CO2019004190A2 - Formulaciones liposomales para uso en el tratamiento del cáncer - Google Patents
Formulaciones liposomales para uso en el tratamiento del cáncerInfo
- Publication number
- CO2019004190A2 CO2019004190A2 CONC2019/0004190A CO2019004190A CO2019004190A2 CO 2019004190 A2 CO2019004190 A2 CO 2019004190A2 CO 2019004190 A CO2019004190 A CO 2019004190A CO 2019004190 A2 CO2019004190 A2 CO 2019004190A2
- Authority
- CO
- Colombia
- Prior art keywords
- compound
- relates
- cancer treatment
- pyrimidin
- phenyl
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 229940126062 Compound A Drugs 0.000 abstract 4
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- PKYIMGFMRFVOMB-UHFFFAOYSA-N 2-[5-[3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid Chemical compound ClC=1C(=C(C=CC=1OCCN1CCN(CC1)C)C1=C(SC=2N=CN=C(C=21)OC(C(=O)O)CC1=C(C=CC=C1)OCC1=NC(=NC=C1)C1=C(C=CC=C1)OC)C1=CC=C(C=C1)F)C PKYIMGFMRFVOMB-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002502 liposome Substances 0.000 abstract 1
- 235000020573 organic concentrate Nutrition 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000003981 vehicle Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se refiere a una composición farmacéutica liposomal que comprende ácido 2-{[5-{3-cloro-2-metil-4-[2-(4-metilpiperazin-1-il)etoxi]fenil}-6-(4-fluorofenil)tieno[2,3-d]pirimidin-4-il]oxi}-3-(2-{[2-(2-metoxifenil)pirimidin-4-il]metoxi}fenil)propanoico, referido en la presente memoria como ‘Compuesto A’, o una sal farmacéuticamente aceptable de éste. Más específicamente, la invención se refiere a un vehículo liposomal, una composición de concentrado orgánico que comprende el Compuesto A, y a una composición farmacéutica para administración parenteral que comprende liposomas y Compuesto A. Además, la invención se refiere al uso de dichas composiciones para el tratamiento del cáncer. El ‘Compuesto A’ tal y como se usa en la presente memoria incluye todos los enantiómeros, diastereoisómeros, y atropoisómeros, o mezclas de éste, y también incluye opcionalmente las sales farmacéuticamente aceptables de éste.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16306415 | 2016-10-28 | ||
| PCT/EP2017/077538 WO2018078064A1 (en) | 2016-10-28 | 2017-10-27 | Liposomal formulation for use in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2019004190A2 true CO2019004190A2 (es) | 2019-07-10 |
Family
ID=57288337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2019/0004190A CO2019004190A2 (es) | 2016-10-28 | 2019-04-26 | Formulaciones liposomales para uso en el tratamiento del cáncer |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US10722466B2 (es) |
| EP (1) | EP3532067B1 (es) |
| JP (1) | JP7041676B2 (es) |
| KR (1) | KR102653436B1 (es) |
| CN (1) | CN109922808B (es) |
| AR (1) | AR109981A1 (es) |
| AU (1) | AU2017350499B2 (es) |
| BR (1) | BR112019008263A2 (es) |
| CA (1) | CA3041592C (es) |
| CO (1) | CO2019004190A2 (es) |
| CU (1) | CU20190046A7 (es) |
| CY (1) | CY1125446T1 (es) |
| DK (1) | DK3532067T3 (es) |
| EA (1) | EA201991025A1 (es) |
| ES (1) | ES2923929T3 (es) |
| GE (1) | GEP20217244B (es) |
| HR (1) | HRP20220952T1 (es) |
| HU (1) | HUE059448T2 (es) |
| IL (1) | IL266198B2 (es) |
| LT (1) | LT3532067T (es) |
| MA (1) | MA46608B1 (es) |
| MD (1) | MD3532067T2 (es) |
| MX (1) | MX391096B (es) |
| MY (1) | MY194730A (es) |
| PH (1) | PH12019500804A1 (es) |
| PL (1) | PL3532067T3 (es) |
| PT (1) | PT3532067T (es) |
| RS (1) | RS63400B1 (es) |
| RU (1) | RU2756755C2 (es) |
| SG (1) | SG11201903326RA (es) |
| SI (1) | SI3532067T1 (es) |
| TN (1) | TN2019000117A1 (es) |
| TW (1) | TWI749091B (es) |
| UA (1) | UA126910C2 (es) |
| UY (1) | UY37459A (es) |
| WO (1) | WO2018078064A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3652184A4 (en) | 2017-08-15 | 2020-05-20 | AbbVie Inc. | MACROCYCLIC INHIBITORS OF MCL-1 AND METHODS OF USE |
| CN110964034B (zh) * | 2018-09-29 | 2022-04-12 | 江苏恒瑞医药股份有限公司 | 嘧啶并噻吩类衍生物、其制备方法及其在医药上的应用 |
| AR116635A1 (es) * | 2018-10-15 | 2021-05-26 | Servier Lab | Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen |
| TWI849001B (zh) | 2018-11-14 | 2024-07-21 | 法商施維雅藥廠 | Mcl-1抑制劑及米哚妥林(midostaurin)之組合，其用途及醫藥組合物 |
| AR119156A1 (es) | 2019-06-17 | 2021-11-24 | Servier Lab | Combinación de un inhibidor de mcl-1 y un tratamiento estándar de atención médica para cáncer de mama, usos y composiciones farmacéuticas de la misma |
| WO2022090443A1 (en) | 2020-10-30 | 2022-05-05 | Les Laboratoires Servier | Administration and dose regimen for a combination of a bcl-2 inhibitor and a mcl1 inhibitor |
| US20240389602A1 (en) | 2021-04-01 | 2024-11-28 | Vestaron Corporation | Liposome formulations for pesticide delivery and methods for producing and using the same |
| EP4351564A1 (en) | 2021-06-11 | 2024-04-17 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-cancer agents |
| WO2022261310A1 (en) | 2021-06-11 | 2022-12-15 | Gilead Sciences, Inc. | Combination mcl-1 inhibitors with anti-body drug conjugates |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS607932A (ja) * | 1983-06-29 | 1985-01-16 | Dai Ichi Seiyaku Co Ltd | リポソーム懸濁液およびその製法 |
| GB8613811D0 (en) | 1986-06-06 | 1986-07-09 | Phares Pharm Res Nv | Composition & method |
| US5580899A (en) * | 1995-01-09 | 1996-12-03 | The Liposome Company, Inc. | Hydrophobic taxane derivatives |
| GB9601120D0 (en) | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
| US20030044454A1 (en) * | 1998-06-30 | 2003-03-06 | Masaru Fukui | Compositions containing liposomes and/or emulsions and process for the preparation thereof |
| IL148372A0 (en) * | 1999-09-09 | 2002-09-12 | Univ California | Cationic liposome delivery of taxanes to angiogenic blood vessels |
| KR20010100194A (ko) * | 2000-03-13 | 2001-11-14 | 박호군 | 여러 가지 물질의 가용화용 조성물과 제형 및 그들의제조방법 |
| JP2002080400A (ja) * | 2000-06-23 | 2002-03-19 | Takeda Chem Ind Ltd | リン脂質含有薬物の製造法 |
| CN1116875C (zh) * | 2000-10-19 | 2003-08-06 | 南京振中生物工程有限公司 | 紫杉醇脂质组合物及其制备方法 |
| CA2442539C (en) | 2001-03-27 | 2011-11-08 | Phares Pharmaceutical Research N.V. | Method and composition for solubilising a biologically active compound with low water solubility |
| US7666876B2 (en) * | 2002-03-19 | 2010-02-23 | Vernalis (R&D) Limited | Buprenorphine formulations for intranasal delivery |
| BRPI0407096A (pt) * | 2003-02-03 | 2006-01-24 | Neopharm Inc | Taxano encapsulado em lipossomo estável, estéril e filtrável e outros fármacos antineoplásicos |
| JP2005075783A (ja) * | 2003-09-01 | 2005-03-24 | Otsuka Pharmaceut Factory Inc | 難溶性化合物の可溶化または分散化用組成物 |
| JP2005225818A (ja) * | 2004-02-13 | 2005-08-25 | Otsuka Pharmaceut Factory Inc | パクリタキセル又はドセタキセルの医薬組成物 |
| AU2008227852B2 (en) | 2007-03-19 | 2011-02-24 | Fresenius Kabi Oncology Ltd. | Proliposomal and liposomal compositions |
| DK2344198T3 (da) | 2008-09-27 | 2020-11-30 | Jina Pharmaceuticals Inc | Lipidbaserede farmaceutiske præparater til topisk anvendelse |
| RU2476216C1 (ru) * | 2009-03-30 | 2013-02-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Липосомальная композиция |
| WO2011066684A1 (zh) * | 2009-12-03 | 2011-06-09 | 江苏恒瑞医药股份有限公司 | 伊立替康或盐酸伊立替康脂质体及其制备方法 |
| JP2012051823A (ja) * | 2010-08-31 | 2012-03-15 | Fujifilm Corp | 難容性薬物含有水中油型乳化組成物及びその製造方法 |
| CN101926757B (zh) * | 2010-09-01 | 2013-01-02 | 北京大学 | 一种难溶性药物的液体组合物及其制备方法 |
| BR112013014291A2 (pt) * | 2010-12-08 | 2016-09-20 | Hoffmann La Roche | formulação lipossômica de calcetrapib |
| JP2014506922A (ja) * | 2011-03-01 | 2014-03-20 | ティーオー − ビービービー ホールディング ベスローテン フェンノートシャップ | 難水溶性物質の高度なアクティブリポソームローディング |
| CN103622911B (zh) | 2013-11-19 | 2015-12-30 | 常州金远药业制造有限公司 | 一种难溶性药物脂质体制备方法 |
| FR3015483B1 (fr) * | 2013-12-23 | 2016-01-01 | Servier Lab | Nouveaux derives de thienopyrimidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
2017
- 2017-10-27 LT LTEPPCT/EP2017/077538T patent/LT3532067T/lt unknown
- 2017-10-27 MA MA46608A patent/MA46608B1/fr unknown
- 2017-10-27 PL PL17787939.2T patent/PL3532067T3/pl unknown
- 2017-10-27 TN TNP/2019/000117A patent/TN2019000117A1/en unknown
- 2017-10-27 KR KR1020197015033A patent/KR102653436B1/ko active Active
- 2017-10-27 PT PT177879392T patent/PT3532067T/pt unknown
- 2017-10-27 EA EA201991025A patent/EA201991025A1/ru unknown
- 2017-10-27 DK DK17787939.2T patent/DK3532067T3/da active
- 2017-10-27 ES ES17787939T patent/ES2923929T3/es active Active
- 2017-10-27 JP JP2019522453A patent/JP7041676B2/ja not_active Expired - Fee Related
- 2017-10-27 GE GEAP201715047A patent/GEP20217244B/en unknown
- 2017-10-27 MX MX2019004941A patent/MX391096B/es unknown
- 2017-10-27 SG SG11201903326RA patent/SG11201903326RA/en unknown
- 2017-10-27 SI SI201731200T patent/SI3532067T1/sl unknown
- 2017-10-27 HU HUE17787939A patent/HUE059448T2/hu unknown
- 2017-10-27 CU CU2019000046A patent/CU20190046A7/es unknown
- 2017-10-27 CN CN201780067045.2A patent/CN109922808B/zh not_active Expired - Fee Related
- 2017-10-27 UA UAA201905614A patent/UA126910C2/uk unknown
- 2017-10-27 UY UY0001037459A patent/UY37459A/es not_active Application Discontinuation
- 2017-10-27 CA CA3041592A patent/CA3041592C/en active Active
- 2017-10-27 BR BR112019008263A patent/BR112019008263A2/pt not_active Application Discontinuation
- 2017-10-27 TW TW106137030A patent/TWI749091B/zh not_active IP Right Cessation
- 2017-10-27 AR ARP170102984A patent/AR109981A1/es not_active Application Discontinuation
- 2017-10-27 US US16/344,431 patent/US10722466B2/en active Active
- 2017-10-27 RU RU2019115688A patent/RU2756755C2/ru active
- 2017-10-27 MY MYPI2019002297A patent/MY194730A/en unknown
- 2017-10-27 WO PCT/EP2017/077538 patent/WO2018078064A1/en not_active Ceased
- 2017-10-27 MD MDE20190973T patent/MD3532067T2/ro unknown
- 2017-10-27 RS RS20220677A patent/RS63400B1/sr unknown
- 2017-10-27 HR HRP20220952TT patent/HRP20220952T1/hr unknown
- 2017-10-27 EP EP17787939.2A patent/EP3532067B1/en active Active
- 2017-10-27 AU AU2017350499A patent/AU2017350499B2/en not_active Ceased
- 2017-10-27 IL IL266198A patent/IL266198B2/en unknown
-
2019
- 2019-04-12 PH PH12019500804A patent/PH12019500804A1/en unknown
- 2019-04-26 CO CONC2019/0004190A patent/CO2019004190A2/es unknown
-
2022
- 2022-08-02 CY CY20221100526T patent/CY1125446T1/el unknown
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