CL2008000784A1 - Compuestos amino-5-[-4-(diflourometoxi) fenil sustituido]-5-fenilmidazolona, inhibidores de b-secretasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar alzheimer, deterioro cognitivo, sindrome de down, disminucion co - Google Patents

Compuestos amino-5-[-4-(diflourometoxi) fenil sustituido]-5-fenilmidazolona, inhibidores de b-secretasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar alzheimer, deterioro cognitivo, sindrome de down, disminucion co

Info

Publication number: CL2008000784A1
Authority: CL; Chile
Prior art keywords: compounds; phenylmidazolone; diflourometoxi; amino; decrease
Prior art date: 2007-03-20

Application number

CL200800784A

Other languages

English (en)

Inventor

Michael Sotirios Robic Malamas

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-20

Filing date

2008-03-18

Publication date

2008-05-30

2008-03-18 Application filed by Wyeth Corp filed Critical Wyeth Corp

2008-05-30 Publication of CL2008000784A1 publication Critical patent/CL2008000784A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CL200800784A 2007-03-20 2008-03-18 Compuestos amino-5-[-4-(diflourometoxi) fenil sustituido]-5-fenilmidazolona, inhibidores de b-secretasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar alzheimer, deterioro cognitivo, sindrome de down, disminucion co CL2008000784A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US91908707P	2007-03-20	2007-03-20

Publications (1)

Publication Number	Publication Date
CL2008000784A1 true CL2008000784A1 (es)	2008-05-30

Family

ID=39564223

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200800784A CL2008000784A1 (es)	2007-03-20	2008-03-18	Compuestos amino-5-[-4-(diflourometoxi) fenil sustituido]-5-fenilmidazolona, inhibidores de b-secretasa; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar alzheimer, deterioro cognitivo, sindrome de down, disminucion co

Country Status (24)

Country	Link
US (1)	US20090042964A1 (es)
EP (1)	EP2137161A1 (es)
JP (1)	JP2010522235A (es)
KR (1)	KR20100015376A (es)
CN (1)	CN101641335A (es)
AR (1)	AR065811A1 (es)
AU (1)	AU2008229327A1 (es)
BR (1)	BRPI0808944A2 (es)
CA (1)	CA2681243A1 (es)
CL (1)	CL2008000784A1 (es)
CO (1)	CO6140056A2 (es)
CR (1)	CR11020A (es)
EC (1)	ECSP099639A (es)
GT (1)	GT200900241A (es)
IL (1)	IL200961A0 (es)
MX (1)	MX2009009699A (es)
NI (1)	NI200900164A (es)
PA (1)	PA8772701A1 (es)
PE (1)	PE20090160A1 (es)
RU (1)	RU2009133807A (es)
SV (1)	SV2009003373A (es)
TW (1)	TW200845965A (es)
WO (1)	WO2008115552A1 (es)
ZA (1)	ZA200906542B (es)

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US7763609B2 (en) *	2003-12-15	2010-07-27	Schering Corporation	Heterocyclic aspartyl protease inhibitors
US7700603B2 (en)	2003-12-15	2010-04-20	Schering Corporation	Heterocyclic aspartyl protease inhibitors
US7592348B2 (en)	2003-12-15	2009-09-22	Schering Corporation	Heterocyclic aspartyl protease inhibitors
CA2609582A1 (en)	2005-06-14	2006-12-28	Schering Corporation	Aspartyl protease inhibitors
US8450308B2 (en)	2008-08-19	2013-05-28	Vitae Pharmaceuticals, Inc.	Inhibitors of beta-secretase
EP2184276A1 (en) *	2008-11-07	2010-05-12	Universite Paul Cezanne Aix-Marseille Iii	Process to prepare new substituted 1H-Benzo(d) imidazol-2(3h)-Ones, New intermediates and their use as bace 1 inhibitors
KR101908255B1 (ko)	2009-03-13	2018-10-15	비타이 파마슈티컬즈, 인코포레이티드	베타세크리타아제 저해제
UA108363C2 (uk)	2009-10-08	2015-04-27		Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
JP5828848B2 (ja)	2010-02-24	2015-12-09	ヴァイティーファーマシューティカルズ，インコーポレイテッド	ベータセクレターゼインヒビター
WO2012138734A1 (en)	2011-04-07	2012-10-11	Merck Sharp & Dohme Corp.	C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
EP2694521B1 (en)	2011-04-07	2015-11-25	Merck Sharp & Dohme Corp.	Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
WO2013028670A1 (en)	2011-08-22	2013-02-28	Merck Sharp & Dohme Corp.	2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use
TWI557112B (zh)	2012-03-05	2016-11-11	百靈佳殷格翰國際股份有限公司	β－分泌酶抑制劑
TW201422592A (zh)	2012-08-27	2014-06-16	Boehringer Ingelheim Int	β－分泌酶抑制劑
EP2900650A1 (en)	2012-09-28	2015-08-05	Vitae Pharmaceuticals, Inc.	Inhibitors of beta-secretase
CN104995176B (zh) *	2013-02-12	2019-02-22	巴克老龄化研究所	调节bace所介导的app加工的乙内酰脲
US20160298151A1 (en)	2015-04-09	2016-10-13	Sher Ali Butt	Novel Method for the cheap, efficient, and effective production of pharmaceutical and therapeutic api's intermediates, and final products
US11584724B2 (en)	2018-04-23	2023-02-21	Merck Sharp & Dohme Llc	Process for synthesis of a phenoxy diaminopyrimidine compound
CN109289696B (zh) *	2018-10-29	2022-03-22	天津先光化工有限公司	一种咪唑啉两性表面活性剂的制备方法

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IE45198B1 (en) *	1976-06-05	1982-07-14	Wyeth John & Brother Ltd	Guanidine derivatives
GB1588096A (en) *	1978-05-20	1981-04-15	Wyeth & Bros Ltd John	Pyrrole derivatives
GB9511694D0 (en) *	1995-06-09	1995-08-02	Fujisawa Pharmaceutical Co	Benzamide derivatives
TW544448B (en) *	1997-07-11	2003-08-01	Novartis Ag	Pyridine derivatives
US6492408B1 (en) *	1999-07-21	2002-12-10	Boehringer Ingelheim Pharmaceuticals, Inc.	Small molecules useful in the treatment of inflammatory disease
DE10046993A1 (de) *	2000-09-22	2002-04-11	Aventis Pharma Gmbh	Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
US6974829B2 (en) *	2002-05-07	2005-12-13	Elan Pharmaceuticals, Inc.	Succinoyl aminopyrazoles and related compounds
US7700603B2 (en) *	2003-12-15	2010-04-20	Schering Corporation	Heterocyclic aspartyl protease inhibitors
ES2332659T3 (es) *	2004-06-16	2010-02-10	Wyeth	Derivados de amino-5,5-difenilimidazolona para la inhibicion de beta-secretasa.
ES2321853T3 (es) *	2004-06-16	2009-06-12	Wyeth	Difenilimidazopiridina e -imidazol aminas como inhibidores de b-secretasa".
RU2007126570A (ru) *	2005-01-14	2009-02-20	Вайет (Us)	Аминоимидазолоны, применяемые для ингибирования бета-секретазы
MX2007009313A (es) *	2005-02-01	2007-09-12	Wyeth Corp	Amino-piridinas como inhibidores de ????-secretasa.
WO2006088694A1 (en) *	2005-02-14	2006-08-24	Wyeth	SUBSTITUTED THIENYL AND FURYL ACYLGUANIDINES AS β-SECRETASE MODULATORS
WO2006088705A1 (en) *	2005-02-14	2006-08-24	Wyeth	Terphenyl guanidines as [beta symbol] -secretase inhibitors
EP1848692A1 (en) *	2005-02-14	2007-10-31	Wyeth	AZOLYLACYLGUANIDINES AS ß-SECRETASE INHIBITORS
AU2006266167A1 (en) *	2005-06-30	2007-01-11	Wyeth	Amino-5-(6-membered)heteroarylimidazolone compounds and the use thereof for beta-secretase modulation
TW200738683A (en) *	2005-06-30	2007-10-16	Wyeth Corp	Amino-5-(5-membered)heteroarylimidazolone compounds and the use thereof for β-secretase modulation
TW200730523A (en) *	2005-07-29	2007-08-16	Wyeth Corp	Cycloalkyl amino-hydantoin compounds and use thereof for β-secretase modulation
WO2007038271A1 (en) *	2005-09-26	2007-04-05	Wyeth	Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (bace)
JP2009520027A (ja) *	2005-12-19	2009-05-21	ワイス	２−アミノ−５−ピペリジニルイミダゾロン化合物およびβ−セクレターゼ調節におけるその使用
WO2007100536A1 (en) *	2006-02-24	2007-09-07	Wyeth	DIHYDROSPIRO[DIBENZO[A,D][7]ANNULENE-5,4'-IMIDAZOL] COMPOUNDS FOR THE INHIBITION OF β-SECRETASE
US7700606B2 (en) *	2006-08-17	2010-04-20	Wyeth Llc	Imidazole amines as inhibitors of β-secretase
JP2010504326A (ja) *	2006-09-21	2010-02-12	ワイスエルエルシー	β−セクレターゼを阻害するためのインドリルアルキルピリジン−２−アミン

2008
- 2008-03-18 CL CL200800784A patent/CL2008000784A1/es unknown
- 2008-03-18 PE PE2008000494A patent/PE20090160A1/es not_active Application Discontinuation
- 2008-03-19 AR ARP080101180A patent/AR065811A1/es unknown
- 2008-03-19 PA PA20088772701A patent/PA8772701A1/es unknown
- 2008-03-20 RU RU2009133807/04A patent/RU2009133807A/ru not_active Application Discontinuation
- 2008-03-20 AU AU2008229327A patent/AU2008229327A1/en not_active Abandoned
- 2008-03-20 BR BRPI0808944-2A patent/BRPI0808944A2/pt not_active Application Discontinuation
- 2008-03-20 CN CN200880008871A patent/CN101641335A/zh active Pending
- 2008-03-20 MX MX2009009699A patent/MX2009009699A/es not_active Application Discontinuation
- 2008-03-20 WO PCT/US2008/003681 patent/WO2008115552A1/en not_active Ceased
- 2008-03-20 TW TW097109933A patent/TW200845965A/zh unknown
- 2008-03-20 EP EP08727031A patent/EP2137161A1/en not_active Withdrawn
- 2008-03-20 CA CA002681243A patent/CA2681243A1/en not_active Abandoned
- 2008-03-20 JP JP2010500934A patent/JP2010522235A/ja not_active Withdrawn
- 2008-03-20 KR KR1020097020772A patent/KR20100015376A/ko not_active Withdrawn
- 2008-03-20 US US12/052,098 patent/US20090042964A1/en not_active Abandoned
2009
- 2009-09-04 NI NI200900164A patent/NI200900164A/es unknown
- 2009-09-09 CR CR11020A patent/CR11020A/es unknown
- 2009-09-10 GT GT200900241A patent/GT200900241A/es unknown
- 2009-09-15 IL IL200961A patent/IL200961A0/en unknown
- 2009-09-16 CO CO09100417A patent/CO6140056A2/es unknown
- 2009-09-18 SV SV2009003373A patent/SV2009003373A/es not_active Application Discontinuation
- 2009-09-18 ZA ZA200906542A patent/ZA200906542B/xx unknown
- 2009-09-18 EC EC2009009639A patent/ECSP099639A/es unknown

Also Published As

Publication number	Publication date
KR20100015376A (ko)	2010-02-12
EP2137161A1 (en)	2009-12-30
ECSP099639A (es)	2009-10-30
SV2009003373A (es)	2010-08-10
MX2009009699A (es)	2009-09-24
ZA200906542B (en)	2010-06-30
RU2009133807A (ru)	2011-04-27
US20090042964A1 (en)	2009-02-12
CR11020A (es)	2009-10-06
CN101641335A (zh)	2010-02-03
WO2008115552A1 (en)	2008-09-25
JP2010522235A (ja)	2010-07-01
PE20090160A1 (es)	2009-02-11
TW200845965A (en)	2008-12-01
BRPI0808944A2 (pt)	2014-09-02
AU2008229327A1 (en)	2008-09-25
IL200961A0 (en)	2010-05-17
GT200900241A (es)	2010-05-07
CA2681243A1 (en)	2008-09-25
AU2008229327A8 (en)	2009-10-15
AR065811A1 (es)	2009-07-01
NI200900164A (es)	2010-07-29
CO6140056A2 (es)	2010-03-19
PA8772701A1 (es)	2008-11-19

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