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RU2005140516A - Применение ингибитора тирозинкиназы для лечения диабета - Google Patents

Применение ингибитора тирозинкиназы для лечения диабета Download PDF

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Publication number
RU2005140516A
RU2005140516A RU2005140516/15A RU2005140516A RU2005140516A RU 2005140516 A RU2005140516 A RU 2005140516A RU 2005140516/15 A RU2005140516/15 A RU 2005140516/15A RU 2005140516 A RU2005140516 A RU 2005140516A RU 2005140516 A RU2005140516 A RU 2005140516A
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RU
Russia
Prior art keywords
diabetes
methylpiperazin
ylamino
benzamide
pyrimidin
Prior art date
Application number
RU2005140516/15A
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English (en)
Other versions
RU2365373C2 (ru
Inventor
Пер Роберт ХЭГЕРКВИСТ (SE)
Пер Роберт ХЭГЕРКВИСТ
Нильс Ричард УЭЛШ (SE)
Нильс Ричард Уэлш
Original Assignee
Хэгерквист Роберт Пер (Se)
Хэгерквист Роберт Пер
Нильс Ричард УЭЛШ (SE)
Нильс Ричард Уэлш
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0312086A external-priority patent/GB0312086D0/en
Priority claimed from GB0402682A external-priority patent/GB0402682D0/en
Application filed by Хэгерквист Роберт Пер (Se), Хэгерквист Роберт Пер, Нильс Ричард УЭЛШ (SE), Нильс Ричард Уэлш filed Critical Хэгерквист Роберт Пер (Se)
Publication of RU2005140516A publication Critical patent/RU2005140516A/ru
Application granted granted Critical
Publication of RU2365373C2 publication Critical patent/RU2365373C2/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (8)

1. Применение 4-(4-метилпиперазин-1-илметил)-N-[4-метил-3-(4-пиридин-3-ил)пиримидин-2-иламино)фенил]-бензамида или его фармацевтически приемлемой соли для получения лекарственного средства для лечения или предупреждения диабета.
2. Применение 4-(4-метилпиперазин-1-илметил)-N-[4-метил-3-(4-пиридин-3-ил)пиримидин-2-иламино)фенил]-бензамида или его фармацевтически приемлемой соли для получения лекарственного средства для лечения диабета.
3. Применение 4-(4-метилпиперазин-1-илметил)-N-[4-метил-3-(4-пиридин-3-ил)пиримидин-2-иламино)фенил]-бензамида или его фармацевтически приемлемой соли для получения лекарственного средства для предупреждения диабета.
4. Применение по одному из пп.1-3, в котором диабетом является диабет I типа.
5. Применение по одному из пп.1-3, в котором диабетом является диабет II типа.
6. Применение по п.4, в котором 4-(4-метилпиперазин-1-илметил)-N-[4-метил-3-(4-пиридин-3-ил)пиримидин-2-иламино)фенил]-бензамид находится в форме монометансульфонатной соли.
7. Применение по п.5, в котором 4-(4-метилпиперазин-1-илметил)-N-[4-метил-3-(4-пиридин-3-ил)пиримидин-2-иламино)фенил]-бензамид находится в форме монометансульфонатной соли.
8. Упаковка лекарственного средства, содержащая 4-(4-метилпиперазин-1-илметил)-N-[4-метил-3-(4-пиридин-3-ил)пиримидин-2-иламино)фенил]-бензамид или его фармацевтически приемлемую соль, вместе с отпечатанными инструкциями, для введения пациентам, болеющим диабетом, например, диабетом I типа, диабетом II типа.
RU2005140516/15A 2003-05-27 2004-05-26 Применение ингибитора тирозинкиназы для лечения диабета RU2365373C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0312086A GB0312086D0 (en) 2003-05-27 2003-05-27 Organic compounds
GB0312086.2 2003-05-27
GB0402682A GB0402682D0 (en) 2004-02-06 2004-02-06 Organic compounds
GB0402682.9 2004-02-06

Publications (2)

Publication Number Publication Date
RU2005140516A true RU2005140516A (ru) 2007-07-10
RU2365373C2 RU2365373C2 (ru) 2009-08-27

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Country Link
US (1) US7875616B2 (ru)
EP (1) EP1631291B1 (ru)
JP (1) JP4776537B2 (ru)
KR (1) KR101102229B1 (ru)
AT (1) ATE439133T1 (ru)
BR (1) BRPI0410704A (ru)
CA (1) CA2526594C (ru)
DE (1) DE602004022540D1 (ru)
DK (1) DK1631291T3 (ru)
ES (1) ES2331800T3 (ru)
IL (1) IL171927A (ru)
IS (1) IS2712B (ru)
MA (1) MA27812A1 (ru)
MX (1) MXPA05012739A (ru)
NO (1) NO331715B1 (ru)
NZ (1) NZ543709A (ru)
PL (1) PL1631291T3 (ru)
PT (1) PT1631291E (ru)
RU (1) RU2365373C2 (ru)
WO (1) WO2004105763A2 (ru)

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JP2007502809A (ja) * 2003-08-15 2007-02-15 アブ サイエンス ＩＩ型糖尿病を治療するためのｃ−ｋｉｔ阻害剤の使用方法
US20060094682A1 (en) * 2004-10-29 2006-05-04 Odyssey Thera, Inc. Kinase inhibitors for the treatment of diabetes and obesity
CN101484427A (zh) * 2006-06-30 2009-07-15 协和发酵麒麟株式会社 Abl激酶抑制剂
MX2014003182A (es) * 2011-09-15 2014-09-22 Novartis Ag Uso de 4-amino-5-fluoro-3-[6-(4-metilpiperazin-1-il)-1h-bencimidaz ol-2-il]-1h-quinolin-2-ona en el tratamiento de cancer en pacientes con insuficiencia hepática moderada.

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Also Published As

Publication number Publication date
US20070072932A1 (en) 2007-03-29
ATE439133T1 (de) 2009-08-15
JP2006528225A (ja) 2006-12-14
DE602004022540D1 (de) 2009-09-24
DK1631291T3 (da) 2009-11-02
NO20056188L (no) 2005-12-23
WO2004105763A2 (en) 2004-12-09
PL1631291T3 (pl) 2010-04-30
US7875616B2 (en) 2011-01-25
PT1631291E (pt) 2009-10-28
RU2365373C2 (ru) 2009-08-27
ES2331800T3 (es) 2010-01-15
IL171927A (en) 2011-10-31
BRPI0410704A (pt) 2006-06-13
NO331715B1 (no) 2012-03-05
WO2004105763A3 (en) 2005-06-02
MXPA05012739A (es) 2006-05-17
NZ543709A (en) 2009-04-30
EP1631291B1 (en) 2009-08-12
AU2004243491A1 (en) 2004-12-09
JP4776537B2 (ja) 2011-09-21
EP1631291A2 (en) 2006-03-08
IL171927A0 (en) 2006-04-10
CA2526594A1 (en) 2004-12-09
IS2712B (is) 2011-01-15
IS8139A (is) 2005-11-22
MA27812A1 (fr) 2006-03-01
CA2526594C (en) 2011-11-08
KR20060021865A (ko) 2006-03-08
HK1087638A1 (en) 2006-10-20
KR101102229B1 (ko) 2012-01-05

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