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CO2023017899A2 - N-(hidroxialquil(hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio - Google Patents

N-(hidroxialquil(hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio

Info

Publication number
CO2023017899A2
CO2023017899A2 CONC2023/0017899A CO2023017899A CO2023017899A2 CO 2023017899 A2 CO2023017899 A2 CO 2023017899A2 CO 2023017899 A CO2023017899 A CO 2023017899A CO 2023017899 A2 CO2023017899 A2 CO 2023017899A2
Authority
CO
Colombia
Prior art keywords
sodium channel
carboxamides
hydroxyalkyl
hetero
tetrahydrofuran
Prior art date
Application number
CONC2023/0017899A
Other languages
English (en)
Inventor
Jinglan Zhou
Yvonne Schmidt
Stephen Andrew Thomson
Steven John Durrant
Elizabeth Mary Beck
Ewa Iwona Chudyk
Jardi Gorka Etxebarria
Bhairavi Galan
Ruah Sara S Hadida
Dennis James Hurley
Ronald Marcellus Knegtel
Timothy Donald Neubert
Joanne Louise Pinder
Joseph Pontillo
Robert Pullin
David Matthew Shaw
Sarah Skerratt
Dean Stamos
Anisa Nizarali Virani
Christopher Wray
Nadia M Ahmad
Meireles Lidio Marx Carvalho
Kiri North
James Dodd
Michael Edward O'donnell
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of CO2023017899A2 publication Critical patent/CO2023017899A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Se proporcionan compuestos de la fórmula I, y sales farmacéuticamente aceptables de estos, útiles como inhibidores de canales de sodio. También se proporcionan composiciones farmacéuticas que comprenden los compuestos o sales farmacéuticamente aceptables y métodos de uso de los compuestos, sales farmacéuticamente aceptables y composiciones farmacéuticas en el tratamiento de diversos trastornos, incluido el dolor.
CONC2023/0017899A 2021-06-04 2023-12-20 N-(hidroxialquil(hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio CO2023017899A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163196946P 2021-06-04 2021-06-04
PCT/US2022/032116 WO2022256622A1 (en) 2021-06-04 2022-06-03 N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels

Publications (1)

Publication Number Publication Date
CO2023017899A2 true CO2023017899A2 (es) 2023-12-29

Family

ID=82483401

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0017899A CO2023017899A2 (es) 2021-06-04 2023-12-20 N-(hidroxialquil(hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio

Country Status (21)

Country Link
US (3) US11827627B2 (es)
EP (1) EP4347031B1 (es)
JP (1) JP2024522292A (es)
KR (1) KR20240031300A (es)
CN (1) CN117794920A (es)
AR (1) AR126073A1 (es)
AU (1) AU2022284886A1 (es)
CA (1) CA3221259A1 (es)
CL (1) CL2023003625A1 (es)
CO (1) CO2023017899A2 (es)
CR (1) CR20230586A (es)
DK (1) DK4347031T3 (es)
DO (1) DOP2023000267A (es)
EC (1) ECSP23095485A (es)
GE (1) GEAP202416430A (es)
IL (1) IL308953A (es)
MX (1) MX2023014378A (es)
PE (1) PE20241335A1 (es)
TW (1) TW202313593A (es)
UY (1) UY39800A (es)
WO (1) WO2022256622A1 (es)

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CN119371405A (zh) * 2023-07-26 2025-01-28 上海闻耐医药科技有限公司 多取代吡咯烷类衍生物、其制备方法及用途
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WO2025131098A1 (zh) * 2023-12-21 2025-06-26 武汉熙瑞医药科技有限公司 一种含苯环的多环化合物、其药物组合物及其应用
WO2025162194A1 (zh) * 2024-01-31 2025-08-07 上海汇伦医药股份有限公司 钠通道调节剂新化合物及其应用
WO2025168043A1 (zh) * 2024-02-08 2025-08-14 上海枢境生物科技有限公司 并环类衍生物、制备方法及其用途
CN120040431A (zh) * 2024-02-23 2025-05-27 山东盛迪医药有限公司 一种取代四氢呋喃衍生物的可药用盐、其结晶形式及用途
CN120040429A (zh) * 2024-02-23 2025-05-27 山东盛迪医药有限公司 一种取代四氢呋喃衍生物的结晶形式及其用途
CN117902972B (zh) * 2024-03-19 2024-06-11 深圳创元生物医药科技有限公司 一种2,4-二羟基苯乙酸的制备方法
CN118388466A (zh) * 2024-04-23 2024-07-26 安润医药科技(苏州)有限公司 作钠通道调节剂的酰胺衍生物及其用途
WO2025252109A1 (zh) * 2024-06-04 2025-12-11 成都苑东生物制药股份有限公司 一种取代四氢呋喃类衍生物、其制备方法及用途
CN119285621B (zh) * 2024-12-13 2025-07-18 嘉兴安帝康生物科技有限公司 作为钠通道调节剂的四氢呋喃甲酰胺类化合物及其在医药上的应用

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