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CY1112949T1 - 2-φαινυλο-υποκατεστημενες ιμιδαζοτριαζινονες ως αναστολεις φωσφοδιεστερασης - Google Patents

2-φαινυλο-υποκατεστημενες ιμιδαζοτριαζινονες ως αναστολεις φωσφοδιεστερασης

Info

Publication number
CY1112949T1
CY1112949T1 CY20121100695T CY121100695T CY1112949T1 CY 1112949 T1 CY1112949 T1 CY 1112949T1 CY 20121100695 T CY20121100695 T CY 20121100695T CY 121100695 T CY121100695 T CY 121100695T CY 1112949 T1 CY1112949 T1 CY 1112949T1
Authority
CY
Cyprus
Prior art keywords
substituted
phosphosteration
imadazatrizinones
phynyl
inhibitors
Prior art date
Application number
CY20121100695T
Other languages
English (en)
Inventor
Ulrich Dr Niewöhner
Mazen Dr Es-Sayed
Helmut Dr Haning
Thomas Dr Schenke
Karl-Heinz Dr Schlemmer
Jörg Dr Keldenich
Erwin Dr Bischoff
Elisabeth Dr Perzborn
Klaus Dr Dembowsky
Peter Dr Serno
Marc Dr Nowakowski
Original Assignee
Bayer Pharma Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27217917&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1112949(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19750085A external-priority patent/DE19750085A1/de
Priority claimed from DE1998112462 external-priority patent/DE19812462A1/de
Priority claimed from DE1998140289 external-priority patent/DE19840289A1/de
Application filed by Bayer Pharma Aktiengesellschaft filed Critical Bayer Pharma Aktiengesellschaft
Publication of CY1112949T1 publication Critical patent/CY1112949T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Οι 2-φαινυλο-υποκατεστημένες ιμιδαζοτριαζινόνες με μικρές, διακλαδισμένες αλκυλο-ρίζες στην θέση 9 παρασκευάζονται από τις αντίστοιχες 2-φαινυλο-ιμιδαζοτριαζινόνες μέσω χλωροσουλφονίωσης και μέσω της μετέπειτα αντίδρασης με τις αμίνες. Οι ενώσεις αναστέλλουν τις με cGΜΡ μεταβολιζόμενες φωσφοδιεστεράσες και είναι κατάλληλες για χρήση ως δραστικά συστατικά σε φαρμακευτικά προϊόντα, για τη θεραπεία των καρδιαγγειακών και εγκεφαλοαγγειακών νοσημάτων και / ή των νοσημάτων του ουρογεννητικού συστήματος, ιδίως για την αντιμετώπιση της στυτικής δυσλειτουργίας.
CY20121100695T 1997-11-12 2012-08-03 2-φαινυλο-υποκατεστημενες ιμιδαζοτριαζινονες ως αναστολεις φωσφοδιεστερασης CY1112949T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19750085A DE19750085A1 (de) 1997-11-12 1997-11-12 2-Phenyl-substituierte Imidazotriazinone
DE1998112462 DE19812462A1 (de) 1998-03-23 1998-03-23 2-[2-Ethoxy-5(4-ethyl-piperazin-1-sulfonyl) -phenyl]-5-methyl-7-prophyl-3H-imidazo[5,1-f][1,2,4]triazin-4-on Dihydrochlorid
DE1998140289 DE19840289A1 (de) 1998-09-04 1998-09-04 2-Phenyl-substituierte Imidazotriazinone
EP01123321A EP1174431B1 (de) 1997-11-12 1998-10-31 2-Phenyl-substituierte Imidazotriazinone als Phoshodiesterase Inhibitoren

Publications (1)

Publication Number Publication Date
CY1112949T1 true CY1112949T1 (el) 2016-04-13

Family

ID=27217917

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100695T CY1112949T1 (el) 1997-11-12 2012-08-03 2-φαινυλο-υποκατεστημενες ιμιδαζοτριαζινονες ως αναστολεις φωσφοδιεστερασης

Country Status (43)

Country Link
US (9) US6362178B1 (el)
EP (3) EP1174431B1 (el)
JP (2) JP3356428B2 (el)
KR (2) KR100430355B1 (el)
CN (2) CN1123573C (el)
AR (2) AR013759A1 (el)
AT (1) ATE213246T1 (el)
AU (1) AU738675B2 (el)
BG (1) BG65257B1 (el)
BR (2) BR9816155B1 (el)
CA (2) CA2395558C (el)
CH (1) CH693954A5 (el)
CO (1) CO4980861A1 (el)
CU (1) CU23063A3 (el)
CY (1) CY1112949T1 (el)
CZ (1) CZ301911B6 (el)
DE (3) DE19881732D2 (el)
DK (3) DK1049695T3 (el)
EE (1) EE04781B1 (el)
ES (3) ES2172945T3 (el)
FI (1) FI113772B (el)
GB (1) GB2346877B (el)
HN (1) HN1998000175A (el)
HR (2) HRP20020585B1 (el)
HU (3) HU228196B1 (el)
ID (1) ID25871A (el)
IL (3) IL135462A0 (el)
IN (1) IN188419B (el)
LU (1) LU90561B1 (el)
MY (1) MY138535A (el)
NO (2) NO314940B1 (el)
NZ (1) NZ504436A (el)
PE (1) PE131799A1 (el)
PL (2) PL194801B1 (el)
PT (2) PT1174431E (el)
SE (1) SE522809C2 (el)
SI (2) SI1049695T1 (el)
SK (1) SK287161B6 (el)
TR (1) TR200001338T2 (el)
TW (2) TW513431B (el)
UA (1) UA46166C2 (el)
UY (2) UY25246A1 (el)
WO (1) WO1999024433A1 (el)

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