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TW200716613A - Tubulin inhibitor and process for its preparation - Google Patents

Tubulin inhibitor and process for its preparation

Info

Publication number
TW200716613A
TW200716613A TW095120855A TW95120855A TW200716613A TW 200716613 A TW200716613 A TW 200716613A TW 095120855 A TW095120855 A TW 095120855A TW 95120855 A TW95120855 A TW 95120855A TW 200716613 A TW200716613 A TW 200716613A
Authority
TW
Taiwan
Prior art keywords
preparation
tubulin inhibitor
hemifumarate
tubulin
pyrazin
Prior art date
Application number
TW095120855A
Other languages
Chinese (zh)
Inventor
David Michael Blum
yan-zhong Wu
Jean Schmid
Timothy John Doyle
Jay Thomas Afragola
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37074929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200716613(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of TW200716613A publication Critical patent/TW200716613A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides 6-chloro-5-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]pyrimidin-4-amine hemifumarate which is a tubulin inhibitor useful in the treatment of cancer and processes of making said hemifumarate.
TW095120855A 2005-06-13 2006-06-12 Tubulin inhibitor and process for its preparation TW200716613A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69001605P 2005-06-13 2005-06-13
US80278106P 2006-05-24 2006-05-24

Publications (1)

Publication Number Publication Date
TW200716613A true TW200716613A (en) 2007-05-01

Family

ID=37074929

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095120855A TW200716613A (en) 2005-06-13 2006-06-12 Tubulin inhibitor and process for its preparation

Country Status (12)

Country Link
EP (1) EP1891052A1 (en)
JP (1) JP2008543838A (en)
AR (1) AR054392A1 (en)
AU (1) AU2006259663A1 (en)
BR (1) BRPI0612145A2 (en)
CA (1) CA2610416A1 (en)
GT (1) GT200600257A (en)
MX (1) MX2007015718A (en)
PE (1) PE20070114A1 (en)
SV (1) SV2007002573A (en)
TW (1) TW200716613A (en)
WO (1) WO2006138180A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9163060B2 (en) 2009-11-12 2015-10-20 R&D Biopharmaceuticals Gmbh Tubulin inhibitors
WO2014047257A2 (en) * 2012-09-19 2014-03-27 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
WO2017181974A1 (en) * 2016-04-20 2017-10-26 苏州苏领生物医药有限公司 Five-membered heterocyclic compound, preparation method therefor, pharmaceutical composition and use
WO2019169111A1 (en) 2018-03-02 2019-09-06 The Trustees Of The University Of Pennsylvania [1,2,4]triazolo[1,5-a]pyrimidine compounds and use in stabilizing microtubules

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0414700A (en) * 2003-09-24 2006-11-14 Wyeth Corp 6 - [(substituted) phenyl] triazolopyrimidines as anti-cancer agents
MXPA06003207A (en) * 2003-09-24 2006-06-23 Wyeth Corp 5-arylpyrimidines as anticancer agents.

Also Published As

Publication number Publication date
WO2006138180A1 (en) 2006-12-28
EP1891052A1 (en) 2008-02-27
GT200600257A (en) 2007-02-14
AU2006259663A1 (en) 2006-12-28
CA2610416A1 (en) 2006-12-28
MX2007015718A (en) 2008-02-21
BRPI0612145A2 (en) 2010-10-19
JP2008543838A (en) 2008-12-04
SV2007002573A (en) 2007-01-03
PE20070114A1 (en) 2007-02-03
AR054392A1 (en) 2007-06-20

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