DE60019968D1 - Verwendung von gepirone metabolite zur erstellungs eines medicaments zur behandlung von neurologischer krankheiten - Google Patents
Verwendung von gepirone metabolite zur erstellungs eines medicaments zur behandlung von neurologischer krankheitenInfo
- Publication number
- DE60019968D1 DE60019968D1 DE60019968T DE60019968T DE60019968D1 DE 60019968 D1 DE60019968 D1 DE 60019968D1 DE 60019968 T DE60019968 T DE 60019968T DE 60019968 T DE60019968 T DE 60019968T DE 60019968 D1 DE60019968 D1 DE 60019968D1
- Authority
- DE
- Germany
- Prior art keywords
- medicament
- preparation
- treatment
- gepirone
- neurological diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- QOIGKGMMAGJZNZ-UHFFFAOYSA-N gepirone Chemical class O=C1CC(C)(C)CC(=O)N1CCCCN1CCN(C=2N=CC=CN=2)CC1 QOIGKGMMAGJZNZ-UHFFFAOYSA-N 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 230000000926 neurological effect Effects 0.000 title 1
- -1 3-OH gepirone (4 Chemical class 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960000647 gepirone Drugs 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17268499P | 1999-12-20 | 1999-12-20 | |
| US172684P | 1999-12-20 | ||
| US709741 | 2000-11-13 | ||
| US09/709,741 US6534507B1 (en) | 1999-12-20 | 2000-11-13 | Methods for treating psychological disorders using bioactive metabolites of gepirone |
| PCT/US2000/034131 WO2001045687A2 (en) | 1999-12-20 | 2000-12-18 | Use of bioactive metabolites of gepirone for the treatment of psychological disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60019968D1 true DE60019968D1 (de) | 2005-06-09 |
| DE60019968T2 DE60019968T2 (de) | 2006-02-02 |
Family
ID=26868346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60019968T Expired - Lifetime DE60019968T2 (de) | 1999-12-20 | 2000-12-18 | Verwendung von gepiron-metaboliten zur erstellung eines medikaments zur behandlung von neurologischen krankheiten |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6534507B1 (de) |
| EP (1) | EP1242061B1 (de) |
| JP (1) | JP4236407B2 (de) |
| KR (1) | KR100602976B1 (de) |
| CN (1) | CN1411375A (de) |
| AT (1) | ATE294572T1 (de) |
| AU (1) | AU776409B2 (de) |
| CA (1) | CA2395458C (de) |
| CZ (1) | CZ300429B6 (de) |
| DE (1) | DE60019968T2 (de) |
| ES (1) | ES2241683T3 (de) |
| HU (1) | HU228963B1 (de) |
| IL (2) | IL150222A0 (de) |
| MX (1) | MXPA02006146A (de) |
| NO (1) | NO323304B1 (de) |
| NZ (1) | NZ519554A (de) |
| PL (1) | PL200378B1 (de) |
| PT (1) | PT1242061E (de) |
| RU (1) | RU2282448C2 (de) |
| WO (1) | WO2001045687A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001295478A1 (en) * | 2000-08-22 | 2002-03-04 | Akzo Nobel N.V. | Active metabolite of gepirone |
| US20040000689A1 (en) * | 2002-06-28 | 2004-01-01 | Erh-Kun Lai | Dual-bit MONOS/SONOS memory structure with non-continuous floating gate |
| US20040002500A1 (en) * | 2002-06-28 | 2004-01-01 | Fabre Kramer Pharmaceutical, Inc. | Methods for treating attention deficit disorder |
| CN1674904A (zh) | 2002-08-12 | 2005-09-28 | 布里斯托尔-迈尔斯斯奎布公司 | 用于羟基氮哌酮类的改进方法 |
| WO2004069339A1 (en) * | 2003-01-29 | 2004-08-19 | Psychogenics Inc. | Treatment for attention-deficit hyperactivity disorder |
| TW200521125A (en) * | 2003-11-18 | 2005-07-01 | Bristol Myers Squibb Co | Continuous process for producing hydroxyazapirones by oxidation |
| WO2006052227A1 (en) * | 2004-11-05 | 2006-05-18 | Fabre-Kramer Holdings, Inc. | High-dosage extended-release formulation of gepirone |
| MX2010012146A (es) * | 2008-05-08 | 2010-12-01 | Fabre Kramer Pharmaceuticals Inc | 3-hidroxi gepirona para el tratamiento de desorden de deficit de atencion y disfuncion sexual. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4423049A (en) | 1981-12-28 | 1983-12-27 | Mead Johnson & Company | 2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines |
| US5185329A (en) * | 1988-08-30 | 1993-02-09 | Bristol-Myers Squibb Company | Method for treatment of substance addiction |
| DK0476016T3 (da) * | 1989-05-31 | 1999-07-05 | Upjohn Co | CNS-aktive 8-heterocyclyl-2-aminotetralin-derivater |
| US4956368A (en) | 1989-07-24 | 1990-09-11 | Bristol-Myers Company | Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione |
| US5478572A (en) * | 1994-09-06 | 1995-12-26 | Bristol-Myers Squibb Co. | Gepirone dosage form |
-
2000
- 2000-11-13 US US09/709,741 patent/US6534507B1/en not_active Expired - Lifetime
- 2000-12-18 WO PCT/US2000/034131 patent/WO2001045687A2/en not_active Ceased
- 2000-12-18 CA CA002395458A patent/CA2395458C/en not_active Expired - Lifetime
- 2000-12-18 DE DE60019968T patent/DE60019968T2/de not_active Expired - Lifetime
- 2000-12-18 CN CN00817455A patent/CN1411375A/zh active Pending
- 2000-12-18 MX MXPA02006146A patent/MXPA02006146A/es active IP Right Grant
- 2000-12-18 AT AT00986449T patent/ATE294572T1/de active
- 2000-12-18 CZ CZ20022137A patent/CZ300429B6/cs not_active IP Right Cessation
- 2000-12-18 EP EP00986449A patent/EP1242061B1/de not_active Expired - Lifetime
- 2000-12-18 PT PT00986449T patent/PT1242061E/pt unknown
- 2000-12-18 IL IL15022200A patent/IL150222A0/xx unknown
- 2000-12-18 NZ NZ519554A patent/NZ519554A/en not_active IP Right Cessation
- 2000-12-18 KR KR1020027007927A patent/KR100602976B1/ko not_active Expired - Lifetime
- 2000-12-18 AU AU22687/01A patent/AU776409B2/en not_active Expired
- 2000-12-18 JP JP2001546426A patent/JP4236407B2/ja not_active Expired - Lifetime
- 2000-12-18 PL PL364936A patent/PL200378B1/pl unknown
- 2000-12-18 RU RU2002119400/14A patent/RU2282448C2/ru active
- 2000-12-18 ES ES00986449T patent/ES2241683T3/es not_active Expired - Lifetime
- 2000-12-18 HU HU0301831A patent/HU228963B1/hu unknown
-
2002
- 2002-06-13 IL IL150222A patent/IL150222A/en active IP Right Grant
- 2002-06-19 NO NO20022954A patent/NO323304B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1242061A2 (de) | 2002-09-25 |
| WO2001045687A3 (en) | 2002-04-25 |
| ES2241683T3 (es) | 2005-11-01 |
| PL364936A1 (en) | 2004-12-27 |
| CA2395458A1 (en) | 2001-06-28 |
| IL150222A0 (en) | 2002-12-01 |
| MXPA02006146A (es) | 2004-08-23 |
| JP2004500362A (ja) | 2004-01-08 |
| DE60019968T2 (de) | 2006-02-02 |
| KR100602976B1 (ko) | 2006-07-20 |
| PL200378B1 (pl) | 2008-12-31 |
| PT1242061E (pt) | 2005-09-30 |
| CN1411375A (zh) | 2003-04-16 |
| ATE294572T1 (de) | 2005-05-15 |
| RU2282448C2 (ru) | 2006-08-27 |
| RU2002119400A (ru) | 2004-01-27 |
| CA2395458C (en) | 2009-05-12 |
| NO20022954D0 (no) | 2002-06-19 |
| HUP0301831A2 (hu) | 2003-09-29 |
| CZ300429B6 (cs) | 2009-05-20 |
| NZ519554A (en) | 2005-01-28 |
| KR20020082470A (ko) | 2002-10-31 |
| NO323304B1 (no) | 2007-03-05 |
| CZ20022137A3 (cs) | 2003-03-12 |
| JP4236407B2 (ja) | 2009-03-11 |
| US6534507B1 (en) | 2003-03-18 |
| AU2268701A (en) | 2001-07-03 |
| EP1242061B1 (de) | 2005-05-04 |
| AU776409B2 (en) | 2004-09-09 |
| WO2001045687A2 (en) | 2001-06-28 |
| HU228963B1 (en) | 2013-07-29 |
| IL150222A (en) | 2009-09-22 |
| NO20022954L (no) | 2002-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |