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BR0208533A - Derivados de sapogenina, sìntese e uso dos mesmos e processos com base em seu uso - Google Patents

Derivados de sapogenina, sìntese e uso dos mesmos e processos com base em seu uso

Info

Publication number
BR0208533A
BR0208533A BR0208533-0A BR0208533A BR0208533A BR 0208533 A BR0208533 A BR 0208533A BR 0208533 A BR0208533 A BR 0208533A BR 0208533 A BR0208533 A BR 0208533A
Authority
BR
Brazil
Prior art keywords
synthesis
cognitive
processes based
derivatives
sapogenin derivatives
Prior art date
Application number
BR0208533-0A
Other languages
English (en)
Inventor
Paul Barraclough
Jim Hanson
Phil Gunning
Daryl Rees
Zongqin Xia
Yaer Hu
Original Assignee
Phytotech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytotech Ltd filed Critical Phytotech Ltd
Publication of BR0208533A publication Critical patent/BR0208533A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

"DERIVADOS DE SAPOGENINA, SìNTESE E USO DOS MESMOS E PROCESSOS COM BASE EM SEU USO". A presente invenção refere-se a certas sapogeninas esteroidais e derivados das mesmas e seu uso no tratamento de disfunção cognitiva, neurodegeneração não-cognitiva, degeneração neuromuscular não-cognitiva e perda de receptores na ausência de danificação cognitiva, neural e neuromuscular. Os processos de síntese, de tratamento e as composições farmacêuticas são também descritos.
BR0208533-0A 2001-03-28 2002-03-28 Derivados de sapogenina, sìntese e uso dos mesmos e processos com base em seu uso BR0208533A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0107822.9A GB0107822D0 (en) 2001-03-28 2001-03-28 Sapogenin derivatives their synthesis and use methods based upon their use
PCT/GB2002/001578 WO2002079221A2 (en) 2001-03-28 2002-03-28 Sapogenin derivatives, their synthesis and use

Publications (1)

Publication Number Publication Date
BR0208533A true BR0208533A (pt) 2004-04-20

Family

ID=9911795

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208533-0A BR0208533A (pt) 2001-03-28 2002-03-28 Derivados de sapogenina, sìntese e uso dos mesmos e processos com base em seu uso

Country Status (24)

Country Link
US (1) US20040147495A1 (pt)
EP (1) EP1383787B1 (pt)
JP (1) JP2004525945A (pt)
KR (1) KR20040007479A (pt)
CN (1) CN1678325A (pt)
AR (2) AR033079A1 (pt)
AT (1) ATE416185T1 (pt)
AU (1) AU2002242894B2 (pt)
BR (1) BR0208533A (pt)
CA (1) CA2442150A1 (pt)
CZ (1) CZ20032620A3 (pt)
GB (1) GB0107822D0 (pt)
HR (1) HRP20030770A2 (pt)
IL (1) IL158115A0 (pt)
MX (1) MXPA03008800A (pt)
NO (1) NO20034364L (pt)
NZ (1) NZ529136A (pt)
PE (1) PE20021042A1 (pt)
PL (1) PL364825A1 (pt)
RU (1) RU2311423C2 (pt)
TR (2) TR200301613T2 (pt)
UA (1) UA78696C2 (pt)
WO (1) WO2002079221A2 (pt)
ZA (2) ZA200307478B (pt)

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CN104177469A (zh) * 2013-05-28 2014-12-03 江苏柯菲平医药有限公司 一种知母中菝葜皂苷元衍生物的制备方法
CN104324038B (zh) * 2013-07-24 2018-11-06 四川京华创生物科技有限公司 一种薯蓣皂苷元-3-位衍生物的用途
WO2015195967A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
BR122021005552B1 (pt) 2015-07-06 2024-01-02 Sage Therapeutics, Inc Compostos oxiesteróis, seus usos e composição farmacêutica
WO2017007832A1 (en) 2015-07-06 2017-01-12 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
AU2016289971C1 (en) 2015-07-06 2022-12-08 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
EP3436022B1 (en) 2016-04-01 2022-03-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
PT3481846T (pt) 2016-07-07 2021-08-13 Sage Therapeutics Inc 24-hidroxiesteroides 11-substituídos para utilização no tratamento de afeções relacionadas com nmda
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RU2019115112A (ru) 2016-10-18 2020-11-24 Сейдж Терапьютикс, Инк. Оксистеролы и способы их применения
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Also Published As

Publication number Publication date
US20040147495A1 (en) 2004-07-29
NO20034364D0 (no) 2003-09-29
ZA200407460B (en) 2009-09-30
KR20040007479A (ko) 2004-01-24
AR033079A1 (es) 2003-12-03
EP1383787B1 (en) 2008-12-03
HRP20030770A2 (en) 2005-08-31
NO20034364L (no) 2003-11-28
PL364825A1 (en) 2004-12-27
GB0107822D0 (en) 2001-05-23
CA2442150A1 (en) 2002-10-10
WO2002079221A3 (en) 2003-04-17
RU2003131883A (ru) 2005-05-10
TR200301613T2 (tr) 2004-08-23
AR040402A1 (es) 2005-04-06
EP1383787A2 (en) 2004-01-28
IL158115A0 (en) 2004-03-28
JP2004525945A (ja) 2004-08-26
RU2311423C2 (ru) 2007-11-27
NZ529136A (en) 2005-12-23
PE20021042A1 (es) 2002-11-19
TR200700134T1 (tr) 2007-02-21
CZ20032620A3 (cs) 2004-04-14
CN1678325A (zh) 2005-10-05
UA78696C2 (en) 2007-04-25
AU2002242894B2 (en) 2008-08-21
WO2002079221A2 (en) 2002-10-10
ATE416185T1 (de) 2008-12-15
ZA200307478B (en) 2009-04-29
MXPA03008800A (es) 2004-10-15

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