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CA2350538A1 - Derives de pyrazolopyrimidinone utiles pour traiter l'impuissance - Google Patents

Derives de pyrazolopyrimidinone utiles pour traiter l'impuissance Download PDF

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Publication number
CA2350538A1
CA2350538A1 CA002350538A CA2350538A CA2350538A1 CA 2350538 A1 CA2350538 A1 CA 2350538A1 CA 002350538 A CA002350538 A CA 002350538A CA 2350538 A CA2350538 A CA 2350538A CA 2350538 A1 CA2350538 A1 CA 2350538A1
Authority
CA
Canada
Prior art keywords
impotence
treatment
derivatives
pyrazolopyrimidinone derivatives
pyrazolopyrimidinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002350538A
Other languages
English (en)
Other versions
CA2350538C (fr
Inventor
Moohi Yoo
Wonbae Kim
Min Sun Chang
Joong In Lim
Dong Sung Kim
Ik Yon Kim
Tae Kyun Lim
Byoung Ok Ahn
Kyung Koo Kang
Miwon Son
Hyounmie Doh
Soonhoe Kim
Hyunjoo Shim
Taeyoung Oh
Heungjae Kim
Dong Goo Kim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mezzion Pharma Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27349839&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2350538(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2350538A1 publication Critical patent/CA2350538A1/fr
Application granted granted Critical
Publication of CA2350538C publication Critical patent/CA2350538C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002350538A 1998-11-11 1999-11-10 Derives de pyrazolopyrimidinone utiles pour traiter l'impuissance Expired - Lifetime CA2350538C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
KR1998/48100 1998-11-11
KR19980048100 1998-11-11
KR19990014972 1999-04-27
KR1999/49384 1999-11-09
KR19990049384A KR100353014B1 (ko) 1998-11-11 1999-11-09 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물
KR1999/14972 1999-11-09
PCT/KR1999/000675 WO2000027848A1 (fr) 1998-11-11 1999-11-10 Derives de pyrazolopyrimidinone utiles pour traiter l'impuissance

Publications (2)

Publication Number Publication Date
CA2350538A1 true CA2350538A1 (fr) 2000-05-18
CA2350538C CA2350538C (fr) 2005-06-28

Family

ID=27349839

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002350538A Expired - Lifetime CA2350538C (fr) 1998-11-11 1999-11-10 Derives de pyrazolopyrimidinone utiles pour traiter l'impuissance

Country Status (17)

Country Link
US (1) US6583147B1 (fr)
EP (1) EP1129093B1 (fr)
JP (1) JP3577630B2 (fr)
KR (1) KR100353014B1 (fr)
CN (1) CN1136219C (fr)
AT (1) ATE245650T1 (fr)
AU (1) AU760422B2 (fr)
BR (1) BRPI9915822B8 (fr)
CA (1) CA2350538C (fr)
DE (1) DE69909818T2 (fr)
DK (1) DK1129093T3 (fr)
ES (1) ES2204169T3 (fr)
HK (1) HK1039328B (fr)
NZ (1) NZ511015A (fr)
PT (1) PT1129093E (fr)
TR (1) TR200101335T2 (fr)
WO (1) WO2000027848A1 (fr)

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ES2294189T3 (es) * 2001-12-13 2008-04-01 Asubio Pharma Co., Ltd. Derivados de pirazolopirimidinona que tienen accion inhibidora de pde7.
PL377657A1 (pl) 2002-12-13 2006-02-06 Warner-Lambert Company Llc Ligand Ó-2-Ű do leczenia dolegliwości dolnych dróg moczowych
MXPA05009242A (es) * 2003-03-17 2006-04-18 Pfizer Prod Inc Tratamiento de la diabetes tipo 1 con los inhibidores de la pde5.
CN100374441C (zh) 2003-06-06 2008-03-12 天津倍方科技发展有限公司 二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途
BRPI0506994A (pt) 2004-01-22 2007-07-03 Pfizer derivados de triazol que inibem a atividade antagonista da vasopressina
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
EP1848437A4 (fr) * 2005-02-18 2012-04-25 Surface Logix Inc Procedes de fabrication de composes a amelioration pharmacocinetique comportant des residus ou groupes fonctionnels et compositions pharmaceutiques comportant lesdits composes
NZ560963A (en) * 2005-02-18 2010-11-26 Surface Logix Inc Pharmacokinetically improved compounds
AU2006237300B2 (en) 2005-04-19 2011-10-13 Takeda Gmbh Roflumilast for the treatment of pulmonary hypertension
RU2369392C2 (ru) * 2005-06-10 2009-10-10 Донг-А Фармасьютикал. Ко., Лтд. Средство для профилактики и лечения заболеваний печени, содержащее производное пиразолопиримидинона
CN1966506A (zh) * 2005-11-17 2007-05-23 上海特化医药科技有限公司 吡唑并嘧啶酮衍生物及其制备方法和用途
MX2008012549A (es) * 2006-04-04 2009-01-14 Dong A Pharm Co Ltd Agente para la prevencion y tratamiento de hiperplasia prostatica que comprende compuesto de pirazolopirimidinona.
WO2007141805A2 (fr) * 2006-06-05 2007-12-13 Matrix Laboratories Limited Nouveau procédé de préparation du citrate de sildénafil
AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
BRPI0716134A2 (pt) 2006-09-07 2013-09-17 Nycomed Gmbh tratamento de combinaÇço para diabetes mellitus
US20090270425A1 (en) * 2006-10-20 2009-10-29 Concert Pharmaceuticals Inc. 3-(dihydro-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use
US20090197899A1 (en) * 2006-10-20 2009-08-06 Concert Pharmaceuticals Inc. 3-(Dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide Derivatives and Methods of Use
JP2010507593A (ja) * 2006-10-20 2010-03-11 コンサート ファーマシューティカルズ インコーポレイテッド ３−（ジヒドロ−１Ｈ−ピラゾロ［４，３−ｄ］ピリミジン−５−イル）−４−プロポキシベンゼンスルホンアミド誘導体および使用方法
US20080194529A1 (en) * 2007-02-12 2008-08-14 Auspex Pharmaceuticals, Inc. HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS
RU2450017C2 (ru) 2007-05-25 2012-05-10 Ипсен Фарма С.А.С. Лиганды меланокортиновых рецепторов, модифицированные гидантоином
EA021544B1 (ru) 2007-06-04 2015-07-30 Бен-Гурион Юниверсити Оф Дзе Негев Рисерч Энд Дивелопмент Оторити Триарильные соединения и фармацевтические композиции, их содержащие
KR101002490B1 (ko) * 2007-06-09 2010-12-17 동아제약주식회사 유데나필을 유효성분으로 함유하는 만성 심부전증 치료용약학적 조성물
JP2010540621A (ja) * 2007-10-02 2010-12-24 ドン ア ファーマシューティカル カンパニー リミテッド 良性前立腺肥大症および下部尿路症状の治療または予防用組成物、およびその治療または予防方法
KR100920125B1 (ko) * 2007-10-02 2009-10-01 동아제약주식회사 양성 전립선 비대증 치료를 위한 피라졸로피리미디논화합물 및 알파 아드레날린성 수용체 길항제를 함유하는약제학적 배합물
WO2009099620A1 (fr) * 2008-02-04 2009-08-13 Concert Pharmaceuticals Inc. Dérivés de 3-(dihydro-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzènesulfonamide et procédés d'utilisation
KR20090087795A (ko) * 2008-02-13 2009-08-18 한양대학교 산학협력단 혈관 재협착 예방 및 치료를 위한 약학 조성물 및 이를포함하는 스텐트
KR101071877B1 (ko) * 2009-02-18 2011-10-10 동아제약주식회사 유데나필 산부가염, 그의 제조방법 및 이를 포함하는 약학적 조성물
GB0903493D0 (en) 2009-02-27 2009-04-08 Vantia Ltd New compounds
CN102970965A (zh) 2010-04-05 2013-03-13 Sk化学公司 含有pde5抑制剂的减少皮肤皱纹的合成物
CN102952138B (zh) * 2011-08-17 2016-07-06 上海特化医药科技有限公司 一种吡唑并嘧啶酮化合物的盐、多晶型物及其药物组合物、制备方法和应用
US10092651B2 (en) 2012-02-28 2018-10-09 Seoul Pharma Co., Ltd. High-content fast dissolving film with masking of bitter taste comprising sildenafil as active ingredient
KR101953735B1 (ko) 2012-12-14 2019-03-04 한미약품 주식회사 포스포다이에스터라제-5 억제제를 포함하는 츄정
AU2014347668A1 (en) 2013-11-05 2016-05-19 Ben-Gurion University Of The Negev Research And Development Authority Compounds for the treatment of diabetes and disease complications arising from same
CN107073001A (zh) 2014-08-12 2017-08-18 美智恩制药公司 使用乌地那非组合物改善丰唐术患者的心肌性能的方法
KR101645652B1 (ko) 2014-11-03 2016-08-08 (주)퓨젠바이오농업회사법인 세리포리아 락세라타에 의해 생산되는 세포외다당체를 유효성분으로 함유하는 성기능개선용 조성물
WO2017168174A1 (fr) 2016-04-02 2017-10-05 N4 Pharma Uk Limited Nouvelles formes pharmaceutiques du sildénafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法
KR102249155B1 (ko) * 2019-07-26 2021-05-07 주식회사 코아팜바이오 유데나필을 함유하는 약제학적 조성물
CN113493459B (zh) * 2020-04-07 2022-12-13 广州白云山医药集团股份有限公司白云山制药总厂 Pde5抑制剂化合物及其制备方法和应用
JP7769648B2 (ja) * 2020-06-19 2025-11-13 アナシス・ファルマ・プロプライエタリー・リミテッド スルホンアミド化合物
TW202237615A (zh) 2020-12-11 2022-10-01 南韓商日東製藥股份有限公司 作為雄激素受體及磷酸二酯酶雙重抑制劑的新穎化合物

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GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9119704D0 (en) * 1991-09-14 1991-10-30 Pfizer Ltd Therapeutic agents
GB9311920D0 (en) * 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
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KR100297814B1 (ko) * 1998-12-29 2001-10-26 조민호 피라졸로피리미디논유도체와이의제조방법그리고이의용도

Also Published As

Publication number Publication date
AU1081700A (en) 2000-05-29
CA2350538C (fr) 2005-06-28
CN1325398A (zh) 2001-12-05
KR20000035324A (ko) 2000-06-26
JP3577630B2 (ja) 2004-10-13
EP1129093B1 (fr) 2003-07-23
DK1129093T3 (da) 2003-10-20
BR9915822A (pt) 2001-08-14
DE69909818T2 (de) 2004-05-27
WO2000027848A1 (fr) 2000-05-18
HK1039328B (zh) 2004-06-25
KR100353014B1 (ko) 2002-09-18
ATE245650T1 (de) 2003-08-15
BRPI9915822B8 (pt) 2021-05-25
PT1129093E (pt) 2003-12-31
HK1039328A1 (en) 2002-04-19
BR9915822B1 (pt) 2013-08-27
AU760422B2 (en) 2003-05-15
JP2002529467A (ja) 2002-09-10
DE69909818D1 (de) 2003-08-28
NZ511015A (en) 2003-09-26
CN1136219C (zh) 2004-01-28
EP1129093A1 (fr) 2001-09-05
US6583147B1 (en) 2003-06-24
ES2204169T3 (es) 2004-04-16
TR200101335T2 (tr) 2001-09-21

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Effective date: 20191112