadhesive pharmaceutical delivery system
US5656284A (en)	1995-04-24	1997-08-12	Balkin; Michael S.	Oral transmucosal delivery tablet and method of making it
US5624677A (en)	1995-06-13	1997-04-29	Pentech Pharmaceuticals, Inc.	Controlled release of drugs delivered by sublingual or buccal administration
US5766620A (en)	1995-10-23	1998-06-16	Theratech, Inc.	Buccal delivery of glucagon-like insulinotropic peptides
RU2095064C1 (ru) *	1995-11-24	1997-11-10	Анатолий Борисович Давыдов	Средство для снижения агрегации тромбоцитов в кровеносной системе
US5783212A (en)	1996-02-02	1998-07-21	Temple University--of the Commonwealth System of Higher Education	Controlled release drug delivery system
DE19619045C1 (de)	1996-05-02	1997-11-13	Jenapharm Gmbh	Verwendung von Kombinationspräparaten zur Behandlung hypogonadaler Männer sowie Männern mit Hypophysenerkrankungen
US5783208A (en)	1996-07-19	1998-07-21	Theratech, Inc.	Transdermal drug delivery matrix for coadministering estradiol and another steroid
US5800832A (en)	1996-10-18	1998-09-01	Virotex Corporation	Bioerodable film for delivery of pharmaceutical compounds to mucosal surfaces
US5807575A (en)	1997-02-14	1998-09-15	Rougier Inc.	Manufacture of cross-linked amylose useful as a excipient for control release of active compounds

1999
- 1999-08-23 US US09/379,310 patent/US6248358B1/en not_active Expired - Lifetime
- 1999-08-24 HU HU0103218A patent/HU226591B1/hu not_active IP Right Cessation
- 1999-08-24 IL IL14144599A patent/IL141445A/xx not_active IP Right Cessation
- 1999-08-24 MX MXPA01002007A patent/MXPA01002007A/es not_active IP Right Cessation
- 1999-08-24 AT AT99942454T patent/ATE306253T1/de active
- 1999-08-24 DK DK99942454T patent/DK1105104T3/da active
- 1999-08-24 RU RU2001107846/15A patent/RU2227022C2/ru not_active IP Right Cessation
- 1999-08-24 BR BRPI9913239-7A patent/BR9913239B1/pt not_active IP Right Cessation
- 1999-08-24 CN CNA2005101375941A patent/CN1879608A/zh active Pending
- 1999-08-24 WO PCT/US1999/019260 patent/WO2000010536A1/en not_active Ceased
- 1999-08-24 NZ NZ509963A patent/NZ509963A/en not_active IP Right Cessation
- 1999-08-24 JP JP2000565858A patent/JP5411398B2/ja not_active Expired - Fee Related
- 1999-08-24 CA CA002341375A patent/CA2341375C/en not_active Expired - Fee Related
- 1999-08-24 AU AU55826/99A patent/AU754880B2/en not_active Ceased
- 1999-08-24 KR KR1020017002347A patent/KR100716702B1/ko not_active Expired - Fee Related
- 1999-08-24 EP EP99942454A patent/EP1105104B1/de not_active Expired - Lifetime
- 1999-08-24 ES ES99942454T patent/ES2251220T3/es not_active Expired - Lifetime
- 1999-08-24 DE DE69927694T patent/DE69927694T2/de not_active Expired - Lifetime
- 1999-08-24 CN CNB998122009A patent/CN1259903C/zh not_active Expired - Fee Related
- 1999-08-24 UA UA2001031967A patent/UA78967C2/uk unknown
- 1999-08-25 MA MA25744A patent/MA24964A1/fr unknown
- 1999-08-25 ZA ZA9905445A patent/ZA995445B/xx unknown
- 1999-08-25 PE PE1999000855A patent/PE20001036A1/es not_active Application Discontinuation
- 1999-08-25 AR ARP990104253A patent/AR036972A1/es active IP Right Grant
- 1999-08-25 MY MYPI99003649A patent/MY125919A/en unknown
2000
- 2000-06-20 MY MYPI20002772A patent/MY133365A/en unknown
2001
- 2001-02-23 NO NO20010919A patent/NO331255B1/no not_active IP Right Cessation
2010
- 2010-07-02 JP JP2010151682A patent/JP2010248231A/ja active Pending

Also Published As

Publication number	Publication date
HUP0103218A2 (hu)	2001-12-28
CA2341375C (en)	2006-07-11
JP5411398B2 (ja)	2014-02-12
MY125919A (en)	2006-08-30
WO2000010536A8 (en)	2000-06-15
HU226591B1 (en)	2009-04-28
UA78967C2 (uk)	2007-05-10
AU5582699A (en)	2000-03-14
DE69927694T2 (de)	2006-08-10
MY133365A (en)	2007-11-30
BR9913239A (pt)	2001-05-15
ZA995445B (en)	2000-11-27
JP2004500317A (ja)	2004-01-08
RU2227022C2 (ru)	2004-04-20
JP2010248231A (ja)	2010-11-04
CN1879608A (zh)	2006-12-20
ES2251220T3 (es)	2006-04-16
PE20001036A1 (es)	2000-10-12
CA2341375A1 (en)	2000-03-02
NO331255B1 (no)	2011-11-07
DK1105104T3 (da)	2006-02-06
AU754880B2 (en)	2002-11-28
NO20010919L (no)	2001-03-22
WO2000010536A9 (en)	2000-08-24
WO2000010536A1 (en)	2000-03-02
IL141445A (en)	2005-12-18
EP1105104A1 (de)	2001-06-13
NZ509963A (en)	2004-11-26
KR20010072924A (ko)	2001-07-31
HK1034895A1 (en)	2001-11-09
NO20010919D0 (no)	2001-02-23
IL141445A0 (en)	2002-03-10
US6248358B1 (en)	2001-06-19
EP1105104B1 (de)	2005-10-12
CN1323201A (zh)	2001-11-21
MA24964A1 (fr)	2000-04-01
KR100716702B1 (ko)	2007-05-14
CN1259903C (zh)	2006-06-21
MXPA01002007A (es)	2002-06-04
AR036972A1 (es)	2004-10-20
BR9913239B1 (pt)	2010-11-16
ATE306253T1 (de)	2005-10-15

Publication	Publication Date	Title
DE69927694D1 (de)	2005-11-17	Orale bioadhäsive tablette mit verlängerter wirkstoffabgabe
DE69928085D1 (de)	2005-12-08	Dosierungsform mit verlängerter wirkstoffabgabe
DE69918074D1 (de)	2004-07-22	Makrolid-formulierung mit verzögerter wirkstoffabgabe
EE200000438A (et)	2001-12-17	Farmatseutiliselt aktiivne morfolinool
PT1220856E (pt)	2005-02-28	Compostos farmaceuticamente activos
NO20011085D0 (no)	2001-03-02	Tablett med umiddelbar frigivningsvirkning
ATE312602T1 (de)	2005-12-15	Orale pharmazeutische dosierungsform mit verlängerter wirkstofffreisetzung
DE59712959D1 (de)	2008-09-25	Orale pharmazeutische zubereitung enthaltend ibandronat
ATE371449T1 (de)	2007-09-15	Feste orale dosierungsformen enthaltend valsartan
DE69908021D1 (de)	2003-06-26	Ziprasidonhaltige Arzneimittel
ATE381320T1 (de)	2008-01-15	Weiche kautablette
FI952033A7 (fi)	1995-11-04	Farmakologisesti aktiiviset pyrrolopyrimidiinijohdannaiset
EE9800116A (et)	1998-10-15	Farmatseutiliselt aktiivsed kinasoliini ühendid
ID24654A (id)	2000-07-27	Formulasi farmasi omeprazola
ATA902296A (de)	1999-02-15	Orale olanzapin-formulierung
DK0873750T3 (da)	2004-10-11	Bioadhæsive tabletter
DE60210784D1 (de)	2006-05-24	Orale antidiabetische wirkstoffe
DE69813602D1 (de)	2003-05-22	Venlafaxinhaltiges arzneimittel mit verlängerter wirkstoffabgabe
ITMI991826A0 (it)	1999-08-19	Nuova formulazione orale
DE59804823D1 (de)	2002-08-22	Arzneimittelformulierung mit kontrollierter wirkstofffreisetzung
DE59910298D1 (de)	2004-09-23	Pharmazeutische levothyroxinzubereitung
DE69919490D1 (de)	2004-09-23	Puder mit fettlöslichem wirkstoff
NO20002439L (no)	2000-05-11	Nye orale doseringsformer for carvediol
ATE237529T1 (de)	2003-05-15	Tablettenspender
ATE246502T1 (de)	2003-08-15	Arzneiformen enthaltend carvedilol

Legal Events

Date	Code	Title	Description
2006-11-02	8364	No opposition during term of opposition