AR062798A1 - Derivados de hexahidropirrolo[3,4-c]pirrol antiviricos - Google Patents
Derivados de hexahidropirrolo[3,4-c]pirrol antiviricosInfo
- Publication number
- AR062798A1 AR062798A1 ARP070104100A ARP070104100A AR062798A1 AR 062798 A1 AR062798 A1 AR 062798A1 AR P070104100 A ARP070104100 A AR P070104100A AR P070104100 A ARP070104100 A AR P070104100A AR 062798 A1 AR062798 A1 AR 062798A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- phenyl
- haloalkyl
- alkoxy
- Prior art date
Links
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 13
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 4
- -1 (q) C4-6-cycloalkyl Chemical group 0.000 abstract 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical group C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000003973 alkyl amines Chemical class 0.000 abstract 2
- 125000002785 azepinyl group Chemical group 0.000 abstract 2
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Chemical group C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicacion 1: Un compuesto de la formula 1 en la que R1 se elige entre el grupo formado por (a) fenilo, (b) piridinilo, (c) pirimidinilo, cada uno está opcionalmente sustituido por alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, hidroxi, ciano, NHSO2-alquilo C1-6, SO2NR9aR10a, -NR9bR10b y halogeno, y (d) formula (5); en la que R8 es cicloalquilo C3-7, fenilo o heteroarilo elegido entre el grupo formado por piridina, pirimidina, pirazina y piridazina, dicho heteroarilo o dicho fenilo están opcionalmente sustituidos por alquilo C1-3 o haloalquilo C1-3; uno de R2 y R3 es hidrogeno y el otro de R2 y R3 es formula (2), formula (3) o formula (4), o bien R2 y R3 juntos son (CH2)mR4(CH2)n; en el que m y n con independencia entre sí son el numero 1 o 2; R4 es alquilo C1-6, haloalquilo C1-6, CH2C:::N, C(=O)R5 o -SO2R5; R5 es (a) alquilo C1-6, (b) cicloalquilo C3-6 sustituido opcionalmente y con independencia por uno o dos alquiloC1-6, halogeno, hidroxi, ciano, oxo o haloalquilo C1-6, (c) haloalquilo C1-6, (d) hidroxialquilo C1-6, ( e) alcoxi C1-3-alquilo C1-3, (f) cicloalquil C3-6-alquilo C1-6, (g) alcoxi C1-6, (h) amino, (i) alquil C1-6-amino, (j) di-alquil C1-6-amino, (k) cicloalquil C3-6-amino, (l) fenil-alquilo C1-3 o (m) fenilo, dicho fenilo está opcionalmente sustituido de 1 a 3 veces por restos elegidos con independencia de cada aparicion entre el grupo formado por alquilo C1-6, alcoxi C1-6, halogeno, SO2NR6aR6b y -NHSO2-alquilo C1-6; (n) tetrahidropiranilo, (o) tetrahidrofuranilo; (p) cicloalcoxi sustituido opcionalmente y con independencia por 1 o 2 halogeno, hidroxi u oxo, (q) cicloalquil C4-6-amino, ( r) tetrahidropiranil-metilo, (s) piridinilo o (t) cianometilo; R6a y R6b son con independencia H, alquilo C1-6 o acilo C1-6; R7 es H o alquilo C1-3; R9a y R10a son: (i) tornados de modo independiente, uno de R9a y R10a es hidrogeno o alquilo C1-6, y el otro de R9a y R10a se elige entre el grupo formado por hidrogeno, alquilo C1-6, y -C(=O)R7; (ii) tomados junto con el átomo de hidrogeno al que están unidos, forman un anillo de azetidina, pirrolidina, piperidina o azepina, dicho anillo de azetidina, pirrolidina, piperidina o azepina está opcionalmente sustituido por hidroxi, amino, alquil C1-3-amina o di-alquil C1-3-amina; o, (iii) tomados juntos son (CH2)2-X-(CH2)2; R9b tiene la misma definicion que R9a y R10b tiene la misma definicion que R10a, R11 es H, alquilo C1-6 o acilo C1-6; X es O, S(O)p o NR11, en el que p es un numero entero de 0 a 2; Ar es fenilo opcionalmente sustituido de una a tres veces por sustituyentes elegidos con independencia de cada aparicion entre el grupo formado por halogeno, alquilo C1-6, alcoxi C1-6,ciano y nitro; m y n son con independencia el numero uno o dos; y las sales farmacéuticamente aceptables del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84533406P | 2006-09-18 | 2006-09-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR062798A1 true AR062798A1 (es) | 2008-12-03 |
Family
ID=38787632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104100A AR062798A1 (es) | 2006-09-18 | 2007-09-17 | Derivados de hexahidropirrolo[3,4-c]pirrol antiviricos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7625905B2 (es) |
| EP (1) | EP2066674B1 (es) |
| JP (1) | JP2010503714A (es) |
| CN (1) | CN101516884A (es) |
| AR (1) | AR062798A1 (es) |
| AT (1) | ATE472549T1 (es) |
| CA (1) | CA2662835A1 (es) |
| CL (1) | CL2007002671A1 (es) |
| DE (1) | DE602007007497D1 (es) |
| ES (1) | ES2345130T3 (es) |
| PE (1) | PE20081375A1 (es) |
| TW (1) | TW200821311A (es) |
| WO (1) | WO2008034731A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8680275B2 (en) | 2009-10-23 | 2014-03-25 | Janssen Pharmaceutica Nv | Fused heterocyclic compounds as orexin receptor modulators |
| US8653263B2 (en) | 2009-10-23 | 2014-02-18 | Janssen Pharmaceutica | Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators |
| US9062044B2 (en) | 2009-10-23 | 2015-06-23 | Janssen Pharmaceutica Nv | Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators |
| WO2012145581A1 (en) | 2011-04-20 | 2012-10-26 | Janssen Pharmaceutica Nv | Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators |
| ES2609817T3 (es) | 2011-06-19 | 2017-04-24 | New York University | Leucotoxina E/D como nuevo agente antiinflamatorio y microbicida |
| EA037928B1 (ru) * | 2014-03-26 | 2021-06-08 | Ф. Хоффманн-Ля Рош Аг | Бициклические соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| ES2686326T3 (es) | 2014-07-15 | 2018-10-17 | Grünenthal GmbH | Derivados de azaspiro(4,5)decano sustituidos |
| CR20180058A (es) | 2015-09-04 | 2018-02-26 | Hoffmann La Roche | Nuevos derivados de fenoximetilo |
| BR112018067906A2 (pt) | 2016-03-10 | 2019-01-29 | Janssen Pharmaceutica Nv | métodos de tratamento de depressão usando antagonistas do receptor de orexina-2 |
| EP3596060B1 (en) | 2017-03-16 | 2023-09-20 | F. Hoffmann-La Roche AG | New bicyclic compounds as atx inhibitors |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002070523A1 (en) * | 2001-03-07 | 2002-09-12 | Pfizer Products Inc. | Modulators of chemokine receptor activity |
| ATE402176T1 (de) * | 2002-12-13 | 2008-08-15 | Smithkline Beecham Corp | Pyrrolidin- und azetidinverbindungen alsccr5- antagonisten |
| CA2509711A1 (en) * | 2002-12-13 | 2004-07-01 | Smithkline Beecham Corporation | Piperidine derivatives as ccr5 antagonists |
| CA2573951A1 (en) * | 2003-07-18 | 2005-01-27 | Virochem Pharma Inc. | Spiro compounds and methods for the modulation of chemokine receptor activity |
| DE602004006424T2 (de) | 2003-07-31 | 2008-05-15 | Astrazeneca Ab | Piperidinderivate als ccr5-rezeptormodulatoren |
| TW200610761A (en) * | 2004-04-23 | 2006-04-01 | Astrazeneca Ab | Chemical compounds |
| PT1761542E (pt) | 2004-06-09 | 2008-03-26 | Hoffmann La Roche | Derivados de octa-hidro-pirrolo[3,4-c) pirrole e o seu uso com agentes antivirais |
| SE0401657D0 (sv) | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | Chemical compounds |
| SE0403106D0 (sv) | 2004-12-20 | 2004-12-20 | Astrazeneca Ab | Chemical compounds |
| RU2008136756A (ru) | 2006-02-15 | 2010-03-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | Гетеробициклические противовирусные соединения |
| JP2009526802A (ja) | 2006-02-15 | 2009-07-23 | エフ．ホフマン−ラ ロシュ アーゲー | 抗ウイルス性複素環式化合物 |
-
2007
- 2007-09-10 DE DE602007007497T patent/DE602007007497D1/de active Active
- 2007-09-10 AT AT07803370T patent/ATE472549T1/de active
- 2007-09-10 JP JP2009528674A patent/JP2010503714A/ja active Pending
- 2007-09-10 WO PCT/EP2007/059453 patent/WO2008034731A1/en not_active Ceased
- 2007-09-10 CA CA002662835A patent/CA2662835A1/en not_active Abandoned
- 2007-09-10 CN CNA2007800345664A patent/CN101516884A/zh active Pending
- 2007-09-10 ES ES07803370T patent/ES2345130T3/es active Active
- 2007-09-10 EP EP07803370A patent/EP2066674B1/en not_active Not-in-force
- 2007-09-14 TW TW096134628A patent/TW200821311A/zh unknown
- 2007-09-14 CL CL200702671A patent/CL2007002671A1/es unknown
- 2007-09-17 AR ARP070104100A patent/AR062798A1/es unknown
- 2007-09-17 PE PE2007001255A patent/PE20081375A1/es not_active Application Discontinuation
- 2007-09-18 US US11/901,498 patent/US7625905B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7625905B2 (en) | 2009-12-01 |
| CL2007002671A1 (es) | 2008-04-18 |
| CN101516884A (zh) | 2009-08-26 |
| WO2008034731A1 (en) | 2008-03-27 |
| TW200821311A (en) | 2008-05-16 |
| PE20081375A1 (es) | 2008-10-17 |
| DE602007007497D1 (de) | 2010-08-12 |
| EP2066674A1 (en) | 2009-06-10 |
| US20080103125A1 (en) | 2008-05-01 |
| ES2345130T3 (es) | 2010-09-15 |
| EP2066674B1 (en) | 2010-06-30 |
| ATE472549T1 (de) | 2010-07-15 |
| CA2662835A1 (en) | 2008-03-27 |
| JP2010503714A (ja) | 2010-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |