NO20034364L - Sapogenin-derivater, deres syntese og anvendelse samt metoder basert pa deres anvendelse - Google Patents

Sapogenin-derivater, deres syntese og anvendelse samt metoder basert pa deres anvendelse

Info

Publication number: NO20034364L
Authority: NO; Norway
Prior art keywords: synthesis; methods based; sapogenin derivatives; sapogenin; derivatives
Prior art date: 2001-03-28

Application number

NO20034364A

Other languages

English (en)

Other versions

NO20034364D0 (no

Inventor

Zongqin Xia

Yaer Hu

Paul Barraclough

Jim Hanson

Phil Gunning

Daryl Rees

Original Assignee

Phytotech Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-28

Filing date

2003-09-29

Publication date

2003-11-28

2003-09-29 Application filed by Phytotech Ltd filed Critical Phytotech Ltd

2003-09-29 Publication of NO20034364D0 publication Critical patent/NO20034364D0/no

2003-11-28 Publication of NO20034364L publication Critical patent/NO20034364L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Nutrition Science (AREA)
Hematology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO20034364A 2001-03-28 2003-09-29 Sapogenin-derivater, deres syntese og anvendelse samt metoder basert pa deres anvendelse NO20034364L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0107822.9A GB0107822D0 (en)	2001-03-28	2001-03-28	Sapogenin derivatives their synthesis and use methods based upon their use
ARP020101170A AR033079A1 (es)	2001-03-28	2002-03-27	Derivados de sapogeninas, sintesis y uso, y metodos en base a su uso
PCT/GB2002/001578 WO2002079221A2 (en)	2001-03-28	2002-03-28	Sapogenin derivatives, their synthesis and use

Publications (2)

Publication Number	Publication Date
NO20034364D0 NO20034364D0 (no)	2003-09-29
NO20034364L true NO20034364L (no)	2003-11-28

Family

ID=9911795

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20034364A NO20034364L (no)	2001-03-28	2003-09-29	Sapogenin-derivater, deres syntese og anvendelse samt metoder basert pa deres anvendelse

Country Status (24)

Country	Link
US (1)	US20040147495A1 (no)
EP (1)	EP1383787B1 (no)
JP (1)	JP2004525945A (no)
KR (1)	KR20040007479A (no)
CN (1)	CN1678325A (no)
AR (2)	AR033079A1 (no)
AT (1)	ATE416185T1 (no)
AU (1)	AU2002242894B2 (no)
BR (1)	BR0208533A (no)
CA (1)	CA2442150A1 (no)
CZ (1)	CZ20032620A3 (no)
GB (1)	GB0107822D0 (no)
HR (1)	HRP20030770A2 (no)
IL (1)	IL158115A0 (no)
MX (1)	MXPA03008800A (no)
NO (1)	NO20034364L (no)
NZ (1)	NZ529136A (no)
PE (1)	PE20021042A1 (no)
PL (1)	PL364825A1 (no)
RU (1)	RU2311423C2 (no)
TR (2)	TR200700134T1 (no)
UA (1)	UA78696C2 (no)
WO (1)	WO2002079221A2 (no)
ZA (2)	ZA200307478B (no)

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HRP20041009A2 (en) *	2002-03-27	2004-12-31	Phytopharm Plc	Theraputic methods and uses of sapogenins and their derivatives
AU2003224308A1 (en) *	2002-10-28	2004-05-13	Phytotech Limited	Stereospecific reduction of sapogen-3-ones
GB0409567D0 (en)	2004-04-28	2004-06-02	Phytopharm Plc	Chemical compounds
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GB0424528D0 (en)	2004-11-05	2004-12-08	Phytopharm Plc	Chemical compounds
MX2011007842A (es)	2009-01-24	2012-01-12	Phytopharm Plc	Tratamiento de trastornos mediados por factores neurotroficos.
CN101768202B (zh) *	2009-02-18	2013-10-30	沈阳药科大学	知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途
US20130210786A1 (en)	2010-07-20	2013-08-15	Patrick Alexander Howson	Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders
TWI422378B (zh) *	2010-11-18	2014-01-11	Univ Chung Shan Medical	使用薯蕷皂素來改善與停經期症候群有關聯的認知缺陷
HUE062616T2 (hu)	2011-09-08	2023-11-28	Sage Therapeutics Inc	Neuroaktív szteroidok, készítmények és alkalmazásaik
CU20110244A7 (es) *	2011-12-27	2013-08-29	Ct De Investigación Y Desarrollo De Medicamentos Cidem	Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
RU2684103C2 (ru)	2013-03-13	2019-04-04	Сейдж Терапьютикс, Инк.	Нейроактивные стероиды и способы их применения
KR101480982B1 (ko) *	2013-03-20	2015-02-03	(주)셀인바이오	골형성 유도 화합물 및 이의 응용
CN104177469A (zh) *	2013-05-28	2014-12-03	江苏柯菲平医药有限公司	一种知母中菝葜皂苷元衍生物的制备方法
CN104324038B (zh) *	2013-07-24	2018-11-06	四川京华创生物科技有限公司	一种薯蓣皂苷元-3-位衍生物的用途
US10259840B2 (en)	2014-06-18	2019-04-16	Sage Therapeutics, Inc.	Oxysterols and methods of use thereof
EP4609866A3 (en)	2015-07-06	2025-10-22	Sage Therapeutics, Inc.	Oxysterols and methods of use thereof
WO2017007832A1 (en)	2015-07-06	2017-01-12	Sage Therapeutics, Inc.	Oxysterols and methods of use thereof
PL3319612T3 (pl)	2015-07-06	2021-12-20	Sage Therapeutics, Inc.	Oksysterole i sposoby ich stosowania
RU2754130C2 (ru)	2016-04-01	2021-08-27	Сейдж Терапьютикс, Инк.	Оксистеролы и способы их применения
US10752653B2 (en)	2016-05-06	2020-08-25	Sage Therapeutics, Inc.	Oxysterols and methods of use thereof
CA3029900A1 (en)	2016-07-07	2018-01-11	Sage Therapeutics, Inc.	Oxysterols and methods of use thereof
MA46351A (fr)	2016-09-30	2021-06-02	Sage Therapeutics Inc	Oxystérols substitués en c7 et procédés en tant que modulateurs nmda
TWI836485B (zh)	2016-10-18	2024-03-21	美商賽吉醫療公司	氧固醇(oxysterol)及其使用方法
JP7118957B2 (ja)	2016-10-18	2022-08-16	セージセラピューティクス，インコーポレイテッド	オキシステロールおよびその使用方法
CN109053854B (zh) *	2018-09-29	2021-05-14	深圳清博汇能医药科技有限公司	基于知母菝契皂苷元结构的衍生物、药物组合物及其应用

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2001
- 2001-03-28 GB GBGB0107822.9A patent/GB0107822D0/en not_active Ceased
2002
- 2002-03-27 AR ARP020101170A patent/AR033079A1/es unknown
- 2002-03-27 PE PE2002000253A patent/PE20021042A1/es not_active Application Discontinuation
- 2002-03-28 CZ CZ20032620A patent/CZ20032620A3/cs unknown
- 2002-03-28 TR TR2007/00134T patent/TR200700134T1/xx unknown
- 2002-03-28 TR TR2003/01613T patent/TR200301613T2/xx unknown
- 2002-03-28 CA CA002442150A patent/CA2442150A1/en not_active Abandoned
- 2002-03-28 HR HR20030770A patent/HRP20030770A2/hr not_active Application Discontinuation
- 2002-03-28 JP JP2002577845A patent/JP2004525945A/ja active Pending
- 2002-03-28 US US10/472,892 patent/US20040147495A1/en not_active Abandoned
- 2002-03-28 NZ NZ529136A patent/NZ529136A/en unknown
- 2002-03-28 PL PL02364825A patent/PL364825A1/xx unknown
- 2002-03-28 BR BR0208533-0A patent/BR0208533A/pt not_active IP Right Cessation
- 2002-03-28 WO PCT/GB2002/001578 patent/WO2002079221A2/en not_active Ceased
- 2002-03-28 CN CNA028074270A patent/CN1678325A/zh active Pending
- 2002-03-28 AU AU2002242894A patent/AU2002242894B2/en not_active Ceased
- 2002-03-28 RU RU2003131883/04A patent/RU2311423C2/ru not_active IP Right Cessation
- 2002-03-28 MX MXPA03008800A patent/MXPA03008800A/es unknown
- 2002-03-28 UA UA2003108904A patent/UA78696C2/uk unknown
- 2002-03-28 KR KR10-2003-7012755A patent/KR20040007479A/ko not_active Ceased
- 2002-03-28 IL IL15811502A patent/IL158115A0/xx unknown
- 2002-03-28 AT AT02708534T patent/ATE416185T1/de not_active IP Right Cessation
- 2002-03-28 EP EP02708534A patent/EP1383787B1/en not_active Expired - Lifetime
2003
- 2003-03-27 AR AR20030101078A patent/AR040402A1/es unknown
- 2003-09-25 ZA ZA200307478A patent/ZA200307478B/xx unknown
- 2003-09-29 NO NO20034364A patent/NO20034364L/no not_active Application Discontinuation
2004
- 2004-09-16 ZA ZA200407460A patent/ZA200407460B/xx unknown

Also Published As

Publication number	Publication date
NO20034364D0 (no)	2003-09-29
AU2002242894B2 (en)	2008-08-21
HRP20030770A2 (en)	2005-08-31
ATE416185T1 (de)	2008-12-15
CN1678325A (zh)	2005-10-05
ZA200407460B (en)	2009-09-30
EP1383787A2 (en)	2004-01-28
AR040402A1 (es)	2005-04-06
ZA200307478B (en)	2009-04-29
TR200301613T2 (tr)	2004-08-23
RU2311423C2 (ru)	2007-11-27
MXPA03008800A (es)	2004-10-15
KR20040007479A (ko)	2004-01-24
US20040147495A1 (en)	2004-07-29
RU2003131883A (ru)	2005-05-10
UA78696C2 (en)	2007-04-25
EP1383787B1 (en)	2008-12-03
IL158115A0 (en)	2004-03-28
PL364825A1 (en)	2004-12-27
GB0107822D0 (en)	2001-05-23
CA2442150A1 (en)	2002-10-10
NZ529136A (en)	2005-12-23
AR033079A1 (es)	2003-12-03
PE20021042A1 (es)	2002-11-19
TR200700134T1 (tr)	2007-02-21
WO2002079221A2 (en)	2002-10-10
WO2002079221A3 (en)	2003-04-17
BR0208533A (pt)	2004-04-20
CZ20032620A3 (cs)	2004-04-14
JP2004525945A (ja)	2004-08-26

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NO20034364L (no)	2003-11-28	Sapogenin-derivater, deres syntese og anvendelse samt metoder basert pa deres anvendelse
DK1455785T3 (da)	2009-06-08	Substituerede 2-thio-3,5-dicyano-4-phenyl-6-aminopyridiner og deres anvendelse
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DK1556382T3 (da)	2008-10-06	3-Phenylpyridoindolderivater, fremstilling og terapeutisk anvendelse deraf
DE60227657D1 (de)	2008-08-28	1-OXA-3,9-DIAZASPIROc5.5ÜUNDECAN-2-ONDERIVATE UND ZEPTORS
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