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CY1112864T1 - Καινουργιες μορφες μεθυλικου εστερα cddo - Google Patents

Καινουργιες μορφες μεθυλικου εστερα cddo

Info

Publication number
CY1112864T1
CY1112864T1 CY20121100542T CY121100542T CY1112864T1 CY 1112864 T1 CY1112864 T1 CY 1112864T1 CY 20121100542 T CY20121100542 T CY 20121100542T CY 121100542 T CY121100542 T CY 121100542T CY 1112864 T1 CY1112864 T1 CY 1112864T1
Authority
CY
Cyprus
Prior art keywords
cddo
crystalline
new models
methyl ester
vitreous
Prior art date
Application number
CY20121100542T
Other languages
English (en)
Inventor
John Walling
Stephan D Parent
David T Jonaitis
Robert M Kral
Original Assignee
Reata Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reata Pharmaceuticals, Inc. filed Critical Reata Pharmaceuticals, Inc.
Publication of CY1112864T1 publication Critical patent/CY1112864T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Glass Compositions (AREA)

Abstract

Μία ένωση τριτερπενοειδούς (triterpenoid), methyl 2-cyano-3,12-dioxoleana- 1,9(1 1)-dien-28-oate (μεθυλικός εστέρας CDDO), έχει μία μη κρυσταλλική, υαλώδη στερεά μορφή και μία μη ένυδρη κρυσταλλική μορφή που μπορούν να παρασκευαστούν, για παράδειγμα, από ένα κεκορεσμένο διάλυμα μεθανόλης (methanol). Η υαλώδης μορφή εμφανίζει μία αυξημένη βιολογική διαθεσιμότητα έναντι της μη ένυδρης κρυσταλλικής μορφής. Κάθε μορφή μεθυλικού εστέρα CDDΟ είναι ένας ανώτερος υποψήφιος για χρήση, τυπικά σε μορφή στερεάς δοσολογίας, για την θεραπεία μιας ποικιλίας καταστάσεων ασθενείας, που σχετίζονται εν γένει με φλεγμονή.
CY20121100542T 2007-08-15 2012-06-13 Καινουργιες μορφες μεθυλικου εστερα cddo CY1112864T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95593907P 2007-08-15 2007-08-15
EP08795303A EP2187741B1 (en) 2007-08-15 2008-08-14 Novel forms of cddo methyl ester

Publications (1)

Publication Number Publication Date
CY1112864T1 true CY1112864T1 (el) 2016-04-13

Family

ID=40351005

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20121100542T CY1112864T1 (el) 2007-08-15 2012-06-13 Καινουργιες μορφες μεθυλικου εστερα cddo
CY20161101205T CY1118329T1 (el) 2007-08-15 2016-11-23 Καινουργιες μορφες μεθυλικου εστερα cddo

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20161101205T CY1118329T1 (el) 2007-08-15 2016-11-23 Καινουργιες μορφες μεθυλικου εστερα cddo

Country Status (28)

Country Link
US (3) US8088824B2 (el)
EP (2) EP2187741B1 (el)
JP (4) JP5005812B2 (el)
KR (2) KR101481764B1 (el)
CN (2) CN103254267B (el)
AR (2) AR073155A1 (el)
AT (1) ATE549035T1 (el)
AU (1) AU2008287388B2 (el)
BR (1) BRPI0815540A8 (el)
CA (2) CA2871864C (el)
CL (1) CL2008002417A1 (el)
CY (2) CY1112864T1 (el)
DK (2) DK2187741T3 (el)
EA (2) EA018704B1 (el)
ES (2) ES2602978T3 (el)
HR (2) HRP20120350T1 (el)
HU (1) HUE031866T2 (el)
IL (2) IL203824A (el)
LT (1) LT2450057T (el)
MX (1) MX2010001628A (el)
NZ (1) NZ583269A (el)
PL (2) PL2187741T3 (el)
PT (2) PT2450057T (el)
SG (2) SG10201504650VA (el)
SI (2) SI2450057T1 (el)
TW (2) TWI419899B (el)
WO (1) WO2009023232A1 (el)
ZA (1) ZA201001066B (el)

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MX2010001628A (es) 2010-06-02
JP2015164939A (ja) 2015-09-17
ES2382571T3 (es) 2012-06-11
HK1143537A1 (en) 2011-01-07
EP2450057B1 (en) 2016-09-28
BRPI0815540A8 (pt) 2023-04-11
JP2012188438A (ja) 2012-10-04
SI2450057T1 (sl) 2017-01-31
CY1118329T1 (el) 2017-06-28
KR20140024063A (ko) 2014-02-27
NZ583269A (en) 2012-03-30
AR073155A1 (es) 2010-10-20
HRP20161503T1 (hr) 2017-01-13
CA2871864A1 (en) 2009-02-19
EP2187741B1 (en) 2012-03-14
US20120071684A1 (en) 2012-03-22
WO2009023232A1 (en) 2009-02-19
SG177905A1 (en) 2012-02-28
EA201070149A1 (ru) 2010-08-30
EA018704B1 (ru) 2013-10-30
KR101544766B1 (ko) 2015-08-17
US20120330050A1 (en) 2012-12-27
PT2450057T (pt) 2016-12-15
JP2010536754A (ja) 2010-12-02
SG10201504650VA (en) 2015-07-30
CN101820758B (zh) 2013-03-06
CA2696330A1 (en) 2009-02-19
US8088824B2 (en) 2012-01-03
HUE031866T2 (en) 2017-08-28
DK2187741T3 (da) 2012-04-16
KR101481764B1 (ko) 2015-01-13
IL251419A0 (en) 2017-05-29
CN101820758A (zh) 2010-09-01
ZA201001066B (en) 2010-10-27
IL203824A (en) 2017-04-30
US8633243B2 (en) 2014-01-21
EA201370109A1 (ru) 2014-01-30
CL2008002417A1 (es) 2009-03-27
CN103254267B (zh) 2016-03-16
SI2187741T1 (sl) 2012-07-31
HRP20120350T1 (hr) 2012-05-31
ATE549035T1 (de) 2012-03-15
AU2008287388A1 (en) 2009-02-19
CA2871864C (en) 2016-05-17
PL2450057T3 (pl) 2017-02-28
EP2450057A1 (en) 2012-05-09
EP2187741A4 (en) 2010-08-25
TW200916476A (en) 2009-04-16
US8309601B2 (en) 2012-11-13
JP5005812B2 (ja) 2012-08-22
KR20100056488A (ko) 2010-05-27
TWI419899B (zh) 2013-12-21
ES2602978T3 (es) 2017-02-23
EA023550B1 (ru) 2016-06-30
CN103254267A (zh) 2013-08-21
TW201402597A (zh) 2014-01-16
AR119704A2 (es) 2022-01-05
BRPI0815540A2 (pt) 2014-09-30
EP2187741A1 (en) 2010-05-26
US20090048204A1 (en) 2009-02-19
DK2450057T3 (en) 2016-12-19
CA2696330C (en) 2015-03-24
JP2018009001A (ja) 2018-01-18
TWI486357B (zh) 2015-06-01
AU2008287388B2 (en) 2014-11-06
LT2450057T (lt) 2016-12-27
PT2187741E (pt) 2012-06-21
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