CY1114803T1 - Παραγωγα πυριμιδινο σουλφοναμιδιου ως ρυθμιστες υποδοχεων χημειοκινης - Google Patents
Παραγωγα πυριμιδινο σουλφοναμιδιου ως ρυθμιστες υποδοχεων χημειοκινηςInfo
- Publication number
- CY1114803T1 CY1114803T1 CY20141100034T CY141100034T CY1114803T1 CY 1114803 T1 CY1114803 T1 CY 1114803T1 CY 20141100034 T CY20141100034 T CY 20141100034T CY 141100034 T CY141100034 T CY 141100034T CY 1114803 T1 CY1114803 T1 CY 1114803T1
- Authority
- CY
- Cyprus
- Prior art keywords
- chemokine receptor
- pyrimidine derivatives
- receptor regulators
- sulfonamide
- sulfonamide pyrimidine
- Prior art date
Links
- 102000009410 Chemokine receptor Human genes 0.000 title 1
- 108050000299 Chemokine receptor Proteins 0.000 title 1
- -1 Sulfonamide pyrimidine derivatives Chemical class 0.000 title 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract
Μια ένωση του τύπου (1), ή ένα φαρμακευτικώς αποδεκτό άλας, διαλύτωμα ή in vivo υδρολύσιμος εστέρας αυτής και φαρμακευτικές συνθέσεις που τα περιλαμβάνουν, όλα για χρήση στη θεραπευτική αγωγή μεσολαβούμενων από χημειοκίνη ασθενειών και διαταραχών.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0419235A GB0419235D0 (en) | 2004-08-28 | 2004-08-28 | Compounds |
| GB0502544A GB0502544D0 (en) | 2005-02-08 | 2005-02-08 | Compounds |
| EP05773278.6A EP1809624B1 (en) | 2004-08-28 | 2005-08-23 | Pyrimidine sulphonamide derivatives as chemokine receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1114803T1 true CY1114803T1 (el) | 2016-12-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20141100034T CY1114803T1 (el) | 2004-08-28 | 2014-01-15 | Παραγωγα πυριμιδινο σουλφοναμιδιου ως ρυθμιστες υποδοχεων χημειοκινης |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US7838675B2 (el) |
| EP (3) | EP2311827A1 (el) |
| JP (3) | JP4795352B2 (el) |
| KR (1) | KR101280095B1 (el) |
| CN (1) | CN102796081B (el) |
| AR (1) | AR050617A1 (el) |
| AU (1) | AU2005279045B2 (el) |
| BR (1) | BRPI0514735B8 (el) |
| CA (1) | CA2578441C (el) |
| CY (1) | CY1114803T1 (el) |
| DK (1) | DK1809624T3 (el) |
| ES (1) | ES2442678T3 (el) |
| HR (1) | HRP20140023T1 (el) |
| IL (1) | IL181241A0 (el) |
| ME (1) | ME01620B (el) |
| MX (1) | MX2007002240A (el) |
| MY (1) | MY148125A (el) |
| NO (1) | NO338749B1 (el) |
| NZ (1) | NZ553335A (el) |
| PL (1) | PL1809624T3 (el) |
| PT (1) | PT1809624E (el) |
| RS (1) | RS53145B (el) |
| RU (1) | RU2408587C2 (el) |
| SI (1) | SI1809624T1 (el) |
| TW (1) | TWI369983B (el) |
| UY (1) | UY29085A1 (el) |
| WO (1) | WO2006024823A1 (el) |
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| JPS6262286A (ja) * | 1985-09-13 | 1987-03-18 | 株式会社東芝 | 沸騰水型原子炉炉心 |
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| PT1809624E (pt) | 2004-08-28 | 2014-01-14 | Astrazeneca Ab | Derivados de pirimidina sulfonamida como moduladores do recetor de quimiocina |
| JP2008540539A (ja) | 2005-05-10 | 2008-11-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャンネルの調節因子としての二環系誘導体 |
| US8450336B2 (en) | 2006-12-14 | 2013-05-28 | Nps Pharmaceuticals, Inc | Use of D-serine derivatives for the treatment of anxiety disorders |
| ATE521609T1 (de) * | 2007-05-04 | 2011-09-15 | Astrazeneca Ab | Aminothiazolylpyrimidinderivate und ihre verwendung bei der behandlung von krebs |
| WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
| RU2011101661A (ru) * | 2008-07-16 | 2012-08-27 | Астразенека Аб (Se) | Пиримидилсульфонамидное производное и его применение для лечения хемокин-опосредованных заболеваний |
| AR076601A1 (es) | 2009-05-21 | 2011-06-22 | Chlorion Pharma Inc | Pirimidinas como agentes terapeuticos |
| AR080375A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida |
| TWI496773B (zh) * | 2010-07-13 | 2015-08-21 | Astrazeneca Ab | N-[2-[[(2,3-二氟苯基)甲基]硫基]-6-{[(1r,2s)-2,3-二羥基-1-甲基丙基]氧基}-4-嘧啶基]-1-三亞甲亞胺磺醯胺之新穎結晶型 |
| SI3255043T1 (sl) * | 2011-07-12 | 2021-04-30 | Astrazeneca Ab | N-(6-((2R,3S)-3,4-dihidroksibutan-2-iloksi)-2-(4-fluorobenziltio) pirimidin-4-il)-3-metilazetidin-1-sulfonamid, kot modulator kemokinskega receptorja |
| TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
| EP3692992A1 (en) | 2015-02-27 | 2020-08-12 | Kyushu University National University Corporation | Method of screening dock1-selective inhibitors for cancer treatment |
| BR112018068393A2 (pt) | 2016-03-11 | 2019-01-15 | Ardea Biosciences Inc | inibidores de cxcr-2 para o tratamento de distúrbios de artropatia por cristais |
| US10660909B2 (en) | 2016-11-17 | 2020-05-26 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| WO2019165315A1 (en) | 2018-02-23 | 2019-08-29 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists alone or in combination |
| WO2023028077A1 (en) | 2021-08-24 | 2023-03-02 | Genentech, Inc. | Sodium channel inhibitors and methods of designing same |
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-
2005
- 2005-08-23 PT PT5773278T patent/PT1809624E/pt unknown
- 2005-08-23 PL PL05773278T patent/PL1809624T3/pl unknown
- 2005-08-23 SI SI200531819T patent/SI1809624T1/sl unknown
- 2005-08-23 EP EP10194614A patent/EP2311827A1/en not_active Withdrawn
- 2005-08-23 MX MX2007002240A patent/MX2007002240A/es active IP Right Grant
- 2005-08-23 HR HRP20140023TT patent/HRP20140023T1/hr unknown
- 2005-08-23 AU AU2005279045A patent/AU2005279045B2/en not_active Expired
- 2005-08-23 RU RU2007106037/04A patent/RU2408587C2/ru active
- 2005-08-23 ME MEP-2014-3A patent/ME01620B/me unknown
- 2005-08-23 US US11/574,340 patent/US7838675B2/en active Active
- 2005-08-23 KR KR1020077004736A patent/KR101280095B1/ko not_active Expired - Lifetime
- 2005-08-23 JP JP2007528961A patent/JP4795352B2/ja not_active Expired - Lifetime
- 2005-08-23 CA CA2578441A patent/CA2578441C/en not_active Expired - Lifetime
- 2005-08-23 EP EP05773278.6A patent/EP1809624B1/en not_active Expired - Lifetime
- 2005-08-23 CN CN201210247005.5A patent/CN102796081B/zh not_active Expired - Lifetime
- 2005-08-23 DK DK05773278.6T patent/DK1809624T3/da active
- 2005-08-23 WO PCT/GB2005/003257 patent/WO2006024823A1/en not_active Ceased
- 2005-08-23 BR BRPI0514735A patent/BRPI0514735B8/pt active IP Right Grant
- 2005-08-23 ES ES05773278.6T patent/ES2442678T3/es not_active Expired - Lifetime
- 2005-08-23 NZ NZ553335A patent/NZ553335A/en not_active IP Right Cessation
- 2005-08-23 EP EP10194616A patent/EP2301933A1/en not_active Withdrawn
- 2005-08-23 RS RS20140015A patent/RS53145B/sr unknown
- 2005-08-25 MY MYPI20054004A patent/MY148125A/en unknown
- 2005-08-26 TW TW094129379A patent/TWI369983B/zh not_active IP Right Cessation
- 2005-08-26 AR ARP050103584A patent/AR050617A1/es active IP Right Grant
- 2005-08-26 UY UY29085A patent/UY29085A1/es not_active Application Discontinuation
-
2007
- 2007-02-08 IL IL181241A patent/IL181241A0/en active IP Right Grant
- 2007-03-27 NO NO20071594A patent/NO338749B1/no unknown
-
2010
- 2010-11-17 US US12/947,916 patent/US8269002B2/en not_active Expired - Lifetime
-
2011
- 2011-01-26 JP JP2011013745A patent/JP5364735B2/ja not_active Expired - Lifetime
- 2011-12-23 US US13/336,269 patent/US8410123B2/en not_active Expired - Lifetime
-
2012
- 2012-09-14 US US13/620,075 patent/US20130012490A1/en not_active Abandoned
-
2013
- 2013-03-15 US US13/833,363 patent/US8722883B2/en not_active Expired - Lifetime
- 2013-06-07 JP JP2013120663A patent/JP5730350B2/ja not_active Expired - Lifetime
-
2014
- 2014-01-15 CY CY20141100034T patent/CY1114803T1/el unknown
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