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UY25671A1 - Procedimiento para preparar imidazotrazinonas sustituidas por 2-fenilo - Google Patents

Procedimiento para preparar imidazotrazinonas sustituidas por 2-fenilo

Info

Publication number
UY25671A1
UY25671A1 UY25671A UY25671A UY25671A1 UY 25671 A1 UY25671 A1 UY 25671A1 UY 25671 A UY25671 A UY 25671A UY 25671 A UY25671 A UY 25671A UY 25671 A1 UY25671 A1 UY 25671A1
Authority
UY
Uruguay
Prior art keywords
treatment
preparing
phenyl
linear
imidazotrazinones
Prior art date
Application number
UY25671A
Other languages
English (en)
Inventor
Marc Dr Nowakowski
Peter Dr Serno
Klaus Dr Dembowsky
Elizabeth Dr Perzborn
Erwin Dr Bischoff
Jorg Dr Keldenich
Karl-Heinz Dr Schiemmer
Thomas Dr Schenke
Mazen Dr Es-Sayed
Ulrich Dr Neiwohner
Helmut Dr Haning
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27217917&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY25671(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19750085A external-priority patent/DE19750085A1/de
Priority claimed from DE1998112462 external-priority patent/DE19812462A1/de
Priority claimed from DE1998140289 external-priority patent/DE19840289A1/de
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of UY25671A1 publication Critical patent/UY25671A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Procedimientos para preparar las imidazotriazinonas sustituidas por 2-fenilo con restos alquilo cortos, no ramificados, en posición 9, se prepararn a partir de las correspondientes 2-fenil-imidazotriazinonas mediante clorosulfonación y transformación posterior con las aminas. Los compuestos inhiben las fosfodiesterasas que metabolizan el GMpc y son adecuados como sustancia activa en medicamentos para el tratamiento de enfermedades del sistema urogenital, especialmente para el tratamiento de la disfunción eréctil. Los compuestos en la cual R1 representa H, alquilo lineal con 4 átomos de C; R2 es alquilo lineal; R3 y R4 son H o alquenilo, alcoxi, etc; R5 y R6 son H, alquilo lineal o ramificado y sus sales, hidratos, N- óxidos y formas isómeras. Tambicn se pueden emplear en el tratamiento de enfermedades cardiovasculares, como hiprtensinn sanguínea, neuronal, angina estable, arritmias, infarto de miocardio, disfuncion ercctil y disfunción sexual femenina
UY25671A 1997-11-12 1999-08-19 Procedimiento para preparar imidazotrazinonas sustituidas por 2-fenilo UY25671A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19750085A DE19750085A1 (de) 1997-11-12 1997-11-12 2-Phenyl-substituierte Imidazotriazinone
DE1998112462 DE19812462A1 (de) 1998-03-23 1998-03-23 2-[2-Ethoxy-5(4-ethyl-piperazin-1-sulfonyl) -phenyl]-5-methyl-7-prophyl-3H-imidazo[5,1-f][1,2,4]triazin-4-on Dihydrochlorid
DE1998140289 DE19840289A1 (de) 1998-09-04 1998-09-04 2-Phenyl-substituierte Imidazotriazinone

Publications (1)

Publication Number Publication Date
UY25671A1 true UY25671A1 (es) 2000-03-31

Family

ID=27217917

Family Applications (2)

Application Number Title Priority Date Filing Date
UY25246A UY25246A1 (es) 1997-11-12 1998-11-12 Imidazotriazinonas sustituidas por 2-fenilo
UY25671A UY25671A1 (es) 1997-11-12 1999-08-19 Procedimiento para preparar imidazotrazinonas sustituidas por 2-fenilo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UY25246A UY25246A1 (es) 1997-11-12 1998-11-12 Imidazotriazinonas sustituidas por 2-fenilo

Country Status (43)

Country Link
US (9) US6362178B1 (es)
EP (3) EP1049695B1 (es)
JP (2) JP3356428B2 (es)
KR (2) KR100548120B1 (es)
CN (2) CN100430396C (es)
AR (2) AR013759A1 (es)
AT (1) ATE213246T1 (es)
AU (1) AU738675B2 (es)
BG (1) BG65257B1 (es)
BR (2) BR9816155B1 (es)
CA (2) CA2395558C (es)
CH (1) CH693954A5 (es)
CO (1) CO4980861A1 (es)
CU (1) CU23063A3 (es)
CY (1) CY1112949T1 (es)
CZ (1) CZ301911B6 (es)
DE (3) DE19881732C1 (es)
DK (3) DK1174431T3 (es)
EE (1) EE04781B1 (es)
ES (3) ES2194567B1 (es)
FI (1) FI113772B (es)
GB (1) GB2346877B (es)
HN (1) HN1998000175A (es)
HR (2) HRP20000292B1 (es)
HU (3) HU227841B1 (es)
ID (1) ID25871A (es)
IL (3) IL135462A0 (es)
IN (1) IN188419B (es)
LU (1) LU90561B1 (es)
MY (1) MY138535A (es)
NO (2) NO314940B1 (es)
NZ (1) NZ504436A (es)
PE (1) PE131799A1 (es)
PL (2) PL194801B1 (es)
PT (2) PT1174431E (es)
SE (1) SE522809C2 (es)
SI (2) SI1174431T1 (es)
SK (1) SK287161B6 (es)
TR (1) TR200001338T2 (es)
TW (2) TW513431B (es)
UA (1) UA46166C2 (es)
UY (2) UY25246A1 (es)
WO (1) WO1999024433A1 (es)

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US7122540B2 (en) 2006-10-17
ID25871A (id) 2000-11-09
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