BR9708706B1 - composiÇço farmacÊutica para administraÇço intravenosa a um paciente - Google Patents

composiÇço farmacÊutica para administraÇço intravenosa a um paciente

Info

Publication number: BR9708706B1
Authority: BR; Brazil
Prior art keywords: patient; pharmaceutical composition; intravenous administration; intravenous; administration
Prior art date: 1996-04-19

Application number

BRPI9708706-8B1A

Other languages

English (en)

Other versions

BR9708706B8 (pt

BR9708706A (pt

Inventor

Maneesh J Nerurkar

William A Hunke

Michael J Kaufman

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-19

Filing date

1997-04-15

Publication date

2013-08-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26309400&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9708706(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-05-24 Priority claimed from GBGB9611006.9A external-priority patent/GB9611006D0/en

1997-04-15 Application filed filed Critical

1999-08-03 Publication of BR9708706A publication Critical patent/BR9708706A/pt

2013-08-06 Publication of BR9708706B1 publication Critical patent/BR9708706B1/pt

2019-03-06 Publication of BR9708706B8 publication Critical patent/BR9708706B8/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BRPI9708706A 1996-04-19 1997-04-15 composição farmacêutica para administração intravenosa a um paciente BR9708706B8 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1563896P	1996-04-19	1996-04-19
GBGB9611006.9A GB9611006D0 (en)	1996-05-24	1996-05-24	Antifungal compositions
PCT/US1997/006284 WO1997039763A1 (en)	1996-04-19	1997-04-15	Compositions comprising antifungal agent and acetate buffer

Publications (3)

Publication Number	Publication Date
BR9708706A BR9708706A (pt)	1999-08-03
BR9708706B1 true BR9708706B1 (pt)	2013-08-06
BR9708706B8 BR9708706B8 (pt)	2019-03-06

Family

ID=26309400

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BRPI9708706A BRPI9708706C8 (pt)	1996-04-19	1997-04-15	composição farmacêutica para administração intravenosa a um paciente
BRPI9708706A BR9708706B8 (pt)	1996-04-19	1997-04-15	composição farmacêutica para administração intravenosa a um paciente

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BRPI9708706A BRPI9708706C8 (pt)	1996-04-19	1997-04-15	composição farmacêutica para administração intravenosa a um paciente

Country Status (35)

Country	Link
EP (1)	EP0904098B1 (pt)
JP (1)	JP3258672B2 (pt)
CN (1)	CN1132624C (pt)
AR (1)	AR006598A1 (pt)
AT (1)	ATE241999T1 (pt)
AU (1)	AU706250B2 (pt)
BG (1)	BG64272B1 (pt)
BR (2)	BRPI9708706C8 (pt)
CA (1)	CA2251928C (pt)
CO (1)	CO4940486A1 (pt)
CY (1)	CY2374B1 (pt)
CZ (1)	CZ289361B6 (pt)
DE (1)	DE69722615T2 (pt)
DK (1)	DK0904098T3 (pt)
DZ (1)	DZ2205A1 (pt)
EA (1)	EA001386B1 (pt)
EE (1)	EE04265B1 (pt)
ES (1)	ES2198569T3 (pt)
HR (1)	HRP970201B1 (pt)
HU (1)	HU228296B1 (pt)
ID (1)	ID16643A (pt)
IL (1)	IL126479A (pt)
IS (1)	IS2159B (pt)
MY (1)	MY126305A (pt)
NO (1)	NO321954B1 (pt)
NZ (1)	NZ332156A (pt)
PE (1)	PE63998A1 (pt)
PL (1)	PL187294B1 (pt)
PT (1)	PT904098E (pt)
RS (1)	RS49566B (pt)
SA (1)	SA97180104B1 (pt)
SK (1)	SK281969B6 (pt)
TR (1)	TR199802102T2 (pt)
UA (1)	UA55409C2 (pt)
WO (1)	WO1997039763A1 (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP970318B1 (en)	1996-06-14	2002-06-30	Merck & Co Inc	A process for preparing certain aza cyclohexapeptides
PT1582204E (pt) *	1999-03-03	2013-11-25	Lilly Co Eli	Formulações farmacêuticas de equinocandina que contêm tensioactivos que formam micelas
TWI233805B (en) *	1999-07-01	2005-06-11	Fujisawa Pharmaceutical Co	Stabilized pharmaceutical composition in lyophilized form as antifungal agent
KR101536781B1 (ko) *	2006-07-26	2015-07-14	산도즈 아게	카스포펀진 제형
CN101516387B (zh) *	2006-07-26	2014-06-04	桑多斯股份公司	卡泊芬净制剂
US20100137197A1 (en) *	2007-06-26	2010-06-03	Sachin Mittal	Lyophilized anti-fungal composition
US8048853B2 (en)	2008-06-13	2011-11-01	Xellia Pharmaceuticals Aps	Process for preparing pharmaceutical compound and intermediates thereof
WO2010008493A2 (en) *	2008-06-25	2010-01-21	Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság	Processes for preparing high purity aza cyclohexapeptides
WO2010108637A1 (en) *	2009-03-27	2010-09-30	Axellia Pharmaceuticals Aps	Crystalline compound
CN102219832B (zh) *	2010-04-15	2013-08-21	上海天伟生物制药有限公司	一种氮杂环六肽或其盐的纯化方法
CN102367267B (zh) *	2010-11-10	2013-09-04	上海天伟生物制药有限公司	一种卡泊芬净的制备方法
CN102367268B (zh) *	2010-11-10	2013-11-06	上海天伟生物制药有限公司	一种卡泊芬净类似物及其用途
CN102367269B (zh) *	2010-11-10	2013-11-06	上海天伟生物制药有限公司	一种卡泊芬净类似物及其制备方法和用途
CN102488887B (zh) *	2011-01-31	2014-06-18	上海天伟生物制药有限公司	一种含有棘白菌素类抗真菌剂卡泊芬净的药用组合物及其制备方法和用途
CN102488888B (zh) *	2011-01-31	2014-07-30	上海天伟生物制药有限公司	一种含有棘白菌素类抗真菌剂的药用组合物及其制备方法和用途
CN102614493B (zh) *	2011-01-31	2013-12-11	上海天伟生物制药有限公司	一种含有棘白菌素类抗真菌剂卡泊芬净的液体药用组合物
NO2680873T3 (pt)	2011-03-03	2018-01-06
CN102166186A (zh) *	2011-04-18	2011-08-31	深圳市健元医药科技有限公司	一种更加稳定的氮杂环己肽类制剂
CN102488886B (zh) *	2011-09-26	2014-03-26	上海天伟生物制药有限公司	一种低杂质含量的卡泊芬净制剂及其制备方法和用途
CN102488889B (zh) *	2011-09-26	2014-01-22	上海天伟生物制药有限公司	一种低杂质含量的卡泊芬净制剂及其制备方法和用途
CN103212059A (zh) *	2012-01-18	2013-07-24	江苏恒瑞医药股份有限公司	含有抗真菌药物和乳酸盐缓冲液的组合物
HRP20231151T1 (hr)	2012-03-19	2024-01-05	Cidara Therapeutics, Inc.	Režimi za doziranje spojeva iz klase ehinokandina
CN105164146B (zh) *	2013-05-02	2019-06-28	灿盛制药有限公司荷兰公司	分离卡泊芬净的方法
PL3058958T3 (pl)	2015-02-23	2019-02-28	Selectchemie Ag	Kompozycja anidulafunginy
CN109154603A (zh)	2016-03-16	2019-01-04	奇达拉治疗公司	用于治疗真菌感染的给药方案
CN111050798A (zh)	2017-07-12	2020-04-21	奇达拉治疗公司	用于治疗真菌感染的组合物和方法
CN109721641B (zh) *	2017-10-31	2021-08-03	鲁南制药集团股份有限公司	一种卡泊芬净的合成方法
CN113801202B (zh) *	2020-06-15	2024-11-05	杭州中美华东制药有限公司	一种醋酸卡泊芬净杂质g的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1234383A (en) *	1982-03-17	1983-09-22	Inter-Yeda Ltd.	Interferon stabilised with polyvinyl-pyrrolidone
WO1989011297A1 (en) *	1988-05-27	1989-11-30	Centocor, Inc.	Freeze-dried formulation for antibody products
US5939384A (en) *	1991-10-01	1999-08-17	Merck & Co., Inc.	Cyclohexapeptidyl propanolamine compounds
DE4305225A1 (de) *	1993-02-19	1994-08-25	Asta Medica Ag	Neues Herstellverfahren für Cetrorelix Lyophilisat
US5378804A (en) *	1993-03-16	1995-01-03	Merck & Co., Inc.	Aza cyclohexapeptide compounds
IL109350A (en) *	1993-05-12	2001-01-28	Genentech Inc	Stable liquid compositions of gamma interferon

1997
- 1997-04-10 AR ARP970101437A patent/AR006598A1/es active IP Right Grant
- 1997-04-10 PE PE1997000281A patent/PE63998A1/es not_active IP Right Cessation
- 1997-04-11 HR HR970201A patent/HRP970201B1/xx not_active IP Right Cessation
- 1997-04-15 DZ DZ970052A patent/DZ2205A1/fr active
- 1997-04-15 UA UA98116109A patent/UA55409C2/uk unknown
- 1997-04-15 JP JP53815697A patent/JP3258672B2/ja not_active Expired - Lifetime
- 1997-04-15 AT AT97921205T patent/ATE241999T1/de active
- 1997-04-15 CZ CZ19983347A patent/CZ289361B6/cs not_active IP Right Cessation
- 1997-04-15 IL IL126479A patent/IL126479A/en not_active IP Right Cessation
- 1997-04-15 HU HU9901586A patent/HU228296B1/hu unknown
- 1997-04-15 DE DE69722615T patent/DE69722615T2/de not_active Expired - Lifetime
- 1997-04-15 BR BRPI9708706A patent/BRPI9708706C8/pt not_active IP Right Cessation
- 1997-04-15 NZ NZ332156A patent/NZ332156A/xx not_active IP Right Cessation
- 1997-04-15 SK SK1448-98A patent/SK281969B6/sk not_active IP Right Cessation
- 1997-04-15 EE EE9800345A patent/EE04265B1/xx unknown
- 1997-04-15 ES ES97921205T patent/ES2198569T3/es not_active Expired - Lifetime
- 1997-04-15 CA CA002251928A patent/CA2251928C/en not_active Expired - Lifetime
- 1997-04-15 TR TR1998/02102T patent/TR199802102T2/xx unknown
- 1997-04-15 BR BRPI9708706A patent/BR9708706B8/pt active IP Right Grant
- 1997-04-15 WO PCT/US1997/006284 patent/WO1997039763A1/en not_active Ceased
- 1997-04-15 CN CN97195514A patent/CN1132624C/zh not_active Expired - Lifetime
- 1997-04-15 PL PL97329442A patent/PL187294B1/pl unknown
- 1997-04-15 EP EP97921205A patent/EP0904098B1/en not_active Expired - Lifetime
- 1997-04-15 PT PT97921205T patent/PT904098E/pt unknown
- 1997-04-15 EA EA199800938A patent/EA001386B1/ru not_active IP Right Cessation
- 1997-04-15 DK DK97921205T patent/DK0904098T3/da active
- 1997-04-15 AU AU27311/97A patent/AU706250B2/en not_active Expired
- 1997-04-17 ID IDP971282A patent/ID16643A/id unknown
- 1997-04-17 CO CO97020212A patent/CO4940486A1/es unknown
- 1997-04-17 MY MYPI97001663A patent/MY126305A/en unknown
- 1997-05-31 SA SA97180104A patent/SA97180104B1/ar unknown
1998
- 1998-10-02 IS IS4858A patent/IS2159B/is unknown
- 1998-10-15 RS YUP-450/98A patent/RS49566B/sr unknown
- 1998-10-16 NO NO19984860A patent/NO321954B1/no not_active IP Right Cessation
- 1998-10-19 BG BG102857A patent/BG64272B1/bg unknown
2003
- 2003-08-25 CY CY0300058A patent/CY2374B1/xx unknown

Also Published As

Publication number	Publication date
CA2251928A1 (en)	1997-10-30
ATE241999T1 (de)	2003-06-15
HRP970201A2 (en)	1998-08-31
SK281969B6 (sk)	2001-09-11
PL329442A1 (en)	1999-03-29
CZ334798A3 (cs)	1999-06-16
EA199800938A1 (ru)	1999-04-29
BR9708706B8 (pt)	2019-03-06
CZ289361B6 (cs)	2002-01-16
NZ332156A (en)	2000-04-28
MY126305A (en)	2006-09-29
JP3258672B2 (ja)	2002-02-18
BRPI9708706C8 (pt)	2021-01-05
AU2731197A (en)	1997-11-12
SK144898A3 (en)	1999-05-07
UA55409C2 (uk)	2003-04-15
BG64272B1 (bg)	2004-08-31
CA2251928C (en)	2003-06-17
WO1997039763A1 (en)	1997-10-30
NO984860L (no)	1998-12-18
ES2198569T3 (es)	2004-02-01
TR199802102T2 (xx)	1999-01-18
IS4858A (is)	1998-10-02
BG102857A (en)	1999-09-30
CO4940486A1 (es)	2000-07-24
HU228296B1 (en)	2013-03-28
DE69722615D1 (de)	2003-07-10
HK1020873A1 (en)	2000-05-26
JPH11509555A (ja)	1999-08-24
PT904098E (pt)	2003-09-30
RS49566B (sr)	2007-04-10
PE63998A1 (es)	1998-10-30
HUP9901586A3 (en)	2002-05-28
CN1222082A (zh)	1999-07-07
EP0904098B1 (en)	2003-06-04
EP0904098A1 (en)	1999-03-31
CY2374B1 (en)	2004-06-04
CN1132624C (zh)	2003-12-31
HUP9901586A2 (hu)	1999-08-30
NO321954B1 (no)	2006-07-31
YU45098A (sh)	1999-07-28
DZ2205A1 (fr)	2002-12-03
ID16643A (id)	1997-10-23
IL126479A (en)	2006-08-01
BR9708706A (pt)	1999-08-03
IL126479A0 (en)	1999-08-17
AU706250B2 (en)	1999-06-10
AR006598A1 (es)	1999-09-08
DE69722615T2 (de)	2004-04-29
EE04265B1 (et)	2004-04-15
IS2159B (is)	2006-11-15
NO984860D0 (no)	1998-10-16
EA001386B1 (ru)	2001-02-26
SA97180104B1 (ar)	2006-02-08
PL187294B1 (pl)	2004-06-30
EE9800345A (et)	1999-04-15
HRP970201B1 (en)	2002-06-30
DK0904098T3 (da)	2003-09-15

Publication	Publication Date	Title
BR9708706B1 (pt)	2013-08-06	composiÇço farmacÊutica para administraÇço intravenosa a um paciente
MX9101175A (es)	1992-05-04	Composicion farmaceutica para administracion nasal
EE9700241A (et)	1998-04-15	Farmatseutiline kompositsioon transdermaalseks manustamiseks
FI904207A7 (fi)	1990-08-24	Rasvahappo-lääkeainekonjugaatti lääkkeen kuljettamiseksi veri-aivo-est een läpi
DK362189A (da)	1990-01-22	Farmaceutisk praeparat til intravenoes indgift
BR9609645A (pt)	1999-02-17	Inalador para a administração de medicamentos a partir de embalagens de ampola
EP0873749A4 (en)	2002-04-24	GELLED PRODUCTS FOR ORAL ADMINISTRATION
EE200000395A (et)	2002-02-15	Peroraalne farmatseutiline pulseeriva vabanemisega annusvorm
IL115097A0 (en)	1996-01-19	Pharmaceutical compositions adapted for oral administration
FI950947L (fi)	1995-09-03	Oraalisesti annettavat farmaseuttiset formulaatiot
FI955310L (fi)	1996-05-09	Farmaseuttinen koostumus flavonoidien antamiseksi oraalisesti
IL127572A (en)	2003-04-10	Pharmaceutical composition and medicament for nasal administration
BR9607095A (pt)	1997-11-11	Composto composição farmacêutica e processos para fabricar e para administrar um composto
FI970331A0 (fi)	1997-01-27	Lääkkeen antokoostumus virustenvastaisten aineiden nenään toteutettavaa antoa varten
DK28795A (da)	1995-09-24	Insulinholdigt polymerpræparat til oral administrering af insulin
NO950134D0 (no)	1995-01-13	Formuleringer for oralt administrerte farmasöytiske midler
NO892764L (no)	1990-01-08	Medikamentell administreringsform for droevtyggere.
EP0953359A4 (en)	2001-12-19	PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION
BR9607433A (pt)	1998-05-26	Composição farmacêutica para administração parental
EE04095B1 (et)	2003-08-15	Ketoliidide ja nende farmatseutiliselt vastuvõetavate soolade kasutamine farmatseutiliste kompositsioonide valmistamiseks
IT1223132B (it)	1990-09-12	Composizione farmaceutica per somministrazione nasale
DE19681529D2 (de)	1999-10-14	Pharmazeutische Darreichungsform
PT1117420E (pt)	2002-10-31	Composicoes farmaceuticas baseadas em alfa-ciclodextrina para administracao oral de analogos de lh-rh
AR018092A1 (es)	2001-10-31	Composicion farmaceutica liquida para administracion oral
FI964663A0 (fi)	1996-11-22	Farmaceutisk analgetisk komposition foer lokal administrering

Legal Events

Date	Code	Title	Description
2004-05-04	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2007-10-09	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2008-03-04	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]	Free format text: O EXAME NECESSAARIO DO PEDIDO DE PATENTE
2008-11-11	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2011-10-11	B25D	Requested change of name of applicant approved	Owner name: MERCK SHARP AND DOHME CORP. (US) Free format text: NOME ALTERADO DE: MERCK AND CO., INC.
2013-06-11	B15W	Others matters related to applications: legal action concerning application	Free format text: INPI-52400.033511/2013-21 ORIGEM: JUIZO DA 08A VARA FEDERAL DE BRASILIA PROCESSO NO 21242-78.2013.4.01.3400 ACAO ORDINARIA DE NULIDADE DA DECISAO PROFERIDA PELA ANVISA QUE DENEGOU ANUENCIA PREVIA AO PEDIDO, COM PEDIDO DE TUTELA ANTECIPADA AUTOR: MERCK SHARP AND DOHME CORP. REU: AGENCIA NACIONAL DE VIGILANCIA SANITARIA - ANVISA.
2013-06-25	B15N	Others concerning applications: notification of judicial decision	Free format text: INPI-52400.033511/13 TRIBUNAL REGIONAL FEDERAL DA 1A REGIAO - 008A VARA FEDERAL DE BRASILIA PROCESSO NO. 21242-78.2013.4.01.3400 AUTOR: MERCK SHARP DOHME CORP REU: AGENCIA NACIONAL DE VIGILANCIA SANITARIA - ANVISA DECISAO: ANTE O EXPOSTO, DEFIRO A TUTELA DE URGENCIA PARA DETERMINAR A REMESSA IMEDIATA DO PEDIDO DE PATENTE PI 9708706-8 AO INPI - INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL, BEM COMO O IMEDIATO PROSSEGUIMENTO DO PROCESSO DE CONCESSAO DE PATENTES.
2013-07-02	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2013-08-06	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/08/2013, OBSERVADAS AS CONDICOES LEGAIS.
2013-09-10	B25A	Requested transfer of rights approved
2013-09-24	B25D	Requested change of name of applicant approved
2013-10-08	B22O	Other matters related to patents and certificates of addition of invention: legal action concerning patent	Free format text: INPI-52400.061601/2013 ORIGEM: JUIZO DA 013A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0132345-04.2013.4.02.5101 ACAO DE NULIDADE DAS PATENTES SUBMETIDAS AO MAILBOX (ART. 229, PARAGRAFO UNICO DA LPI); ALTERNATIVAMENTE, A DECRETACAO DA NULIDADE PARCIAL PARA CORRECAO DO PRAZO DE VIGENCIA; SUBSIDIARIAMENTE, CASO SE ENTENDA NAO SER O CASO DE NULIDADE, A CORRECAO DO ATO ADMINISTRATIVO PARA ADEQUACAO DA VIGENCIA DAS PATENTES. AUTOR: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI REU: MERIAL, SCHERING CORPORATION, FLAMEL TECHNOLOGIES E WARNER-LAMBERT COMPANY LLC
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