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CY1114570T1 - Βελτιωμενα κυστιδια βακτηριακης εξωτερικης μεμβρανης - Google Patents

Βελτιωμενα κυστιδια βακτηριακης εξωτερικης μεμβρανης

Info

Publication number
CY1114570T1
CY1114570T1 CY20131100752T CY131100752T CY1114570T1 CY 1114570 T1 CY1114570 T1 CY 1114570T1 CY 20131100752 T CY20131100752 T CY 20131100752T CY 131100752 T CY131100752 T CY 131100752T CY 1114570 T1 CY1114570 T1 CY 1114570T1
Authority
CY
Cyprus
Prior art keywords
pellet
collecting
detergent
outer membrane
bacterial
Prior art date
Application number
CY20131100752T
Other languages
English (en)
Inventor
Mariagrazia Pizza
Davide Serruto
Rino Rappuoli
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9943238&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1114570(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1114570T1 publication Critical patent/CY1114570T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/06—Lysis of microorganisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Οι υπάρχουσες μέθοδοι παρασκευής μηνιγγιτιδοκικκικού ΟΜV παρασκευάσματος περιλαμβάνουν την χρήση απορρυπαντικού κατά την διάρκεια της διάσπασης της βακτηριακής μεμβράνης. Σύμφωνα με την εφεύρεση, η διάσπαση της μεμβράνης διεξάγεται ουσιαστικά απουσία απορρυπαντικού. Τα ΟΜVs που προκύπτουν διατηρούν σημαντικά βακτηριακά ανοσογόνα συστατικά, ειδικά (i) προστατευτική ΝspΑ πρωτεΐνη επιφάνειας, (ii) πρωτεΐνη ΝΜΒ2132 και (iii) πρωτεΐνη ΝΜΒ1870. Μία τυπική διαδικασία περιλαμβάνει τα ακόλουθα βήματα: (α) κατεργασία των βακτηριακών κυττάρων ουσιαστικά απουσία απορρυπαντικού˙ (β) φυγοκέντρηση της σύνθεσης από το βήμα (α) για να διαχωριστούν τα κυστίδια εξωτερικής μεμβράνης από τα κατεργασμένα κύτταρα και τα κυτταρικά υπολείμματα και συλλογή του υπερκείμενου˙ (γ) διεξαγωγή φυγοκέντρησης υψηλής ταχύτητας στο υπερκείμενο από το βήμα (β) και συλλογή των κυστιδίων εξωτερικής μεμβράνης σε ένα ίζημα˙ (δ) επανα-διάσπορά του ιζήματος από το βήμα (γ) σε ένα ρυθμιστικό διάλυμα˙ (ε) διεξαγωγή μιας δεύτερης φυγοκέντρησης υψηλής ταχύτητας, σύμφωνα με το βήμα (γ), συλλογή των κυστιδίων εξωτερικής μεμβράνης σε ένα ίζημα˙ (ζ)επαναδιασπορά του ιζήματος από το βήμα (ε) σε ένα υδατικό μέσο.
CY20131100752T 2002-08-30 2013-09-02 Βελτιωμενα κυστιδια βακτηριακης εξωτερικης μεμβρανης CY1114570T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0220194.5A GB0220194D0 (en) 2002-08-30 2002-08-30 Improved vesicles
EP10179783.5A EP2258389B1 (en) 2002-08-30 2003-09-01 Improved bacterial outer membrane vesicles

Publications (1)

Publication Number Publication Date
CY1114570T1 true CY1114570T1 (el) 2017-01-25

Family

ID=9943238

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20071101197T CY1107737T1 (el) 2002-08-30 2007-09-17 Βελτιωμενα κυστιδια εξωτερικης μεμβρανης βακτηριων
CY20131100752T CY1114570T1 (el) 2002-08-30 2013-09-02 Βελτιωμενα κυστιδια βακτηριακης εξωτερικης μεμβρανης
CY20141100736T CY1115777T1 (el) 2002-08-30 2014-09-11 Βελτιωμενα κυστιδια εξωτερικης μεμβρανης βακτηριων

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20071101197T CY1107737T1 (el) 2002-08-30 2007-09-17 Βελτιωμενα κυστιδια εξωτερικης μεμβρανης βακτηριων

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20141100736T CY1115777T1 (el) 2002-08-30 2014-09-11 Βελτιωμενα κυστιδια εξωτερικης μεμβρανης βακτηριων

Country Status (21)

Country Link
US (2) US20060166344A1 (el)
EP (5) EP2258388B1 (el)
JP (3) JP2006503822A (el)
CN (2) CN1688334A (el)
AT (1) ATE366117T1 (el)
AU (1) AU2003263534B2 (el)
BR (1) BRPI0314094A8 (el)
CA (1) CA2497165C (el)
CY (3) CY1107737T1 (el)
DE (1) DE60314756T2 (el)
DK (3) DK1534326T3 (el)
ES (4) ES2289351T3 (el)
FR (1) FR13C0046I2 (el)
GB (1) GB0220194D0 (el)
LU (1) LU92239I2 (el)
MX (1) MXPA05002316A (el)
NZ (1) NZ538673A (el)
PT (3) PT1534326E (el)
RU (1) RU2325184C2 (el)
SI (2) SI2258389T1 (el)
WO (1) WO2004019977A2 (el)

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JP2006503822A (ja) 2006-02-02
DE60314756T2 (de) 2008-03-06
US20150258188A1 (en) 2015-09-17
RU2005108994A (ru) 2006-02-10
CA2497165A1 (en) 2004-03-11
WO2004019977A2 (en) 2004-03-11
CN102188700A (zh) 2011-09-21
EP1864679B1 (en) 2014-06-18
CY1115777T1 (el) 2017-01-25
ATE366117T1 (de) 2007-07-15
DK2258389T3 (da) 2013-08-26
CN1688334A (zh) 2005-10-26
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EP2258389B1 (en) 2013-06-05
BRPI0314094A8 (pt) 2018-04-03
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