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DE69923300D1 - Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung - Google Patents

Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung

Info

Publication number
DE69923300D1
DE69923300D1 DE69923300T DE69923300T DE69923300D1 DE 69923300 D1 DE69923300 D1 DE 69923300D1 DE 69923300 T DE69923300 T DE 69923300T DE 69923300 T DE69923300 T DE 69923300T DE 69923300 D1 DE69923300 D1 DE 69923300D1
Authority
DE
Germany
Prior art keywords
substituents
hydrocarbon group
group optionally
aliphatic hydrocarbon
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69923300T
Other languages
English (en)
Other versions
DE69923300T2 (de
Inventor
Yuzo Ichimori
Masayuki Ii
Katsumi Itoh
Tomoyuki Kitazaki
Junji Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69923300D1 publication Critical patent/DE69923300D1/de
Publication of DE69923300T2 publication Critical patent/DE69923300T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/14—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Silicon Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69923300T 1998-03-09 1999-03-08 Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung Expired - Lifetime DE69923300T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP5649298 1998-03-09
JP5649298 1998-03-09
JP28436298 1998-10-06
JP28436298 1998-10-06
PCT/JP1999/001103 WO1999046242A1 (en) 1998-03-09 1999-03-08 Cycloalkene derivatives, process for producing the same, and use

Publications (2)

Publication Number Publication Date
DE69923300D1 true DE69923300D1 (de) 2005-02-24
DE69923300T2 DE69923300T2 (de) 2006-01-05

Family

ID=26397446

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69923300T Expired - Lifetime DE69923300T2 (de) 1998-03-09 1999-03-08 Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung

Country Status (19)

Country Link
US (1) US6495604B1 (de)
EP (2) EP1063228B1 (de)
JP (2) JP3665712B2 (de)
KR (4) KR20050071719A (de)
CN (1) CN100432049C (de)
AT (1) ATE287393T1 (de)
AU (1) AU747521B2 (de)
BR (1) BR9908610A (de)
CA (1) CA2320467C (de)
DE (1) DE69923300T2 (de)
DK (1) DK1063228T5 (de)
ES (1) ES2232114T3 (de)
HU (1) HU230061B1 (de)
ID (1) ID25649A (de)
NO (1) NO326426B1 (de)
NZ (1) NZ505874A (de)
PT (1) PT1063228E (de)
RU (1) RU2214398C2 (de)
WO (1) WO1999046242A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69923300T2 (de) 1998-03-09 2006-01-05 Takeda Pharmaceutical Co. Ltd. Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung
US20040220103A1 (en) * 1999-04-19 2004-11-04 Immunex Corporation Soluble tumor necrosis factor receptor treatment of medical disorders
KR100778256B1 (ko) * 1999-08-06 2007-11-27 다케다 야쿠힌 고교 가부시키가이샤 치환 방향환 화합물, 그의 제조법 및 용도
AU1553001A (en) * 1999-11-29 2001-06-12 Takeda Chemical Industries Ltd. Process for the production of optically active cyclohexene derivatives and intermediates therefor
CA2400804C (en) 2000-02-04 2009-09-01 Takeda Chemical Industries, Ltd. Stable emulsion compositions of cycloalkene derivatives
JP4863553B2 (ja) * 2000-02-04 2012-01-25 武田薬品工業株式会社 安定な乳化組成物
AU2001278705A1 (en) * 2000-08-10 2002-02-25 Takeda Chemical Industries Ltd. Pharmaceutical composition
JP4922507B2 (ja) * 2000-08-10 2012-04-25 武田薬品工業株式会社 医薬組成物
CA2426277C (en) 2000-10-18 2010-11-30 Takeda Chemical Industries, Ltd. Process for preparation of optically active sulfonamides and intermediates for their synthesis
CA2431206C (en) * 2000-12-08 2009-09-01 Takeda Chemical Industries, Ltd. Combination drugs containing anti-sepsis cycloalkene compound
US7579325B2 (en) 2001-03-21 2009-08-25 Eisai R & D Management Co., Ltd. Drugs containing reduced of vitamin B2
EP1420783A4 (de) * 2001-08-03 2009-09-30 Takeda Pharmaceutical Stabile emulsionszusammensetzung
KR20040099418A (ko) * 2002-04-08 2004-11-26 다케다 야쿠힌 고교 가부시키가이샤 중증 패혈증 예방 치료제
CA2547410C (en) 2003-12-03 2013-07-30 Boehringer Ingelheim Pharmaceuticals, Inc. 1,2,3-triazole amide derivatives as inhibitors of cytokie production
TWI462745B (zh) * 2005-04-28 2014-12-01 Takeda Pharmaceutical 安定的乳化組成物
EP1935879B1 (de) * 2005-09-14 2016-05-11 Daiichi Sankyo Company, Limited Substituiertes cycloalkenderivat
WO2007114296A1 (ja) 2006-03-30 2007-10-11 Hiroshima University スクリーニング方法
US20090062355A1 (en) * 2006-04-20 2009-03-05 Takeda Pharmaceutical Company Limited Pharmaceutical Product
JPWO2007132825A1 (ja) 2006-05-15 2009-09-24 武田薬品工業株式会社 医薬
EP2039681A4 (de) * 2006-07-07 2009-10-28 Takeda Pharmaceutical Cycloalkenderivate, verfahren zur herstellung der derivate und deren verwendung
JP2008260760A (ja) * 2007-03-12 2008-10-30 Daiichi Sankyo Co Ltd 置換シクロアルケン誘導体を含有する医薬組成物
GEP20166441B (en) 2010-01-27 2016-03-10 Takeda Pharmaceutical Compounds for suppressing a peripheral nerve disorder induced by an anti-cancer agent
JP5778161B2 (ja) 2010-09-24 2015-09-16 第一三共株式会社 置換シクロアルケン誘導体の結晶
US20150174160A1 (en) * 2012-07-03 2015-06-25 Jay Pravda Methods for treating, diagnosing and/or monitoring progression of oxo associated states
WO2014050910A1 (ja) 2012-09-26 2014-04-03 武田薬品工業株式会社 固体粒子の製造方法
EA033083B1 (ru) 2015-05-08 2019-08-30 Такеда Фармасьютикал Компани Лимитед Циклические соединения
WO2018047888A1 (ja) 2016-09-09 2018-03-15 武田薬品工業株式会社 環状化合物
CN110352189A (zh) * 2017-02-24 2019-10-18 景凯生物科技股份有限公司 用于预防及/或治疗自体免疫、发炎或感染相关障碍的磺酰胺或酰胺化合物、组合物与方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007552A1 (fr) 1990-11-06 1992-05-14 Nippon Shinyaku Co., Ltd. Preparation lyophilisee et sa production
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
US5576016A (en) 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
US5814324A (en) 1994-02-25 1998-09-29 Takeda Chemical Industries, Ltd. Injectable composition and a method of producing the same
JPH08109165A (ja) * 1994-08-18 1996-04-30 Chugai Pharmaceut Co Ltd 一酸化窒素合成酵素阻害作用を有するアミノ酸誘導体
AU3230895A (en) * 1994-08-18 1996-03-14 Chugai Seiyaku Kabushiki Kaisha Amino acid derivative having nitrogen monoxide synthetase inhibitor activity
DE69923300T2 (de) 1998-03-09 2006-01-05 Takeda Pharmaceutical Co. Ltd. Cycloalken-derivate, verfahren zu ihrer herstellung und ihre verwendung
CA2400804C (en) 2000-02-04 2009-09-01 Takeda Chemical Industries, Ltd. Stable emulsion compositions of cycloalkene derivatives

Also Published As

Publication number Publication date
EP1063228A1 (de) 2000-12-27
ID25649A (id) 2000-10-19
KR20050071719A (ko) 2005-07-07
PT1063228E (pt) 2005-05-31
CN100432049C (zh) 2008-11-12
HUP0101192A3 (en) 2003-09-29
DK1063228T3 (da) 2005-04-25
JP2005232168A (ja) 2005-09-02
RU2214398C2 (ru) 2003-10-20
KR100492098B1 (ko) 2005-06-01
WO1999046242A1 (en) 1999-09-16
HUP0101192A2 (hu) 2001-08-28
JP4342453B2 (ja) 2009-10-14
CA2320467C (en) 2010-05-04
CN1291184A (zh) 2001-04-11
EP1063228B1 (de) 2005-01-19
US6495604B1 (en) 2002-12-17
PL342826A1 (en) 2001-07-02
KR20050026075A (ko) 2005-03-14
JP2000178246A (ja) 2000-06-27
NO20004485D0 (no) 2000-09-08
KR100779889B1 (ko) 2007-11-28
NO20004485L (no) 2000-09-08
BR9908610A (pt) 2000-12-05
NZ505874A (en) 2003-09-26
AU747521C (en) 1999-09-27
KR20010034555A (ko) 2001-04-25
ATE287393T1 (de) 2005-02-15
AU2746499A (en) 1999-09-27
KR100577044B1 (ko) 2006-05-08
DK1063228T5 (da) 2009-06-15
ES2232114T3 (es) 2005-05-16
CA2320467A1 (en) 1999-09-16
DE69923300T2 (de) 2006-01-05
JP3665712B2 (ja) 2005-06-29
EP1063228A4 (de) 2001-08-08
HK1031723A1 (en) 2001-06-22
NO326426B1 (no) 2008-12-01
EP1524263A1 (de) 2005-04-20
HU230061B1 (hu) 2015-06-29
KR20060017921A (ko) 2006-02-27
AU747521B2 (en) 2002-05-16

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