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CL2011002989A1 - Compuestos heterociclicos inhibidores de la endopeptidasa neutra (nep); composicion farmaceutica; combinacion farmaceutica; uso del compuesto patra tratar un trastorno o enfermedad tal como hipertencion, insuficiencia cardiaca, insuficiencia renal, epilepsia, sindrome metabolico, entre otros. - Google Patents

Compuestos heterociclicos inhibidores de la endopeptidasa neutra (nep); composicion farmaceutica; combinacion farmaceutica; uso del compuesto patra tratar un trastorno o enfermedad tal como hipertencion, insuficiencia cardiaca, insuficiencia renal, epilepsia, sindrome metabolico, entre otros.

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Publication number
CL2011002989A1
CL2011002989A1 CL2011002989A CL2011002989A CL2011002989A1 CL 2011002989 A1 CL2011002989 A1 CL 2011002989A1 CL 2011002989 A CL2011002989 A CL 2011002989A CL 2011002989 A CL2011002989 A CL 2011002989A CL 2011002989 A1 CL2011002989 A1 CL 2011002989A1
Authority
CL
Chile
Prior art keywords
nep
epilepsy
hypertension
disorder
inhibitor
Prior art date
Application number
CL2011002989A
Other languages
English (en)
Inventor
Gary Mark Coppola
Yuki Karki Rajeshri Ganesh Kawanami Toshio Ksander Gary Michael Mogi Muneto Sun Robert Iwaki
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2011002989A1 publication Critical patent/CL2011002989A1/es

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    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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Abstract

Compuestos heterocíclicos inhibidores de la endopeptidasa neutra (NEP); composición farmacéutica; combinación farmacéutica; uso del compuesto para tratar un trastorno o enfermedad tal como hipertensión, insuficiencia cardíaca, insuficiencia renal, epilepsia, síndrome metabólico, entre otros.
CL2011002989A 2009-05-28 2011-11-25 Compuestos heterociclicos inhibidores de la endopeptidasa neutra (nep); composicion farmaceutica; combinacion farmaceutica; uso del compuesto patra tratar un trastorno o enfermedad tal como hipertencion, insuficiencia cardiaca, insuficiencia renal, epilepsia, sindrome metabolico, entre otros. CL2011002989A1 (es)

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US18175309P 2009-05-28 2009-05-28
US26314109P 2009-11-20 2009-11-20
US32493810P 2010-04-16 2010-04-16

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CL2011002989A1 true CL2011002989A1 (es) 2012-08-31

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CR (1) CR20110617A (es)
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HRP20151115T1 (en) 2010-12-15 2015-11-20 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
KR101854874B1 (ko) 2011-02-17 2018-05-04 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 네프릴리신 억제제로서 치환된 아미노부티릭 유도체
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US20100305145A1 (en) 2010-12-02
JP5466759B2 (ja) 2014-04-09
US9006249B2 (en) 2015-04-14
WO2010136474A3 (en) 2011-01-20
EP2435402B1 (en) 2016-04-13
EA201101672A1 (ru) 2012-06-29
CU20110216A7 (es) 2012-03-15
CO6470846A2 (es) 2012-06-29
US8263629B2 (en) 2012-09-11
CN102448928B (zh) 2014-10-01
CN102448928A (zh) 2012-05-09
TW201100393A (en) 2011-01-01
SV2011004077A (es) 2012-01-04
US20120252830A1 (en) 2012-10-04
JP2012528107A (ja) 2012-11-12
US9603819B2 (en) 2017-03-28
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MX2011012627A (es) 2011-12-14
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EP2435402A2 (en) 2012-04-04
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