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AR053890A1 - Proceso para la sintesis de derivados de piridinil-pirimidinilo - Google Patents

Proceso para la sintesis de derivados de piridinil-pirimidinilo

Info

Publication number
AR053890A1
AR053890A1 ARP060102369A ARP060102369A AR053890A1 AR 053890 A1 AR053890 A1 AR 053890A1 AR P060102369 A ARP060102369 A AR P060102369A AR P060102369 A ARP060102369 A AR P060102369A AR 053890 A1 AR053890 A1 AR 053890A1
Authority
AR
Argentina
Prior art keywords
piridinil
synthesis
lower alkyl
pyrimidinyl derivatives
phenyl
Prior art date
Application number
ARP060102369A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR053890A1 publication Critical patent/AR053890A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Reivindicacion 1: Un proceso para la preparacion de compuestos de la formula (1) el cual comprende hacer reaccionar el compuesto de la formula (2) con R1-NH-R2, en donde: R1 es arilo sustituido o insustituido; R2 es H, alquilo inferior, o arilo; R4 es H, alquilo inferior, o halogeno; y R3 es alquilo inferior, fenilo, fenil-alquilo inferior, o fenilo sustituido, y en donde el proceso se cataliza mediante una base en un solvente orgánico.
ARP060102369A 2005-06-09 2006-06-07 Proceso para la sintesis de derivados de piridinil-pirimidinilo AR053890A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68897705P 2005-06-09 2005-06-09
US70559005P 2005-08-04 2005-08-04

Publications (1)

Publication Number Publication Date
AR053890A1 true AR053890A1 (es) 2007-05-23

Family

ID=37091153

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060102369A AR053890A1 (es) 2005-06-09 2006-06-07 Proceso para la sintesis de derivados de piridinil-pirimidinilo

Country Status (31)

Country Link
US (2) US8124763B2 (es)
EP (1) EP1924574B1 (es)
JP (1) JP5118024B2 (es)
KR (3) KR101216249B1 (es)
AR (1) AR053890A1 (es)
AT (1) ATE487709T1 (es)
AU (1) AU2006258051B2 (es)
BR (1) BRPI0611663A2 (es)
CA (1) CA2610105C (es)
CY (1) CY1111428T1 (es)
DE (1) DE602006018156D1 (es)
DK (1) DK1924574T3 (es)
EC (1) ECSP077982A (es)
EG (1) EG25039A (es)
GT (1) GT200600217A (es)
IL (1) IL187421A (es)
JO (1) JO2636B1 (es)
MA (1) MA29599B1 (es)
MX (1) MX2007015423A (es)
MY (1) MY147436A (es)
NO (1) NO340743B1 (es)
NZ (1) NZ563740A (es)
PE (1) PE20070015A1 (es)
PL (1) PL1924574T3 (es)
PT (1) PT1924574E (es)
RU (1) RU2444520C2 (es)
SA (1) SA06270147B1 (es)
SI (1) SI1924574T1 (es)
TN (1) TNSN07463A1 (es)
TW (1) TWI430999B (es)
WO (1) WO2006135641A2 (es)

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EP2152079A4 (en) 2007-06-04 2011-03-09 Avila Therapeutics Inc HETEROCYCLIC COMPOUNDS AND USES THEREOF
EP2305667A3 (en) 2008-07-17 2011-05-11 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
ES2394258T3 (es) 2008-11-05 2013-01-30 Teva Pharmaceutical Industries Ltd. Formas cristalinas de Nilotinib HCL
WO2010060074A1 (en) * 2008-11-24 2010-05-27 Teva Pharmaceutical Industries Ltd. Preparation of nilotinib and intermediates thereof
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
JO3634B1 (ar) 2009-11-17 2020-08-27 Novartis Ag طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r
MX2013010977A (es) 2011-03-31 2013-10-30 Procter & Gamble Sistema, modelos y metodos para identificar y evaluar agentes dermoactivos eficaces para tratar la caspa/dermatitis seborreica.
AR086913A1 (es) * 2011-06-14 2014-01-29 Novartis Ag 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida amorfa, forma de dosificacion que la contiene y metodo para prepararlas
GB2514285B (en) 2012-02-13 2018-07-18 Grindeks Jsc Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors
JP2015527630A (ja) 2012-06-06 2015-09-17 ザ プロクター アンド ギャンブルカンパニー ヘア／頭皮ケア組成物向け化粧剤の同定システム及び方法
WO2015092624A1 (en) 2013-12-16 2015-06-25 Ranbaxy Laboratories Limited Nilotinib mono-oxalate and its crystalline form
CN103694176B (zh) 2014-01-07 2015-02-18 苏州立新制药有限公司 尼洛替尼中间体的制备方法
EP3095782A1 (en) 2015-05-18 2016-11-23 Esteve Química, S.A. New method for preparing 3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)benzenamine
CN111683976B (zh) 2018-02-05 2022-11-18 生物辐射实验室股份有限公司 具有阴离子交换-疏水混合模式配体的色谱树脂
TWI770624B (zh) 2018-06-15 2022-07-11 漢達生技醫藥股份有限公司 尼洛替尼十二烷基硫酸鹽在製備用於治療慢性骨髓性白血病之劑型的用途
JP2020007240A (ja) * 2018-07-04 2020-01-16 住友化学株式会社 ベンズアミド化合物の製造方法

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AU5539294A (en) 1992-12-24 1994-07-19 Hemagen/Pfc Fluorocarbon emulsions
TW406020B (en) 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
US5597829A (en) 1994-05-09 1997-01-28 Bionumerik Pharmaceuticals, Inc. Lactone stable formulation of camptothecin and methods for uses thereof
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US6323366B1 (en) 1997-07-29 2001-11-27 Massachusetts Institute Of Technology Arylamine synthesis
AR013261A1 (es) 1997-08-01 2000-12-13 Smithkline Beecham Corp Formulaciones farmaceuticas para analogos de camptotecina en capsula de gelatina
US20030059465A1 (en) 1998-05-11 2003-03-27 Unger Evan C. Stabilized nanoparticle formulations of camptotheca derivatives
US6395916B1 (en) * 1998-07-10 2002-05-28 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
SI1044977T1 (en) 1999-03-09 2002-08-31 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Camptothecin derivatives having antitumor activity
IT1306129B1 (it) 1999-04-13 2001-05-30 Sigma Tau Ind Farmaceuti Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
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JP4426749B2 (ja) 2002-07-11 2010-03-03 株式会社産学連携機構九州 Ｏ／ｗ型エマルション製剤
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JP2006199590A (ja) 2003-09-04 2006-08-03 Nano Career Kk 水溶性の塩基性薬物内包ナノ粒子含有組成物
JP2007509978A (ja) 2003-10-29 2007-04-19 ソーナス ファーマシューティカルズ， インコーポレイテッド トコフェロール修飾治療薬化合物
CA2548078C (en) 2003-12-17 2009-05-12 Bionumerik Pharmaceuticals, Inc. Pharmaceutical formulations of camptothecins and process for making same
GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos

Also Published As

Publication number Publication date
GT200600217A (es) 2007-03-28
JP2008545786A (ja) 2008-12-18
TNSN07463A1 (en) 2009-03-17
KR20120066067A (ko) 2012-06-21
EG25039A (en) 2011-07-06
CA2610105C (en) 2014-03-25
KR101216249B1 (ko) 2012-12-28
SA06270147B1 (ar) 2009-12-22
AU2006258051A1 (en) 2006-12-21
BRPI0611663A2 (pt) 2010-09-28
NO340743B1 (no) 2017-06-12
PE20070015A1 (es) 2007-02-06
IL187421A0 (en) 2008-02-09
KR20080022093A (ko) 2008-03-10
MY147436A (en) 2012-12-14
ATE487709T1 (de) 2010-11-15
NO20080157L (no) 2008-01-09
KR20130118394A (ko) 2013-10-29
DK1924574T3 (da) 2011-02-14
JP5118024B2 (ja) 2013-01-16
US20080188656A1 (en) 2008-08-07
WO2006135641A3 (en) 2007-03-29
WO2006135641A2 (en) 2006-12-21
TWI430999B (zh) 2014-03-21
EP1924574A2 (en) 2008-05-28
MX2007015423A (es) 2008-02-21
HK1117524A1 (en) 2009-01-16
CA2610105A1 (en) 2006-12-21
TW200726756A (en) 2007-07-16
RU2007148231A (ru) 2009-07-20
KR101514593B1 (ko) 2015-04-22
NZ563740A (en) 2011-03-31
SI1924574T1 (sl) 2011-02-28
EP1924574B1 (en) 2010-11-10
IL187421A (en) 2011-11-30
DE602006018156D1 (de) 2010-12-23
JO2636B1 (en) 2012-06-17
AU2006258051B2 (en) 2010-09-09
US8946416B2 (en) 2015-02-03
MA29599B1 (fr) 2008-07-01
PT1924574E (pt) 2011-02-08
RU2444520C2 (ru) 2012-03-10
CY1111428T1 (el) 2015-08-05
ECSP077982A (es) 2008-01-23
PL1924574T3 (pl) 2011-04-29
US8124763B2 (en) 2012-02-28
US20120116081A1 (en) 2012-05-10

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