AR054392A1 - Hemifumarato de 6- cloro-5-(2,6-difluoro-4-(3-(metilamino) proxi) fenil)-2-pirazin-2-il-n-((1s)-2,2,2-trifluoro-1-metiletil) pirimidin -4- amina, procesos para su preparcion, compuesto del hemifumarato, metodo para tratar o inhibir el crecimiento de celulas de tumor cancerosas y enfermedades asociad - Google Patents
Hemifumarato de 6- cloro-5-(2,6-difluoro-4-(3-(metilamino) proxi) fenil)-2-pirazin-2-il-n-((1s)-2,2,2-trifluoro-1-metiletil) pirimidin -4- amina, procesos para su preparcion, compuesto del hemifumarato, metodo para tratar o inhibir el crecimiento de celulas de tumor cancerosas y enfermedades asociadInfo
- Publication number
- AR054392A1 AR054392A1 ARP060102470A ARP060102470A AR054392A1 AR 054392 A1 AR054392 A1 AR 054392A1 AR P060102470 A ARP060102470 A AR P060102470A AR P060102470 A ARP060102470 A AR P060102470A AR 054392 A1 AR054392 A1 AR 054392A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- phenyl
- hemifumarate
- amine
- reacting
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- OYRRZWATULMEPF-UHFFFAOYSA-N pyrimidin-4-amine Chemical compound NC1=CC=NC=N1 OYRRZWATULMEPF-UHFFFAOYSA-N 0.000 title 1
- 210000004881 tumor cell Anatomy 0.000 title 1
- 239000000010 aprotic solvent Substances 0.000 abstract 5
- 150000001412 amines Chemical class 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 101100313649 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) POT1 gene Proteins 0.000 abstract 1
- 101100161758 Yarrowia lipolytica (strain CLIB 122 / E 150) POX3 gene Proteins 0.000 abstract 1
- 150000001414 amino alcohols Chemical class 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69001605P | 2005-06-13 | 2005-06-13 | |
| US80278106P | 2006-05-24 | 2006-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR054392A1 true AR054392A1 (es) | 2007-06-20 |
Family
ID=37074929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060102470A AR054392A1 (es) | 2005-06-13 | 2006-06-12 | Hemifumarato de 6- cloro-5-(2,6-difluoro-4-(3-(metilamino) proxi) fenil)-2-pirazin-2-il-n-((1s)-2,2,2-trifluoro-1-metiletil) pirimidin -4- amina, procesos para su preparcion, compuesto del hemifumarato, metodo para tratar o inhibir el crecimiento de celulas de tumor cancerosas y enfermedades asociad |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1891052A1 (fr) |
| JP (1) | JP2008543838A (fr) |
| AR (1) | AR054392A1 (fr) |
| AU (1) | AU2006259663A1 (fr) |
| BR (1) | BRPI0612145A2 (fr) |
| CA (1) | CA2610416A1 (fr) |
| GT (1) | GT200600257A (fr) |
| MX (1) | MX2007015718A (fr) |
| PE (1) | PE20070114A1 (fr) |
| SV (1) | SV2007002573A (fr) |
| TW (1) | TW200716613A (fr) |
| WO (1) | WO2006138180A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102648208B (zh) | 2009-11-12 | 2016-04-27 | R&D生技药品有限责任公司 | 微管蛋白抑制剂 |
| US9649317B2 (en) * | 2012-09-19 | 2017-05-16 | The Trustees Of The University Of Pennsylvania | Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies |
| WO2017181974A1 (fr) * | 2016-04-20 | 2017-10-26 | 苏州苏领生物医药有限公司 | Composé hétérocyclique à cinq chaînons, procédé de préparation correspondant, composition pharmaceutique et utilisation |
| US11623927B2 (en) | 2018-03-02 | 2023-04-11 | The Trustees Of The University Of Pennsylvania | Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1663241B1 (fr) * | 2003-09-24 | 2009-05-27 | Wyeth Holdings Corporation | 5-arylpyrimidines utilisees comme agents anticancereux |
| AU2004276240A1 (en) * | 2003-09-24 | 2005-04-07 | Wyeth Holdings Corporation | 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents |
-
2006
- 2006-06-08 BR BRPI0612145-4A patent/BRPI0612145A2/pt not_active Application Discontinuation
- 2006-06-08 AU AU2006259663A patent/AU2006259663A1/en not_active Abandoned
- 2006-06-08 EP EP06784720A patent/EP1891052A1/fr not_active Withdrawn
- 2006-06-08 MX MX2007015718A patent/MX2007015718A/es not_active Application Discontinuation
- 2006-06-08 CA CA002610416A patent/CA2610416A1/fr not_active Abandoned
- 2006-06-08 WO PCT/US2006/022574 patent/WO2006138180A1/fr not_active Ceased
- 2006-06-08 JP JP2008516956A patent/JP2008543838A/ja not_active Withdrawn
- 2006-06-12 AR ARP060102470A patent/AR054392A1/es unknown
- 2006-06-12 TW TW095120855A patent/TW200716613A/zh unknown
- 2006-06-13 SV SV2006002573A patent/SV2007002573A/es not_active Application Discontinuation
- 2006-06-13 GT GT200600257A patent/GT200600257A/es unknown
- 2006-06-13 PE PE2006000657A patent/PE20070114A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GT200600257A (es) | 2007-02-14 |
| PE20070114A1 (es) | 2007-02-03 |
| JP2008543838A (ja) | 2008-12-04 |
| SV2007002573A (es) | 2007-01-03 |
| AU2006259663A1 (en) | 2006-12-28 |
| TW200716613A (en) | 2007-05-01 |
| MX2007015718A (es) | 2008-02-21 |
| BRPI0612145A2 (pt) | 2010-10-19 |
| WO2006138180A1 (fr) | 2006-12-28 |
| EP1891052A1 (fr) | 2008-02-27 |
| CA2610416A1 (fr) | 2006-12-28 |
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