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DE60112607T2 - 3-arylindolderivate und deren verwendung als cb2-rezeptoragonisten - Google Patents

3-arylindolderivate und deren verwendung als cb2-rezeptoragonisten Download PDF

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Publication number
DE60112607T2
DE60112607T2 DE60112607T DE60112607T DE60112607T2 DE 60112607 T2 DE60112607 T2 DE 60112607T2 DE 60112607 T DE60112607 T DE 60112607T DE 60112607 T DE60112607 T DE 60112607T DE 60112607 T2 DE60112607 T2 DE 60112607T2
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DE
Germany
Prior art keywords
receptor agonists
arylindole derivatives
arylindole
derivatives
agonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60112607T
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English (en)
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DE60112607D1 (de
Inventor
Francis Barth
Christian Congy
Carole Guillaumont
Murielle Rinaldi
Fabienne Vasse
Claude Vernhet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
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Sanofi Aventis France
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Publication of DE60112607D1 publication Critical patent/DE60112607D1/de
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Publication of DE60112607T2 publication Critical patent/DE60112607T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
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  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • AIDS & HIV (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
DE60112607T 2000-11-22 2001-11-21 3-arylindolderivate und deren verwendung als cb2-rezeptoragonisten Expired - Lifetime DE60112607T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0015158A FR2816938B1 (fr) 2000-11-22 2000-11-22 Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant
PCT/FR2001/003665 WO2002042269A1 (fr) 2000-11-22 2001-11-21 Derives de 3-aroylindole et leur utilisation en tant qu'agonistes des recepteurs cb2

Publications (2)

Publication Number Publication Date
DE60112607D1 DE60112607D1 (de) 2005-09-15
DE60112607T2 true DE60112607T2 (de) 2006-06-14

Family

ID=8856819

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60112607T Expired - Lifetime DE60112607T2 (de) 2000-11-22 2001-11-21 3-arylindolderivate und deren verwendung als cb2-rezeptoragonisten

Country Status (32)

Country Link
US (1) US6995184B2 (de)
EP (1) EP1339679B1 (de)
JP (1) JP4264258B2 (de)
KR (1) KR20030048161A (de)
CN (1) CN1234688C (de)
AR (1) AR033594A1 (de)
AT (1) ATE301638T1 (de)
AU (1) AU2002222001A1 (de)
BG (1) BG107827A (de)
BR (1) BR0115580A (de)
CA (1) CA2427444A1 (de)
CZ (1) CZ20031392A3 (de)
DE (1) DE60112607T2 (de)
DK (1) DK1339679T3 (de)
DZ (1) DZ3443A1 (de)
EA (1) EA005854B1 (de)
EE (1) EE200300244A (de)
ES (1) ES2247201T3 (de)
FR (1) FR2816938B1 (de)
HR (1) HRP20030417A2 (de)
HU (1) HUP0400561A2 (de)
IL (1) IL155634A0 (de)
IS (1) IS6802A (de)
MA (1) MA26959A1 (de)
MX (1) MXPA03004549A (de)
NO (1) NO20031952L (de)
NZ (1) NZ525609A (de)
PL (1) PL362276A1 (de)
SK (1) SK6042003A3 (de)
TW (1) TWI224592B (de)
WO (1) WO2002042269A1 (de)
ZA (1) ZA200303728B (de)

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EP1487436A4 (de) 2002-03-08 2009-06-03 Signal Pharm Inc Kombinationstherapie zur behandlung, prävention oder versorgung von proliferativen erkrankungen und krebs
JP2006517194A (ja) 2002-06-06 2006-07-20 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティ オブ エルサレム 骨成長を調節するための方法、組成物および製造物
AU2003257145B2 (en) 2002-08-02 2008-11-13 Merck Sharp & Dohme Corp. Substituted furo (2,3-b) pyridine derivatives
FR2843964B1 (fr) * 2002-08-29 2004-10-01 Sanofi Synthelabo Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique
FR2847899B1 (fr) * 2002-11-29 2006-04-28 Sanofi Synthelabo Derives d'indole-3-carboxamide, leur preparation et leur application en therapeutique
FR2854633B1 (fr) * 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
FR2856684B1 (fr) * 2003-06-26 2008-04-11 Sanofi Synthelabo Derives de diphenylpyridine, leur preparation et leur application en therapeutique
FR2865205B1 (fr) * 2004-01-16 2006-02-24 Sanofi Synthelabo Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique
EP1758566A2 (de) * 2004-06-22 2007-03-07 Pharmos Limited Verwendung von agonisten des cb-2-rezeptors zur behandlung von chorea huntington
CN101014605A (zh) 2004-07-12 2007-08-08 卡地拉健康护理有限公司 用作大麻素受体调节物的三环吡唑衍生物
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FR2893615B1 (fr) * 2005-11-18 2008-03-07 Sanofi Aventis Sa Derives de 3-acylindole, leur preparation et leur application en therapeutique
RU2306906C1 (ru) * 2006-04-21 2007-09-27 Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по здравоохранению и социальному развитию" Способ повышения зрительных функций при сублюксации хрусталика в случаях нарушения обмена в системе соединительной ткани
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GB0702862D0 (en) * 2007-02-14 2007-03-28 Univ Aberdeen Therapeutic compounds
EP2142522A1 (de) 2007-03-28 2010-01-13 Abbott Laboratories 1,3-thiazol-2(3h)-ylidene verbindungen als cannabinoid rezeptor liganden
US7872033B2 (en) 2007-04-17 2011-01-18 Abbott Laboratories Compounds as cannabinoid receptor ligands
FR2915199B1 (fr) * 2007-04-18 2010-01-22 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
MX2009012374A (es) * 2007-05-18 2009-12-01 Abbott Lab Compuestos novedosos como ligandos del receptor de canabinoides.
US9193713B2 (en) 2007-10-12 2015-11-24 Abbvie Inc. Compounds as cannabinoid receptor ligands
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EP1339679A1 (de) 2003-09-03
MA26959A1 (fr) 2004-12-20
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NO20031952L (no) 2003-07-22
EA200300453A1 (ru) 2003-10-30
US6995184B2 (en) 2006-02-07
FR2816938A1 (fr) 2002-05-24
ZA200303728B (en) 2004-05-14
EA005854B1 (ru) 2005-06-30
FR2816938B1 (fr) 2003-01-03
DZ3443A1 (fr) 2002-05-30
EP1339679B1 (de) 2005-08-10
NO20031952D0 (no) 2003-04-29
US20040034090A1 (en) 2004-02-19
AU2002222001A1 (en) 2002-06-03
CN1483023A (zh) 2004-03-17
AR033594A1 (es) 2003-12-26
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CN1234688C (zh) 2006-01-04
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JP2004514668A (ja) 2004-05-20
JP4264258B2 (ja) 2009-05-13
DE60112607D1 (de) 2005-09-15
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TWI224592B (en) 2004-12-01
ATE301638T1 (de) 2005-08-15
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CA2427444A1 (fr) 2002-05-30
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