CN109333883A - A kind of bionic ileum and preparation method thereof - Google Patents
A kind of bionic ileum and preparation method thereof Download PDFInfo
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
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- B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
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Abstract
本发明公开了一种仿生回肠及其制备方法，属于仿生技术领域以及生物技术领域。本发明的仿生回肠是通过将基材(硅胶、乳胶或水凝胶中的一种或多种)和辅材(硅油和/或固化剂)按照一定的质量比混合后涂抹于医学消化科精准人体肠道解剖模型回肠中制作而成的；本发明的仿生回肠的仿真性能优越(邵尔A硬度为32±5、膨胀率为28±5％、弹性为220±50％)，且具有人真实回肠的形态和生理结构，可真实的模拟人回肠内的消化环境，例如，此仿生回肠的内部具有环形皱褶，可增加肠内表面积，供回肠内微生物菌群更好的消化吸收食物，同时，此仿生回肠的内部具有小肠绒毛且小肠绒毛为中空结构，可分泌肠液，极大地重现回肠内的消化吸收的功能。
The invention discloses a bionic ileum and a preparation method thereof, belonging to the technical field of bionics and the field of biotechnology. The bionic ileum of the present invention is applied to medical gastroenterology precision medicine by mixing the base material (one or more of silica gel, latex or hydrogel) and auxiliary materials (silicon oil and/or curing agent) according to a certain mass ratio. The bionic ileum of the present invention has superior simulation performance (Shore A hardness is 32±5, expansion rate is 28±5%, elasticity is 220±50%), and it has human The shape and physiological structure of the real ileum can realistically simulate the digestive environment in the human ileum. For example, the interior of this bionic ileum has annular folds, which can increase the surface area of the intestines for better digestion and absorption of food by the ileum microbial flora. At the same time, the interior of the bionic ileum has small intestinal villi and the small intestinal villi is a hollow structure, which can secrete intestinal juice and greatly reproduce the function of digestion and absorption in the ileum.
Description
Technical field
The present invention relates to a kind of bionical ileums and preparation method thereof, belong to bionics techniques field and field of biotechnology.
Background technique
Food, drug research process in, it is objective accurately evaluate food, drug the intracorporal digestion process of people for
It determines food component, pharmaceutical ingredients and they is most important to the effect of human body alimentary canal.
The in-vitro simulated device of people's alimentary canal (such as SHIME, IViDiS, TIM, DGM, HGS) be to the digestive system of people and
Its digestive environments, computational fluid dynamics behavior in the digestive tract carry out the device of human simulation, analog difference sample model in vitro
In the influence to enteric microorganism of digestion process and these samples, so that the research and development for new type functional food provide largely
Valuable data replace completely if predicting live test as " preceding test " or part replace live test, reachable
To the purpose for reducing cost and time, raising repeatability and accuracy, and without theoretical limitation.
Therefore, the in-vitro simulated device of people's alimentary canal is more crucial in the research to food, drug or even microorganism etc.,
Huge convenience is provided for the research of Food Science, human nutriology, is that mouse experiment or human volunteer experiment cannot
Analogy.
And main body of the alimentary canal (mainly including stomach, small intestine, large intestine) as the in-vitro simulated device of people's alimentary canal is simulated, it is right
Really gastral emulator is most important in the simulation performance of the entire in-vitro simulated device of people's alimentary canal by people.
Currently, people make simulation alimentary canal model usually using materials such as silica gel, latexes, digestion can be reappeared well
Digestive environments in road, such as it is inviscid, not soluble in water, do not react with soda acid, high-low temperature resistant.
But the internal physiological structures of these existing alimentary canal models made of silica gel, latex are smooth, single
, for example, small intestine model, these small intestine models are often with there is following fault of construction: first is that not having intestinal villi, contacting enteral
Food area is too small, causes the function to the enteral digestion and absorption of realization limited；Second is that intestinal juice is embodied in the form of directly adding,
Intestinal fluid secretion is uneven, leads to the measurement result inaccuracy of experiment.
Also, these alimentary canal models are usually simply made as overall structure, for example, disposable with silica gel or latex
It is molded into whole stomach, these whole stomaches cannot simulate " returning jet flow " function between antrum and body of stomach, lead to the measurement result of experiment
Inaccuracy.
Meanwhile these alimentary canal models made by silica gel, latex are in simulation performance, such as hardness, expansion rate, elasticity side
Face is actually and not fully up to expectations, and still there are a certain distance with the true alimentary canal of people.
Therefore, it is badly in need of carrying out Bionic digestion road innovation upgrading to promote its simulation performance, promote its simulation real human body
The function at gastral digestive environments (inviscid, not soluble in water, do not react with soda acid, high-low temperature resistant) and each position of alimentary canal
The authenticity of energy.
Summary of the invention
To solve the above problems, the present invention provides a kind of bionical ileums and preparation method thereof.This bionical ileum is to pass through
By substrate (one of silica gel, latex or hydrogel or a variety of) and auxiliary material (silicone oil and/or curing agent) according to certain quality
Than being applied to doctor after (mass ratio between the substrate, silicone oil and curing agent is 100:2.5~3.5:0.5~1.5) mixing
It is made in the accurate human body intestinal canal anatomical model ileum of chemical digestion section；The simulation performance of this bionical ileum is superior, and (Shao Er A is hard
Degree be 32 ± 5, expansion rate be 28 ± 5%, elasticity is 220 ± 50%), and have the true ileum of people form and physiological structure,
The digestive environments in people's ileum can be really simulated, for example, the inside of this bionical ileum has annular corrugations, enteral table can be increased
Area, and then food is preferably digested and assimilated for returning gut microflora, meanwhile, the inside of this bionical ileum has small intestine
Villus and intestinal villi are hollow structure, can secrete intestinal juice, the greatly function of the digestion and absorption in reproduction ileum, therefore, this
The truth function in digestive system ileum such as bionical ileum analog food, drug, microorganism, in the research of food, drug
There is great application prospect in the process.
Technical scheme is as follows:
The present invention provides a kind of preparation method of bionical ileum, the method is that plastic material is put into medicine digestion
Modeled in the accurate human body ileum anatomical model of section, remove human body ileum anatomical model, plastic material each with
The corresponding recess of intestinal villi stabs out duck eye with spicule on human body ileum anatomical model, and spicule is remained in can
Curing molding is carried out on plastic material and to plastic material, obtains the ileum mold with true ileum internal physiological structures；
The substrate for making bionical ileum and auxiliary material are mixed according to certain mass ratio, obtain bionical ileum raw material；According to one
Bionical ileum raw material are applied to the one side that ileum mold is in contact with human body ileum anatomical model by fixed thickness, and standing makes to apply
It is put on the bionical ileum raw material coagulation forming of ileum die surface, extract spicule and sloughs ileum mold, obtains having small
Intestinal villus and be hollow bionical ileum；
Or the method is that plastic material is put into the accurate human body ileum anatomical model of medicine Gastroenterology dept. to model,
Human body ileum anatomical model is removed, each in plastic material is corresponding with intestinal villi on human body ileum anatomical model
Recess stabs out duck eye with spicule, and spicule is remained on plastic material and is solidified into plastic material
Type obtains the ileum mold with true ileum internal physiological structures；The base of bionical ileum will be made according to certain mass ratio
Material and auxiliary material are mixed, and bionical ileum raw material are obtained；Bionical ileum raw material are applied to ileum according to certain thickness
The one side that mold is in contact with human body ileum anatomical model, standing keep the bionical ileum raw material for being applied to ileum die surface solidifying
Gu molding, only extracts spicule, obtain having intestinal villi and for hollow bionical ileum；Bionical ileum not with ileum mold
In the side being in contact cover one layer of spacer, according to certain thickness by bionical ileum raw material be applied to spacer not with
In the side that bionical ileum is in contact, the bionical ileum raw material coagulation forming for making to be applied to separator surface, removal are stood
Spacer simultaneously sloughs ileum mold, obtains with ileum physiological structure villus, and can secrete the bionical ileum of intestinal juice；
The substrate includes one of silica gel, latex or hydrogel or a variety of；The auxiliary material includes silicone oil and/or solidification
Agent.
In one embodiment of the invention, the accurate human body intestinal canal anatomical model of the medicine Gastroenterology dept. is true enteron aisle
1:1 hollow mold.
In one embodiment of the invention, the plastic material includes clay, paraffin, glass or steel.
In one embodiment of the invention, the plastic material includes clay, paraffin, glass or steel.
In one embodiment of the invention, the clay is soft ceramic mud.
In one embodiment of the invention, the method is that soft ceramic mud is put into the accurate human body ileum of medicine Gastroenterology dept.
Modeled in anatomical model, remove human body ileum anatomical model, soft ceramic mud each on human body ileum anatomical model
The corresponding recess of intestinal villi stabs out duck eye with spicule, by spicule remain on soft ceramic mud and by soft ceramic mud into
Row baking makes its curing molding, and natural cooling generates crack to prevent mold to be quickly cooled down, and obtains having raw inside true ileum
Manage the ileum mold of structure；After the substrate for making bionical ileum and auxiliary material being mixed according to certain mass ratio be put into vacuum
The row of vacuumizing steeps in machine, obtains bionical ileum raw material；Bionical ileum raw material are applied to ileum mould according to certain thickness
The inside of tool stands the bionical ileum raw material coagulation forming for making to be applied to ileum die surface, extracts needle and sloughs ileum mould
Tool obtains having intestinal villi and for hollow bionical ileum；
Or the method is that first soft ceramic mud is put into the accurate human body ileum anatomical model of medicine Gastroenterology dept. to model, and is taken
Lower human body ileum anatomical model, in each recess corresponding with intestinal villi on human body ileum anatomical model of soft ceramic mud
Duck eye is stabbed out with spicule, remaining on soft ceramic mud and soft ceramic mud is carried out baking spicule makes its curing molding, from
It is so cooling to generate crack to prevent mold to be quickly cooled down, obtain the ileum mold with true ileum internal physiological structures；According to
Certain mass ratio is put into the row of vacuumizing in vacuum machine and steeps after being mixed the substrate for making bionical ileum and auxiliary material, imitated
Raw ileum raw material；Bionical ileum raw material are applied to the inside of ileum mold according to certain thickness, standing makes to be applied to
The bionical ileum raw material coagulation forming of ileum die surface, only extracts needle, obtains having intestinal villi and is hollow bionical
Ileum；One layer of spacer is covered in the side that bionical ileum is not in contact with ileum mold, according to certain thickness by nothing
Bubble mixed raw material is applied in the side that spacer is not in contact with bionical ileum, and standing makes to be applied to separator surface
Bionical ileum raw material coagulation forming, removal spacer simultaneously slough ileum mold, obtain with ileum physiological structure villus, and
The bionical ileum of intestinal juice can be secreted.
In one embodiment of the invention, the roasted time is 15~30min.
In one embodiment of the invention, the diameter of the duck eye is 0.2~1mm
In one embodiment of the invention, each and the small intestine on human body ileum anatomical model in soft ceramic mud
When the corresponding recess of villus stabs out duck eye, spicule should be made to penetrate soft ceramic mud and make one end of spicule beyond soft ceramic mud with
The side at least 2mm that human body ileum anatomical model is in contact.
In one embodiment of the invention, the diameter of the ileum mold is 1.5~2.5cm, 20~30cm of length.
In one embodiment of the invention, the mass ratio between the substrate, silicone oil and curing agent is 100:
(2.5~3.5): (0.5~1.5).
In one embodiment of the invention, the mass ratio between the substrate and auxiliary material is 100:3:1.
In one embodiment of the invention, the substrate is silica gel.
In one embodiment of the invention, the silica gel is transparent silica gel or translucent silica gel.
In one embodiment of the invention, the curing agent includes ethyl orthosilicate, vinyl triamine, DETA ammonia second
One of base piperazine AE, m-phenylene diamine (MPD) m-PDAMPD, diaminodiphenyl-methane DDM or HT-972DEH-50 or a variety of.
In one embodiment of the invention, the condition of the row of vacuumizing bubble be vacuum machine negative pressure -0.1~
0.09MPa, 5~10min of time.
In one embodiment of the invention, the condition of the row's of vacuumizing bubble is vacuum machine negative pressure 0.09MPa, time
7min。
In one embodiment of the invention, the bionical ileum raw material be applied to ileum die surface with a thickness of
2~3mm.
In one embodiment of the invention, the bionical ileum raw material be applied to ileum die surface with a thickness of
2.5mm。
In one embodiment of the invention, the time of the standing is 2~4h.
In one embodiment of the invention, the time of the standing is 3h.
In one embodiment of the invention, the spacer includes oiliness paper or preservative film.
In one embodiment of the invention, the bionical ileum raw material are applied to the thickness on separator surface surface
For 2~3mm.
In one embodiment of the invention, the bionical ileum raw material are applied to the thickness on separator surface surface
For 2.5mm.
The present invention provides apply a kind of above-mentioned bionical ileum that the preparation method of bionical ileum is prepared.
The present invention provides a kind of preparation methods of above-mentioned bionical ileum or the above-mentioned bionical ileum being prepared to simulate
Application in the practical digestive system of human body.
The utility model has the advantages that
(1) bionical ileum simulation performance of the invention it is superior (shore a hardness be 32 ± 5, expansion rate be 28 ± 5%, elasticity
It is 220 ± 50%), form and physiological structure with the true ileum of people can really simulate the digestive environments in people's ileum；
(2) inside of bionical ileum of the invention has annular corrugations, can increase enteral surface area, and then in ileum
Microbial flora preferably digests and assimilates food；
(3) inside of bionical ileum of the invention, which has intestinal villi and intestinal villi, to be double-deck hollow structure, if
Intestinal juice, which is filled to hollow space, can make intestinal villi secrete intestinal juice automatically during wriggling, greatly in reproduction ileum
The function of digestion and absorption；
(4) bionical ileum of the invention can be dynamically transparent or translucent, be able to achieve inside true and real-time ileum
The observation in vitro of Digestive States；
(5) bionical ileum of the invention is using silica gel as substrate, have it is inviscid, not soluble in water, do not react with soda acid, be resistance to
The advantages such as high/low temperature can reappear the digestion and absorption environment in ileum well；
(6) the true function in digestive system ileum such as bionical ileum analog food of the invention, drug, microorganism
Can, food, drug research process in have great application prospect.
Detailed description of the invention
Fig. 1: the full face of the bionical ileum of the present invention；
Fig. 2: the reverse side photo of the bionical ileum of the present invention；
Fig. 3: the intestinal villi photo of the bionical ileum of the present invention；
Fig. 4: the intestinal villi photo of the bionical ileum of the present invention.
Specific embodiment
The present invention will be further elaborated combined with specific embodiments below.
Detection method involved in following embodiments is as follows:
Intestinal surface accumulates detection method:
S=2 π r1h1+n(π-1)r2h2；
Wherein, S is intestinal surface product, r1For intestines radius, h1For intestines height, n is intestinal wall quantity, r2For intestinal wall radius, h2For intestinal wall
It is high.
Transparency detection method:
Using range estimation, whether observation silica gel is transparent, bright, has bubble, and stretch silica gel, sees whether whiten, whiten
Be it is opaque, the foods such as rice, corn are put into silica gel inside, the appearance that whether can clearly see food seen.
If the surface of food can be clearly apparent, transparency is good；If it can be seen that the profile of food, transparency are moderate；If
It can't see the image of food, then poor transparency.
Hardness (Shao Er hardness) detection method:
It is measured with Shao Er hardometer, the surface of stomach is pressed in scleroscopic pressing, measurement pressing indentation stomach surface
Depth.
Expansion rate detection method:
Pe=(W*m/A) × 100%；
Wherein, Pe is expansion rate, and W is overall balance loading, and A is silica gel area, and m is the lever ratio of pressurized equipment.
Elastomeric check method:
Extension test is carried out to silica gel on tensile testing machine, measures silica gel axial elongation and transverse extension amount, until
Until silica gel is broken.
C=(D-d) × 100%/d；
Wherein, C is spring rate, and D is elongation, and d is silica gel just long amount.
Villus secretes intestinal juice Function detection:
Obtained bionical duodenum is fixed on enteron aisle by the flange-interface of pipeline and visualizes (intestines in bionical reactor
Road visualizes bionical reactor referring to the patent of invention of Publication No. CN108318625A), it is bionical to silica gel that 100ml pancreatic juice is added
In duodenum, reactor 10min, the volume of observation secretion pancreatic juice are run.
Embodiment 1: the preparation of bionical ileum
(1) prepare pottery mud: by soft ceramic mud kneading repeatedly, obtaining the preferable soft ceramic mud of ductility；
(2) ileum mold is suppressed: the soft ceramic mud mixed being carried out to be put into the accurate human body ileum anatomical model of medicine Gastroenterology dept.
In, it firmly squeezes, removes human body ileum anatomical model, obtain the soft ceramic mud ileum mould with true ileum internal physiological structures
Tool, mould diameter 1.5cm, length 25cm；
(3) hollow villus production: taking diameter is that 0.5mm needle is several, is pricked at each marking on above-mentioned mold, and stamp is straight
Diameter 1mm, the duck eye of deep 5mm, needle remain in mould inside
(4) ileum mold baking molding: ileum mold is put into 140 DEG C of oven and is baked 15 minutes, ileum mold cured is made
Molding, natural cooling obtain bionical ileum mold；
(8) prepare silica gel: will be placed in a beaker, fill by the transparent silica gel of 100:3:1, silicone oil and curing agent ethyl orthosilicate
Divide stirring, is uniformly mixed；
(9) uniformly mixed silica gel is put into vacuum machine, negative pressure 0.09MPa, the row's of vacuumizing bubble the time 5 minutes, obtains
Bubble-free silica gel；
(10) bionical ileum die surface obtained above is uniformly smeared into bubble-free silica gel, thickness about 2mm；
(11) uniform ileum mold will be smeared and stand 2 hours, after making its thorough coagulation forming, the needle outside mold will be pulled out
Fall, obtains having intestinal villi and for hollow ileum silica gel model；
(12) needle is only pulled out by above-mentioned, the ileum die surface for not falling off silica gel covers an oiliness paper, and outside places one
Diameter is 2cm, the hollow cylinder of high 4cm, and fixation glues；
(13) gap between the oiliness paper and cylindrical body of ileum mold is uniformly smeared to the silica gel of bubble-free, it is small to stand 2
When, to its thorough coagulation forming；
(14) silica gel mould solidified is placed in water 10 minutes, after water by oiliness paper softening after, by oiliness paper from
It is taken out in hollow cylinder；
(15) it after silica gel being sloughed ileum mold, using certain pruning modes, can obtain with ileum physiological structure
Intestinal wall gauffer and villus, and villus can secrete the bionical ileum silica gel model of intestinal juice.
Embodiment 2: the preparation of bionical ileum
(1) prepare pottery mud: by soft ceramic mud kneading repeatedly, obtaining the preferable soft ceramic mud of ductility；
(2) ileum mold is suppressed: the soft ceramic mud mixed being carried out to be put into the accurate human body ileum anatomical model of medicine Gastroenterology dept.
In, it firmly squeezes, removes human body ileum anatomical model, obtain the soft ceramic mud ileum mould with true ileum internal physiological structures
Tool, mould diameter 2cm, length 25cm；
(3) hollow villus production: taking diameter is that 0.3mm needle is several, is pricked at each marking on above-mentioned mold, and stamp is straight
Diameter 0.5mm, the duck eye of deep 5mm, needle remain in mould inside
(4) ileum mold baking molding: ileum mold is put into 150 DEG C of oven and is baked 20 minutes, ileum mold cured is made
Molding, natural cooling obtain bionical ileum mold；
(8) prepare silica gel: will be placed in a beaker by the transparent silica gel of 100:3:1.5, silicone oil and curing agent vinyl triamine,
It is sufficiently stirred, is uniformly mixed；
(9) uniformly mixed silica gel is put into vacuum machine, negative pressure 0.09MPa, the row's of vacuumizing bubble the time 5 minutes, obtains
Bubble-free silica gel；
(10) bionical ileum die surface obtained above is uniformly smeared into bubble-free silica gel, thickness about 2.5mm；
(11) uniform ileum mold will be smeared and stand 4 hours, after making its thorough coagulation forming, the needle outside mold will be pulled out
Fall, obtains having intestinal villi and for hollow ileum silica gel model；
(12) needle is only pulled out by above-mentioned, the ileum die surface for not falling off silica gel covers an oiliness paper, and outside places one
Diameter is 2cm, the hollow cylinder of high 4cm, and fixation glues；
(13) gap between the oiliness paper and cylindrical body of ileum mold is uniformly smeared to the silica gel of bubble-free, it is small to stand 1
When, to its thorough coagulation forming；
(14) silica gel mould solidified is placed in water 10 minutes, after water by oiliness paper softening after, by oiliness paper from
It is taken out in hollow cylinder；
(15) it after silica gel being sloughed ileum mold, using certain pruning modes, can obtain with ileum physiological structure
Intestinal wall gauffer and villus, and villus can secrete the bionical ileum silica gel model of intestinal juice.
Embodiment 3: the preparation of bionical ileum
(1) prepare pottery mud: by soft ceramic mud kneading repeatedly, obtaining the preferable soft ceramic mud of ductility；
(2) ileum mold is suppressed: the soft ceramic mud mixed being carried out to be put into the accurate human body ileum anatomical model of medicine Gastroenterology dept.
In, it firmly squeezes, removes human body ileum anatomical model, obtain the soft ceramic mud ileum mould with true ileum internal physiological structures
Tool, mould diameter 2.5cm, length 30cm；
(3) hollow villus production: taking diameter is that 0.1mm needle is several, is pricked at each marking on above-mentioned mold, and stamp is straight
Diameter 0.2mm, the duck eye of deep 5mm, needle remain in mould inside
(4) ileum mold baking molding: ileum mold is put into 130 DEG C of oven and is baked 30 minutes, ileum mold cured is made
Molding, natural cooling obtain bionical ileum mold；
(8) prepare silica gel: will be set by the transparent silica gel of 100:2.5:1, silicone oil and curing agent diaminodiphenyl-methane DDM
It in beaker, is sufficiently stirred, is uniformly mixed；
(9) uniformly mixed silica gel is put into vacuum machine, negative pressure 0.09MPa, the row's of vacuumizing bubble the time 5 minutes, obtains
Bubble-free silica gel；
(10) bionical ileum die surface obtained above is uniformly smeared into bubble-free silica gel, thickness about 3mm；
(11) uniform ileum mold will be smeared and stand 1 hour, after making its thorough coagulation forming, the needle outside mold will be pulled out
Fall, obtains having intestinal villi and for hollow ileum silica gel model；
(12) needle is only pulled out by above-mentioned, the ileum die surface for not falling off silica gel covers an oiliness paper, and outside places one
Diameter is 2cm, the hollow cylinder of high 4cm, and fixation glues；
(13) gap between the oiliness paper and cylindrical body of ileum mold is uniformly smeared to the silica gel of bubble-free, it is small to stand 1
When, to its thorough coagulation forming；
(14) silica gel mould solidified is placed in water 10 minutes, after water by oiliness paper softening after, by oiliness paper from
It is taken out in hollow cylinder；
(15) it after silica gel being sloughed ileum mold, using certain pruning modes, can obtain with ileum physiological structure
Intestinal wall gauffer and villus, and villus can secrete the bionical ileum silica gel model of intestinal juice.
Comparative example 1: the preparation (no villus) of bionical ileum
(1) prepare pottery mud: by soft ceramic mud kneading repeatedly, obtaining the preferable soft ceramic mud of ductility；
(2) ileum mold is suppressed: the soft ceramic mud mixed being carried out to be put into the accurate human body ileum anatomical model of medicine Gastroenterology dept.
In, it firmly squeezes, removes human body ileum anatomical model, obtain the soft ceramic mud ileum mould with true ileum internal physiological structures
Tool, mould diameter 2.5cm, length 30cm；
(4) ileum mold baking molding: ileum mold is put into 130 DEG C of oven and is baked 30 minutes, ileum mold cured is made
Molding, natural cooling obtain bionical ileum mold；
(8) prepare silica gel: beaker will be placed in by the transparent silica gel of 100:3.5:0.5, silicone oil and curing agent ethyl orthosilicate
In, it is sufficiently stirred, is uniformly mixed；
(9) uniformly mixed silica gel is put into vacuum machine, negative pressure 0.09MPa, the row's of vacuumizing bubble the time 5 minutes, obtains
Bubble-free silica gel；
(10) bionical ileum die surface obtained above is uniformly smeared into bubble-free silica gel, thickness about 2.5mm；
(11) uniform ileum mold will be smeared and stand 1 hour, make its thorough coagulation forming；
(15) it after silica gel being sloughed ileum mold, using certain pruning modes, can obtain with ileum physiological structure
The bionical ileum silica gel model of intestinal wall gauffer.
Comparative example 2: the preparation of bionical ileum (silica gel does not vacuumize after mixing)
(1) prepare pottery mud: by soft ceramic mud kneading repeatedly, obtaining the preferable soft ceramic mud of ductility；
(2) ileum mold is suppressed: the soft ceramic mud mixed being carried out to be put into the accurate human body ileum anatomical model of medicine Gastroenterology dept.
In, it firmly squeezes, removes human body ileum anatomical model, obtain the soft ceramic mud ileum mould with true ileum internal physiological structures
Tool, mould diameter 2cm, length 30cm；
(3) hollow villus production: taking diameter is that 0.2mm needle is several, is pricked at each marking on above-mentioned mold, and stamp is straight
Diameter 0.5mm, the duck eye of deep 5mm, needle remain in mould inside
(4) ileum mold baking molding: ileum mold is put into 140 DEG C of oven and is baked 20 minutes, ileum mold cured is made
Molding, natural cooling obtain bionical ileum mold；
(8) prepare silica gel: will be placed in a beaker by the transparent silica gel of 100:3:0.5, silicone oil and curing agent ethyl orthosilicate,
It is sufficiently stirred, is uniformly mixed；
(9) bionical ileum die surface obtained above is uniformly smeared into silica gel, thickness about 2.5mm；
(10) uniform ileum mold will be smeared and stand 2 hours, after making its thorough coagulation forming, the needle outside mold will be pulled out
Fall, obtains having intestinal villi and for hollow ileum silica gel model；
(11) needle is only pulled out by above-mentioned, the ileum die surface for not falling off silica gel covers an oiliness paper, and outside places one
Diameter is 2cm, the hollow cylinder of high 4cm, and fixation glues；
(12) gap between the oiliness paper and cylindrical body of ileum mold is uniformly smeared to the silica gel of bubble-free, it is small to stand 2
When, to its thorough coagulation forming；
(13) silica gel mould solidified is placed in water 10 minutes, after water by oiliness paper softening after, by oiliness paper from
It is taken out in hollow cylinder；
(14) it after silica gel being sloughed ileum mold, using certain pruning modes, can obtain with ileum physiological structure
Intestinal wall gauffer and villus, and villus can secrete the bionical ileum silica gel model of intestinal juice.
Comparative example 3: the preparation (smearing silica gel thickness to increase) of bionical ileum
(1) prepare pottery mud: by soft ceramic mud kneading repeatedly, obtaining the preferable soft ceramic mud of ductility；
(2) ileum mold is suppressed: the soft ceramic mud mixed being carried out to be put into the accurate human body ileum anatomical model of medicine Gastroenterology dept.
In, it firmly squeezes, removes human body ileum anatomical model, obtain the soft ceramic mud ileum mould with true ileum internal physiological structures
Tool, mould diameter 2cm, length 30cm；
(3) hollow villus production: taking diameter is that 0.4mm needle is several, is pricked at each marking on above-mentioned mold, and stamp is straight
Diameter 0.6mm, the duck eye of deep 5mm, needle remain in mould inside
(4) ileum mold baking molding: ileum mold is put into 130 DEG C of oven and is baked 30 minutes, ileum mold cured is made
Molding, natural cooling obtain bionical ileum mold；
(8) prepare silica gel: beaker will be placed in by the transparent silica gel of 100:2.5:1.5, silicone oil and curing agent ethyl orthosilicate
In, it is sufficiently stirred, is uniformly mixed；
(9) uniformly mixed silica gel is put into vacuum machine, negative pressure 0.09MPa, the row's of vacuumizing bubble the time 5 minutes, obtains
Bubble-free silica gel；
(10) bionical ileum die surface obtained above is uniformly smeared into bubble-free silica gel, thickness about 6mm；
(11) uniform ileum mold will be smeared and stand 2 hours, after making its thorough coagulation forming, the needle outside mold will be pulled out
Fall, obtains having intestinal villi and for hollow ileum silica gel model；
(12) needle is only pulled out by above-mentioned, the ileum die surface for not falling off silica gel covers an oiliness paper, and outside places one
Diameter is 2cm, the hollow cylinder of high 4cm, and fixation glues；
(13) gap between the oiliness paper and cylindrical body of ileum mold is uniformly smeared to the silica gel of bubble-free, it is small to stand 2
When, to its thorough coagulation forming；
(14) silica gel mould solidified is placed in water 10 minutes, after water is by the softening of oiliness paper, by oiliness paper from sky
It is taken out in heart cylindrical body；
(15) it after silica gel being sloughed ileum mold, using certain pruning modes, can obtain with ileum physiological structure
Intestinal wall gauffer and villus, and villus can secrete the bionical ileum silica gel model of intestinal juice.
Comparative example 4: the preparation (not adding silicone oil) of bionical ileum
(1) prepare pottery mud: by soft ceramic mud kneading repeatedly, obtaining the preferable soft ceramic mud of ductility；
(2) ileum mold is suppressed: the soft ceramic mud mixed being carried out to be put into the accurate human body ileum anatomical model of medicine Gastroenterology dept.
In, it firmly squeezes, removes human body ileum anatomical model, obtain the soft ceramic mud ileum mould with true ileum internal physiological structures
Tool, mould diameter 2cm, length 30cm；
(3) hollow villus production: taking diameter is that 0.4mm needle is several, is pricked at each marking on above-mentioned mold, and stamp is straight
Diameter 0.6mm, the duck eye of deep 5mm, needle remain in mould inside
(4) ileum mold baking molding: ileum mold is put into 130 DEG C of oven and is baked 30 minutes, ileum mold cured is made
Molding, natural cooling obtain bionical ileum mold；
(8) prepare silica gel: will be placed in a beaker, be sufficiently stirred by the transparent silica gel of 100:1 and curing agent ethyl orthosilicate,
It is uniformly mixed；
(9) uniformly mixed silica gel is put into vacuum machine, negative pressure 0.09MPa, the row's of vacuumizing bubble the time 5 minutes, obtains
Bubble-free silica gel；
(10) bionical ileum die surface obtained above is uniformly smeared into bubble-free silica gel, thickness about 2mm；
(11) uniform ileum mold will be smeared and stand 2 hours, after making its thorough coagulation forming, the needle outside mold will be pulled out
Fall, obtains having intestinal villi and for hollow ileum silica gel model；
(12) needle is only pulled out by above-mentioned, the ileum die surface for not falling off silica gel covers an oiliness paper, and outside places one
Diameter is 2cm, the hollow cylinder of high 4cm, and fixation glues；
(13) gap between the oiliness paper and cylindrical body of ileum mold is uniformly smeared to the silica gel of bubble-free, it is small to stand 2
When, to its thorough coagulation forming；
(14) silica gel mould solidified is placed in water 10 minutes, after water is by the softening of oiliness paper, by oiliness paper from sky
It is taken out in heart cylindrical body；
(15) it after silica gel being sloughed ileum mold, using certain pruning modes, can obtain with ileum physiological structure
Intestinal wall gauffer and villus, and villus can secrete the bionical ileum silica gel model of intestinal juice.
Comparative example 5: the preparation (addition glycerol) of bionical ileum
(1) prepare pottery mud: by soft ceramic mud kneading repeatedly, obtaining the preferable soft ceramic mud of ductility；
(2) ileum mold is suppressed: the soft ceramic mud mixed being carried out to be put into the accurate human body ileum anatomical model of medicine Gastroenterology dept.
In, it firmly squeezes, removes human body ileum anatomical model, obtain the soft ceramic mud ileum mould with true ileum internal physiological structures
Tool, mould diameter 2cm, length 30cm；
(3) hollow villus production: taking diameter is that 0.4mm needle is several, is pricked at each marking on above-mentioned mold, and stamp is straight
Diameter 0.6mm, the duck eye of deep 5mm, needle remain in mould inside
(4) ileum mold baking molding: ileum mold is put into 130 DEG C of oven and is baked 30 minutes, ileum mold cured is made
Molding, natural cooling obtain bionical ileum mold；
(8) prepare silica gel: will be placed in a beaker, fill by the transparent silica gel of 100:3:1, glycerol and curing agent ethyl orthosilicate
Divide stirring, is uniformly mixed；
(9) uniformly mixed silica gel is put into vacuum machine, negative pressure 0.09MPa, the row's of vacuumizing bubble the time 5 minutes, obtains
Bubble-free silica gel；
(10) bionical ileum die surface obtained above is uniformly smeared into bubble-free silica gel, thickness about 2mm；
(11) uniform ileum mold will be smeared and stand 2 hours, after making its thorough coagulation forming, the needle outside mold will be pulled out
Fall, obtains having intestinal villi and for hollow ileum silica gel model；
(12) needle is only pulled out by above-mentioned, the ileum die surface for not falling off silica gel covers an oiliness paper, and outside places one
Diameter is 2cm, the hollow cylinder of high 4cm, and fixation glues；
(13) gap between the oiliness paper and cylindrical body of ileum mold is uniformly smeared to the silica gel of bubble-free, it is small to stand 2
When, to its thorough coagulation forming；
(14) silica gel mould solidified is placed in water 10 minutes, after water is by the softening of oiliness paper, by oiliness paper from sky
It is taken out in heart cylindrical body；
(15) it after silica gel being sloughed ileum mold, using certain pruning modes, can obtain with ileum physiological structure
Intestinal wall gauffer and villus, and villus can secrete the bionical ileum silica gel model of intestinal juice.
Embodiment 4: the detection of bionical ileum
It is prepared by bionical ileum, the comparative example 1-5 for taking human body ileum anatomical model, the embodiment 1-3 of same length to be prepared
(silica gel of 3 model of Fast purchased from Dragon Skin company of the U.S. is bionical for obtained bionical ileum and same kind of products at abroad
Ileum) carry out intestinal surface product, transparency, hardness, expansion rate, elastomeric check and villus Function detection, testing result such as table 1.
As shown in Table 1, the index comparison of bionical ileum of the invention and true ileum is closer to, with same kind of products at abroad
Comparison, index is more excellent, and therefore, bionical ileum of the invention alternative true ileum predicts live test, replaces completely or portion
Divide and replace live test, achievees the purpose that reduce cost and time, improves repeatability and accuracy, and not theoretical limit
System.
1 performance test results of table
Although the present invention has been described by way of example and in terms of the preferred embodiments, it is not intended to limit the invention, any to be familiar with this skill
The people of art can do various change and modification, therefore protection model of the invention without departing from the spirit and scope of the present invention
Enclosing subject to the definition of the claims.
Claims (10)
1. a kind of preparation method of bionical ileum, which is characterized in that the method is that plastic material is put into medicine Gastroenterology dept.
It is modeled in accurate human body ileum anatomical model, removes human body ileum anatomical model, in each and people of plastic material
The corresponding recess of intestinal villi stabs out duck eye with spicule on body ileum anatomical model, spicule is remained in plastic
Property material on and to plastic material carry out curing molding, obtain the ileum mold with true ileum internal physiological structures；It presses
The substrate for making bionical ileum and auxiliary material are mixed according to certain mass ratio, obtain bionical ileum raw material；According to certain
Thickness bionical ileum raw material are applied to the one side that ileum mold is in contact with human body ileum anatomical model, standing makes to smear
In the bionical ileum raw material coagulation forming of ileum die surface, extracts spicule and slough ileum mold, obtain with small intestine
Villus and be hollow bionical ileum；
Or the method is that plastic material is put into the accurate human body ileum anatomical model of medicine Gastroenterology dept. to model, and is removed
Human body ileum anatomical model, in each recess corresponding with intestinal villi on human body ileum anatomical model of plastic material
Duck eye stabs out with spicule in place, and spicule is remained on plastic material and carries out curing molding to plastic material,
Obtain the ileum mold with true ileum internal physiological structures；According to certain mass ratio by make bionical ileum substrate and
Auxiliary material is mixed, and bionical ileum raw material are obtained；Bionical ileum raw material are applied to ileum mold according to certain thickness
The one side being in contact with human body ileum anatomical model, standing are frozen into the bionical ileum raw material for being applied to ileum die surface
Type only extracts spicule, obtains having intestinal villi and for hollow bionical ileum；Do not connect with ileum mold in bionical ileum
In the side of touching cover one layer of spacer, according to certain thickness by bionical ileum raw material be applied to spacer not with it is bionical
In the side that ileum is in contact, the bionical ileum raw material coagulation forming for making to be applied to separator surface, removal isolation are stood
Object simultaneously sloughs ileum mold, obtains with ileum physiological structure villus, and can secrete the bionical ileum of intestinal juice；
The substrate includes one of silica gel, latex or hydrogel or a variety of；The auxiliary material includes silicone oil and/or curing agent.
2. a kind of preparation method of bionical ileum as described in claim 1, which is characterized in that the plastic material includes pottery
Soil, paraffin, glass or steel.
3. a kind of preparation method of bionical ileum as claimed in claim 1 or 2, which is characterized in that the diameter of the duck eye is
0.2~1mm.
4. a kind of preparation method of bionical ileum a method according to any one of claims 1-3, which is characterized in that described in plasticity material
When each recess corresponding with intestinal villi on human body ileum anatomical model of material stabs out duck eye, spicule should be made to penetrate
The plastic material and side for making one end of spicule be in contact with human body ileum anatomical model beyond plastic material is at least
2mm。
5. a kind of preparation method of bionical ileum as described in claim 1-4 is any, which is characterized in that the substrate, silicone oil
And the mass ratio between curing agent is 100:(2.5~3.5): (0.5~1.5).
6. a kind of preparation method of bionical ileum a method as claimed in any one of claims 1 to 5, which is characterized in that the bionical ileum is former
Material just can be applied after need to carrying out the row's of vacuumizing bubble to ileum mold；The condition of the row's of vacuumizing bubble is vacuum machine negative pressure-
0.1~0.09MPa, 5~10min of time.
7. a kind of preparation method of bionical ileum as described in claim 1-6 is any, which is characterized in that the bionical ileum is former
Applying material is in ileum die surface with a thickness of 2~3mm.
8. a kind of preparation method of bionical ileum as claimed in claim 1, which is characterized in that the time of the standing
For 2~4h.
9. the bionical ileum that a kind of preparation method of any bionical ileum of application claim 1-8 is prepared.
10. the preparation method of any bionical ileum of claim 1-8 a kind of as claimed in claim 9 is prepared
Application of the bionical ileum in the simulation practical digestive system of human body.
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| CN201811143747.7A CN109333883B (en) | 2018-09-29 | 2018-09-29 | A kind of bionic ileum and preparation method thereof |
| PCT/CN2018/117135 WO2020062521A1 (en) | 2018-09-29 | 2018-11-23 | Bionic digestive tract and preparation method and application for bionic digestive tract |
| US16/875,106 US11721241B2 (en) | 2018-09-29 | 2020-05-15 | Bionic digestive tract as well as preparation method and application thereof |
| US18/325,338 US12131665B2 (en) | 2018-09-29 | 2023-05-30 | Preparation method and application of bionic large intestine |
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